TP53
|
BAD
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17000778
22869582
|
MAPK9
|
BAD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14673001
17555943
|
NOS3
|
CDC37
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
21163940
114280
|
TP53
|
CSNK2A2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12393879
11239457
|
VSX2
|
DDIT4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
TP53
|
DDIT4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
19210572
|
TP53
|
DDIT4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
SMARCA4
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11950834
33476981
|
AR
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19481544
7103716
|
TP53
|
HSPB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
TP53
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
10823891
5212595
|
TP53
|
CSNK2A1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12393879
11239457
|
TP53
|
HPSE
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16474844
16901744
|
TP53
|
PRDM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TP53
|
NOS3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TP53
|
RB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
LHX2
|
PAX6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19146846
24262147
|
VSX2
|
RNF11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
DR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
NEFL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HTT
|
DNALI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
DNALI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
DNALI1
|
HTT
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
15383276
5217202
|
VSX2
|
NDUFV2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
SP3
|
CREBBP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12200429
20096088
|
CHMP1A
|
HTT
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HTT
|
KLF11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
AR
|
CARM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16492776
16344550
|
USP12
|
AR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20501646
24056413
|
VSX2
|
AR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16492776
12466965
|
AR
|
IGHG1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12734361
|
AR
|
AHR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20610535
23689136
|
AHR
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19815066
17392787
|
VSX2
|
HSPB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
AHR
|
HSPB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
14973392
11174852
|
VSX2
|
GTF2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
KLF11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PAX6
|
RB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23622063
15558475
|
TARDBP
|
PRPS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
PRPS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
WFS1
|
PRPS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
GTF3C3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
GRN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
NEUROG3
|
PAX6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12403815
18506085
|
NOS3
|
VSX2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
WFS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
TTR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
LRIF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
JPH3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
NUP58
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
GFAP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
VSX2
|
TARDBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
WFS1
|
GFAP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
JPH3
|
GFAP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
WFS1
|
ZDHHC17
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
MAPK8
|
MAPK9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
805.0
|
0.8
|
STRING
|
36370105
|
CSK21
|
CDC37
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
12930845
16335536
15082798
|
CDC37
|
GFAP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
32296183
24189400
|
GRN
|
SAHH3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
26186194
|
VSX2
|
CSK21
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
26186194
|
VSX2
|
PAX6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
11069920
|
VSX2
|
WDR20
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX1
|
CSK21
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX2
|
UBP33
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX2
|
UBP12
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX2
|
CSK22
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX2
|
UBP20
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX2
|
ZN703
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX2
|
CHM1A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX2
|
SAHH3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX1
|
CSK22
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
VSX1
|
UBP12
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
35140242
33961781
|
CSK22
|
CDC37
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
12930845
23455922
27705803
|
SMARCA4
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
HSPB1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
848.0
|
0.84
|
STRING
|
36370105
|
CARM1
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
857.0
|
0.85
|
STRING
|
36370105
|
AHR
|
RB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
858.0
|
0.85
|
STRING
|
36370105
|
CSNK2A1
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
CREBBP
|
HTT
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
RB1
|
SMARCA4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
MAPK8
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
CSNK2A1
|
CSNK2A2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
885.0
|
0.88
|
STRING
|
36370105
|
CREBBP
|
GTF2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
892.0
|
0.89
|
STRING
|
36370105
|
VSX2
|
MITF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15576400
15459106
10903182
|
PAX6
|
MITF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11350962
16189514
12756174
|
MITF
|
VSX2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15576400
15459106
10903182
|
UBP12
|
WDR20
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
32296183
26462181
29655804
30466959
21183687
26811477
33961781
24981860
19615732
27373336
|
CSK22
|
CSK21
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
19011756
26496610
30279146
27705803
25519132
33961781
24981860
26186194
25852190
32707033
23455922
26344197
|
USP12
|
WDR20
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
PAX6
|
MITF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
16189514
11350962
|
CREBBP
|
TP53
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
MAPK8
|
BAD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
11983683
12189144
14673001
16166315
15526032
29795446
15907327
14967141
15725726
17555943
|
CSNK2A1
|
CDC37
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
26755559
18566753
20068231
15082798
18922470
19413330
12930845
27105117
|
CSNK2A2
|
CDC37
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
20068231
15082798
19413330
12930845
|
CSNK2A2
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16083285
1088347
10348343
10884347
16552184
9315650
10747897
|
CSNK2A2
|
CSNK2A1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
26186194
27705803
25519132
19011756
26496610
25852190
23455922
|
AHR
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17070097
15111621
11191113
20478272
|
TP53
|
CREBBP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
19057620
15632413
11466559
19448667
19880525
9891054
22198284
10833421
11709699
10435630
11390631
9890939
21191649
12501250
11928223
17434128
12164786
24330748
11779500
10435595
21513889
10777477
|
TP53
|
HTT
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
22399227
15996546
16978870
16278683
|
TP53
|
AR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17202838
18084622
18945670
11504717
|
TP53
|
HLA-DRB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15289308
16230375
11382926
15964798
|
TP53
|
ACHE
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
20935676
9649502
10514438
17209038
9288775
22243239
9525640
2936901
7823921
10435630
|
TP53
|
RB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
23.0
|
1.0
|
Omnipath
|
11850820
10029406
16931621
9774636
8845569
8270002
11244564
15618023
12444079
12749855
21496227
11818069
15827088
8720930
1608930
8119988
23474762
11121443
22729911
22894933
8355507
|
TP53
|
MAPK8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
22607268
23376463
18374905
15958553
10854211
22353755
|
CSNK2A1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
53.0
|
1.0
|
Omnipath
|
23443559
15358769
9315650
19413330
11285227
11551930
11883897
22975381
11709713
16083285
1088347
33745968
16552184
10884347
10747897
10673501
7936649
12628923
25241761
21127074
16964247
24725084
10606744
10348343
10951572
|
MAPK9
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
79.0
|
1.0
|
Omnipath
|
12356735
14665630
26158765
18778462
12969974
12861053
15254178
17135248
18669630
12384533
17363488
17698850
11283254
10706102
21454683
18931691
11551930
11397945
14612532
15064747
15963507
11175334
11423984
27147566
29234486
24657168
10581258
14517211
17353187
10673500
22030623
14527925
22728651
17525747
15629715
9393873
11447225
15671037
22285752
17245430
15140942
28673515
23871434
11078726
20041275
11896587
16731759
17121812
33514736
11861384
25431954
12810724
17967874
12955074
21832239
16818520
12756247
23798621
11526498
20009884
16713569
10202145
11850826
11896572
10710310
10570149
12959929
15269203
11583595
21148320
|
HSPB1
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
25241761
16169070
16713569
17184779
|
CREBBP
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
49.0
|
1.0
|
Omnipath
|
17303408
25545885
27618436
19220000
16713569
10823891
15632413
19805293
25451029
15279786
10473588
12154097
7575488
16537920
10848610
18485870
19880525
10648616
20144767
14722092
14759370
18590585
26976603
9194564
19788416
25314079
19166313
12426395
9288775
11782467
17660363
19234109
21390126
10196247
17434128
19357310
10551785
22084066
|
MAPK8
|
TP53
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
11108663
12531896
16713569
11283254
10706102
19651615
27147566
9724739
15538975
9732264
10581258
10436023
17570479
9393873
11896587
12514174
15580310
18813780
11078726
|
TP53
|
HTT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
18431400
32814053
16713569
10823891
|
AR
|
CREBBP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9822653
15350180
16492776
16344550
11161315
18819102
18031230
20610535
|
CARM1
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15731352
11701890
12374746
17043108
|
HTT
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
11264541
11607033
16456924
15994095
17500595
16713569
10823891
|
CREBBP
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
20541699
9822653
15691881
12810069
9482849
16713569
|
PAX6
|
SIX3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11069887
11069920
12072567
|
CSNK2A1
|
MAPK9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11062067
|
AR
|
PRPS1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20610535
|
HSPB1
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
19767773
17974989
|
MAPK8
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
24424504
21512132
21820033
16282370
|
MITF
|
PAX6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
9466887
23610061
17277739
15978250
|
SP3
|
NOS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
14555463
12759366
15180995
|