Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
IRS1 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
EGFR IRS4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
EGFR NRAS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 23220880 22908275
GRB2 NR1H4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 TGOLN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
PTGER4 NISCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
RPL19 NISCH â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
NR1H4 NISCH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12519762 16957179
RAC1 PAK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 11278486 11804587
NTRK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11147812
IRS1 IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 11912194
IRS1 ALK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17145710 9174053
IRS2 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8662806 5221055
PIK3R3 IGF1R â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0611271104 17360667
RHOB INSR â—¼   COLOCALIZATION 2.0 0.8 intact 14722096 6672086
EEA1 RAB14 â—¼   COLOCALIZATION 2.0 0.8 intact 5219066 16962593
UBC12 CUL3 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 21247897 28581483 26286618 28475037
IRS4 EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24797263 16273093
RHOB EGFR â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
EGFR IGF1R â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
RHOB EPHA2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
RAC1 GRB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 31980649
RHOB NISCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
U119A NISCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
CNKR3 NISCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
P55G NISCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
HAVR2 NISCH â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NISCH P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32203420 27173435
RHOB ROR2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
CUL3 P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27708159 21145461
RHOB P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
P55G P85A â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB IRS4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
IRS4 P55G â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33961781 25036637
HAVR2 P55G â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
EPHA7 EPHA4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
RHOB EPHA7 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 34079125 31871319
EGFR EPHA2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 24797263 15657067
UBC12 NISCH â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 28581483 33961781
EPHA4 FGFR1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16365308 18790757
IRS2 NTRK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25921289 11147812
GRB2 IRS2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 7559579 22974441 9852124 21706016
IRS4 P85A â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 33961781 25036637 18165436 11912194
ALK GRB2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
EPHA7 EPHA2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 22036564 33961781
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
IGF1R IRS1 â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 17827393
IRS4 GRB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21706016 9553137
GRB2 P55G â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 32296183 21706016
RAB9A NISCH â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 34079125 29568061 23386062
EPHA7 EPHA3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 28514442 22036564 33961781
IGF1R PIK3R3 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CUL3 UBE2M â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
EGFR NTRK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24658140 25402006 31980649
FGFR1 P85A â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 25241761 18412956 8321198 15117958
P85A IGF1R â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 8603569 25241761 7642582 8697095 7589433
NISCH IRS4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25036637 11912194
IGF1R IRS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 7559507 8776723 10082579 7541045 8530377 33991522 8895367 12220227 15629149 8662806
P55G IRS1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9415396 10417350 25814554 7542745
IRS2 P55G â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 10417350
NTRK1 P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25921289 8226808 8384556
HAVR2 P85A â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 26492563
P55G EGFR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 25241761 31980649 22973453 24658140 16273093 25402006
EGFR PAK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 24658140 12522133 25402006
NTRK1 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11733534 25921289 10748052
RAC1 P85A â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8034624 12086876 25284480 32814053 7629060 31871319 26475863
INSR IRS2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 8662806 8626379 9195949
P85A EGFR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21701776 25241761 16713569 7499252 19531499 22973453 25187647 8662998 16273093 25754235 7797556 31959764 16230374 7531698
IRS2 GRB2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19109239 7890616 9535722
IRS4 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9553137 15316024
ITGA5 NISCH â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 11121431 15157156 15229651
NRAS PAK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 15520807 17462920 20363321
STK11 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20400510
P55G IGF1R â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17360667 9415396 25241761 9524259
IRS2 P85A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9334184 12107746 15514089 12506011 26496610 11438664 8910607 23439647 19561084 9852124 21241768
GRB2 IRS1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
IRS1 PIK3R3 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
INSR IRS1 â—¼   PHOSPHORYLATION ✅ + 0.91 0.91 Signor 7651388
EGFR GRB2 â—¼   PHOSPHORYLATION 0.92 0.92 Signor 11726515
INSR IRS1 â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
INSR P85A â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 11796522 8276809 8385099 1334490 10500481 8567177 14729945 9593725 7589433 15629149 7659087
EGFR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19254954 7518560 31980649 9416834 7592693 23956138 14679214 10085134 7510700 27059931 21706016 25402006 16799092 16729043 8665853 15657067 24797263 12577067 8810325 7650032 11960376 23799367 25187647 8626525 10026169 19289468 18271526 21278786 7506413 17971399 8940013 20124286 11726515 9886492 10595738 24189400 9020117 19531499 20473329 9020193 8662998 8647858 1322798 8887653 10229072 16273093 25754235 31959764 11370743 16713569 21596750 9685397 24658140 31985874 22973453 11896612 20067773 17242169 19836242 8810340 21278788 30544639 7527043 9050991 11408594 8621459
IRS1 GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 7488107 8388384 7486683 8810325 22974441 21706016 8491186 7629070 12173038 8536716
P85A GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25416956 9174058 11418612 21706016 7544353 18346204 7737969 9886492 16219545 19380743 7642581 7759531 16713569 8621719 7642542 9541596 8647120 32814053 20936779
GRB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16729043 5218694
RAC1 PAK1 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 5217506 15688026
IGF1R IRS1 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
PAK1 RAC1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 24625804 19327867 15143066 9535855 17245428 11134022 15673687 15289329 16492808 16551621 21029865 16678097 19596003 26175416 17389360 31871319 24056087 25843002 25150978 12879077 15212766 19693014 11030651 16630611 20810653 8107774 11130076 25468898 29615491 19732720 19270716 21474670 10706722 19277120 10802735 21167153 24172987 21454543 15548653 16002993 12650940 18426980 19961560 11950930 24792722 15688026 7744004 20936779 25819133 15075243 22581261
INSR IRS1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 11781100 25667086 16582879 17167487 7935368 10455177 11606564 7499194 15629149 8662806 8626379
P85A IRS1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 29526746 16150444 14632132 22974441 8628286 26839216 8382612 7680095 33991522 25814554 16880210 19561084 16230374 8175658 7659087 8388384 1381348 23643389 23439647 7935461 12107746 11403293 15514089 7680644 12173038 25273559 14511371 12730242 11416002 7486683 17640984 1334490 30240640 16354680 12220227 9564850 16043515
PAK1 RAC1 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
EGFR GRB2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
EGFR GRB2 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 10404636 20430953 23010081 25987127 28513565
EGFR GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 109.0 1.0 Omnipath 9544989 10595738 23956138 27059931 10026169 16273093 11726515 24697349 21596750 19289468 7518560 21706016 23799367 9050991 16317285 16713569 25402006 11370743 24797263 8647858 8887653 9416834 21278786 16799092 8662998 10229072 11896612 7592693 19509291 8810325 24189400 19836242 11960376 7506413 18271526 15657067 10085134 24658140 17242169 7510700 8940013 7650032 8810340 11084343 12577067 7527043 31980649 11408594 19531499 20124286 23178716 9886492 23181695 9020117 8479540 14679214 12648464 1322798 17991782 16729043 17971399
EGFR PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 17496910 31980649 25241761 16273093 24658140 25402006
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
IRS1 GRB2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 8316835 8810325 9832424 8621421 8530377 9852124 9003010
FGFR4 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
GRB2 RAC1 â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
GRB2 RAC1 â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10982827 11274345 11447289 11756498 11777939 12040186 12175651 12640133 12738796 14585353 15567848 15574420 15863030 16102570 16582911 16887996 17496910 17673906 18000759 18855897 19151919 19449109 19568798 21614932 24027568 26552706 27331412 7510700 8551221
IRS1 GRB2 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10086337 10826997 12175651 12444011 12767520 16931767 17604717 19030972 21540285 22465479 24036369 8621421
NRAS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
IRS1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 8265614 7862167 11788580 8388384 8491186 8536716 7488107 7486683 10358772 10592173 8196603 12173038 12679424 8114695 11259577 8810325
NTRK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733534 10748052
IRS2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7559579 11788580 10358772 11305324 9852124
GRB2 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12522133
PAK1 NISCH â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 10661401 11062502 11121431 11385609 11907067 12885870 14764585 15157156 15229651 15536084
PAK1 NISCH â—¼   PROTEIN_INTERACTION 10.0 1.0 ACSN 10661401 11062502 11121431 11385609 11907067 12885870 14764585 15157156 15229651 15536084
RAC1 NISCH â—¼   UP_REGULATES ✅ + 11.0 1.0 ACSN 11121431 11274345 11544274 11756498 15157156 15229651 18000759 19151919 24459205 27331412 9655398
RAC1 PAK1 â—¼   UP_REGULATES ✅ + 11.0 1.0 ACSN 11121431 11274345 11544274 11756498 15157156 15229651 18000759 19151919 24459205 27331412 9655398
RAC1 PAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 130.0 1.0 Omnipath 17145710 15229651 21167153 8107774 24792722 16551621 14579272 10023776 8805275 18325335 11134022 19693014 19277120 21474670 12650940 15673687 19961560 20711231 11950930 16678097 12123608 19270716 9744077 9148763 11689432 23331499 21029865 16368433 11121431 16492808 15075243 21454543 10592173 24172987 15212766 7493928 10793146 21070974 10706722 8910277 17245428 25819133 20936779 11030651 9989831 15157156 9535855 19359598 25150978 16049136 18854161 19628037 15688026 12879077 7744004 11728826 16002993 9764820 9032259 25843002 10224076 19732720 19596003 10802735 19893577 16212495 11130076 12480336 11152757 19327867 22117219 22581261
RAC1 ROR2 â—¼   PHYSICAL_INTERACTION 28.0 1.0 ACSN 11226259 11274345 11756498 12533515 14704854 14747478 15265686 15618519 17127310 17884187 18000759 18497258 18851840 18953287 19020754 19151919 19565474 19853559 20006983 20093472 20215527 21087212 21380625 21796133 22017973 27331412 7641885 8655584
RAC1 ROR2 â—¼   SHARES_COMPLEX 28.0 1.0 ACSN 11226259 11274345 11756498 12533515 14704854 14747478 15265686 15618519 17127310 17884187 18000759 18497258 18851840 18953287 19020754 19151919 19565474 19853559 20006983 20093472 20215527 21087212 21380625 21796133 22017973 27331412 7641885 8655584
UBE2M CUL3 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 19617556 18826954 25349211 23912815 25314029 18206966 21940857 23201271 26906416 19250909 30610225 25531226
NRAS FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196
IRS1 ALK â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 23201355 16878150 29455642 15226403
IGF1R IRS1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10086337 10826997 11274345 12175651 12444011 12556535 12655147 12767520 16931767 17145802 17673906 19030972 21540285 24103846 24782617
INSR IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 10655627 7651388 25472611 1385403 18083107 12220227 23331499 28328746 7504175 19534553 7499194 7537849 7935368 11572799 11781100 10592173 17570479 17575262 18988627 12446583 15629149 10455177 15870194 11416002 12101187 17167487 8530377 8626379 8662806 11606564 2159922 8626723 16020478 16582879
IGF1R IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 7541045 12444011 19030972 10082579 16931767 21798082 12220227 11259577 12767520 10826997 23331499 17827393 7504175 21071413 7559507 11572799 27856640 12175651 17570479 15829723 18988627 15629149 11557037 20670944 8530377 21540285 8776723 25886138 8662806
IRS1 PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 12767520 10826997 12444011 21540285 19030972 9415396 16931767 12175651 10417350 7542745 25814554
IGF1R IRS4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 9553137 18988627 11316748
IGF1R PIK3R3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17496910 25241761 9415396 9524259
IGF1R IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 8662806 9852124 10471495
INSR IRS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 19901323 7629118 9195949 18083107 23331499 19534553 7537849 17570479 18988627 7675087 11584304 7526222 12101187 8626379 8662806 8626723
NRAS FGFR4 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 Reactome 19946327 11429702 11157491 18757403 21666749 21711248 18381441 19103595 21160078 9857065 20179196