Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
NECTIN2 SSH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ARPC2 ACTB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 9600938
ACTB ARPC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10592173 9600938
YWHAZ ACTN4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217040 15161933
CFL2 CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8153045 21516116
YWHAZ CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215799 12361576
LIMK1 CFL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20133759 0914492107
CFL1 YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217411 15598710
CFL1 LIMK1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 6173882 17853892
SSH1 CFL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12684437
YWHAZ EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217069 15225635
EGFR IRS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
EGFR YWHAZ â—¼   COLOCALIZATION 2.0 0.8 intact 5217069 15225635
ERBB2 IRS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
YWHAZ IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6547842 9581554
IGF1R YWHAG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5217174 15324660
YWHAZ LIMK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215799 12361576
YWHAZ SSH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19371722 8008908
YWHAQ SSH1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19371722 8008908
ACTB DSTN â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
1433B IRS4 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25036637 24255178
SSH1 1433E â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 27880917 28675297
1433E TMOD3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 23472066 22863883
SSH1 COF1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 25100728 12684437 16713569 21525957 11832213 32015554
TMOD3 SVIL â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SVIL ACTB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 12202484 34079125
TMOD3 GELS â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SSH1 GELS â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SSH1 ACTBL â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TMOD3 ACTBL â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SSH1 ACTA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TMOD3 ACTA â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
EGFR ACTB â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 22366308 31980649
IRS4 EGFR â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 16273093 24797263
EGFR IGF1R â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
IGF1R ERBB2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 30898150 17307140
TMOD3 MYO5B â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SSH1 TMOD2 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
SSH1 TMOD3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
ACTB SVIL â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
SSH1 1433B â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 27432908 15159416 28675297 19329994
SSH1 1433G â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 28514442 27432908 28675297
1433G IRS4 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 25036637 15324660
1433Z IGF1R â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 27684187 9581554
EGFR COF1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31980649 24658140 20029029
TMOD2 GELS â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
SSH1 1433T â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 27432908 19371722 28675297
ACTN4 GELS â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 16713569 11733011
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
CFL2 DSTN â—¼   PHYSICAL_INTERACTION 863.0 0.86 STRING 36370105
EGFR 1433B â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 31980649 25402006 24658140
SSH1 1433Z â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 27432908 28514442 19371722 28675297
TMOD3 ACTB â—¼   PHYSICAL_INTERACTION 0.87 0.87 HIPPIE 33961781 28514442 34079125
EGFR YWHAZ â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ACTB CFL1 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
LIMK1 1433Z â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 12323073 12361576
1433Z ACTB â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 15161933 17361185 20618440
1433E IGF1R â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 9111084 27684187
ACTBL GELS â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442
ACTB ACTBL â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 34079125
ACTBL ACTA â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33961781 28514442
CFL2 ACTB â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 8153045 21516116
YWHAG YWHAZ â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
1433G 1433T â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 15324660 17085597 28514442 22863883 20618440
1433G IGF1R â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15324660 27684187 17353931
AKT1 1433Z â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 11956222 16027165
COF1 1433Z â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 15161933 12323073 12361576
1433Z 1433T â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 26496610 28514442 22863883 20618440
1433T 1433E â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 31980649 20936779 21988832 17085597 28514442 17979178 20618440
ACTB COF1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 32296183 25416956 16713569 29892012 16189514 32015554
SSH1 ACTB â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 33961781 28514442 11832213
EGFR ACTN4 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 26320552 25402006 24658140
EGFR AKT1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 31980649 25402006 24658140
ACTA2 ACTB â—¼   CORRELATES + 0.89 0.89 CCLE 31978347
1433B IGF1R â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 14651979 9581554 15629149 17353931
1433E 1433G â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 26344197 31980649 20936779 21988832 17085597 28514442 31536960 17979178 12507503
1433Z 1433G â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 31536960 33961781 26344197 26496610 28205554 28628118 28514442 22863883 20618440
1433Z EGFR â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 19531499 15389569 15657067 24658140 31980649 23956138 15225635 25402006
LIMK1 COF1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 17500066 11925442 12963706 16456544 10436159 17853892 11418599 9655398 19424295 15220930 23082153 16278681 16713569 20133759 23093407 11340065 32015554
EGFR 1433T â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 15657067 24658140 31980649 25402006 20029029 24189400
MYCN EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16093321
LIMK1 SSH1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 15660133 7600543 8217581
LIMK1 SSH1 â—¼   COLOCALIZATION 3.0 0.9 intact 15660133 7600543 8217581
SSH1 LIMK1 â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 15660133 7600543 8217581
MYCN SSH1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16093321
ACTB CFL2 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
GELS ACTB â—¼   PHYSICAL_INTERACTION 0.94 0.94 HIPPIE 33961781 15215896 10945978
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
1433G 1433B â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 15324660 24981860 26344197 24255178 17085597 28514442
1433T 1433B â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 24255178 17085597 28514442 22863883 20618440
1433Z 1433B â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 26344197 26496610 24255178 28514442 31536960 20618440
1433B 1433E â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 33961781 26344197 31980649 24255178 30135474 20936779 17085597 28514442 31536960 17979178 12507503
1433Z 1433E â—¼   PHYSICAL_INTERACTION 0.96 0.96 HIPPIE 19766566 31536960 33961781 26344197 31980649 22939629 26496610 20936779 21988832 28514442 22863883 17979178 20618440 16376338
CFL1 LIMK1 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
ACTB CFL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 8913641 25416956 15364581 10592173 19704022 16189514 31515488 32296183 16713569 29892012 10980704
AKT1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22505453 23092893
AKT1 YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 11756412 9705322 11923280 16697215 20398329 18372248 12865427 15071501 15808505 20138985 20214616 15883165 15169778 10949026 12861023 11715018 18636226 9812896 17680028 11956222 10722653 20832730 18570873 16376338 17052453
AKT1 YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
AKT1 YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 20138985 15169778 9812896 17680028 11756412 11923280 20214616 16697215 10949026 10722653 20832730 18570873 18372248 11715018 20398329 17052453 18636226 15808505
LIMK1 CFL1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 10652353 11698448 21178402 9655398
SSH1 CFL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12684437 21525957 14531860 10592173 16713569 11832213 16230460
LIMK1 CFL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 74.0 1.0 Omnipath 11784854 16456544 10559936 17522712 25814227 8079118 9655398 17853892 11418599 16713569 19413330 18079118 27153537 19424295 23093407 18578522 12963706 20068231 10592173 11925442 10436159 11340065 18491316 18669648 22154077 11413130 12361576 15866889 11950587 19651622 20058876 18702456 16278681 25784483 15220930 29605806 10613909 20133759 10461188
LIMK1 CFL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 19651622 17081983 12684437 8079118 20068231 9655398 19413330 8824278
SSH1 CORO1B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17350576
PRKD1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17081983 3138233 18220336 19369195 18691976 2987962 10523301 2984676 19413330 16083266 17192257 26465157 18669648 15302935
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
IGF1R IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 9553137 18988627 11316748
IGF1R YWHAZ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 16931767 9581554 12175651
IGF1R YWHAG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12767520 10826997 12444011 21540285 17145710 17353931 19030972 16931767 15324660 12175651
YWHAQ PRKD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 16713569 10092600
PRKD1 SSH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23737525 23153585 24840177 21525957 15159416 25266776 24962708 26873625 19567672 19329994
PRKD2 SSH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 24840177 21525957
YWHAG YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17085597 21827211 12426317 15324660 15071501 12657644
YWHAZ YWHAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21827211 12657644 12426317 15071501
CBX1 CBX1 â—¼   KO_DOWN_REGULATES ✅ - -2.99 2.98 PKG 28854368