Protein list:

Seperate proteins by space | Example

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
E2F1 CDC45 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10692433
E2F1 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24076372 18439978
CDO1 TOPB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
CBLN4 TOPB1 â—¼   PHYSICAL_INTERACTION 0.82 0.82 HIPPIE 33961781 28514442
TOPB1 PML â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 19023333 12773567
TOPB1 TP53B â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 29656893 11756551
PLK1 TOPB1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 33961781 28514442 26811421 26186194
PLK1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HIPPIE 31730000 25483079 29656893 24067368
ESR1 TOPB1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 31527615 20348541
TOPB1 PARP1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 17340632 34079125
PARP1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HIPPIE 34079125 26831064 25252691
BRCA1 TOPB1 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 12697828 23901102 33010150 16391231 23157317 29656893 11395493 19766185 25184681
TOPB1 CDC45 â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 23364835 17887956 20065034
TOPB1 TICRR â—¼   PHYSICAL_INTERACTION 0.85 0.85 HIPPIE 28439015 30295604 23696651 23704573 21700459 30695077
BRCA1 MDC1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
TOPB1 FANCJ â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 33010150 23157317 16391231 30295604 24573678 20159562 21127055
TOPB1 MDC1 â—¼   PHYSICAL_INTERACTION 0.88 0.88 HIPPIE 24239288 21482717 29656893 27590578
MDC1 TP53B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 18986980 30179224 29656893 12607005 17925396
TP53B BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 22884692 17525332 21552324 29656893 12364621 31009828 18001824 26831064
PLK1 TP53B â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 25607646 20126263 25659891 32707033 26291670
MDC1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 21622030 17525332 15569676 29656893 12607005 19766185 12611903
PARP1 E2F1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HIPPIE 20133863 14627987
TOPB1 ZBT17 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18923429 17006541 12408820
TOPB1 RAD9A â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 26312135 25091155 25602520 26088138 17575048 17006541 12941802 11395493 20545769 30295604 22925454
TOPB1 E2F1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 28439015 12697828 17006541 20413589 14576432 14576433
FANCJ BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 18285836 22032289 19369211 17664283 29656893 20173781 11301010 14576432 17525342 28911102 17525341 25252691 27399284 30257991 20159462 20681793 15242590 16713569 19452558 21240188 15208681 15125843 14578343 17525340 17581638 23157317 11877378 24573678 26831064 22792074 17596542 15133502 23530059 18628483 16391231 14576433 25184681 18717574 28398198
ESR1 BRCA1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 11493692 27977889 10334989 11782371 16713569 17505062 15674350 19887647 20060929 11244506 16860316 17392432 31527615 16061635 16260778 12400015 1244506 25499220 29367421
BRCA1 ESR1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BRCA1 PARP1 â—¼   PHYSICAL_INTERACTION 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 E2F1 â—¼   PHYSICAL_INTERACTION 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 E2F1 â—¼   SHARES_COMPLEX 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
BRCA1 PARP1 â—¼   SHARES_COMPLEX 56.0 1.0 ACSN 11850621 11877377 12607003 14726013 15459660 15485915 15496928 15549137 15655342 15703371 16697054 17088286 17116881 17965729 18001825 18087292 18171670 18171986 18212739 18584027 18716619 18809224 19202191 19208614 19217833 19270065 19357644 19364882 19490890 196269035 19772495 19793801 19847258 20021983 20029420 20051983 20064462 20603072 20723763 21060331 21270334 21337561 21376743 22055391 22469522 22713970 22743550 22921416 23145148 23562323 23568489 24050180 24210699 24684389 24976506 9721205
BRCA1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10884389 11877377 12496474 15175241 15220350 15279786 15459660 16581787 17218262 17303408 17660363 17713585 18458534 18590585 18660752 19525936 19793801 20029420 20376879 21060331 21337561 24254977 7575488 7935440
MDC1 BRCA1 â—¼   DOWN_REGULATES ✅ - 13.0 1.0 ACSN 12607003 15279786 15459660 17303408 17660363 18001824 18006705 18087291 18583988 18590585 18678890 7575488 9407949
E2F1 BRCA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10660629 23285190 18660752 19466541 17106239 20068145 23108140
E2F1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 9244350 18660752 18319725 11278247 12697828 16713569 12909625
MDC1 BRCA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 18087291 17525332 12607005
BRCA1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 11244506 12400015 15674350 10334989 16713569 11493692
ESR1 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22791811 20215421 12697671 10446910
PARP1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14627987 20133863
MDC1 MDC1 â—¼   KO_DOWN_REGULATES ✅ - -3.38 3.37 PKG 28854368
PARP1 PARP1 â—¼   KO_DOWN_REGULATES ✅ - -7.28 7.27 PKG 28854368