Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CDKN1A E2F5 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11157749 9144196
PML CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10356361 16007146
PITX2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23131154 20816801
AR CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10076995
TGFB1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23741479 12058028
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
EP300 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22000024 19419955
SKI EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17469184 10575014
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
KAT7 AR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5212855 10930412
KAT7 PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0712063105 18250300
KAT7 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16547255 17532302
MAPK1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AR MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14619959 20610535
HGF MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
HGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
MYC TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
E2F5 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17132729
NR1H3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10890879 12551904
MYC HDAC2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20697349
MYC TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15466196 12080469
E2F5 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12150994 18319725
MYC TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11139609
MYC TFRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10737792
AXIN2 PLK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0604206103 16815967
PLK1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PLK1 TGIF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
E2F4 PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15510213 18319725
ZFYVE9 PML â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18511908 6798777
TGIF1 PML â—¼   COLOCALIZATION 2.0 0.8 intact 18511908 6798777
PML JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9671405 10620019
RIF1 PNP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RIF1 TGIF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
RIF1 ID2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SMAD2 SKIL â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 SKIL â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22674574
SKIL SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12419246 12426322
TFRC TF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20404192 0914898107
AR TF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17011549 11250938
APP TNF â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NR1H3 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11741944 16461908
MDFI TGIF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
SMAD1 BMP7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20375015 17127702
ID1 ID3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21156287 22564737
ID2 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ID1 ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9779825 19896442
CTNNB1 ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11572874 12095419
E2F4 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11799067
E2F4 SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
E2F4 RBL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17531812
SMAD4 E2F4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994
ID1 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24177224 19567783
SMAD9 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SMAD5 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD4 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
SMAD4 TGIF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
SMAD4 EEF1A1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD4 TGIF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
SMAD4 ID1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19079362 12296825
SMAD4 BAMBI â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15240101
SMAD4 THBS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12622415 18505344
SMAD4 APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12099698 15242331
SMAD4 HAMP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17187402 16330325
ACVR1B SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 9892009
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
SMAD4 E2F5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
SMAD4 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12150994
HTT TGFBR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TGFBR2 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
TGFBR2 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
TGFBR2 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
SMURF2 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 15221015
BMPR1B SMAD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMURF2 SMAD7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD7 ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
SMAD7 ACVR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMPR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 BMPR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD7 TGFB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
SMAD7 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15684397 1568439
SMAD7 TGFB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15855641 19385040
AXIN1 SMAD7 â—¼   COLOCALIZATION 2.0 0.8 intact 16601693 5218493
SMAD7 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10564272 23331499
SMAD7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10564272 23331499
TGIF1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
TGFB1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 21358634 9679059
SMAD9 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
PPP2R1A SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
EEF1A1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TGFBR1 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18511908 6798777
ZFYVE9 SMAD2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 RARB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 ROCK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD2 TGIF2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
ZFYVE9 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 19620243 9865696
SMAD2 FST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18184649 11181520
TGFBR1 SMAD2 â—¼   PHOSPHORYLATION ✅ + 0.8 0.8 Signor 10973958
PPP2CA SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20704570 23331499
SMAD9 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15231748
SMAD2 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15292219
SMURF2 SMAD3 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 8308197 22045334
SMURF1 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
TGIF1 SMAD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SMAD3 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
SMAD3 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD3 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AR SMAD3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20739403 20610535
SMAD3 BAMBI â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15240101
SMAD3 ACTG2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20123992 12702545
ACVR1C SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 9920806
SMAD3 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15292219
TGFB1 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
FMOD TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16189514 8093006
TGFBR1 BAMBI â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10519551 19758997
SMURF2 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 14722617 15265520
WWP1 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15221015
BAMBI TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10519551 23331499
TGFBR1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19726546 15761153
EEF1A1 AXIN1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
SMURF1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF1 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 17317136
SMURF1 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 17317136
SP1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12847090 5216518
PPP2R1B HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8208439 17540176
HDAC1 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19166851 6823802
HTT SIN3A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10823891 5212595
AR SIN3A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18945670 16254079
SIN3A KLK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16254079
AR NCOR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19351840 20610535
TCF7L2 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath
JUN BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11044605 21898398
JUN RARB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9377582
JUN BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19009553 18495116
ID1 THBS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12498716 19710505
RHOA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
ZFYVE9 BMP4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ZFYVE9 PPP2R1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
ZFYVE9 CTNNB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF2 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF2 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMURF2 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16950122
SP1 KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8887648 19994725
SP1 HDAC4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16280357
SP1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21411747 17350185
SP1 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12220517 19009553
PPP2CA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24382322
TGIF1 CTBP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SMAD9 SMAD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8893010 11779505
SMAD1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
AR SMAD1 â—¼   COLOCALIZATION 2.0 0.8 intact 5219486 17183365
PPP2CA HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18045992
MED31 HTT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
HTT APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
EEF1A1 TGIF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
PNP APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
PPP2CA APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TGIF1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
APP PLPP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
AR APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20610535 16987234
PPP2CA RBL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15467457 8204372
PPP2CA RBL1 â—¼   DEPHOSPHORYLATION ✅ 2.0 0.8 intact 15467457 8204372
PPP2CA CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10644691 19061640
PPP2CA RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18927618 15467457
CTNNB1 A2M â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CTNNB1 BAMBI â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14660579 12782598
AR KRAS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8423674 24172884
HFE TFRC â—¼   COLOCALIZATION 2.0 0.8 intact 7896039 20618438
MED31 TGIF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
ACVR2B ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
BMP8B ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10504300
ACVR2A ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9748228 8612709
BMPR1B ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7644468 7791754
BMPR1B ACVR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7644468 7791754
BMPR1A BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10712517
ACVR2B BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
BAMBI BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10519551 23331499
BMPR1B SMAD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19620713 11792802
SMAD6 ACVR2A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
INHBE ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22710174
ID1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20970407 21996749
WWP1 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15231748 5217094
SMAD9 SMAD5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8893010 11779505
SMAD6 BMP2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
SMAD6 ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
BMPR1A ACVR2B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7644468 7791754
ACVR2B ACVR1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
SMAD6 BMPR1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
BMP8B BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 10504300
BAMBI BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10519551 23331499
SMAD6 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10564272 23331499
NOG BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 12478285
BMPR1A SMAD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19620713 11792802
SMAD6 BMPR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12857866 12519765
NEO1 HJV â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 32589946 18335997
NOG GDF5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21976273 19956691
NOG BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22298955 12478285
PNP TGIF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TGIF1 PLPP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
BMP6 AMHR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16446785
PITX2 LEFTY2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18222420 10662647
ACVR1 BMP7 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
SMAD6 SMURF1 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
GDF5 RGMB â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
GDF5 RGMA â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
EP300 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14968110 30110629 22778253 16787918 33742100 18722353 22731250
TFDP1 E2F4 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 24981860
SMURF2 SMAD2 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 5217094 15231748
ACVR1 BMPR2 â—¼   PHYSICAL_INTERACTION 814.0 0.81 STRING 36370105
CTBP1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21102443 15834423 35016035 16122695
NR1H3 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 25962847 33742100
EP300 SMAD5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16516194 16613856
MYC KAT7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC CTBP2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30415952 29467282
MYC CTBP1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 34147029
MYC JUN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 20232342
MYC RIF1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21150319 29467282
AXIN1 AXIN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22682247 20128690
ID2 ID4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SMAD4 SMAD6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15817471 9256479
SMAD2 SMAD9 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15231748 33961781
JUN HDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17056544 25609649
KRAS MAPK1 â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
PML SMAD3 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 15356634
SMAD4 JUN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10220381 25609649
SMAD3 WWP1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 32296183 25416956 25910212 15221015 15359284
HDAC4 SIN3A â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 17011572 10220385 17210713
CTNNB1 PITX2 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
CTBP1 RBL1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
BMPR2 BMP6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 11401330 10504300
AXIN2 CTNNB1 â—¼   DOWN_REGULATES ✅ - 0.83 0.83 Signor 11940574
NEO1 RGMB â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CTNNB1 SMAD3 â—¼   PHYSICAL_INTERACTION 837.0 0.83 STRING 36370105
SMURF1 SMAD6 â—¼   RELOCALIZATION ✅ - 0.83 0.83 Signor 22298955
MYC SP1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
HDAC1 SMAD2 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
SMAD4 RBL1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 12150994
SMAD3 SKI â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 5216533 12857746
SMAD1 SMAD3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9111321 15761153 18729074
TGFB2 TGFB1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 27684187 11483955 33961781 11157754
HDAC1 TGIF1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 11427533 11226163 10995736
SMAD5 ACVR1 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10652350 16189514 10583507 9748228
HDAC2 PML â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
CDKN1A EP300 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
SKI SKIL â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
JUN PML â—¼   PHYSICAL_INTERACTION 848.0 0.84 STRING 36370105
EP300 SMAD1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10205054 20851880 22365546 16613856 10673036
SMAD2 HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10199400 11226163 31130994 14699069
TGIF1 SMAD3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 11427533 11306568 32814053
FMOD TGFB1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 8093006
SMAD4 SMAD5 â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
SMAD1 SMAD6 â—¼   PHYSICAL_INTERACTION 855.0 0.85 STRING 36370105
JUN SP1 â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
EP300 SMAD3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 15824515 15688032 16109717 15345715 20564330 9843571 15133024 10497242 17469184 15623506 10575014 15588252 18055455 16876108 21567395 11134049 12743039 11058129
SKIL NCOR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12764135 15231748 16713569 10049357
BMP7 ACVR1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 8006002 18070108 16189514
SMAD7 AXIN1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 16601693 18593713
TGIF1 SIN3A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11416139 11682623
ACVR2B TGFBR1 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
ACVR2B BMPR1A â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
JUN MAPK1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
DCN TGFB1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
HDAC1 TGIF1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
AXIN1 PPP2CA â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
MYC EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 15616592 16287840 32140074 16126174 17157259 12776737
MYC HDAC2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 17314511 20195357 22286234 30415952
PML TGIF1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 18511908 16916642
E2F4 HDAC1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 23060449 9858615 9724731 21102443
SMAD5 SMAD4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10531362 16516194 16189514 15231748
SMAD7 SMAD6 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 26555259 9256479
TGIF1 SMAD2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10199400 11371641
SMAD3 SMAD9 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 15231748 33961781 26186194
HDAC1 TFDP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 27705803
AR SP1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
ACVR2B BMP2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CREBBP HTT â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CTNNB1 SKP1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
SMURF2 SMAD7 â—¼   UBIQUITINATION ✅ - 0.87 0.87 Signor 18448069
SMAD7 SMURF2 â—¼   RELOCALIZATION ✅ + 0.87 0.87 Signor 19352540
RHOA SMURF1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
SMAD4 SMAD7 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
SMAD3 SMAD9 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
ZFYVE9 SMAD3 â—¼   RELOCALIZATION ✅ + 0.87 0.87 Signor 20515759
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
EP300 SMAD2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11371641 21988832 10199400 12237408 11264182 15623506
MYC PLK1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 27773673 17314511 33494392 29467282 30415952
BMPR2 BMP7 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7644468 7791754
SMAD2 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9111321 28628118 18729074 28205554
SMAD2 SP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11114293 10878024 22227581
SMAD3 RBL1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 12150994
SMURF1 SMURF2 â—¼   PHYSICAL_INTERACTION 879.0 0.88 STRING 36370105
HDAC2 SP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 17312152 18059533 16713569 15713621 17894944 12091390 16036112 12151407 21159880 12176973 20697349
NR1H3 NCOR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12663743 26120082 15604093 33961781
ACVR1 SMAD1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 10583507 10652350 9748228 28847510 10085121 9136927
TFR2 HFE â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9465039 10638746
SMAD6 CTBP1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14645520 24850914
GDF5 BMPR2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 19229295 9525338
LTBP1 TGFB1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
BMP4 BMPR2 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
AR EP300 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CTNNB1 HDAC1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
CTBP1 CTBP2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
BMP2 BMPR1B â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
AR KLK3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CREBBP SMAD3 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CREBBP JUN â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
CREBBP SMAD2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
MYC SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 11274368 18003922 17418410 15780936 32115405
MYC PML â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17146439 15735755 21150319 32592588 30415952
MYC SKP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12963825 21988832 17314511 29467282 30415952
PML JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 15626733 9671405 16916642 10620019
PML HDAC2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25812002 18073335 11259576 18644863
SMAD3 SKIL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22442258 16959829 11306568 10531062 12764135 17469184 12426322 15231748 11691834
SMAD2 SKIL â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18729074 16959829 22442258 10531062 12764135 33961781 12426322 15231748 25059663 11691834
SP1 SMAD4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10878024 18215124 21297662 16714330 11114293 22033265
SMAD4 SMAD9 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 32296183 16189514 10583507 25502805 25609649 31932471 15231748
TGFBR2 TGFB1 â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8044119 21054789
SMAD2 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11371641 20195357 10220381 25609649
SP1 SMAD3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11432852 10878024 12228247 22227581 16714330 11114293
HDAC2 CTBP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 17967884 31041561 16713569 28947780 16036112 10766745 18212045 11022042
SP1 JUN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25879517 10506225 16713569 33572115 16478997 17215518
CTBP2 CTBP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 31041561 16189514 25416956 16713569 21988832 28947780 30585266 26496610 33961781 35016035 26186194 24722188 27107012 9858600 26344197
SMAD6 SMAD1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11483516 12857866 9436979 9256479
SMAD1 SKI â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12874272 14699069 12426322
PPP2R1B PPP2CA â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 8392071 8286818
CTNNB1 AR â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 5216126 12588987
BMPR2 ACVR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7890683 28514442 7791754
ACVR2A INHBA â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
BMPR2 BMP4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28126904 12045205 7673243 7644468 8702914
SMAD5 WWP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16713569 16189514 15221015 15231748
INHBA FST â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 7887917 16198295
RGMB BMP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25938661 15671031
TGIF1 CTBP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 25416956 16713569 10995736 25910212 20361981
FBN1 ELN â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19570982 10825173
HDAC2 SP1 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
LRRC32 TGFB1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
SKIL SMAD3 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
SMURF2 TGFBR1 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
SKIL SMAD2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
FOXH1 SMAD2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
SMURF1 SMAD7 â—¼   UBIQUITINATION ✅ - 0.89 0.89 Signor 12519765
SMAD7 SMURF1 â—¼   RELOCALIZATION ✅ + 0.89 0.89 Signor 19352540
BMPR1A GDF5 â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
SMAD5 SMURF1 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
SMAD1 SMURF2 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ACVR2A BMPR1A â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
SMAD3 TGFBR1 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
A2M CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
MED31 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
EEF1A1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
RBL1 CDKN1A â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDKN1A E2F4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
CDKN1A TFDP1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11884610 7797074 9144196
SMAD1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19819988 11786386
TFDP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10029406 10702805 9191053
KAT7 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22713239 20123734 12609999
SKP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16376880 25241761
EP300 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27956703 21268080 21937452 24069158 11689449 14630807 11980644 10327051 12437352 12471036 24636898
PPP2CA MAPK1 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
RHOA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
PPP2CA MAPK3 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
RHOA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10617617 9854026 12810709
MAPK3 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15093545
SMAD2 MYC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11804592 28628118 28205554
MYC HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17314511 18271930 34147029 26496610 30415952 18003922 22286234 24951594
SMAD1 MYC â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 15576399 22290435 22761862
MYC TGFB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC RARB â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12695333 11085504
MYC CUL1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10970882 12835716
MYC TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19149881 24299953
MYC BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12695333
MYC RHOA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22159222 20383141 22235332
AXIN1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19131971 20399964
E2F4 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11564866 12150994 18319725
MYC CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16376880 16915296
MYC SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11274368 16713569
HDAC1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 11259576 18644863 25812002 11430826 23563092
SP1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9819401 21360626 24728382 16713569
NCOR1 PML â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11430826 10882117 16713569
PML SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 15356634
SMAD4 SKIL â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10531062 12764135 15761153 17469184 25609649 33961781 15231748 25059663
SKIL SKI â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9927733 16959829 12764135 33961781 25059663
SKIL SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23154975 16442497
PPP2CB AXIN2 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 1203359 10698523 8285077
SMAD1 ID3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18372118 21056086
E2F4 ID3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17531812
SMAD5 ID3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18372118 21056086
E2F4 TFDP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 16360038 9501179 8657117 7958924 7958925 10540350 27705803 9343408 24981860 9199321 7892279
E2F4 RBL1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17671431 16360038 12150994 9501179 8657117 7958924 9233764 9858615 8832394 7958925 8643455 9343408 9724731 11573202 12401786
SMAD2 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 25514493 11927552 28443643 21988832 20211142 15467747 12732634 25609649 15922743 12419246 9288972 21454478 19139564 24157709 18729074 22442258 17283070 16916642 15350224 17591701 11274206 15761153 31591477 26555259 9892009 9311995 10085121 9389648 10781087 12167862 10878024 18783722 27703004 18511908 28468752 19135894 10531362 12794086 15231748 21297662 12621041 19917253 11027280 24584437 16751102 31932471 10199400 21532621 12808092 33961781 11264182 11102446 11114293 12543979 23788427 15817471
SMAD1 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 17183365 16189514 32296183 31467278 12167862 14701756 12874272 28468752 15761153 24412244 10531362 15231748 11700304 11779505 26555259 9436979 21454478
SMAD3 SMAD4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9111321 16189514 25514493 11927552 28443643 21988832 20211142 15084259 12732634 19768112 15467747 20142324 25609649 15922743 12917407 12419246 20564330 24382352 19139564 32296183 24157709 18729074 22442258 10092624 17283070 15350224 17591701 15761153 31591477 10995777 26555259 9892009 9311995 15588252 12167862 10878024 25910212 27703004 33990575 28115363 18055455 22310290 19135894 10531362 12794086 15231748 21297662 22045334 19917253 24584437 27107012 29892012 29997244 21532621 27845895 21597466 25502805 11114293 12543979 23788427
SMAD4 SKI â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12732634 12764135 25609649 12419246 25670202 14699069 15761153 17469184 19032343 12874272 28468752 12857746 31932471 15231748 20959473 10531062 26977879 33961781 14525983
SMAD7 SMAD4 â—¼   DOWN_REGULATES ✅ - 3.0 0.9 ACSN 11279127 15265520 23784029
SP1 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21421563
SMAD4 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12374795 10022869
SMAD4 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12429655 22710759 19419955
SMAD4 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12226080 16713569
TGFBR2 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
TGFBR2 SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
TGFBR2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8774881 15104092
SP1 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16714330 10843994
JUN SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15579469 10843994
SKI SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15128733 19032343
AXIN1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16601693
SMAD7 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10564272 23331499 15761153
SMAD2 SMAD3 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
SMAD2 SKI â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25670202 20959473 18729074 10485843 22442258 17283070 12874272 12732634 14699069 28468752 12764135 26977879 33961781 21149449 19032343 10575014
ACVR1B SMAD2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11024047 12063393 14978253
SMAD2 ACVR1C â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11024047 12063393 14978253
SMAD2 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 27974707 11456453 16284942
ACVR1C SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9920806 16709598
HDAC1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10199400
SMAD2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18729074 9111321
SMAD3 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10903323 11306568 10220381 9732876 21829441
SMAD3 SKI â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25670202 12154125 22442258 17283070 12874272 12732634 11306568 19875456 14699069 10575014 12764135 12857746 17469184 19032343 12426322 14525983
ACVR1B SMAD3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11024047 12063393 14978253
SMAD3 ACVR1C â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 11024047 12063393 14978253
SMAD3 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12374795 10022869
ACVR1B SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14517293 23331499 9605406
SMAD6 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 9892110
HDAC1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11306568 19049980 10575014
NR1H3 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23686490 16484597 24438183
TGFB1 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
TGFB1 SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
LTBP1 TGFB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10930463 12429738 21677751
LTBP1 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8432736 21677751
TGFBR1 SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15496141 11163210 11278251
ACVR2A SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMP2 SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
ACVR2B SMURF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
SMURF1 SMAD6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11278251 22298955 29950561
CTBP1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21102443 9650586 16189514 23752268 31041561 16713569 28947780 10995736 34147029 18765668 11022042
SIN3A HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15695521 28514442 9520398 10640275 14647463 12398767 9150133 10444591 14593184 21258344 12943729 12374985 17956988 11102443 9885572 17962807 26496610 12453419 11171972 16331260 20585571 10220385 25314079 12091390 11931768 17643391 11602581 17827154 12724404 11784859 23752268 18059533 9790534 9804427 26949739 24981860 33961781 19182791 11118440 15451426 12920132 26344197
HDAC1 SP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15647279 20072153 19062177 11909966 17894944 21636851 18003922 12176973 11896613 15557281 10409740 11517158 15713621 12665570 15722551 17906119 16478997 18850004 16121030 16883603 12091390 15155736 18948152 18059533 16713569 20385359 15528196 16734381 12200149 12847090
HDAC1 CTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9650586 16713569
SIN3A SKI â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10049357 21149449 11430826 10823891 14525983
HDAC4 NCOR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31040226 23752268 16713569 10640275 10860984 11804585 17956988 27684187
NCOR1 SKI â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10049357 12764135 19032343 11430826 14525983
JUN FSHB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9794452 23178797 21659477
THBS1 TGFB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22943793 8349738 21900405
THBS1 TGFB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22943793 8349738 21900405
THBS1 LTBP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22943793 8349738 21900405
ACVR2A SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMP2 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMPR1B SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMPR2 SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
ACVR2B SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
BMPR1A SMURF2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12151385 12857866 11278251
SP1 ELN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12055073 21880723 7896792
SP1 HTT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22399227 20018729
SP1 HDAC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18632985 18850004
KRAS EEF1A1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PPP2R1A PPP2CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15936019 16039140
PPP2CB RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 2826472 11124802 10200280
AR CTNNB1 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
CTNNB1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10601040 12782598 15907834
CTNNB1 FST â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18948405 15579438 24667650
AR TCF7L2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12799378 20610535
AMHR2 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 14746809 16446785
SMAD6 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23455153 23331499 10564272
INHBC ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12651901
ACVR1 SMAD9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10583507 16189514 11792802
BMPR1B ZFYVE16 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17356069 8893010 9136927
SMAD6 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10564272 23331499 15761153
ACVR2A ZFYVE16 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17356069 8893010 9136927
ACVR2A ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12682303 9032295 8612709
NOG BMP4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10657699 12700180 11706034
BMP2 ZFYVE16 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17356069 8893010 9136927
BMPR2 BMP2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10880444 10712517 25938661 7791754
ACVR2B ZFYVE16 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17356069 8893010 9136927
INHBE ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22710174
ACVR2B BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 17295905 16446785
BMPR1A ZFYVE16 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17356069 8893010 9136927
ID1 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 11427735 11507043 10728702
E2F5 TFDP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7760804 27705803 24981860 7892279 9464260
BMPR2 ZFYVE16 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 17356069 8893010 9136927
A2M TGIF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
INHBC ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12651901
EP300 HDAC1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
SMAD2 TGFBR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BMPR1B GDF5 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
AR NCOR1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
HDAC4 NCOR1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
SMAD4 SKI â—¼   PHYSICAL_INTERACTION ✅ 0.91 0.91 mint 25609649
SMAD3 SMURF2 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
ZFYVE9 SMAD2 â—¼   RELOCALIZATION ✅ + 0.91 0.91 Signor 20515759
SMAD2 SMURF2 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
CREBBP CTNNB1 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
SKI SMAD2 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
PPP2R1A PPP2CB â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5217765 15936019
BMP4 BMPR1A â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HDAC1 SP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
SKI SMAD3 â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
RBL1 TFDP1 â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
BMP7 NOG â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
CTNNB1 EP300 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
BMP2 RGMA â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
RHOA ROCK1 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
CTNNB1 AXIN1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 5219694 17318191
HDAC2 HDAC1 â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 26949739
ACVR2A BMP7 â—¼   PHYSICAL_INTERACTION 940.0 0.94 STRING 36370105
FST INHBA â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
TGFB3 TGFBR1 â—¼   PHYSICAL_INTERACTION 944.0 0.94 STRING 36370105
EP300 SMAD3 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
SMAD4 SMAD1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 17183365 5219486
NCOR1 SIN3A â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 17210713 11430826 16713569
SKP1 CUL1 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 7304783 18818696
SMAD4 SMAD9 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
ACVR2B INHBA â—¼   PHYSICAL_INTERACTION 953.0 0.95 STRING 36370105
ACVR2A BMP2 â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
FOXH1 SMAD3 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 32296183 9858566 21828274 15750622
HDAC1 RBL1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10490602 9724731 16189514
SMAD1 SMAD4 â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
PPP2CB PPP2R1B â—¼   PHYSICAL_INTERACTION 960.0 0.96 STRING 36370105
E2F5 RBL1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
RBX1 SKP1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16189514 12504025 12840033 12481031 26540345 11245432 29507117 10531037 16357137 30349055 15452136 12813041 23770852 29499133 12628165 11961546 29863914 33692209 27705803 33504946 12684064
AXIN2 CTNNB1 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
FOXH1 SMAD2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 9389648 9858566 11371641 32296183 10199400 12732634 10938097 16916642 9702198 21828274 15750622 9288972
HDAC2 HDAC1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 25241761 9520398 11287668 19703393 30737378 17894944 10444591 11466315 11777905 21258344 15297431 17956988 11102443 9885572 12032298 19041848 26496610 22416134 12493763 11739383 10581039 11804585 11564889 21670149 22939629 9150135 11919195 23752268 18059533 16713569 9804427 20388487 9790534 26949739 24981860 33961781 15987735 19182791 15451426 12920132 26344197
SIN3A HDAC2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16254079 12398767 21258344 12943729 9885572 9150134 12453419 12493763 14749338 22493095 12082111 25314079 12091390 17827154 12724404 23752268 18059533 9804427 26949739 24981860 15451426 26344197
ROCK1 RHOA â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 21281639 31431478 8816443 14660612 12773565 8798490 31871319
TCF7L2 CTNNB1 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 11713475 5214798
BMPR1A BMP2 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 19804412 7261592
E2F4 RBL1 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
SMAD7 SMURF2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
SMAD2 ZFYVE9 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
SMAD3 ZFYVE9 â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
BMP2 RGMB â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
HFE TFRC â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
TF TFRC â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
TGFB3 TGFBR2 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
TGFBR1 TGFBR2 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
SKIL SMAD4 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
SMAD7 SMURF1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
SMAD1 SMURF1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
E2F5 TFDP1 â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
BMP2 BMPR1A â—¼   PHYSICAL_INTERACTION 988.0 0.98 STRING 36370105
RBX1 CUL1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 16189514 12504025 20832730 15448697 10230407 19933270 12840033 12904573 18723677 12504026 12481031 17452440 12609982 26540345 27697867 22474075 11245432 22767593 28152074 22822056 19245792 12706828 11861641 20399188 10748083 11956208 11483504 27910872 16759355 30349055 10713156 11027288 21765416 20638939 22405651 23770852 19942853 10648623 12565873 18826954 18805092 32145688 21169563 27591266 22660580 11961546 32313199 15361859 19250909 29863914 24949976 10230406 32726803 30653357 32015321 33692209 16123592 34237211 29958295 29103612 33961781 33504946 12684064 26725323 26344197
E2F4 TFDP1 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
PPP2R1A PPP2R1B â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
SKI SMAD4 â—¼   PHYSICAL_INTERACTION 993.0 0.99 STRING 36370105
AXIN1 CTNNB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CTNNB1 TCF7L2 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
PPP2CB PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1B â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
PPP2CA PPP2R1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
NCOR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 22253232 20466759 20696891 24821728 24821727
ID2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17639499 16557594 21900881 16428453 11706002
AR CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 16281084 10076995 11606392 10606230 20610535 10809237
SMAD2 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9618481 12200968 17516505 14762439 10506225 24052079 14583455
SMAD4 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10878024 9618481 9865717 11786386 9307274 24052079 12429655 10962574 10415848
MYC CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 41.0 1.0 Omnipath 15190211 14519204 15616584 12408868 19174556 21949397 10319992 12553001 16204065 12545156 20878079 21042278 21400515 20190815 16706751 23804320 15757889 10920185 19270520 16452181 12408820 15528212 22371483 12565816 17885207 12384701 11274368 19150257 20551174 15899785 21120446 15071503 15474507 22814619 12835716 12748190 16738884 15711923 18636159
HDAC1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12665570 19182791 15130752 18210215 16287849 17172847
SMAD7 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 10878024 15922743 20104486 12185267 15555279 11180003
ID3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23342268 22564737 17639499 20191379
SMAD3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10878024 9618481 14755691 10601254 16819512 17516505 10506225 14647420 14583455
JUN CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11136975 12717415 21278055 10506225 19628677 12054510 18094076 10072388 18210215 10733944
ID1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 20388787 17639499 10728702 20191379 23342268 20484992 19217708 9315646 22564737 18092003
EP300 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10362258 15509808 21858218 22000024 21245169
SP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 9580699 15978937 15557281 11064455 16103879 19584258 20301197 20935676 15961274 15361832 11274368 11842244 15489892 15302882 10212208 12796485 23184467 14529564 12806965 9819384 10321829 10649433 12434298 18270969 18850004 16081043 9183012 21858218 10809237 9618481 16298343 11574165 10362258 11384995 15659839 14744793 10030670 17090534 10733944 19318349 12665570 18202149 17516505 15033443 22001409 17885207 10485470 9553133 15345676 15694838 22427654 17556661 10506225 23066038 15979845 18636159 14527674 24821727 15899840 14755691 12151347 24589735 18210215 23877711 11953011 21311948 15528212 15790310 10878024 22132221 12782287 12773551 8995437 21184768 12379120 17026958 24451377 10601254 8557703 16810128 16533812 7499379 10625687 15389873 16706751 12727210 21325288 16818630 18419600 15041706 23235480 19244234 15694666 23329847 18509005
MAPK1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20519948 19364816 28368408
MYC CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15528212 9618481 12545156 17550342 10454538 15155580 11283613 10920185 11283614
RBX1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11278750 15340381 12820959 15688063 18381890 19440234
ELAVL1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19528229 18519672
SMAD3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 9618481 17550342 12545156 11013220 15155580 11074002
SMAD2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9389648 9618481 12545156 17550342 11013220 15155580 9670020 11074002 11283614
SMAD4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 9618481 17550342 12545156 11013220 15155580 11074002
SP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17026958 9389648 9618481 17550342 12545156 11013220 15155580 11074002
HDAC4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18632985 18850004
CDKN1A TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 9190208 10498883 9315635 10385618 10778858 9736735 7736585 9425340 11520855
ELAVL1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18519672 19574298
IFNG EP300 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11971970 10779504 24480624 17011549 16713569
EP300 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 21988832 23331499 9169454 12237408 10199400 11264182 7878020 8047140 12958365 19171760 11371641 16027720 17074756 17469772 21269274 15623506
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12419246 14500836 10673036 22298955
EP300 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9843571 11134049 12743039 15133024 15824515 15623506 16876108 21567395 16109717 17074756 20564330 10497242 15588252 17469184 15345715 11058129 10575014 16862174
EP300 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 17145710 22290435 19623618 11804596 23343194 22761862 16039586 12776737 17157259 17143292 12660246 15576399 21151179 15522869 17306568 19407812 17666529 21285352 19619488
EP300 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11050151 18987336 15806138 15060161 17410209
EP300 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 12408818 10887155 15831498 21269274
KAT7 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15507644 11006273 14966289 21632823 11747826 17720252 12748286
PLK1 KAT7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 19007248 18250300 19690332 22309699 23188630 19413330 17525332 18669648
KAT7 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10930412 16713569
MAPK1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAPK1 RBX1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MAPK1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MAPK1 SKP1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MAPK1 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MYC MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22789855 21933022 16596619 23617883 8013639 20144848
SP1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12220517 16797880 20506264 20121399 20882567 18372343 10727414 21170990 17889508
PPP2CA MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 12624094 12840032 18039929 16680151 16456541 10995457 18042541 10592173 7780739 18588945 2154696 20626350
PPP2CB MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18039929 16680151 16456541 10995457 18042541 7780739 18588945 2154696
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 8072547 11313929 15378002 12531896 12853483 23720779 9662434 1496019 17570479 1922387 11278277 11739718 16023596 20086174 25557171 7737130 26755651 8224842 14676207 17920329 25201974 9022811 22327296 18650425 8137421 18443042 12881422 18572021 17001009 33767435 7744008 23616010 26745678 14617628 11432833 16819515 22606284 12040039
MAPK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19318349 20882567 16377629 18775330 8226933 14744793 16079281 11904305 9604935 15212693 14593115 8388392
MAPK1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12801888
MAPK1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 23331499 10197981 34504019 18775330 20659902 8226933 9620846 16156666 9604935 18988627 12193595 11027280 8388392 27153775 31995604
MAPK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 12054624 15547943 20080742 14967450 12040186 15173823 12697810 11940578 7545671 16227978 21035469 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 19085255 11279232 9271440 18039929 18775330 11705993 10601235 12792650 11431469
MAPK1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 19218245 18032789 18729074 16156666 19914161 23331499 19914168 24080014 8226933 14512875 15520018 20736297 26497676 12193595 26297431 18988627 8388392 10197981 15241418 18775330 9604935 9380693
MAPK1 PML â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 22935031 29416846 23293771 23316480 15093545
MAPK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10551811 17081983 8386367 17251036 91332050 17570479 1748630 7957875 27167001 15212693 1651323 15210690
MAPK1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18511414 9725910 10318905
MAPK1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 17289590 19914168 9335504 19914161
KRAS MAPK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 15035987 21779496 24957944 22510884 23352452 25907612
MAPK3 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
MAPK3 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 10197981 16156666 27153775 29577978
PPP2CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 12624094 12840032 18039929 16680151 16456541 10995457 18042541 18588945
MAPK3 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18463697 9155018 21071413 32482868 18988627 15210690
MAPK3 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 32205409 20150555 21983342 11904305 14593115 18199680 8226933 14744793 16079281 19318349 20882567 22266860 28574228 21097497 8388392 32615164 16377629 19245816 18775330 9604935 15212693
MAPK3 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 17081983 16156666 19413330 11027280 9620846 33676893 23331499 8226933 20068231 18988627 12193595 18491316 18691976 8388392 19651622 10197981 18775330 19115199 9604935 15212693
MAPK3 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 15547943 20080742 14967450 12040186 15173823 12697810 11940578 16227978 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 11279232 9271440 18039929 18775330 10601235 12792650 11431469
MAPK3 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 10197981 9335504
MAPK3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28115363 12801888
MAPK3 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10197981 15241418 24080014 18775330 8226933 16156666 9604935 12193595 8388392
MYC AXIN1 â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
MYC AXIN1 â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 11274345 11283614 16713974 16940750 17558397 17873522 19131971 19366350 19751508 19836308 20027199 20237412 20551172 20581311 20713526 21406394 2191300 22067385 22270359 23732914 25002027 26885856
PLK1 MYC â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11073952 17596790 18931676 19270156 19622404 19686080 8127874
JUN MYC â—¼   ENZYMATIC_REACTION ✅ 40.0 1.0 ACSN 11274345 11929833 11955436 11967263 12051714 15001769 15576399 15768032 15806138 16007074 16039586 16169192 16510874 17050667 17143292 17291450 17439715 17936032 18347071 18627596 19619488 19623618 20006983 20122174 20530697 20705860 20920541 21285352 21767405 22290435 22705350 22761862 23306204 23343194 24023259 25730849 26587781 7542250 8545107 8666229
MYC TGFB1 â—¼   ENZYMATIC_REACTION ✅ 22.0 1.0 ACSN 10432118 11274345 11283614 11875494 16327802 17558397 17873522 20027199 20237412 20551172 20581311 20713526 21093321 21372296 21406394 21765015 2191300 22067385 22461508 23124025 23390297 25002027
JUN MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21835891 8276360 1774959 2498162 21607323 20410304 14523011 18037408
TCF7L2 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 12095419 19561604 19895682 15579438 26947016 16204248 12799378 12907606 17360646 9727977 21533051 20133699 15576399 19784072 24447505 12591729 20818421 18852287 11973610
E2F4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 24573694 17132729 17699159 11689553 12757710
SMAD4 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11689553 17132729
CTNNB1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21533051 19778454 16510874 12095419 17360646 18852287 15576399 19561604 20300972 19662654 15579438 17724465 9727977 24447505 18679417 12907606
SMAD3 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 15930298 20516082 14993291 17132729 16205635 25238097 11689553 17114344
SP1 MYC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11470523 9492315 2284094 8437848 7753559 8355712 2057364
MYC TFRC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 3302722 12695333 14519204 16466700 20631077
MYC THBS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 14519204 20876797 10871348 18583030
MYC CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 12244100 22610535 11804592 12565816 19164764 12835716 11283613 14519204 24618291 19201832 23722468
MYC ID2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12447693 12695333 12824180 18437010 18483244 12545167
MYC TGFB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9196027 12695333
MYC ID3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22564737 12695333
CREBBP MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 7575488 18590585 17303408 15522869 12776737 20144767 17660363 16878156 15279786
PLK1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18931676 19270156 25915540 23887393 19622404 19686080
JUN MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 29.0 1.0 Omnipath 15806138 16510874 22290435 18627596 19623618 11929833 23343194 15768032 22761862 17050667 16039586 20122174 17291450 20920541 17143292 20006983 17439715 15576399 21767405 23306204 8545107 22705350 18347071 16007074 16169192 21285352 20530697 19619488 11274345
HDAC1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
PPP2CB MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16987807 16680151 15048125
PPP2CA MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 19131971 10026142 10995457 18042541 18559511 16680151 15048125
TCF7L2 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
CTNNB1 MYC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19751508 7542250 11967263 22290435 19623618 16574648 23343194 11955436 22270359 22761862 16039586 15810077 17143292 12051714 8666229 22943793 15576399 21151179 16940750 17306568 17666529 21285352 19619488
MYC SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
MYC CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 10454538 10373560 9308237 17936558 12738781 17873522 11283613 21406394 9312026 15095404 10504341 17558397 20551172 19901969 19815509 11283614
MYC SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 11804592
E2F4 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17531812 15105433 17981789
PML SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 15356634 16189514 18988627
PML ZFYVE9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 21071413 15356634 18511908 16189514 18988627
CUL1 RBX1 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
RBX1 SKP1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
RBX1 CUL1 â—¼   PHYSICAL_INTERACTION 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
RBX1 CUL1 â—¼   SHARES_COMPLEX 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
RBX1 SKP1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
RBX1 CUL1 â—¼   ENZYMATIC_REACTION ✅ 76.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 14536078 15001769 15071497 15147722 15340381 15459660 15489953 15688063 1570337 15703371 16039586 16469695 16697054 16713974 16940750 17053147 17143292 17652783 17884153 17928543 17936032 18196958 18636226 18787170 18805092 18931676 19143635 19150432 19250909 19258535 19270156 19352404 19366350 19411070 19557001 19576224 19597341 19619488 19622404 19686080 19751508 19797085 19809470 19836308 19847258 19849719 20006983 20211143 20558317 20705860 20832730 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26159692 26885856 7542250 7641885 8666229 9694792
RBX1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11359933
RBX1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 154.0 1.0 Omnipath 17053147 12684064 20638939 11967263 19797085 19258535 26540345 18826954 15071497 15448697 21765416 25730849 10230406 23343194 21169563 22270359 19250909 23732914 11359933 12051714 20006983 15361859 10748083 19352404 22682247 18787170 12504025 18636226 16469695 15459660 20211143 10535940 15001769 26725323 19411070 11861641 26159692 16697054 1570337 19751508 22822056 11348595 7542250 7641885 19849719 16759355 12820959 17452440 19622404 15703371 10648623 19245792 23331499 9694792 19150432 23180781 19597341 16189514 22474075 18988627 22767593 17143292 24949976 10713156 23770852 22405651 19942853 18196958 20399188 16713974 26192618 11027288 17884153 19933270 22730322 21411632 11961546 17936032 19809470 15147722 19270156 19576224 11483504 20976471 12504026 24023259 12840033 15340381 12904573 20558317 11900249 14536078 19686080 12565873 18805092 15489953 19557001 26885856 17652783 12481031 20843316 11955436 21071413 16039586 11956208 20705860 8666229 17928543 10023660 19836308 16940750 12706828 19143635 15688063 10671552 16123592 19366350 19847258 12417738 11245432 20832730 12648680 12609982 19619488 10230407 18931676
SMURF2 SKIL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11389444 23331499 15221015
SKIL SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 12764135 23331499 21071413 22442258 11306568 16959829 10531062 12793438 17469184 15231748 11691834 12426322
SKIL SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12764135 25609649 23331499 25059663 15761153 10531062 17510063 12793438 17469184 15231748
SKIL SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 12764135 15221015 23331499 18729074 22442258 25059663 16959829 18334480 10531062 17510063 15496141 12793438 15231748 11691834 12426322
TF TFRC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 11027676 21788477 9546397 6270680 16271884 29302006 14691533 12210842 20404192 16354665 6268632
HDAC1 TNF â—¼   DOWN_REGULATES ✅ - 15.0 1.0 ACSN 10754326 10952726 11875494 12907458 14660645 14668329 15465827 15644117 16878026 17404308 17485448 21234400 22796940 23390297 7594497
SP1 TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 23733894 12759366 27030318 22534375 7649977 12509451 12378384 15175554 18357389 10829018 11390427 17897957 18218727 8258705 12560487 17047073 21320120 7918637 16847329 10559188 18930140 20068037 1618817 21784970 10688670 10913190 17307735 18467438 21411747 11500175 20221720 20701940
JUN TNF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 12759366 11087751 7935377 21059644 16881863 24548427 12509451 9826775 10318823 8998076 18408586 15546613 20164416 7896795 9211933 10952728 9566900 23583459 10748079 24009130 10954918 10754326 9813054 10837498 9988757 11739517 16365438 19285436 16199883 8816436 10551799 8552071 9160673 11490006 21098092 16483936 10688670 10913190 16888805 9030359 25567680 9760243
TCF7L2 AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15473860 11809809 24447505 11809808 12711682 11940574
CTNNB1 AXIN2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 24447505 15473860 11809809 22615875 11809808 12711682 11940574
HDAC1 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 21734722 17666529 15576399 22761862 22290435 19923891 20682799
CTNNB1 AXIN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 10966653 19751508 7542250 8666229 17143292 11955436 11967263 23343194 22270359 9554852 22699938 16039586 16940750 9566905 19619488 15766563 12051714
NOG BMP7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 17145710 12478285
BMP7 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 9748228 7790373 12667445
BMP7 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11282024 8006002 31619522 122976748006002 16189514 12297674
BMP7 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15621726 106311828605097 8605097 10631182
BMP7 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 18342887 16446785 7791754 7644468
BMP7 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9748228 23331499 16446785
BMP7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16189514 7791754 12297674 8605097
FOXH1 NODAL â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20227405 17038485 21741376 15459100 12642485
FOXH1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 9389648 23331499 21828274 9858566 9288972 16916642 10199400 10938097 12191473 15750622 32296183 12374795 11371641 9702198 12732634
TGFB1 ID3 â—¼   DOWN_REGULATES ✅ - 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
TGFB1 ID2 â—¼   DOWN_REGULATES ✅ - 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
CTNNB1 ID2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15252039 19751508 7542250 17615296 8666229 11708773 11967263 11955436 22270359 16940750 12051714 15181457
SMAD3 E2F4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12150994
E2F4 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 12150994 17671431 9858615 7958925 11573202 7958924 18319725 8657117 9724731 9144196 9501179 8643455 10766737 16135806 16360038
SP1 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9223667 17967179 12482909
SMAD3 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD2 SMAD4 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
SMAD4 SMAD3 â—¼   PHYSICAL_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PHYSICAL_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SMAD3 â—¼   PROTEIN_INTERACTION 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD4 SMAD2 â—¼   PROTEIN_INTERACTION 52.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11399519 11792802 11875494 12193690 12545156 12702545 12809600 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 17055429 17260466 17550342 17689680 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23390297 23784029 23869868 6357187 8515656 8871614 9312026 9389648 9618481 9670020
SMAD4 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
TGFBR2 SMAD4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFBR1 SMAD4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD4 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 ID1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 15265520 16713975 16831886 17490644 18832382 21614932 23850759 9389648
SMAD4 IFNG â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
SMAD4 SMAD3 â—¼   LOCALISATION ✅ 72.0 1.0 ACSN 10454538 10925299 10964912 11007770 11013125 11013220 11074002 11114293 11224571 11279127 11283613 11283614 11376132 11399519 11792802 11875494 12193690 12545156 12702545 12809600 14976548 15001984 15095404 15155580 15265520 15644117 16127449 16179589 16713975 16831886 17018611 17055429 17260466 17550342 17563753 17689680 17705132 18353785 18768831 18832382 19208835 19597490 19815509 19901969 20027199 20713526 20731704 21041997 21042762 21098712 21252118 21317430 21577210 21614932 2191300 22331441 22514743 22652804 23140366 23338822 23390297 23784029 23869868 25374926 6357187 8515656 8871614 8893010 9312026 9389648 9618481 9670020
SMAD2 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16052471 11376804 11456453 9812998
SMAD4 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10823886 15183844 10887185 19032343 10839991 16442497 10753944 10843994 15128733 10559222
SMAD4 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10964912 15647271 10843986 21968601
SMAD4 FSHB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15375186 12554780 14764653 18339718 15707600 20371653
SMAD3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 104.0 1.0 Omnipath 25609649 9843571 15084259 20211142 21532621 24584437 18729074 23788427 12419246 18923419 9892009 19768112 10531362 15231748 9679060 12167862 21988832 12150994 23331499 12543979 18568018 21071413 19135894 15467747 25502805 9732876 11927552 16189514 12917407 25514493 15350224 10995777 18988627 10092624 12732634 25910212 10878024 9111321 20564330 27107012 9311995 12957874 20142324 11114293 32296183 15588252 15761153 24157709 26555259 29892012 17469184 22442258 16714330 21597466 15922743 22045334 17591701 24382352 22310290 19139564 19917253 29997244 31515488 28115363 10942775 21297662 17283070 12794086
SMAD5 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 20957627 23331499 14534577 16516194 16189514 10531362 15231748
JUN SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10220381 9312063 9732876
SMAD2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 110.0 1.0 Omnipath 15613484 17145710 25609649 15817471 20211142 21532621 24584437 18729074 23788427 12419246 16916642 9288972 9892009 21454478 17510063 10531362 15231748 11027280 12167862 21988832 9389648 23331499 12543979 18568018 21071413 19135894 18511908 15467747 12808092 11927552 25514493 15350224 18988627 12732634 10878024 9111321 9311995 9346908 10199400 11264182 12957874 11114293 15761153 11274206 12621041 17272273 24157709 26555259 12374795 22442258 10781087 15922743 11102446 17591701 18783722 16751102 19139564 19917253 9346966 21297662 17283070 12794086
TGFBR2 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8774881 20060931 11274345 21614932
SKI SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 17145710 12764135 25609649 12419246 20959473 10485843 15231748 23331499 21071413 12874272 12732634 25670202 14525983 12857746 15761153 12793438 17469184 19032343 14699069 10531062
SMAD1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17183365 9436979 24412244 11779505 31467278 21454478 10531362 15231748 12167862 23331499 21071413 11700304 12874272 16189514 18988627 20957627 9111321 15761153 32296183 26555259 14701756 14534577
TGFBR1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8774881 20060931 11274345 21614932
SMAD9 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 20957627 25502805 10583507 31515488 16189514 15231748
SMAD4 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 11013220 10454538 9670020 11283613 11074002 11283614
SMAD4 ID1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 9389648 18832382 16831886 11074002 17490644
SMAD4 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12150994 16189514
TGFB1 TGFBR2 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 TGFBR1 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 TGFBR1 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 TGFBR2 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFBR2 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFBR2 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFBR2 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
SP1 TGFBR2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 18053089 11507078 22028617 15647279 11687969 10982796 12750289 15895377 10766860 9632722 15905358
SMURF1 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 11278251 15221015 22298955 15761148 21572392 27048878 22949611
TGFB2 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8106553 1310899 23331499 21071413 12729750 16446785 12809600 11157754
TGFB1 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 122.0 1.0 Omnipath 1310899 22874531 8047140 11279127 22710166 7878020 16424049 17673906 24132110 18922473 22943793 12729750 16446785 20519943 7706250 15761153 7594497 15548370 15761148 15265520 19010789 26194464 7852346 12717440 17768418 19050695 11133108 14557817 11278410 19920116 22949611 22703233 23331499 23070005 20060931 17070508 21614932 1333888 10716993 16572188 20860622 11323414 21900405 12724770 8106553 23034983 26192618 2871107 12809600 11382746 21372296 20538542 16200688 11792802 26201938 24403530 15099563 11013220 17979848 21054789 23784029 15003992 20644162 8515656 7935686 11157754 20856203 18382895 15282297 18855897 9865696 21441952 10678166 16127449 21041659 10026191 22315516 12767520 17404308 19732719 20616810 21071413 17934056 12738796 18423981 21098712 19747910 9311995 15034927 11274345 12154066 18758450 24336330 21278795 26966341 9261125 16474430 15653932 18490733 8242742 19038247 19109155
TGFB3 TGFBR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 17145710 15017149 18243111 23331499 21071413 23180781 7878020 11850637 18988627 12729750 16446785 11157754 8106553 21423151 9872992 11382746 29170498
TGFBR2 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 10678166 9463378 11792802 11133108 19920116 14557817 11278410 15178549 20060931 17934056 21614932 8980228 9311995 20519943 21900405 15548370 19010789 15104092 16474430 30093905 11274345 9865696
TGFBR2 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11278251 15221015 11163210
TGFBR2 ZFYVE9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 9865696
TGFBR2 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 48.0 1.0 Omnipath 7774578 9463378 19556242 8047140 23868260 18243111 7890683 10026191 23331499 8576253 21071413 7878020 21791611 10716993 18988627 11278251 19758997 25825445 22802914 16446785 11483955 8947046 11323414 11124802 15221015 11102446 11387212 12809600 7566156 26194464
SMAD3 SMAD7 â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD2 SMAD7 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD7 TGFBR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11279127 15265520 22286770 23784029
SMAD2 SMAD7 â—¼   PROTEIN_INTERACTION 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD3 SMAD7 â—¼   PROTEIN_INTERACTION 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
SMAD7 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 11279127 15265520 22286770 23784029
SMAD2 SMAD7 â—¼   DOWN_REGULATES ✅ - 10.0 1.0 ACSN 11074002 11279127 15265520 16179589 16713975 21042762 21614932 22331441 23784029 9670020
SMAD3 SMAD7 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 11279127 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21614932 22331441 23784029 8515656
TGFB1 SMAD7 â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11133108 11708773 12490555 14557817 15111329 15181457 15252039 15548370 16474430 16607286 16716598 17615296 17934056 18403754 19010789 19109155 19920116 20519943 20644162 21041997 21278795 21900405 21909923 22703233 7594497 9157999 9335507
SMAD3 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10823886 15183844 12761881 10887185 10973944 10839991 10753944 10843994 15579469 10559222
SMAD2 SMAD7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15183844 10887185 10753944 10843994 10559222
SMAD7 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10887185 15855807 9886263 20631490 22656308 19214138 23633623 14600158 10753944 11912247 11385614 11180003 17928287 19010789 22496417 22841502 17074765 15496141 11448947
SMAD7 ACTG2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15788410 17475816 20628268 19861282 18065393 18992195
CTNNB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 15684397 21071413 18988627
SMURF1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 22773947 12151385 23331499 22921829 21071413 18988627 11278251 12408818 12519765 22152476 27292644 20937913 15221015 24700460 14722617 16720724 23959799
TGFB1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19010789 14718519 16474430 17934056 20519943 9335507 21900405 11133108 14557817 15548370 19920116
WWP1 SMAD7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15221015
SMAD7 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 21071413 9892009 26555259 9892110
SMAD7 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 9335505 21897371 9335507 17314099 12151385 9892110 23331499 22921829 21071413 21791611 18988627 11278251 16571110 14657019 18725536 15761153 11163210 15221015 30017632 22286770 15148321 20663871 14722617 9215638
SMAD7 SMURF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 26435193 22773947 15231748 23331499 22921829 16641086 17719543 21791611 26679521 11163210 27292644 20937913 15221015 18448069 22624557 32283253 23973329 16061177 14722617 19352540
SMAD7 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 17438144 21071413 9892009 9892110
NCOR1 SMAD2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10549282 10485843 10535941 10531062 11389444
SMAD3 SMAD2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD2 SP1 â—¼   PHYSICAL_INTERACTION 40.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020
SMAD3 SMAD2 â—¼   PROTEIN_INTERACTION 41.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020 9865696
SMAD2 SP1 â—¼   SHARES_COMPLEX 40.0 1.0 ACSN 10454538 10964912 11007770 11013220 11074002 11279127 11283613 11283614 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21252118 21614932 2191300 22331441 23140366 23338822 23869868 8515656 9312026 9389648 9618481 9670020
TGFB1 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
TGFBR1 SMAD2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
SMAD2 IFNG â—¼   DOWN_REGULATES ✅ - 24.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 21042762 21614932 22331441 23390297 6357187 8871614 9389648 9670020
SMAD2 FSHB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15375186 17082263 12554780 14764653 18339718 14701940 15707600 20371653
SMAD2 ACTG2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20628268 18631173 18065393 17105765
CREBBP SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16751102 18003620 9679056 15750622 17283070 20403362 17074756 15231748
TGIF1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18511908 10199400 11371641
TGFB1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15548370 19010789 10678166 16474430 9311995 23831640 17934056 20519943 24075003 11792802 11133108 21900405 14557817 11278410 19920116 9865696
SMURF1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10458166 23331499 15221015 20207742 15231748
SKI SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 12764135 26977879 18729074 20959473 10485843 23331499 21071413 12874272 12732634 25670202 12793438 22442258 21149449 19032343 14699069 10575014 17283070
TGFBR1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 74.0 1.0 Omnipath 10678166 12220225 9892009 9463378 16024789 9136927 14625308 11792802 11133108 19920116 14557817 11278410 15134444 10085140 23331499 21071413 20060931 17934056 18511908 21614932 18988627 10973958 23221174 8980228 9311995 9346908 9235954 20519943 21900405 15350225 15548370 26057631 19010789 15104092 16474430 9346966 30093905 12957874 11744690 9525694 15212693 11274345 9865696
ACVR1B SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 9346908 11389842 9892009 18988627 14517293
ZFYVE9 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15613484 23331499 10615055 18729074 21071413 16916642 18511908 15356634 18988627 20515759 11094085 23687300 11243848 17272273 15231748 9865696
SMAD6 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9256479 21071413 9892110
SMURF2 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 35509688 27447855 15221015 11016919 23331499 22045334 18729074 35379779 11389444 19122240 11158580 15231748 14507671 19620243 20937913
WWP1 SMAD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 15221015 15946939 15359284
SMAD2 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 21988832 26186194 12543979 9111321 15084259 9311995 25878769 18729074 12700238
SMAD2 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 11013220 10454538 9670020 11283613 11074002 11283614
SMAD2 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19558215 10878024 12631740 11013220 11114293
NCOR1 SMAD3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10549282 10485843 10535941 10531062 11389444
TGFB1 SMAD3 â—¼   PHYSICAL_INTERACTION 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
TGFB1 SMAD3 â—¼   SHARES_COMPLEX 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
TGFBR1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 14557817 15265520 16474430 17934056 20060931 20519943 21614932 22703233 24132110 24336330
TGFB1 SMAD3 â—¼   ENZYMATIC_REACTION ✅ 30.0 1.0 ACSN 10678166 11013220 11133108 11278410 11792802 12154066 12717440 12724770 14557817 15265520 15548370 16474430 17934056 19010789 19050695 19109155 19920116 20060931 20519943 20644162 21278795 21614932 21900405 22703233 22710166 24132110 24336330 7594497 9311995 9865696
SMAD3 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD3 IFNG â—¼   DOWN_REGULATES ✅ - 25.0 1.0 ACSN 10925299 11074002 11279127 11399519 11792802 11875494 12193690 12702545 12809600 15265520 15644117 16127449 16179589 16713975 17260466 17689680 18768831 21042762 21614932 22331441 23390297 6357187 8515656 8871614 9389648
SMAD3 FSHB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 18022758 15375186 24601881 12554780 14764653 14701940 15761025 15707600 21664424 20371653
SMAD3 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 26553048 27974707 10708950 19214138
SMAD3 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14647420 15326485 23032366 16819512
CUL1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 11359933
PPP2CA SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20704570 23331499 19951945
AXIN1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11438668 23331499 18988627
SKI SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 17145710 12764135 12154125 10485843 23331499 21071413 19049980 12874272 12732634 25670202 14525983 12857746 11306568 12793438 17469184 22442258 19032343 14699069 19875456 10575014 10549282 17283070 12426322
TGFBR1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 15104092 9311995 8774881 25714018 11438668 19458083 11792802 12957874 19701891 9380693
CREBBP SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 15849193 10497242 15467747 18003620 9679056 15990875 15750622 19589780 17074756 17283070 9679060
SMURF1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10458166 23331499 15221015 15761153 15231748
ZFYVE9 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 26186194 18729074 15356634 25502805 20515759 31515488 16189514 12154125 15231748 9865696
TGFB1 SMAD3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21557273 24899689 24075003 24485922 28756206 32196115
SMAD3 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9732876 10220381 11306568 21829441 10903323
SMAD3 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12150994 16189514
SMAD3 E2F5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12150994
SMAD3 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 11013220 10454538 9670020 11283613 11074002 11283614
SMAD3 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 23331499 11248024 11280774 12226080 16713569 11707452
SP1 IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24019072 17023546 12576336 8756632 18793716 9503023
JUN IFNG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20006311 22123848 14734615 15187132 11943142 20304822 17556653 1314139 17105733 22413812 19265145 11801649 16713974 7759501 12836278 15522880 12626576 9558063 8756632 18641343 22351517
TGFB1 TGFBR1 â—¼   PHYSICAL_INTERACTION 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
TGFB1 LTBP1 â—¼   PHYSICAL_INTERACTION 36.0 1.0 ACSN 10025398 10544215 11133108 11766992 14557817 15548370 15611103 16139227 16474430 16710477 17934056 18342983 18423981 18802007 19010789 19109155 19741094 19854168 19909365 19920116 20519943 20535745 20644162 21278795 21883891 21900405 21909923 22703233 23620508 25732845 26552706 26711338 7594497 8570922 9314552 9931372
TGFB1 LTBP1 â—¼   SHARES_COMPLEX 36.0 1.0 ACSN 10025398 10544215 11133108 11766992 14557817 15548370 15611103 16139227 16474430 16710477 17934056 18342983 18423981 18802007 19010789 19109155 19741094 19854168 19909365 19920116 20519943 20535745 20644162 21278795 21883891 21900405 21909923 22703233 23620508 25732845 26552706 26711338 7594497 8570922 9314552 9931372
TGFB1 TGFBR1 â—¼   SHARES_COMPLEX 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
THBS1 TGFB1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10657674 11982756 14568985 14996710 21900405 22943793 8349738
TGFB1 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 75.0 1.0 ACSN 10678166 11013220 11133108 11274345 11278410 11279127 11792802 12154066 12717440 12724770 12738796 12767520 12809600 14557817 15003992 15099563 15265520 15282297 15548370 15653932 15761148 15761153 16127449 16200688 16424049 16474430 16572188 17070508 17404308 17673906 17768418 17934056 17979848 18423981 18490733 18758450 18855897 18922473 19010789 19038247 19050695 19109155 19732719 19747910 19920116 20060931 20519943 20538542 20616810 20644162 21041659 21098712 21278795 21372296 21614932 21900405 22315516 22703233 22710166 22874531 22943793 22949611 23034983 23070005 23784029 24132110 24336330 24403530 26201938 26966341 2871107 7594497 8515656 9311995 9865696
JUN TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 8058069 16327802 16730810 23437118 8183578 16365456 22429882 23936544 15546613 10843986 16978906 23762330 7521696 8631909 12794825
SP1 TGFB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12186868 9580699 2808430 12615726 22415074 27974707 12138160 10964912 9242631 15178441 23437118 23936544 11114293 8325508 16714330 11278686 10212284 9837963 11054406 23806282 15979845
THBS1 TGFB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22943793 8349738 21900405 1550960
TGFB1 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 22326956 10187774 7852346 22703233 12809600 7706250 11323414 8047140 8235612 26194464
TGFB1 APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12867422 25241761 16189514 2119582
SMURF1 TGFBR1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 14657501 14722617 14744429 15265520 15761148 21572392 22949611
TGFB2 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 22326956 10187774 7608141 11157750 12809600 11157754
ZFYVE9 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 9865696 23331499 12134149 14718519 12052882 18988627
SMAD6 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 11278251 23331499 22921829 9335505 21897371 22286770 20663871 9335507 15761153 12151385 11163210 9215638 9892110
SMURF1 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 9335505 21897371 9335507 17317136 22949611 12151385 12857866 23331499 22921829 11278251 21572392 14657019 12519765 15761153 11163210 15221015 15761148 22286770 9215638
TGFB3 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 10187774 21423151 11850637 12060054 18243111 12607775
SMURF2 TGFBR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11278251 15221015 22921829 22624557 9335505 21897371 22286770 14722617 9335507 17317136 15761153 12151385 11163210 9215638
TGFBR1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19651622 9748228 9335504 10085121 9136927 15212693
TGFBR1 EEF1A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20832312
PPP2CA AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 19131971 23331499 10644691 9920888 10026142 11742073 10995457 18042541 18559511 16680151 10421629
AXIN1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 52.0 1.0 Omnipath 20128690 20531388 16890161 27902311 22509369 18593713 16199882 23331499 9482734 21071413 26496610 19244247 22773187 17318191 10196136 18988627 17208333 19131971 24976009 22682247 10228155 12805222 12000790 10488109 9501208 9601641 18632848 9554852 19166851 23959799 12421363 9734785 11940574
SMURF1 RHOA â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14657501 14722617 14744429 15265520 15761148 16472676 21572392 22949611
SMURF1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 14701756 17676934 15221015 19914168 21708152 22298955 24828823 19917253 16611643 17510966 15761153 22670624 22152476 17289590 15231748 21685363 27447855
SMURF1 RHOA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 15761148 21572392 16472676 16622418 28658604 15710384 14744429 14657501 22949611
SMURF1 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17676934 20484049 11278251 15221015 19914168 22298955 18641638 22670624 15231748 12857866
HDAC1 HDAC2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 TCF7L2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 10485845 11266540 10559189 20405012
HDAC1 SIN3A â—¼   PHYSICAL_INTERACTION 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 NCOR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 HDAC2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 SIN3A â—¼   SHARES_COMPLEX 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 NCOR1 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 SIN3A â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 HDAC2 â—¼   UP_REGULATES ✅ + 28.0 1.0 ACSN 11283614 12545156 12668723 14673164 15151915 15155580 15465827 16232121 17018611 17055429 17508028 17550342 17563753 20027199 20713526 20818389 21234400 21577210 21685935 21733352 2191300 21919891 22370643 22514743 22796940 23140366 23869868 9618481
HDAC1 AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11994312 16713569 15640443 12612053 10428808
HDAC2 SIN3A â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
HDAC2 SIN3A â—¼   SHARES_COMPLEX 8.0 1.0 ACSN 14673164 15465827 17018611 17563753 21234400 21577210 22514743 22796940
NCOR1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20462215 17400812 12392082 10612426
AR NCOR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 15598662 11971970 16469706 14593076 15256534 23518348 16713569 12089345 16914745 20812024 20974212
SP1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 20148354 8355696 8892460 1406636 19437621 9054614 17502875
CTNNB1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20300972 19671687 16007074 9990071
JUN DCN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 7499226 8798756 8940199
JUN APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8063812 11677255 8015372
JUN ELN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11967999 1281483 11557580 10559225 1637804 12135766
AR JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11577103 11518798 9211894 8798722 16713569 9591784 17721441
CREBBP JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8028671 10327051 2138276 9659924 9786917 16713569 17296604 8545107 18443043 16055710
JUN CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17146436 18347071 16007074
CUL1 SKP1 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11516665 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15668399 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
CUL1 SKP1 â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 14685242 16189514 17290223 20832730 12504025 12904573 10230407 19933270 23324393 12504026 9636170 26540345 12609982 27697867 26753747 21145461 22474075 28007894 18818696 9736735 9990852 22767593 28152074 10023660 29070679 9827542 23951410 16357137 16759355 10713156 15452136 19270694 11027288 26474281 23770852 10648623 29499133 21249194 34499862 12628165 15966899 21169563 22660580 11961546 9430629 32313199 29863914 10230406 30653357 19945379 9663463 21778237 34237211 18094045 26976582 27705803 32249768 29103612 33961781 12684064 26725323
CUL1 SKP1 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11516665 11900249 12648680 12820959 14536078 15071497 15147722 15340381 15459660 15489953 15668399 15688063 15703371 16697054 17053147 17884153 18636226 18787170 18931676 19150432 19270156 19622404 19686080 19797085 19809470 19847258
SKP1 CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 9663463 19945379 12684064 19270694 16759355 23951410 10648623 11961546 26540345 26976582 26474281 17290223 9736735 21169563 14685242 16357137 21145461 29070679 15452136 15966899 12628165 21778237 22474075 16189514 22767593 11359933 9430629 10713156 10023660 10228155 12504026 18818696 9827542 12504025 18094045 10066435 23324393 23770852 9990852 12417738 27705803 9636170 21249194 12904573 34499862 11027288 26725323 20832730 19933270 12609982 10230407
CUL1 CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10228155 10713156 10023660
CTNNB1 CREBBP â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
CREBBP TCF7L2 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
AR CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9822653 15350180 16492776 16344550 11161315 18819102 18031230 20610535
HTT CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 11264541 11607033 16456924 15994095 17500595 16713569 10823891
CREBBP CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10769018 21751375 11973335 17410209 18347063 16476742 23273993
CREBBP AR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 20541699 9822653 15691881 12810069 9482849 16713569
THBS1 LTBP1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10657674 11982756 14568985 14996710 21900405 22943793 8349738
RHOA ROCK1 â—¼   ENZYMATIC_REACTION ✅ 25.0 1.0 ACSN 11698448 11729192 11739775 11992112 12194823 12361600 12740575 14657501 14744429 15761148 17517963 18037882 18423981 20535745 21178402 22949611 24857661 24919149 26885855 27048821 27066895 7479854 9362522 9660866 9822605
RHOA ROCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 55.0 1.0 Omnipath 17145710 12361600 25010901 23151663 7479854 27048821 22949611 21281639 26885855 8798490 12727213 17673200 11729192 8816443 10592173 11698448 27066895 11739775 11992112 20535745 18423981 24857661 21178402 23109003 9660866 9822605 17517963 14660612 15774750 12740575 14744429 9535835 12773565 15761148 24919149 26192618 9362522 18037882 14657501 12194823
SMURF2 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20484049 15221015 22298955 15231748
SMURF2 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 14701756 23331499 15221015 11016919 22298955 11158580 32296183 15231748 20937913
SP1 ID1 â—¼   UP_REGULATES ✅ + 21.0 1.0 ACSN 10048576 10964912 11007770 11013220 11114293 15001984 15592504 16079281 16556862 16716598 16831886 17490644 17705132 18353785 18832382 19564415 20589835 21252118 22439866 23338822 8844971
SP1 AR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8864062 16928829 16704988 23662037 10773882 9353275 15661808 17984071 18430409 22347450 20739403 8994183
SP1 APP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19049493 8427604 15673661 9361293 21557719 18449948 14701757 8015372
SP1 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10649433 16298343 11804592 11013220 20121949 7592908 21872590
SP1 PPP2CA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19750005 19420015 12076969 21420382
SP1 KLK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15708372 9154804 14726517 15661808 23662037
SP1 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 11013220 10454538 9670020 11283613 11074002 11283614
SMAD1 SMAD6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10692396 17215250 22219353 22072987
SMAD1 ID1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18381431 15331632 20522807 12296825
SMAD1 BMP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 14551209 11786386 21471203 19836350 11585340 22072987
BMPR1A SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11438941 24412244 19620713 9136927 16189514 11792802
ACVR1 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 19651622 9748228 23331499 9335504 10085121 10652350 9136927 10583507 16189514 11792802 18988627
BMPR1B SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 9748228 23331499 9335504 10085121 19620713 9766532 9136927 11792802 15212693
SMAD6 SMAD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 9256479 9335505 9436979 21071413 18988627 11483516 12857866
PPP2R1B PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18715871 17540176 19114990
PPP2R1A PPP2CA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 21159657 23443559 19818709 19293187 24841198 28330616 18715871 19915589 18782753 33633399 17274953 26496610 17540176 15761952 17374643 17529992 22379092 17055435 8617797 12370081 17632056 16039140 16769727 19156129
PPP2CA RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16109716 2826472 16899564 11438723 11124802 10200280
TCF7L2 CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 24214913 14706452 19347947 24317174
AR CTNNB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18535113 18673534 20610535 11916967
AR CTNNB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 21741601 16713569 12799378 12944908 10809237 23331499 15060161 21071413 21885566 18988627 16428447 11916967 12588987 11792709 10987273 14593076 15256534 22187462
CTNNB1 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 17145710 9488439 11713475 12446687 17143293 27902311 16569639 22014570 16724116 11955446 16442529 26350900 19202075 17050667 20126258 22056988 16306047 17914096 19443654 18391971 21670201 22155184 10080941 17283121 16230076 22304967 16630820 15684397 11713476 12861022 19304756 20492721 19816403 18772112
CTNNB1 PITX2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 25241761 21071413 19174163 12464179 15728254
AR KLK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 106.0 1.0 Omnipath 17433535 8626436 11059779 15640443 7686046 11006269 12111703 15368351 24307657 9316650 9719026 11867260 12376473 14767470 16275987 11994312 17075604 20181722 9211894 16342680 12917209 18092350 12648523 17011549 11238180 20069563 10547578 16140973 22245379 12539223 20568894 20103546 18758709 21981678 21541973 12463425 12958311 11894840 19389135 17534890 23662037 15923603 16434977 14517289 22695118 10075669 11377978 16137620 11299734 15131260 21780100 16508948 16425097 22473899 14715080 10625666 18640093 21885566 12670590 14729601 16452400 16081584 10898343 11571582 9044850 15833875 16914734 23884959 15640095 15543614 7514587 12376534 12114445 15557561 18780293 23667504 18829551 12782640 16724108 17426252 11504717 19274665 11034093 17566103 12651911 22179832 21308712 16373397 19013180 22155408 9052414 11532861 17094454 17653089 20709811 22654108 22597536 15514031
AR KLK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1712248 19345326 25241761
INHBB ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11266516
AMH ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14656470
BMPR2 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 21071413 16446785 7791754 7890683
INHBA ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16189514 11266516
BMP6 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12297674
BMP2 ACVR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8006002 28977600
ACVR1 SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9748228 23331499 10652350 10583507 16189514 11792802 10504300
BMP4 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7811286 8702914 11282024 8006002
GDF5 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8702914 15890363 9525338 11282024 16127465 15569154 19229295
BMPR2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 16446785 18756288 10712517 7791754
AMHR2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16446785 14746809 11420127
BMP6 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11401330 10504300
BMP2 BMPR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 7811286 12700180 9872992 10712517 15064755 19229295
BMPR1B SMAD5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 19620713 9766532 11792802
INHBA ACVR2A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
INHBB ACVR2A â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
GDF5 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8702914
NODAL ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11952836
INHBA ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 11266516 10746731 1646080 11266510 24018044 9605406 12466190
GDF7 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
INHBC ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12651901 22710174
BMP2 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17483092 10880444 21702718 17295905 25938661 20959140
BMP6 ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10504300
INHBB ACVR2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11266516 1246619011266510 12466190
BMP4 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 8702914 23331499 21071413 16446785 12045205 8006002 7673243 7644468
BMP4 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 8702914 26330344 20860622 21054789 11241215 8006002 16189514 7644468
SMAD5 SMAD6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10692396 16436528 22219353
INHBB FST â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 7678220 8033815 12697670 1592877 16198295
INHBA FST â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 7678220 8033815 12697670 1592877 16198295
FST INHBA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16198295 24627466 7887917 22037168
NOG BMP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 10657699 12700180 19804412 15064755
BMP2 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 20385559 16446785 28977600 15064755 18988627 17295905
BMP2 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 51.0 1.0 Omnipath 17145710 17483092 10880444 10712517 26330344 21054789 16672363 10881198 11263668 20860622 15064755 18937504 25938661 15621726 12700180 10692589 19804412
BMP2 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10880440 23331499 11263668 23180781 18342887 16446785 10880444 10712517 7791754 17295905 25938661 24337809
INHBA ACVR2B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
INHBB ACVR2B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
LEFTY2 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11952836
GDF5 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 8702914 16446785
INHBC ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12651901 22710174
INHBB ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9202237
INHBA ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 8622651 16446785 9202237
BMP6 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 21071413 16446785 10504300
NODAL ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 16446785 11952836
ACVR2B ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 23180781 8622651 16446785 12364468 18988627
BMP5 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11580864 16189514
BMPR2 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18756288 7791754 10712517
BMP6 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 11401330 12297674 10504300
GDF6 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9525338 160490149525338 16049014
GDF7 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
GDF5 BMPR1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 21543859 9525338 11282024 16127465 19229295
RGMA NEO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 18485097 15258590
CTBP1 TCF7L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12711682
GDF5 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 8702914 23331499 9525338 23180781 18342887 16446785 19229295 87029149525338
PITX2 FSHB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12554780 18022758 18339718
TFDP1 RBL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 7958925 12150994 7739537
RBL1 TFDP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7958925 12150994 7739537
A2M KLK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 1702714 8583572 25241761
BMP6 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 21071413 16446785 11401330 10504300
GDF7 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16049014
GDF6 BMPR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 9525338 16446785 18988627 160490149525338 16049014
TGIF1 WWP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 23331499 18511908 15359284
INHBA ACVR1B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
INHBA ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 81675688397373 8167568 8397373 16189514 9605406 7890768
INHBA BAMBI â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10918299
INHBB ACVR1B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 11117535 8196624 15123686 8622651 9032295
INHBB ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 11266516 15196700 12032389
INHBB ACVR1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15196700
AMH AMHR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 8889695 23331499 8119126 16446785 18988627 79972308889695 7997230
NODAL ACVR1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19874624 11952836
ACVR1C NODAL â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15485907 21229555 21356369 15150278 15531507
NODAL ACVR1C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12606401 15531507