Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CDK5RAP3 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19223857
SRPRB CDK5RAP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CRMP1 CDK5RAP3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
CDK5RAP3 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19223857
ESR1 CDKN2A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24559156 10851069
NOS3 ELAVL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21163940 114280
ELAVL1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19884656
ELAVL1 ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18644987
TAB1 MAPK14 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5215125 11847341
MDM2 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 23839035
UBC NPM1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6541703 18259216
RPS3 RELA â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 24457201
UBC RHOA â—¼   UBIQUITINATION ✅ 2.0 0.8 intact 5217531 15710384
UBC TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5218828 16845370
HSPA4 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSPA8 TAB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
ZRANB1 UBC â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19373254 7288828
UBC ZRANB1 â—¼   DEUBIQUITINATION ✅ 2.0 0.8 intact 19373254 7288828
ESR1 HSPA8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11085516
ESR1 NOS3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17921256 0704315104
EGFR JUP â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
MAPK14 TAB1 â—¼   PHOSPHORYLATION ✅ - 0.8 0.8 Signor 19393267
MDM2 CDKN2A â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 7989562 20713054
RELA RPS3 â—¼   PHYSICAL_INTERACTION 815.0 0.81 STRING 36370105
HSPB1 CDK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 26344197 30669930
EGFR IGF1R â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17047074 17307140
ESR1 HUWE1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19805454 25604459
UBC MDM2 â—¼   PHYSICAL_INTERACTION ✅ 0.82 0.82 mint 19166840 6823655
IGF1R ERBB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17307140 30898150
ESR1 OTUD4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33731348 31527615
MDM2 NPM1 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
UFC1 UFM1 â—¼   PHYSICAL_INTERACTION 838.0 0.83 STRING 36370105
ESR1 IGF1R â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 10749889 24051437 14764897 28555617 16113100
UBC MDM2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17290220 19166840 18566590 19098711
UFC1 UFM1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 24966333 22939629 15071506 26344197
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
DHX36 DISC1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 31413325 29961565
HUWE1 HSPB1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 25147182 25277244
CDK5RAP3 FKBP6 â—¼   PHYSICAL_INTERACTION 864.0 0.86 STRING 36370105
DDRGK1 UFL1 â—¼   PHYSICAL_INTERACTION 869.0 0.87 STRING 36370105
HSPA4 PARK2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EGFR HSPA8 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ESR1 EGFR â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16713569 28065597 20935677 11887937 17284441
EGFR HSPB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 24189400 23397142 15657067
IGF1R MDM2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 25241761 12821780 20195357 28092675 18632619 19165858
ESR1 HSPA8 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
IGF1R MDM2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
ESR1 HSPA4 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
EGFR RET â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 24658140 25402006 31980649 28460442
EGFR TAB1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 31980649 24658140 25402006 18271526
MDM2 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12897156 11178989 16713569 10766163 17545634 31012223
CDKN2A NPM1 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
TSPYL4 ZRANB1 â—¼   PHYSICAL_INTERACTION 0.89 0.89 HuRI 32296183
EGFR CDK1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 31980649 23956138 24658140 25402006 18271526 15657067
EGFR RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
EGFR ERBB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500850 25241761 30898150 17486068 11526509 9461599 23866081 17426253 10572067 11500516 24557338 8665853 15657067 19060928 16516204 19650109 20211985 25315821 23436906 21278786 25898135 32669362 1346931 24189400 21044682 18803307 16843263 28369073 7531698 16713569 17148612 21203579 17307140 1706616 16207817 7797556 12354693 11408594
RELA EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17881446 23379415
RELA MAPK14 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ERBB2 RHOA â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18955552 20937854 15156151
ESR1 RET â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21737465 21947652 22878616
PRKAB1 NOS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11729179
CDK5RAP3 UFL1 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
HSPA4 HSPA8 â—¼   PHYSICAL_INTERACTION 912.0 0.91 STRING 36370105
CDKN2A MDM2 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
ERBB2 EGFR â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 5218411 16516204
CDK5RAP3 DDRGK1 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
MAPK14 TAB1 â—¼   PHYSICAL_INTERACTION 966.0 0.96 STRING 36370105
MDM2 UBC â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
HUWE1 UBC â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
RPL36 RPS3 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
UBC ZRANB1 â—¼   PHYSICAL_INTERACTION 979.0 0.98 STRING 36370105
EGFR ERBB2 â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
RPL10A RPS3 â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
PARK2 UBC â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
RPL10A RPL36 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ERBB2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 55.0 1.0 Omnipath 18927589 17938195 10770932 17276342 17396146 11836499 17409144 29088738 19276355 26673326 19933706 28335434 20372791 7743995 11322924 19683496 27889260 17466630 14681223 12384528 12049736 7841526 12110582 25744022 18393321 15582998 19861462 14987992 20144215 17466629 16546994 19858290 15136770 14767478 20368335 25994202 10504341 1850698 15350223 24910099 9268380 15296723 8428596 24391510 18469858 8662825 20530684 11782384 15141014 15940258 12766774
CDK1 RPS3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21871177 19081932 19059439 19458393
CDK1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20798862 19837665 18691976 21765472 21907702 29092815 18983824 16629900 22686412 24242917
CDK1 NPM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 49.0 1.0 Omnipath 17081983 12058066 27253419 22285574 25908633 20333249 16912078 27553022 19933706 16083285 20068231 27619510 17570479 18669648 7213797 81161106 26536659 11278991 17287340 17924679 15190079 14670079
CDK1 ELAVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20798862 27679857 18927508 27932253 29563610 26821046 22936947 27303922 23837869 27307117 18593881 18948743 28272405 30154469 21935886
CDK1 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17145710 31980649 8360196 23956138 15901825 28150246 18271526 15657067 24658140 25402006 15302935
NPM1 CDKN2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 16957780 20208519 15289458 16199867 16915296
CDKN2A MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 12167711 18541670 23416275 9529249 17426254 12630860 17116689 12085228 15856024 10822382 19166854 12209154 12740913 17158541 16915296 17909018 25809483 9653180 14612427 22120712 16173922 10871849 18418067 24769896 9724636 21133853 10801444 19049976 9529248 16107876 18813780 20713054 18467333 15355988 18583933 20395212 11223036
CDKN2A HUWE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17145710 16915296 15989956
PPM1D CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 18265945 15870257 23396447 11390642
ESR1 EGFR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12894229 12421825 8200909 21705183
MAPK14 EGFR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15187187 18039929 19138820 7535770 12738796 17139251 16932740 23397142 16785992 11274345
EGFR ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 20809984 17284441 16713569 11887937
EGFR ERBB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 65.0 1.0 Omnipath 17081983 16207817 21044682 17148612 24557338 16713569 21203579 10233167 20471394 17389395 17486068 21278786 11500516 11279155 11500850 17426253 16843263 19650109 25241761 24189400 15657067 17307140 18803307 1706616 12354693 10572067 24355130 11408594 19060928 12648464 16516204 15951569 23436906 20211985
MAPK14 ELAVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 21745814 24865968 21862584 19528229 24968827 17317627
PPM1D MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 12758252 15659558 11101524 19713933
RET MAPK14 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 44.0 1.0 Omnipath 19901323 17081983 8622669 16497976 15592455 15735649 7535770 17126298 16083285 20068231 18452278 18669648 16153436 18691976 18088087 17548358 15972258 10781613 19651622 15674326 7750576 17016520 15659558
MAPK14 TAB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 28.0 1.0 Omnipath 24443058 22216226 33204339 19393267 25241761 11847341 16648477 12429732 14592977 22307082 17570479 26391660 17126905 21900206
MAPK14 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23216744 22431515 12138194 15879307
MAPK14 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 15187187 18039929 18411303 12738796 20626350 11274345
MAPK14 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12842894 15128824 15485852 10521409 15489227 15849198 15212693 12767944
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
PPM1D MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 18265945 17936559 17939684
MDM2 IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 25241761 28092675 12821780 18632619 17303558 19165858 36042202 20195357
ROR2 RHOA â—¼   PHYSICAL_INTERACTION 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
ROR2 TAB1 â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 23070005
ROR2 TAB1 â—¼   SHARES_COMPLEX 15.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 23070005
ROR2 RHOA â—¼   SHARES_COMPLEX 53.0 1.0 ACSN 11226259 11698448 11729192 11739775 11779461 11992112 12194823 12361600 12740575 14657501 14704854 14744429 14747478 15265686 15279786 15618519 15761148 16713974 17127310 17303408 17517963 17660363 17884187 18037882 18256687 18423981 18497258 18590585 18851840 19020754 19366350 19565474 19836308 19853559 20006983 20535745 21178402 22017973 22949611 23732914 24857661 24919149 26885855 26885856 27048821 27066895 7479854 7575488 7641885 8655584 9362522 9660866 9822605
ROR2 TAB1 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 23070005
ROR2 TAB1 â—¼   UP_REGULATES ✅ + 15.0 1.0 ACSN 10391247 11274345 12620219 14660645 14704854 14960582 15082531 17127310 17884187 18264787 18762249 18855897 19020754 19136967 23070005
RELA NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18397880 14570928 17081374
ESR1 IGF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17170218 20021813 16087727 19250214 10982795 24281069 18414489 15595626
ESR1 LTF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16861234 8873065 10738912 10779508 15525592 8441416
ESR1 ERBB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 24559156 16115928 16467118 17992604 19915977 15199112 21127199 21761336 21907803 20551150 11713584 1358436 20629094 18768663 19005469 9242384 20889718 10698518 16467117
ERBB2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 15173068
ESR1 HSPB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15833836 10960840 11174852 8923463
ESR1 NOS3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22052999 11029009 10690351 14742696 19914929