Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CSNK1E CDH1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20940130
STAT3 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6731598 14966128
IRS1 EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
BMX EGFR â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218056 16273093
ICAM1 CDH5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18783313 26556953
STAT3 PLK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22108192
STAT3 ICOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23923047 21765024
ITGB2 JAM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 17379836 17525755
ITGB2 ITGAL â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 19161977 21270398
ITGB2 ITGAL â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 19161977 21270398
SPN GLG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7509040 21659548
SPN SELPLG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7509040 21659548
SPN SELE â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7509040 21659548
ITGAV PECAM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8838667 7542249
ITGB1 JAM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12070135 17525755
ITGB1 JAM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12070135 17525755
ITGA4 JAM2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12070135 17525755
ITGA4 ITGB7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12626562 19454690
ITGA4 JAM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12070135 17525755
ITGA4 ITGB7 â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 12626562 19454690
CDH1 ITGB7 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15330449 16002701
PVR CDH1 â—¼   COLOCALIZATION 2.0 0.8 intact 5224413 17717529
HLA-C CD8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12899833 10809759
PTPRD IL1RAP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25908590 22357843
ICOSLG ICOS â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 11007762 20116985
CD226 NECTIN2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15607800 16904340
NECTIN1 NECTIN3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215384 12011057
CD4 HLA-DRA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 HLA-DQA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 HLA-DQA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CD4 HLA-DPA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DQB1 CD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 11535811
HLA-DPA1 CD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12899833 16189514
HLA-B CD8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9331948 10809759
HLA-DRA HLA-DQA2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA HLA-DPA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DRA HLA-DQA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
CNTNAP1 CNTN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11069942 9118959
SDC2 SDC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC3 SDC4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC4 SDC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC4 SDC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
NTNG2 LRRC4C â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8300478 21946559
HLA-DQB1 HLA-DQA1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11376336 5214072
HLA-DQA2 HLA-DQA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DQA1 HLA-DPA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
HLA-DQB1 HLA-DQA1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
HLA-DQA2 HLA-DPA1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
PTPRD LRRC4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20139422 19252495
PTPRF LRRC4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20139422 19252495
SDC2 SDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC3 SDC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC1 SDC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC2 SDC3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SDC3 SDC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18093920 0708909105
SELE SELPLG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7509040 21659548
SELE GLG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7509040 21659548
NLGN4X NRXN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20543817 18923512
NRXN3 NLGN2 â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 22626547
NFASC NRCAM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 32822567 11724816
SELPLG GLG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 7509040 21659548
MTNR1A MTNR1B â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20859254 8087006
PTPRS LRRC4B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 20139422 19252495
CLDN16 CLDN19 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 22373575 8387781
NRXN2 NLGN2 â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 22626544
NLGN3 NRXN2 â—¼   PHYSICAL_INTERACTION ✅ + 0.8 0.8 Signor 18923512
JAM3 JAM2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11823489 21982860
PPFIA3 PTPRD â—¼   PHYSICAL_INTERACTION 813.0 0.81 STRING 36370105
EGFR CNTN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 20029029 31980649
CD83 PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
IL2RG PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
CD22 PTPRC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10648410 10228003
LITAF PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
PCD20 PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
I17RD PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LRRT2 PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
PCDBG PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ICOSL PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
PCDGG PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LIRB4 PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LRRN1 PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
IZUM1 PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
LIGO2 PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ABCG8 PTPRD â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NLGN3 NLGN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
PCDBG PTPRF â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
NLGN3 NLGN2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
ITGA4 MADCAM1 â—¼   PHYSICAL_INTERACTION 823.0 0.82 STRING 36370105
HLA-DQA2 HLA-DQB1 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
PLK1 TBK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 25659891 33961781
LPAR6 PTPRD â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
PTPRF IRS1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10660596 15588985 8732688 8995282
SCN2B PTPRD â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
SCN2B PTPRF â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
ICAM1 ITGB2 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
EGFR PTPRC â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31980649 19167335
HLA-DRB1 HLA-DRA â—¼   PHYSICAL_INTERACTION ✅ 0.84 0.84 mint 5220278 7477400
ITGA4 ITGB1 â—¼   PHYSICAL_INTERACTION 844.0 0.84 STRING 36370105
ITGAV ITGB1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
CD86 CD28 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 27708164 21931534 11021528 7513726
CD8A CD8B â—¼   PHYSICAL_INTERACTION 851.0 0.85 STRING 36370105
EGFR PTPRD â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31980649 24189400
IL1RAPL1 PTPRD â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
EGFR PTPRF â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 24797263 31980649 24189400
EGFR STAT3 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 22693070
ITGAL ITGB2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
SELP SELPLG â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ALCAM CD6 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
BMX STAT3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32296183 16189514 25416956 10688651 25814554 21516116
TIGIT PVR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 27978489 21982860 28515320
PTPRD PTPRS â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9566880 22357843 28675297
CD226 PVR â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
LRRC4C NTNG1 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
BMX STAT3 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
PPFIA1 PTPRF â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
AURKA PLK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22939629 18615013 18773538
LIPA1 PTPRS â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 16713569 27880917 9624153 8524829
CD274 CD80 â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
PPFIA3 PTPRF â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CD86 CTLA4 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11021528 25241761 7694153 12606712 21982860 7513726 11162656 12582153 11279501 12071705
CTLA4 CD80 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11279502 20587542 21982860 7545666
EGFR STAT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 31980649 23956138 20145033 21573184 25402006 15485908 15657067 14966128 9756944 18258752 15284024 24189400 24240702 25754235 24135280 15950906 24658140 12873986 20067773 10358079
STAT3 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18367518 21590492 23504318
CD2 CD58 â—¼   PHYSICAL_INTERACTION 3.0 0.9 ACSN 19398758 19494291 26794910
CD2 CD58 â—¼   PROTEIN_INTERACTION 3.0 0.9 ACSN 19398758 19494291 26794910
CD2 CD4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
CD28 CD80 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 2164219 7964482 21982860 1847722 7545666
CD226 PVR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 30591568 21982860 12913096
CD58 CD4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 19398758 19494291 26794910
CADM3 CADM1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12050160 16467305 17967169
HLA-DRA HLA-DPA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9312039 1956401 16618111
HLA-DRA HLA-DQA2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9312039 1956401 16618111
HLA-DRA HLA-DQA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9312039 1956401 16618111
PTPRD PPFIA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
PTPRF PPFIA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
ICAM2 ITGAL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15023143
HLA-DQA2 HLA-DQA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9312039 1956401 16618111
HLA-DQA1 HLA-DPA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9312039 1956401 16618111
HLA-DQA2 HLA-DPA1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 9312039 1956401 16618111
PPFIA4 PTPRD â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
PTPRD PPFIBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
PTPRD PPFIBP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
NCAM1 L1CAM â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8509458 10611478 2295682
LIPA1 PTPRF â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 27880917 9624153 7796809 8524829
PPFIA4 PTPRF â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
PTPRF PPFIBP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
PTPRF PPFIBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
LRRC4B PTPRF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23345436 32589946 19252495
PTPRS PPFIBP1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
PTPRS PPFIBP2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
SELL SELPLG â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7521878 17322099 14615387
SELPLG ESAM â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7521878 17322099 14615387
PPFIA4 PTPRS â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7796809 15750591 9624153
HLA-DMA HLA-DRB1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
HLA-DPA1 HLA-DPB1 â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
ITGA6 ITGB1 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
PTPRD SLITRK1 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
EGFR STAT3 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
CD40 CD40LG â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
PVR TIGIT â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
ICAM3 ITGAL â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
LRFN5 PTPRD â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
HLA-DMA HLA-DRA â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
PDCD1 PDCD1LG2 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
LIPA1 PTPRD â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 9624153 16713569 8524829
CD80 CTLA4 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
CD86 CTLA4 â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
HLA-DRA HLA-DRB5 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
HLA-DMB HLA-DRA â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
ICOS ICOSL â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 10657606 11956294 11023515 16951355
ICAM1 ITGAL â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CD274 PDCD1 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
HLA-DMA HLA-DMB â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
HLA-DRA HLA-DRB1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
HLA-DQA1 HLA-DQB1 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CD80 CTLA4 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26405600 7512027 7523569 9359474
CD86 CTLA4 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10477595 11207245 11964292 14764699 15034038 15197224 17513775 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 7523569 8920882 9359474
CTLA4 CD28 â—¼   DOWN_REGULATES ✅ - 12.0 1.0 ACSN 10921877 11093160 12370081 16227604 16885030 16916641 18292600 19890961 21159657 21376459 22116087 22437870
CD80 CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 21530327 21422170 17953528 22437870 11279501 23954143 11279502 20587542 31757674 7545666 10583602 21982860
CD86 CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 17145710 23223433 11162656 9856951 11976720 12582153 11279501 12071705 7694153 7513726 21530327 25241761 22437870 10583602 21982860 23954143 12606712 11021528
CDH1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 17548604 10969083 15662113 31980649 14681060 25241761 24189400 25468996 24658140 25402006
ICAM1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16799092 17145710
EGFR STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17145710 23956138 12070153 20145033 14967450 20032199 21573184 25402006 10358079 23894143 14966128 24135280 25241761 14963038 24189400 15657067 24658140 15485908 15950906 18258752 31980649 9756944 22693070 12873986 15951569 15284024
CD226 ICAM1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 10591186 12913096 14676297 19029380 22285893 24337740 24658051 26552706 26840537 28893624 8673704
STAT3 ICAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20680966 19741199 8675499 23178493 21354136 23690481 18616672 10830295 15860735
ICAM1 ITGAL â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 11786177 16595626 16354667 12526797 23602662 11279101 16189514 14507735
ICAM1 ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 4062888 12208882 11279101 16189514 10352278 20187292 14507735 7642561
CSNK1D MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 26294215 11850850 12167711 16055726 15610030 15688025 15703839 20708156 28049764 33618712 15024078 19630168 26636645 19008219 27617579
PAK6 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 28007610 11960368 11923280 18467333 22349818 23132866 11504915 11715018 28196907
PLK1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12383858 19833129 23948487 24265276 26754547
AURKA PLK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 63.0 1.0 Omnipath 18566290 23618492 27721411 24338364 15713655 28126323 34260926 19364923 33805672 33771996 32284347 27504491 33898950 10980711 26206521 21474997 32060423 27662907 28994651 33963314 18615013 23695676 34197606 18669648 25925375 26114094 19228686 28591578 22281053 18691976 20603326 15611664 27068477 27908669 26919439 26012549 18477460 34140642 25660017 27899378 19369195 21454580 25871386 24349352 12207013 20869364 11854496 20633640 28351953 24667170 25042804
PLK1 IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15849359 8349691
IL2RG STAT3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
IL2RG STAT3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
STAT3 CD274 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19088198 21268011 27141364
PTPRD STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20418918 19478061
ITGB2 F11R â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15681301 15528364 17525755 11812992
VCAM1 ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10438935
ICAM3 ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15728350 11353828 7822326
ICAM2 ITGB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 15023143 16189514 9786897
ITGAV L1CAM â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 11553709 19161977 8636223 9003039
ITGB1 ITGA4 â—¼   PHYSICAL_INTERACTION 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
ITGB1 ITGA4 â—¼   PROTEIN_INTERACTION 9.0 1.0 ACSN 12626562 19161977 19454690 19487819 22470492 9003039 9456329 9763606 9973479
VCAM1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 12097820 22623428 19738201 19057841 11751331
CD40LG CD40 â—¼   PHYSICAL_INTERACTION 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG CD40 â—¼   PROTEIN_INTERACTION 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
ICOS CD40LG â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10426994 11907067 15536084 16713974 20116985 21708958
CD40LG CD86 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG CD80 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD40LG CD40 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 1280226 1374165 19426221 7516405 11163401 7543281 12324477 10647992 17183360
CD58 CD2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 30368623 23602662 16189514 7544396 21982860 11575926 7525848 1377404
MADCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10702270 9873398 8600538
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
MADCAM1 ITGB7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8600538 9233649 7687523 12100519 15958805
CDH1 ITGB7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7969453 10837471
CD80 CD86 â—¼   PHYSICAL_INTERACTION 25.0 1.0 ACSN 10477595 11207245 11964292 12810107 14764699 15034038 15197224 17513775 17629517 18585785 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 25582338 26405600 7512027 7523569 8920882 9359474
CD80 CD86 â—¼   PROTEIN_INTERACTION 25.0 1.0 ACSN 10477595 11207245 11964292 12810107 14764699 15034038 15197224 17513775 17629517 18585785 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 25582338 26405600 7512027 7523569 8920882 9359474
CD40 CD80 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD80 CD28 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26405600 7512027 7523569 9359474
CD80 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 21530327 7964482 22437870 2164219 1847722 23954143 15610849 7545666 21982860 21487479
CD80 CD274 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23417675 24819296 18585785 17629517 20587542 31000591 31757674 21982860 18173375
CDH1 CDH4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 11884419 16424155 16461340 17307799 17617594
CDH1 CDH2 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 11884419 16424155 16461340 17307799 17617594
CDH1 CDH2 â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 11884419 16424155 16461340 17307799 17617594
CDH1 CDH4 â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 11884419 16424155 16461340 17307799 17617594
CDH2 CDH4 â—¼   PHYSICAL_INTERACTION 5.0 1.0 ACSN 11884419 16424155 16461340 17307799 17617594
CDH2 CDH4 â—¼   SHARES_COMPLEX 5.0 1.0 ACSN 11884419 16424155 16461340 17307799 17617594
HLA-G CD8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1908512 10843658 10809759
CD40 CD86 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11207245 11581322 11698286 11964292 14764699 15034038 15197224 17200410 17317815 17371980 17513775 23002440 23125331 7523569 8760829 9359474
CD86 CD28 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10477595 11207245 11964292 14764699 15034038 15197224 17513775 20231889 20805416 21220452 22076556 22437870 23390297 24218453 25215878 25384214 7523569 8920882 9359474
CD86 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 21530327 22437870 18205792 23954143 11021528 21931534 21487479 7513726
ICOSLG ICOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 21955433 16951355 23954143 29879883 11023515 14599850 25769613 10657606 11956294
NECTIN2 CD226 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12913096 19098271 22285893 26755705
NECTIN2 TIGIT â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 12913096 19098271 22285893 26755705
PVR TIGIT â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 12913096 16730454 18657862 19098271 19801517 22285893 24343663
PVR CD226 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 12913096 16730454 18657862 19098271 19801517 22285893 24343663
PVR CD226 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12913096 15034010 15607800 21982860 30591568
NECTIN3 TIGIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 1313846 26927206 21982860 30759143
TIGIT CD226 â—¼   DOWN_REGULATES ✅ - 7.0 1.0 ACSN 22285893 22427644 25866972 26755705 26763253 27620276 28893624
CD4 HLA-DQA2 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 HLA-DRA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 HLA-DQA1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 HLA-DPA1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 20346773 23580664 11827988 21543337 22426112 16461343 2530588
CD4 PTPRC â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10398592 10652356 12731048 12740575 17544292 19290918 20814939 21127503 22513334 23620508 3263576 8478617 8986721 9438848 9738502 9751747
CD4 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
CD274 PDCD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23417675 26681673 21422170 12893276 18841514 23954143 11015443 20587542 12719480 31757674 12889478 21982860 26602187
PDCD1LG2 PDCD1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23417675 12893276 23954143 20587542 23223433 31727844 12810690
PTPRF IRS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 15588985 10660596 10592173 8732688 22899729 18988627
HLA-DQA2 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
HLA-DRA PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
HLA-DQA1 PTPRC â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
PTPRC HLA-DPA1 â—¼   DEPHOSPHORYLATION ✅ 5.0 1.0 Reactome 20346773 23580664 11827988 21543337 2530588
HLA-DRA HLA-DOA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DRA HLA-DOB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DRA HLA-DMA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-A CD8A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9177355 10809759
PPFIA1 PTPRF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 9624153 16713569 8524829 7796809
HLA-DQA1 HLA-DMA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DPA1 HLA-DMA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DQA2 HLA-DMA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
ITGAL F11R â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 15681301 15528364 17525755 11812992
NTNG1 LRRC4C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21946559 1459544314595440 19467332 14595443
HLA-DQA1 HLA-DMB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DQA1 HLA-DOA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DQA1 HLA-DOB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DQA2 HLA-DOA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DQA2 HLA-DOB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DQA2 HLA-DMB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
SELPLG SELP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 17145710 19118202 23994464 9128259 10713099 12393589 9129046 26627825 11081633 17064811 9829984
HLA-DOB HLA-DPA1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DOA HLA-DPA1 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
HLA-DPA1 HLA-DMB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
NLGN1 NRXN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 8576240 18923512 12796785 14522992
NLGN1 NRXN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18923512 8576240
NLGN1 NRXN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7736595 18923512
NTNG2 LRRC4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 25411505 17973922 21946559 19467332
NLGN3 NRXN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 18923512 8576240 9325340
NLGN3 NRXN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18923512 8576240 85762408576240
NLGN3 NRXN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18923512 8576240
SELPLG SELE â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9024699 9128259 11402070 8621728 26124272
NLGN2 NRXN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18923512 8576240 85762408576240
NLGN2 NRXN2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18923512 8576240
NLGN2 NRXN3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18923512 8576240