Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
APAF1 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 5214497 11550094
EIF4G2 APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11943866
XIAP APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11230124 12181739
HSPA5 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
EIF4G2 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18450493
EIF4G2 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14960583
BIRC2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17145710 12887920
CASP1 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18667412
CASP2 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 11399776
CASP2 TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15590671
CASP6 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
CASP9 CASP3 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
CASP3 CASP9 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 12011067 15573119
CASP3 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10672017
CASP3 EIF2S1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10432301 10734073
CASP3 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17899380
CASP6 SMG6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CASP6 CASP7 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
XIAP CASP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9545235 15200957
XIAP CASP7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547707 9525868
CASP9 CASP7 â—¼   CLEAVAGE ✅ 2.0 0.8 intact 0707715105 18723680
HSPA5 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11943137
XIAP CASP9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11242052 5213680
XIAP CASP9 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
CDK1 EIF4G2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 29530922
EIF2S1 EIF4G2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16932749 5219000
EIF2S2 EIF3M â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EIF2S2 EIF3L â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EIF2S2 EIF3H â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EIF2S2 EIF3E â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EIF3A EIF4A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 17353931
EIF3C EIF4G1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EIF3E EIF4G1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EIF3M EIF3H â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18599441 0801313105
EIF3J EIF4G2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16932749 5219000
EIF3M EIF4G1 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EIF4A1 ZC3HAV1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8409681 23023399
EIF4A2 EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17353931
EIF4G1 RPS6 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
EIF4G1 HSPB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10859165 5212678
EIF4G2 SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
EIF4G2 XIAP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11943866
HSPA5 TANK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA5 TRAF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPB1 NGEF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MKNK1 OPTN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TRAF2 TANK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
EIF3J EIF4A1 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
EIF2S1 EIF3J â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
EIF2S2 EIF4A1 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
EIF3L EIF4A1 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
EIF4A1 RPS6 â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
EIF3L EIF4G1 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
XIAP CASP3 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 9525868 6547707
CASP5 CASP4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
HSPB1 CDK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30669930 26344197
VCAM1 CDK1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 EIF3A â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 EIF3E â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
EIF3E RPS6 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
EIF3H RPS6 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
VCAM1 EIF3L â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
EIF3L RPS6 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
EIF3M RPS6 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
VCAM1 HSPB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
EIF2S1 EIF3E â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
EIF2S1 EIF3H â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
EIF2S1 EIF3L â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
EIF2S1 EIF3M â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
EIF2S2 EIF4G1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
EIF3A EIF3M â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
EIF2S1 EIF4G1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
EIF3A EIF3H â—¼   CORRELATES + 0.82 0.82 CCLE 31978347
EIF2S1 EIF4A1 â—¼   PHYSICAL_INTERACTION 829.0 0.82 STRING 36370105
TANK BIRC2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 30561431 23524849 21903422
RPA2 ESR1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31527615 11953755
MDM2 NPM1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
EIF3H EIF3M â—¼   CORRELATES + 0.83 0.83 CCLE 31978347
EIF2S1 RPS6 â—¼   PHYSICAL_INTERACTION 839.0 0.83 STRING 36370105
EIF3H EIF4G1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
ESR1 RRP1B â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31527615 21182205
EIF2S2 EIF3J â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
EIF2S2 RPS6 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
EIF3H EIF3L â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
PARK2 TRAF2 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
EIF3J EIF3L â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
EIF3L EIF3M â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
CASP9 CASP3 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 1067155 11242052 11230124 18723680 25241761 15941357 17437405 8900201 15507451
EIF3C EIF3M â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
EIF4G2 EIF4G3 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
EIF3A EIF3L â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
EIF3J EIF4G1 â—¼   PHYSICAL_INTERACTION 857.0 0.85 STRING 36370105
EIF3C EIF3H â—¼   CORRELATES + 0.85 0.85 CCLE 31978347
CASP8 BCL2 â—¼   PHYSICAL_INTERACTION 0.86 0.86 HIPPIE 16183855 11406564
BIRC2 CASP8 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
EIF4G1 EIF4G3 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
EIF3A EIF3C â—¼   CORRELATES + 0.86 0.86 CCLE 31978347
EIF3A EIF4G1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
CASP8 BIRC2 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 27810922 15069192 12887920 22274400
CASP8 CASP3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 11832478 11437602 8962078 18669646 15254227
CASP6 CASP3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 25241761 8900201 18723680
CASP3 CASP9 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CASP8 TRAF2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EIF4A1 EIF4A2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
EIF3J RPS6 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EIF3E EIF3H â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
CASP3 MDM2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
EIF3C RPS6 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
EIF3C EIF3L â—¼   CORRELATES + 0.87 0.87 CCLE 31978347
BIRC2 XIAP â—¼   PHYSICAL_INTERACTION 879.0 0.87 STRING 36370105
BIRC2 TRAF2 â—¼   UBIQUITINATION ✅ - 0.87 0.87 Signor 20651737
CASP10 CASP8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
EIF3E EIF3M â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
EIF3A EIF3E â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
CASP7 BIRC2 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 9384571 15580265 19258326 16339151 11084335 16189514
MDM2 ESR1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 12897156 17545634 10766163 11178989 16713569 31012223
HTRA4 XIAP â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31036715 31470122
EIF3J EIF3M â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
TANK TRAF2 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
EIF4A1 EIF4G2 â—¼   PHYSICAL_INTERACTION 899.0 0.89 STRING 36370105
ARIH1 EIF4E2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14623119
CASP4 CASP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12843244 9491891 9039262
CASP10 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8755496 8962078
CASP3 EIF3J â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10672017
CSNK2A1 EIF4G2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 29530922
EIF4G2 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 29530922 16932749
EIF3J EIF3A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14519125 9822659 23623729 18599441
EIF3L EIF3E â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 24981860 26344197 16189514 22939629 19748344 18599441 22863883 28514442 11590142 17403899 23623729
EIF3J EIF4G2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11022043 16932749
EIF4G2 EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10394359 16467844 10944120
EIF4G3 MKNK1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EIF3E EIF3L â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
EIF3E EIF3J â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
EIF3C EIF3E â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
EIF4A1 EIF4E â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
BIRC2 CASP9 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
EIF4A2 EIF4G1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
EIF3A RPS6 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
BIRC2 TRAF2 â—¼   PHYSICAL_INTERACTION 919.0 0.91 STRING 36370105
EIF3H EIF3J â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
EIF2S1 EIF3C â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
EIF3M EIF4A1 â—¼   PHYSICAL_INTERACTION 928.0 0.92 STRING 36370105
EIF2S2 EIF3C â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
EIF3E EIF4A1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
EIF3H EIF4A1 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
XIAP CASP3 â—¼   UBIQUITINATION ✅ - 0.94 0.94 Signor 11447297
EIF4A1 EIF4G3 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
EIF4A2 EIF4G3 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
EIF3A EIF4A1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
EIF3C EIF4A1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
CASP9 APAF1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5221774 9390557
EIF3H EIF3E â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 24981860 26344197 19615732 22939629 32269044 26186194 32867821 28514442 22863883 17403899 23623729
EIF4G1 EIF4A1 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 5219000 16932749
TRAF2 BIRC2 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 16891304 33961781 23524849 20184394 24276241 21331077 11907583 8943045 19815541 9384571 23007157 8548810 20447407 16713569 16282325 30561431 32296183 25681446 25716317 19584093 21988832 8643514 19506082 28514442 30359437 15861135 16189514 20348096 21653699 20562859 21903422 25241761 10753917 11181075 16263936 27534557 25882049
EIF3H EIF3C â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 24981860 26344197 19615732 22939629 18599441 32269044 26186194 28514442 22863883 23623729 30021884
EIF4E EIF4G3 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
EIF4E EIF4G1 â—¼   PHYSICAL_INTERACTION 981.0 0.98 STRING 36370105
CASP3 XIAP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CASP9 XIAP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
EIF3C EIF3J â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CASP7 XIAP â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
EIF2S1 EIF3A â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
EIF2S2 EIF3A â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
APAF1 CASP9 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
EIF3C EIF3L â—¼   PHYSICAL_INTERACTION 989.0 0.98 STRING 36370105
EIF4A1 EIF4G1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
EIF3A EIF3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3E EIF3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3H EIF3L â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3L EIF3M â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
EIF3A EIF3C â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3C EIF3H â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3C EIF3E â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3C EIF3M â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF3A EIF3J â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EIF3A EIF3H â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EIF3A EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3A EIF3E â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3E EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3E EIF3H â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EIF3H EIF3M â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CASP3 APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12874265 21827945 11550094
APAF1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 17145710 15829969 15024710 9390557 19494828 11113115 10617566 9539746 10364241 10722681 27476169 21060833 19118655 20829884 16977332 10329646 15210107 10393175 16352606 11242052 14555243 10376594 12773388 10206961 19337385 10428850 9488720 19788417 15262985 9922454 21827945 10749135 9651578 19698783 12792650 9837928 11227497
UBE2L6 ARIH1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16407192 17289916 16815975 16352599
ISG15 ARIH1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16407192 17289916 16815975 16352599
CASP3 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11511102 11447317 10712510
BCL2 TRAF2 â—¼   DOWN_REGULATES ✅ - 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
ESR1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19148464 19160418 9306964 11261829 21841772 10542244 20664923 18414489
CDK1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 24097825 24677263 23638364 19917720 27231850 11774038 11326318 10766756
CASP3 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10409669 9395403 20139069 11948397
BCL2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16183855 11406564
TRAF2 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 21653699 25681446 8943045 8643514 11907583 16713569 20184394 18621737 18997794 21988832 25882049 9384571 21903422 16891304 10753917 20447407 18981220 16189514 15861135 11181075 20348096 20562859 25241761 19584093 32296183 21331077 23007157 16282325 19506082 25716317 23524849 24276241 16263936 12887920 8548810 19815541
BIRC2 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 9990849 12042762 9384571 17069460 11382748 11106668 16189514 11084335
BIRC2 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 16339151 9990849 15069192 25241761 19153467 9545235 25416956 31515488 16189514 32296183 16701639 11084335
BIRC2 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16339151 9384571 16189514 11084335
CASP1 CASP5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11051551 11536016 11432859 15383541
CASP8 CASP10 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 22864571 17159907 17145710 12887920 11832478 11717445 21737330 15280356 12198154 3031469 15659383 170210 8962078 22421964
CASP10 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 11717445 8755496 9765224
CASP3 CASP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9261102 9922454
CSNK2A1 CASP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16193064
CASP2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15262979 16193064
CASP8 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 15755874 17179148 9501089 9950028 18669646 23308069 10988287 18458084 16964285 9885230 9765224 11437602 15014070 21295084 8962078 9208847
XIAP CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 70.0 1.0 Omnipath 23074197 16543147 22072751 12624662 18521960 22815893 11157976 15650747 15200957 11927604 11230124 9384571 16869888 9545235 23979166 18723680 16189514 11359776 15507451 9230442 19273858 26186194 10508158 25241761 12529384 19559631 11257230 12874265 9525868 17291493 11583623 11257232 17069460 12181739 10548111 11447297 15014070 19698783
CASP9 CASP3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 10708865 9390557 10508159 11230124 18723680 15657060 16977332 15507451 1067155 9708736 25241761 8900201 11242052 9765224 17437405 19788417 9812896 12620238 15941357 12181739 19465923 12792650 15725726
CASP3 CASP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 25241761 17899380 8900201 9922454 18723680
CASP3 EIF4G3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10611228 10672017
CASP3 EIF4G2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10672017 11175261 10371215 10611228
CASP3 EIF4G1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10611228 9819442
CASP3 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 25241761 9278461 21726810 24842904 9840926
CASP9 CASP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14686614 9651578 16521476 12097334
CASP8 CASP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18329793 12232792 9727491
CASP7 CASP9 â—¼   CLEAVAGE ✅ 5.0 1.0 Reactome 16916640 9922454 11752425 11701129 12824163
CASP9 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17899380 9922454 16352606 9598997 9651578
XIAP CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 45.0 1.0 Omnipath 11447297 11257231 18521960 31467278 15200957 9384571 9545235 14512414 23979166 16189514 11359776 9230442 10508158 19559631 11257230 9525868 11583623 15580265 11257232 23074197 19698783
CASP8 CASP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18073771 9545235 10872455 18329793 9727491 9463409
TRAF2 CASP8 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15024054 20696707 19278658 10837247 19416807 21235526
CDK1 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20937773
TRAF2 CASP8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17145710 12887920 20203691 16227629 21741934 17047155 22421964 30054040 11340079
CDK1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 19081073 19016842 16287866 29844931 19586613 29416675 17466630 12792650
XIAP CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 62.0 1.0 Omnipath 15069192 15280366 25416956 18022362 11157976 31467278 15200957 11927604 11230124 12042762 16322207 9545235 11801603 25502805 14512414 16189514 15300255 15507451 10508158 25241761 27107012 14523016 17179183 16352606 11242052 32296183 16701639 17291493 12620238 15749826 12181739 11390657 29997244 31515488 23074197 19698783
CDK1 RPA2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 14551205 15279786 17102137 17116885 17296725 17303408 17582221 17660363 18414028 18590585 19793801 7575488
CDK1 CSNK2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 7592773 30392930 18691976 19387552 20068231 96029687 16371510 1400350 19941816
CDK1 NPM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 49.0 1.0 Omnipath 17081983 12058066 27253419 22285574 25908633 20333249 16912078 27553022 19933706 16083285 20068231 27619510 17570479 18669648 7213797 81161106 26536659 11278991 17287340 17924679 15190079 14670079
CDK1 RPA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 9139719 17303408 9295339 19793801 15279786 7575488 20068231 17116885 19671522 17582221 26237679 18590585 1318195 22977173 17660363 20932174 17296725 17102137 21664290
CSNK2A1 EIF3J â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 25887626 22113938
CSNK2A1 EIF2S2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 16225457 19651622 17081983 18691976 20068231 18452278 8024572 22113938 18669648 12901717
CSNK2A1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11139588 26703694 9337862 20043841 11432835 11507039 9528769 7838153
EIF2S1 EIF2S2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S1 EIF4E â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 641056 592399 9732867 6853548
EIF2S1 EIF4A2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 641056 592399 9732867 6853548
EIF2S1 EIF2S2 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF2S1 EIF2S2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12601012 12667446 16246152 23850759
EIF4E EIF2S2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 641056 592399 9732867 6853548
EIF2S2 EIF4A2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 641056 592399 9732867 6853548
MKNK1 EIF4E â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 18775330 9155017 9604935 9878069
EIF4G1 EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 17145710 8521827 22509910 17689282 23665581 22586265 16648488 16467844 9372926 16541103 15361857 16720573 9418880 16281055 18955708 12071973 21191102 26186194 10753870 15153109 10600798 7651417 20212144
MKNK1 EIF4E â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 17145710 7782323 27050281 25403230 95301551 9878069 19694499 17689282 28745319 32066877 17724079 23331499 15591312 25915158 16540463 8662663 9155017 16720573 20679199 15542544 15574771 21949767 20626350 25921059 19663871 23359369 17130135 16982703 20299272 12897141 11154262 26097864 11606200 10022874 11723111 11463832 21635931 12193593 25193863 24551240 30211342 12138083 22392765 20722422 25923732 24504069 34012509 31903169
MKNK1 EIF4G1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17145710 15234964 9878069
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
ESR1 HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15833836 10960840 11174852 8923463
UBE2L6 HERC5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16407192 17289916 16815975 16352599
ISG15 HERC5 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16407192 17289916 16815975 16352599
UBE2L6 ISG15 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11157743 15485925 18583345 15131269
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
TANK TRAF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 24.0 1.0 Omnipath 20562859 21988832 21903422 8710854 12005438 14743216 10581243 16713569 23007157 10759890