Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
NEDD8 CUL1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 0806155105 18723677
CUL1 UBE2M â—¼   NEDDYLATION ✅ 2.0 0.8 intact 17914462 6175264
APOE UBA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
OTUB1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TUBA1B APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBA3 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
NAE1 APP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
UBA3 CHD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
TP53 HLA-A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15501971 12857899
UBA3 KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
OTUB1 KDM1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 23455924 8417751
KDM1A KLK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17707232
TP53 PRNP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24339999 19064990
RAD23A UBA3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16712842 5218673
SAE1 TP53 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 intact 15327968 5217177
UBA3 UBE2F â—¼   PHYSICAL_INTERACTION 804.0 0.8 STRING 36370105
NEDD8 OTUB1 â—¼   PHYSICAL_INTERACTION 0.81 0.81 HIPPIE 24654937 18954305 33665565
UBC12 SAE1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28581483 26344197
ZBT44 ULA1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
ZBT44 UBA3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
KDM1A CHD3 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 21937684 19703393
MTNB UBA3 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26186194
CUL1 FBXO11 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
APP PRNP â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
TUBA1B TUBB4B â—¼   CORRELATES + 0.84 0.84 CCLE 31978347
UBE2F NEDD8 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 24654937 23201271
APOE APP â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
CUL1 UBC12 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 18805092 17914462 27591266 18826954 27348078 19245792 28475037 12565873 21247897 24949976 28581483 21946088
NAE1 NEDD8 â—¼   PHYSICAL_INTERACTION 889.0 0.88 STRING 36370105
NAE1 UBA3 â—¼   CORRELATES + 0.88 0.88 CCLE 31978347
NEDD8 ULA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 24654937 23936405 18274552 14690597 21145461 16503656 9694792 18264111 23824602 17220875 18652489 33857374 16620772
UBC12 UBA3 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 33961781 17353931 32145688 19250909 10207026 27348078 29547696 15361859 19549727 28475037 30097011 27182664 28581483 18652489 28514442 29973603 15694336
APP NAE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25568892 16189514 8626687
NEDD8 CUL5 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18805092 24654937 33961781 18274552 10597293 21119685 21145461 23201271 24076655 18247557 28522566 22405651 31253590 28514442 20847044
TP53 UBA3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16980608
SAE1 UBA2 â—¼   CORRELATES + 0.9 0.9 CCLE 31978347
NAE1 UBE2M â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
UBE2M NEDD8 â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 19713960 7294536
RAD18 ETF1 â—¼   KO_DOWN_REGULATES ✅ - -0.94 0.93 PKG 28854368
RAD18 UBA3 â—¼   KO_UP_REGULATES ✅ + 0.95 0.95 PKG 28854368
NEDD8 CUL1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 21765416 16177058 18723677 18627766 17438373 32726803 24654937 11027288 18274552 10772955 16503656 24076655 18247557 22405651 17318178 10713156 19713960 10318914 21102408 23267066 23201271 22959436 17206147 16620772 18805092 10597293 21119685 21145461 18826954 19245792 19617556 12565873 18264111 24949976 22474075
UBC12 ULA1 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 33961781 17353931 19250909 17220875 18652489 28514442 33857374 28581483
UBC12 NEDD8 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 21765416 33961781 16735510 28581483 24654937 18274552 16503656 10828074 18652489 23936405 19713960 17353931 23267066 23201271 9694792 28514442 25416956 30804002 16620772 21145461 19245792 18264111 10207026
UBA3 NEDD8 â—¼   PHYSICAL_INTERACTION 0.97 0.97 HIPPIE 24654937 14690597 21145461 16503656 9694792 27182664 18652489 10207026 16620772
NEDD8 UBE2M â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
CUL5 NEDD8 â—¼   PHYSICAL_INTERACTION 979.0 0.97 STRING 36370105
CUL1 UBE2M â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
UBA3 UBE2M â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
NAE1 UBA3 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
SAE1 UBA2 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
UBE2M CUL1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 16647857 19617556 18826954 25349211 25314029 18206966 21940857 23201271 26906416 19250909 25531226 21863050
CUL1 NEDD8 â—¼   PHYSICAL_INTERACTION 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
CUL1 NEDD8 â—¼   SHARES_COMPLEX 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
CUL1 NEDD8 â—¼   ENZYMATIC_REACTION ✅ 61.0 1.0 ACSN 10023660 10671552 11348595 11900249 11955436 11967263 12051714 12648680 12820959 15001769 15071497 15340381 15459660 15688063 15703371 16039586 16697054 16713974 16940750 17143292 17652783 17884153 17928543 17936032 18196958 18805092 18931676 19250909 19258535 19270156 19352404 19366350 19411070 19576224 19597341 19619488 19622404 19686080 19751508 19809470 19836308 19847258 19849719 20006983 20558317 20705860 20843316 20976471 21411632 22270359 22682247 22730322 23343194 23732914 24023259 25730849 26885856 7542250 7641885 8666229 9694792
UBE2M CUL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 24949976 10713156 17914462 21247897 18805092 21946088 19245792 18826954
ULA1 UBA3 â—¼   PHYSICAL_INTERACTION 1.0 1.0 HIPPIE 32296183 26344197 22939629 15361859 18264111 12646924 17220875 10722740 9694792 22863883 29973603 12740388 10207026
APOE APP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9202294 10559559 10428074 10842709 17116874
FBXO11 TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 17145710 17098746
KDM1A TP53 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 17805299 26334721 19381457
TP53 KLK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 15540784 11791186 11504717
NEDD8 UBE2F â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 25314029 15361859 19250909 17220875 25531226
NEDD8 UBA3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16620772 21145461 16503656 14690597 10207026
UBE2M UBA3 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 25531226 15361859 19250909 17220875
RAD18 RAD18 â—¼   KO_DOWN_REGULATES ✅ - -4.39 4.38 PKG 28854368