EGFR
|
NRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
KRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
EGFR
|
HRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
23220880
22908275
|
TP53
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
EGFR
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
17673906
|
TP53
|
HMOX1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24366007
21552291
|
TFRC
|
TF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20404192
0914898107
|
TP53
|
JUN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11350971
10984493
|
TP53
|
SAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
TP53
|
ATG7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
1218395
22499945
|
TP53
|
PRNP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24339999
19064990
|
TP53
|
TCF7L2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
14990988
|
TP53
|
STEAP3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
19302216
|
TP53
|
STEAP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
TP53
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18431400
|
PCBP2
|
PCBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16713569
5218676
|
PCBP1
|
ALOX15
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
20884783
|
SAT2
|
SAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
TCF7L2
|
JUN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
|
NFE2
|
GCLC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16054171
|
ATG7
|
ATG5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11265251
|
NFE2L2
|
NFE2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24613345
15790560
|
TFRC
|
FTH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0913192107
20133674
|
NRF1
|
NFE2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10601325
8248256
|
VDAC3
|
VDAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
000924
30021884
|
NRF1
|
GSS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10601325
15890065
|
RHOB
|
CD44
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31871319
|
RHOB
|
EGFR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31871319
|
RAC2
|
RAC3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
RHOB
|
ACSL4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
34079125
31871319
|
SAT1
|
SAT2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
32296183
16189514
33961781
|
EGFR
|
CD44
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
11606076
16565089
12093135
15597342
23265944
|
FTH1
|
TFRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
KRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
FTH1
|
NCOA4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
860.0
|
0.86
|
STRING
|
36370105
|
VDAC2
|
VDAC3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
31536960
22939629
30021884
|
HRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
PCBP1
|
PCBP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
27684187
23640898
16713569
26344197
|
KRTAP1-1
|
SLC7A11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.88
|
0.88
|
HuRI
|
32296183
|
ATG7
|
MAP1LC3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
KRTAP1-3
|
SLC7A11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HuRI
|
32296183
|
HRAS
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
TCF7L2
|
CD44
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18483247
12782598
10027409
|
EGFR
|
TRAF2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
31980649
24658140
23972990
25402006
18271526
|
TERT
|
TCF7L2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
19571879
11532957
21654818
|
JUN
|
RHOB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21565167
24636898
|
GCLC
|
GCLM
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
ACSN
|
26653790
26794443
27048822
|
GCLC
|
GCLM
|
â—¼ PROTEIN_INTERACTION
|
|
|
3.0
|
0.9
|
ACSN
|
26653790
26794443
27048822
|
NFE2L2
|
GCLC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9601066
11909699
|
NFE2L2
|
SLC7A11
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17113054
12235164
25092871
|
SAT1
|
SAT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.91
|
0.91
|
HuRI
|
32296183
|
ACSL3
|
ACSL4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.93
|
0.93
|
HIPPIE
|
22939629
26496610
|
FTL
|
FTH1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.93
|
0.93
|
mint
|
8153045
21516116
|
ATG7
|
MAP1LC3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
TF
|
TFRC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
JUN
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16170369
23455325
15923621
16423552
10803405
18604200
|
TP53
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
20190820
18359760
9664135
10029407
8152794
11713584
8887630
9285564
19597475
11546792
1586628
18604200
18391986
|
NFE2L2
|
HMOX1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
10441483
10821856
10874044
11279008
11909699
12356737
12511571
15521073
16219762
17512463
18761713
19027064
19747488
23850759
|
NFE2L2
|
HMOX1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
72.0
|
1.0
|
Omnipath
|
24211276
21382013
23000247
21908612
17942419
18381655
31257023
12745069
22107958
18586007
23904790
24434148
21622983
21808062
22245129
16951197
22370642
23571756
24844779
21658364
11274184
20083128
14747657
15870071
17313370
24759106
20558128
14688281
23525690
21597468
22541814
21443188
21635873
18704831
22521774
16407140
22793650
18006113
22459801
24035498
24140584
23413426
22901690
18771089
24755082
20345481
16551619
23294286
23046979
15122755
16945925
23347118
23738042
21037234
23479260
19056485
19679681
22484158
18202225
24024136
16480751
19931411
20402460
17408602
21982894
25337552
24503931
19454702
23826208
20643109
18567745
|
JUN
|
HMOX1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8774698
24755082
8872603
20486760
20833713
18689604
|
NFE2L2
|
HMOX1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
10874044
18241676
12356737
18535259
12511571
10821856
|
TP53
|
TERT
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
15656906
12807729
15067344
15734740
11064449
15262117
16234237
10778946
15371422
22496369
18754863
19649288
19787269
|
TF
|
TFRC
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
38.0
|
1.0
|
Omnipath
|
17145710
11027676
21788477
9546397
6270680
16271884
29302006
14691533
12210842
20404192
16354665
6268632
|
JUN
|
TP53
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
22859294
17321721
20697347
10348347
12963547
10072388
22353755
18604200
|
TP53
|
KRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
11514734
18555006
10953306
14741382
19107228
20124454
8274455
16061648
10448271
|
TP53
|
HRAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
21552926
9662334
11127813
21552928
|
NFE2L2
|
SAT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12020345
10419538
9852135
12804587
11256947
16647090
23943804
|
FTH1
|
FTL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
ACSN
|
17603935
26653790
26794443
27048822
|
FTH1
|
FTL
|
â—¼ SHARES_COMPLEX
|
|
|
4.0
|
1.0
|
ACSN
|
17603935
26653790
26794443
27048822
|
TRAF2
|
FADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
74.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
1134007
11438547
11460167
11583996
11875494
12215447
12646658
12702723
12724420
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
15760909
16406523
16498403
16713974
16940415
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19597341
19632174
19838173
20038811
20184663
20435894
20452955
20531300
21133840
21232017
21411734
21826665
22427918
22955274
23010170
23069999
23170255
23377657
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
27984721
28574505
8910423
9488730
9759866
|
FADD
|
ATG5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
11003656
11583996
15325588
16498403
17462996
20531300
22362782
23377657
23725295
23787782
24070470
26587781
26972597
27984721
28574505
9488730
|
TRAF2
|
FADD
|
â—¼ SHARES_COMPLEX
|
|
|
74.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
1134007
11438547
11460167
11583996
11875494
12215447
12646658
12702723
12724420
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
15760909
16406523
16498403
16713974
16940415
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19597341
19632174
19838173
20038811
20184663
20435894
20452955
20531300
21133840
21232017
21411734
21826665
22427918
22955274
23010170
23069999
23170255
23377657
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
27984721
28574505
8910423
9488730
9759866
|
FADD
|
ATG5
|
â—¼ SHARES_COMPLEX
|
|
|
16.0
|
1.0
|
ACSN
|
11003656
11583996
15325588
16498403
17462996
20531300
22362782
23377657
23725295
23787782
24070470
26587781
26972597
27984721
28574505
9488730
|
TRAF2
|
FADD
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
74.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
1134007
11438547
11460167
11583996
11875494
12215447
12646658
12702723
12724420
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
15760909
16406523
16498403
16713974
16940415
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19597341
19632174
19838173
20038811
20184663
20435894
20452955
20531300
21133840
21232017
21411734
21826665
22427918
22955274
23010170
23069999
23170255
23377657
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
27984721
28574505
8910423
9488730
9759866
|
FADD
|
ATG5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15778222
|
TNFAIP3
|
TRAF2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
20448643
25416956
24008839
8692885
31515488
32296183
10544141
16713569
10755617
|
JUN
|
GCLC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
10751553
11007940
11233143
11912197
9610371
9613591
10350652
16054171
10218647
|
NFE2L2
|
GCLC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
10441483
10821856
10874044
11279008
11909699
12356737
12511571
15521073
16219762
17512463
18761713
19027064
19747488
23850759
|
NFE2L2
|
GCLC
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
19282378
14978030
17173895
22212472
19540342
17109620
14500406
15988009
18458092
9601066
16054171
10741850
22459801
15629866
19133322
18721845
16426233
11118612
14985508
18926903
23633659
24024136
18845239
11909699
|
NFE2L2
|
GCLM
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
10441483
10821856
10874044
11279008
11909699
12356737
12511571
15521073
16219762
17512463
18761713
19027064
19747488
23850759
|
NFE2L2
|
GCLM
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
19808663
12070177
18535259
16485034
10441483
|
SLC3A2
|
SLC7A11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
18250477
20028852
20414655
26653790
26794443
27048822
2880923
3115975
|
SLC3A2
|
SLC7A11
|
â—¼ PROTEIN_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
18250477
20028852
20414655
26653790
26794443
27048822
2880923
3115975
|
CYBB
|
RAC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11145705
1660188
18347018
11090627
10455184
|
ATG7
|
MAP1LC3A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
20562859
22170151
16303767
|
ATG7
|
MAP1LC3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
20562859
17145710
11890701
16303767
22170151
11100732
|