CYCS
|
APAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
9267021
5221616
|
APAF1
|
CASP3
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
intact
|
5214497
11550094
|
BAX
|
APAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11709054
|
IRF3
|
BAX
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
7900384
20360684
|
SMAD3
|
BAX
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
11906909
16603637
|
CASP3
|
BID
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
intact
|
0707715105
18723680
|
FAS
|
BID
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15659383
25241761
|
FASLG
|
BID
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15659383
25241761
|
FADD
|
BID
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15659383
25241761
|
BID
|
CYCS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9873064
9727491
|
CASP8
|
CASP3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18669646
0712034105
|
CASP9
|
CASP3
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
intact
|
0707715105
18723680
|
AKT3
|
CASP3
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
intact
|
17544405
5219985
|
CASP3
|
AKT1
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
intact
|
17544405
5219985
|
CASP3
|
CASP9
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12011067
15573119
|
CASP3
|
AKT2
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
intact
|
17544405
5219985
|
CASP3
|
EIF2S1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10432301
10734073
|
CASP3
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
9500443
|
DNAJB1
|
DNAJC3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16189514
9920933
|
NFKB1
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12456660
16135789
|
EP300
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
23403292
24998469
|
EP300
|
RELA
|
â—¼ ACETYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
5214468
11533489
|
MAPK3
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24530506
|
STAT1
|
ICAM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19935876
|
TNF
|
ICAM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21474822
22846676
|
IFIH1
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0700544104
17600090
|
ACTG1
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
IKBKE
|
IFIH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0700544104
17600090
|
IRF3
|
IKBKE
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20304918
21182093
|
XPO1
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
SLC25A5
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
SLC25A6
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
ACTG1
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TBK1
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
FADD
|
IKBKG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16227629
23131831
|
IL1A
|
IRAK4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12538665
17507369
|
TRIM25
|
IRF7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15361868
19479062
|
MAVS
|
IRF7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15361868
19479062
|
IRF7
|
IFIH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15361868
19479062
|
IRF9
|
IRF7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10924517
12768031
|
STAT2
|
IRF7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10924517
12768031
|
IRF7
|
IFNA5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19349300
12242290
|
IRF7
|
IFNA7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10938111
19349300
|
IRF7
|
IL12A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19164128
16824573
|
IRF7
|
IFNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16410796
|
RAF1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK1
|
MAP2K1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
23241949
8412360
|
PRKCB
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8903320
10327068
|
MAPK1
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8941362
|
MAPK3
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219611
17290218
|
RAF1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
PRKCB
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8903320
10327068
|
MAPK3
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16888388
16691505
|
TLR3
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218855
16858407
|
TPSB2
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PIK3R1
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PIK3R1
|
TPSAB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
IRF9
|
PML
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8681971
|
PML
|
JUN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9671405
10620019
|
NLRP3
|
PYCARD
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
5215008
11786556
|
RAE1
|
HNRNPUL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19745842
7293793
|
RAE1
|
NUP98
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17172455
0609582104
|
RAE1
|
NXF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10668806
|
TNF
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21887257
19287455
|
SLC25A5
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
SLC25A6
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
ACTG1
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TNFRSF1A
|
CASP8
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
8095238
21157428
|
IRF3
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6540704
18309294
|
IRF3
|
IFNA7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19349300
12821121
|
IRF3
|
IFNA14
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19349300
11303025
|
IRF3
|
CXCL8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17035306
20483755
|
IRF3
|
TBK1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
18583960
6948053
|
IRF3
|
TBK1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
17599067
5220070
|
IRF3
|
CCL5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11991981
|
IRF3
|
CXCL10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12354379
|
IRF3
|
IFNB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16410796
|
RELA
|
CDK6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18504428
|
CDK6
|
CCND3
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
JUN
|
ACTB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10840940
11082319
|
PRKCA
|
ACTB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15590896
10592173
|
ACTG1
|
IKBKB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
ACTG1
|
NFKBIA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
ACTG1
|
TRADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
ACTG1
|
NFKBIB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
ACTG1
|
CHUK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
SOCS3
|
IFNG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10421843
10064597
|
SOCS3
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10421843
10064597
|
SOCS3
|
IFNGR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10421843
10064597
|
SOCS3
|
IFNGR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10421843
10064597
|
NFKB1
|
SOCS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23335796
|
JUN
|
SOCS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18571793
17609438
|
KPNA2
|
NFKBIB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
FADD
|
FAS
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
16498403
5218359
|
SLC25A5
|
NFKBIA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
NFKBIB
|
NFKBIA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
CHUK
|
NFKBIA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
ACSN
|
12799363
23430059
|
IFNB1
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10022928
18508557
|
TYK2
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
15261459
23124025
|
IL6
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
8662591
8662795
|
STAT1
|
IFNAR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
9121453
6730748
|
STAT1
|
IFNAR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
9121453
6730748
|
RELA
|
STAT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
25040843
|
STAT1
|
TLR3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16628196
|
STAT1
|
IL12B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
19029990
24012417
|
IFNAR2
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11301323
9121453
|
STAT1
|
FASLG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12108949
|
STAT1
|
FAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17992189
|
CREBBP
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
9679056
9679060
|
SMAD4
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9679056
9679060
|
PRKCA
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219626
17290288
|
JAK1
|
IL12A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
22306691
12829785
|
IFNGR2
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15120645
23331499
|
IFNB1
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
10918594
|
SMAD3
|
CHUK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0712044105
18268325
|
SMAD3
|
TPSAB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16730810
14527958
|
SMAD3
|
MMP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20869563
16018191
|
IL1B
|
IRAK4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12538665
17507369
|
IFNGR1
|
IFNG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
376230
7617032
|
IFNAR1
|
IFNGR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18929502
23331499
|
STAT2
|
IFNG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9218597
21178011
|
PIK3CD
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
NCK1
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
JAK2
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
JAK2
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11598010
12506011
|
JAK2
|
IL12A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
22306691
12829785
|
TYK2
|
PRKCA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219626
17290288
|
IFNB1
|
TYK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
10542297
|
TYK2
|
EIF2AK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23236554
17290288
|
NFKBIB
|
CCL5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15609310
24383830
|
CASP8
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
RAF1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19197339
7014125
|
RAF1
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
30761125
27554335
|
RELA
|
JUN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17310108
10646503
|
JUN
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12832543
11192249
|
JUN
|
CASP8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18196534
17922191
|
JUN
|
TNFRSF10A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12082627
|
JUN
|
CXCL10
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19299558
23250032
|
JUN
|
MAP2K1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9733728
20353950
|
CASP8
|
TNFSF10
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
23678861
8429107
|
IL1B
|
CASP8
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
Reactome
|
1574116
22267217
|
MAVS
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16406812
21419663
|
CASP8
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11002417
|
CASP8
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11002417
|
EIF2S1
|
EIF2AK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
9431994
6735217
|
EIF2S1
|
EIF2AK2
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
9431994
6735217
|
NFKBIB
|
CHUK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
CHUK
|
IKBKB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
ACSN
|
12799363
23430059
|
CHUK
|
IKBKB
|
â—¼ PROTEIN_INTERACTION
|
|
|
2.0
|
0.8
|
ACSN
|
12799363
23430059
|
RELA
|
KITLG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19197368
14563684
|
RELA
|
CDK4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18425349
|
RELA
|
HLA-DRB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18421578
15964798
|
RELA
|
IKBKB
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
12842894
5216511
|
NFKB1
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12456660
16135789
|
CREBBP
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
|
TRAF3
|
TRADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8565075
5220916
|
SLC25A6
|
TRADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
SLC25A5
|
TRADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14743216
5216883
|
TPSAB1
|
NCK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
TPSB2
|
NCK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
NCK1
|
PIK3CD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
NFKBIB
|
IL1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
1905804
20975042
|
IL1B
|
CASP1
|
â—¼ CLEAVAGE
|
✅
|
|
2.0
|
0.8
|
intact
|
0812690106
19439663
|
NFKB1
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18031796
|
NFKB1
|
TNFRSF10A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21243522
|
NFKB1
|
TLR7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20658750
16423052
|
IKBKB
|
EIF2AK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10848580
16600570
|
MAVS
|
NLRP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
25816776
24048902
|
PIK3CA
|
TICAM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15940673
|
HLA-DRA
|
HLA-DQA2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8520027
9850860
|
HLA-DRA
|
HLA-DPA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8520027
9850860
|
HLA-DRA
|
HLA-DQA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8520027
9850860
|
PIK3CD
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
PIK3CA
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
PIK3CD
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
NUP98
|
HNRNPUL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19745842
7293793
|
NLRX1
|
MAVS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
18200010
|
CIITA
|
HLA-DMA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7495736
9300700
|
MITF
|
PRKCB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16411896
|
MITF
|
TPSAB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20513998
|
TRIM25
|
IFIH1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18353649
|
NR1I2
|
HLA-DRB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20371638
11297522
|
IRF9
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
7843405
20038197
|
HLA-DQB1
|
HLA-DQA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
11376336
5214072
|
HLA-DQA2
|
HLA-DQA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8520027
9850860
|
HLA-DQA1
|
HLA-DPA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8520027
9850860
|
HLA-DQB1
|
HLA-DQA1
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
HLA-DQA2
|
HLA-DPA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8520027
9850860
|
NXT2
|
NXF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
8153045
21516116
|
PRSS1
|
F2RL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9349532
10978167
|
TPSAB1
|
F2RL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21999702
9020112
|
TICAM1
|
TRAF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
808.0
|
0.8
|
STRING
|
36370105
|
NFKB1
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
11739381
23811396
14662860
12471036
20065107
22013068
12960163
|
JAK1
|
SOCS3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
10707961
10373548
|
IKBKG
|
MAVS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
812.0
|
0.81
|
STRING
|
36370105
|
ACTB
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
33742100
21988832
|
ACTB
|
ICAM1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
31536960
23463506
|
IRAK4
|
TLR4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
21829704
21220427
|
AKT3
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
IFNA4
|
IFNA2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
IFNA4
|
IFNA8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
IFNA4
|
IFNA7
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
HLA-DQA2
|
HLA-DQB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
826.0
|
0.82
|
STRING
|
36370105
|
PML
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
16189514
15356634
|
IFNA5
|
IFNA6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
SMAD4
|
JUN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
10220381
25609649
|
TRADD
|
TRAF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
8565075
30561431
|
CASP1
|
IL1B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
7797510
28147281
8999548
32122970
7642516
1919001
19439663
|
IFNA2
|
IFNA5
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
IFNA5
|
IFNA4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
CHUK
|
NFKBIB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
830.0
|
0.83
|
STRING
|
36370105
|
KPNA1
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
IFNAR2
|
STAT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
838.0
|
0.83
|
STRING
|
36370105
|
NFKBIA
|
IKBKG
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.84
|
0.84
|
mint
|
8209688
16126728
506093200
|
IKBKG
|
NFKBIA
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.84
|
0.84
|
mint
|
8209688
16126728
506093200
|
JAK1
|
TYK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
8702790
7589562
|
HLA-DRB1
|
HLA-DRA
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.84
|
0.84
|
mint
|
5220278
7477400
|
NXT1
|
NXF1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.84
|
0.84
|
mint
|
23299939
|
IKBKB
|
NFKB1
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.84
|
0.84
|
Signor
|
11158290
|
MAPK1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
JUN
|
PML
|
â—¼ PHYSICAL_INTERACTION
|
|
|
848.0
|
0.84
|
STRING
|
36370105
|
CASP9
|
CASP3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
11242052
8900201
25241761
1067155
15941357
11230124
15507451
18723680
17437405
|
STAT2
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
15154850
10464260
18678383
|
FADD
|
MYD88
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
16189514
11828002
10880445
21988832
|
AKT2
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28514442
12149249
9736715
12176337
11445557
33961781
14500673
11278835
11546794
|
APAF1
|
CYCS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
853.0
|
0.85
|
STRING
|
36370105
|
BAK1
|
BID
|
â—¼ PHYSICAL_INTERACTION
|
|
|
853.0
|
0.85
|
STRING
|
36370105
|
CHUK
|
RELA
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.85
|
0.85
|
Signor
|
10521409
|
SLC25A4
|
SLC25A5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
858.0
|
0.85
|
STRING
|
36370105
|
SMAD4
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
9679056
25514493
18215124
9843571
14612423
10887155
22033265
|
EP300
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
9679056
15824515
15688032
16109717
15345715
20564330
9843571
15133024
10497242
17469184
15623506
10575014
15588252
18055455
16876108
21567395
11134049
12743039
11058129
|
PYCARD
|
CASP1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.86
|
0.86
|
mint
|
34589402
|
JAK1
|
STAT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
32123171
11722592
34521819
32953130
11294897
10982844
15322115
12637327
7690989
14978237
15284024
10918587
7543024
32814877
12817007
34950606
7657660
11839738
|
AKT1
|
FAS
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
25640309
31980649
|
TLR4
|
TRAF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
32802180
21903422
|
NXF1
|
NXT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
859.0
|
0.86
|
STRING
|
36370105
|
NLRX1
|
MAVS
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
18200010
28542569
|
CALCOCO2
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
863.0
|
0.86
|
STRING
|
36370105
|
CYCS
|
CASP9
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.86
|
0.86
|
Signor
|
9390557
|
IKBKE
|
TNF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
866.0
|
0.86
|
STRING
|
36370105
|
JUN
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
867.0
|
0.86
|
STRING
|
36370105
|
BAX
|
VDAC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
868.0
|
0.86
|
STRING
|
36370105
|
IKBKG
|
RELA
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.86
|
0.86
|
Signor
|
15489227
|
CASP8
|
BID
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
9727492
15659383
9727491
12097160
11832478
12196516
11085743
|
CASP3
|
BID
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
10364179
11399776
18723680
|
CASP8
|
CASP3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
15254227
11832478
18669646
11437602
8962078
|
AKT1
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
21901101
15224190
21775285
20333651
18182168
11116148
|
EP300
|
IRF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
12473110
11940575
9660935
11314014
20604809
9488451
21903422
|
IRF3
|
MAVS
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
16153868
22908223
25636800
24379373
21903422
|
JAK2
|
STAT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
11294897
15322115
11152457
12637327
7690989
20353823
19834108
14978237
15284024
10918587
24255956
7543024
12817007
7657660
11839738
|
JAK2
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
9689060
11134016
8876196
10205168
|
CASP8
|
TRADD
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
19524513
18776134
17047155
12887920
29108854
30561431
|
CASP3
|
CASP9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
IKBKE
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
FAS
|
FASLG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
CASP8
|
FASLG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
EP300
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
AKT1
|
CHUK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
IKBKE
|
MAVS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
IFNAR1
|
STAT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
IFIH1
|
MAVS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
EP300
|
NFKB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
IFNGR1
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
PIK3R2
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
PIK3R1
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
CHUK
|
CREBBP
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
IKBKE
|
IRF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
IFNA14
|
IFNA6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
NFKBIA
|
NFKBIB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
IRF3
|
MAVS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
CHUK
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
NFKB1
|
NFKBIB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
IKBKE
|
TRAF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
IRF7
|
IRF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
18641315
11162841
|
CDK4
|
CDK6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
23455922
28205554
28628118
33961781
|
FADD
|
TNFRSF10A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
FADD
|
TNFRSF10B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
CASP8
|
TRADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
879.0
|
0.88
|
STRING
|
36370105
|
TBK1
|
NCK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
16189514
7706279
|
TBK1
|
MAVS
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
23028469
16153868
32366851
28346439
21813773
29125880
32511263
24643253
25636800
33372174
21903422
29743353
|
MAVS
|
IFIH1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
22623778
16127453
19881509
19416887
32612200
22301138
17600090
33372174
33649232
30193849
27312109
21903422
|
IKBKG
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
AKT1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
AKT1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
TBK1
|
TICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
IKBKB
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
IKBKG
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
MAVS
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
EP300
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
NLRP3
|
PYCARD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
CHUK
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
AKT1
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
885.0
|
0.88
|
STRING
|
36370105
|
CREBBP
|
SMAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
886.0
|
0.88
|
STRING
|
36370105
|
MAPK1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
CREBBP
|
JUN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
JAK2
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
888.0
|
0.88
|
STRING
|
36370105
|
VDAC1
|
BAX
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
9843949
16189514
15637055
28760928
12767928
|
PML
|
JUN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
15626733
9671405
16916642
10620019
|
STAT2
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.89
|
0.89
|
mint
|
24065129
|
TRAF3
|
TBK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
22330071
32324863
29125880
27135603
22792062
23986588
20174559
22079989
22908223
33608556
28049150
32779804
24763515
33372174
24622840
23717208
19380580
23308279
34084167
17991829
29920243
33187908
26928339
33411856
31404116
|
NXF1
|
NUP98
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
22334672
16713569
11551912
10668806
16314397
29395067
11073998
|
NXT2
|
NXF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
32296183
16189514
25416956
33961781
21516116
11073998
|
NXT1
|
NXF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
32296183
16189514
25416956
34133714
33961781
19060904
11073998
|
IKBKG
|
TNF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
CREBBP
|
RELA
|
â—¼ ACETYLATION
|
✅
|
+
|
0.89
|
0.89
|
Signor
|
16382138
|
CASP8
|
BID
|
â—¼ CLEAVAGE
|
✅
|
+
|
0.89
|
0.89
|
Signor
|
9727492
|
IKBKB
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
896.0
|
0.89
|
STRING
|
36370105
|
NFKBIB
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
896.0
|
0.89
|
STRING
|
36370105
|
FADD
|
TNFSF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
897.0
|
0.89
|
STRING
|
36370105
|
BAX
|
BID
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25241761
15574335
20956295
23374347
17289999
|
SMAD4
|
BAX
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15886208
16603637
18620728
|
AKT3
|
BAX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
14766748
15642728
17525161
|
CASP3
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9367996
29752472
|
EP300
|
IRF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.9
|
STRING
|
36370105
|
EP300
|
JUN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
27956703
21268080
21937452
24069158
11689449
14630807
11980644
10327051
12437352
12471036
24636898
|
EP300
|
KPNA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10801418
15342649
|
IKBKE
|
TRIM25
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
23453971
22619329
24722368
|
IKBKG
|
IKBKB
|
â—¼ PHOSPHORYLATION
|
✅
|
|
3.0
|
0.9
|
intact
|
8209688
506093200
16126728
|
IKBKG
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15489227
|
IL1A
|
MYD88
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
17507369
17890055
9430229
|
NFKB1
|
IL1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
17513725
17612514
|
CASP1
|
IL1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18329368
|
IRF7
|
IRAK4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
15361868
15767370
15492225
|
IRF7
|
TLR7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
15361868
15767370
15492225
|
IRF3
|
IRF7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20483755
15367631
15664995
|
MAVS
|
IRF7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
17020950
16153868
|
MAPK1
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK1
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK1
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18378670
7569900
14963018
|
MAPK3
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK3
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK3
|
MITF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12819038
10841026
|
MAPK3
|
PML
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15093545
|
STAT1
|
PML
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21115099
15519999
22589541
|
STAT2
|
PML
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17062732
|
NR1I2
|
TNFRSF1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19129222
|
TRIM25
|
IRF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12692549
16153868
16846591
|
CREBBP
|
IRF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
ACSN
|
15265520
22331441
23422957
|
IRF3
|
IFIH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12692549
16153868
16846591
|
CREBBP
|
IRF3
|
â—¼ PROTEIN_INTERACTION
|
|
|
3.0
|
0.9
|
ACSN
|
15265520
22331441
23422957
|
IRF3
|
TBK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
23028469
31534043
25636800
16394098
30267576
21903422
22079989
15695821
32241891
20628368
18636086
15841462
19380580
28346439
18583960
25803835
17599067
12692549
19153231
22388039
24807708
19656901
22072751
|
IRF3
|
CREBBP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19349300
15355347
18309294
|
IRF3
|
IL6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
20483755
27337441
|
IRF3
|
TBK1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23843640
20304918
18636086
|
IRF3
|
IL12A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16219795
19164128
16824573
|
SOCS3
|
JAK2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
24438103
14517242
19543316
10421843
15514089
22342841
29752723
9344848
10882725
24354892
11314018
|
RELA
|
SOCS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23386688
23335796
|
TNFRSF10B
|
FADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12721308
17327223
10894160
|
IFNG
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12040185
7796299
8156998
|
KITLG
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11494148
10358045
9355737
|
IFNGR2
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
12040185
7796299
8156998
|
STAT2
|
STAT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
8621447
8605877
28514442
26966684
10446176
31836668
17923090
10490982
9724754
24065129
15825084
35140242
33961781
12048190
|
STAT1
|
IRF9
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17923090
8943351
24065129
|
STAT1
|
OAS1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23110939
2456211
22305621
|
STAT1
|
JAK2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12223098
21239533
|
STAT1
|
CXCL8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
18370868
15057743
2606351
|
STAT1
|
STAT2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16918696
19122651
|
STAT1
|
IRF9
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22951020
|
STAT1
|
MYD88
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18024894
7567467
|
STAT1
|
IL1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17386941
23922745
|
STAT1
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
16481475
|
AKT1
|
SMAD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16362038
23397142
|
SMAD3
|
SMAD4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
9111321
16189514
25514493
11927552
28443643
21988832
20211142
15084259
12732634
19768112
15467747
20142324
25609649
15922743
12917407
12419246
20564330
24382352
19139564
32296183
24157709
18729074
22442258
10092624
17283070
15350224
17591701
15761153
31591477
10995777
26555259
9892009
9311995
15588252
12167862
10878024
25910212
27703004
33990575
28115363
18055455
22310290
19135894
10531362
12794086
15231748
21297662
22045334
19917253
24584437
27107012
29892012
29997244
21532621
27845895
21597466
25502805
11114293
12543979
23788427
|
SMAD4
|
JUN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12374795
10022869
|
XPO1
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11074002
23331499
|
IL6
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
8134389
8272873
9382798
|
AKT1
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16362038
25241761
|
SMAD3
|
JUN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10903323
11306568
10220381
9732876
21829441
|
SMAD3
|
JUN
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12374795
10022869
|
IRAK4
|
MYD88
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
32296183
16189514
25416956
24735611
17548806
12860405
25910212
18221795
24316379
25502805
20485341
22011580
11960013
26871637
12538665
|
IL1B
|
MYD88
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
17507369
17890055
9430229
|
IRF9
|
IFNG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8864350
22252317
9218597
|
JAK2
|
IL12B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18389480
7638186
7528775
|
JAK2
|
IL5
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
2681215
1400495
1396555
|
IL12A
|
TYK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18389480
7638186
7528775
|
IL12B
|
TYK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
18389480
7638186
7528775
|
AKT1
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
25241761
28628118
10576742
19197339
19058874
28205554
|
JUN
|
TPSAB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16730810
15464728
11157480
|
JUN
|
KITLG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
7521696
17145782
15464728
|
JUN
|
TPSD1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16730810
11157480
11741327
|
JUN
|
IL12A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16600913
22904313
|
CASP8
|
TNFSF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
899.0
|
0.9
|
STRING
|
36370105
|
NR1I2
|
EIF2S1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19129222
|
AKT3
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19609947
|
PRKCB
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12070292
|
TBK1
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10783893
21138416
|
RELA
|
TNFRSF10A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12615723
21243522
|
RELA
|
MMP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19303700
20352621
17498959
|
RELA
|
IL18
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10227974
17399992
15963597
|
NFKB1
|
IL18
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10227974
17399992
15963597
|
CASP1
|
IL18
|
â—¼ CLEAVAGE
|
✅
|
|
3.0
|
0.9
|
Reactome
|
1574116
9121587
8999548
|
CREBBP
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17923090
|
TLR4
|
TICAM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22664090
14519765
19656901
|
PRKCA
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11463380
17570479
20577053
|
CREBBP
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12789342
16835236
|
CREBBP
|
IRF9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8848048
17923090
|
STAT2
|
IRF9
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
8943351
17923090
24065129
33961781
9242679
21903422
|
NFKB1
|
TNFSF10
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20542572
21243522
11544302
|
NFKB1
|
MMP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19303700
20352621
17498959
|
NFKB1
|
CDK4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
24296733
18425349
|
PRKCB
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12070292
|
TRAF3
|
IFIH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
16858409
16306936
17190786
|
TRAF3
|
TICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
16306937
19898473
16306936
|
TRAF3
|
TRIM25
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
16858409
16306936
17190786
|
TRAF3
|
MAVS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
16858409
16306936
17190786
|
IFIH1
|
TRAF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
17020950
16306936
16858409
|
HLA-DRA
|
HLA-DPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
9312039
1956401
16618111
|
HLA-DRA
|
HLA-DQA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
9312039
1956401
16618111
|
HLA-DRA
|
HLA-DQA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
9312039
1956401
16618111
|
NR1I2
|
MAP2K1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19129222
|
PIK3R2
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22402981
8596638
11733063
|
TRIM25
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
23453971
22619329
24722368
|
IFIH1
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
23453971
22619329
24722368
|
TBK1
|
CALCOCO2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19820708
21903422
|
CASP1
|
IL33
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19439663
16286016
|
HLA-DQA2
|
HLA-DQA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
9312039
1956401
16618111
|
HLA-DQA1
|
HLA-DPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
9312039
1956401
16618111
|
HLA-DQA2
|
HLA-DPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
9312039
1956401
16618111
|
IL12B
|
IL12A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
10899108
10779781
7527811
|
CASP8
|
TNFRSF10A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
HLA-DMA
|
HLA-DRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
BAX
|
BID
|
â—¼ PHYSICAL_INTERACTION
|
|
|
901.0
|
0.9
|
STRING
|
36370105
|
JAK2
|
SOCS3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
903.0
|
0.9
|
STRING
|
36370105
|
ACTB
|
ACTG1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.9
|
0.9
|
HuRI
|
32296183
|
EIF2AK2
|
EIF2S1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
905.0
|
0.9
|
STRING
|
36370105
|
TYK2
|
IFNAR1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.9
|
0.9
|
Signor
|
8605876
|
TNFSF10
|
FADD
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.91
|
0.91
|
mint
|
10894160
5212774
|
FAS
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.91
|
0.91
|
mint
|
11717445
5214823
|
CASP8
|
FAS
|
â—¼ COLOCALIZATION
|
✅
|
|
0.91
|
0.91
|
mint
|
5219431
17159907
|
FAS
|
CASP8
|
â—¼ COLOCALIZATION
|
✅
|
|
0.91
|
0.91
|
mint
|
16498403
5218359
|
HLA-DPA1
|
HLA-DPB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
910.0
|
0.91
|
STRING
|
36370105
|
EP300
|
JUN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
911.0
|
0.91
|
STRING
|
36370105
|
CASP8
|
TNFRSF10B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
911.0
|
0.91
|
STRING
|
36370105
|
NXF3
|
NXT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
916.0
|
0.91
|
STRING
|
36370105
|
NXF3
|
NXT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
IRF3
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
918.0
|
0.91
|
STRING
|
36370105
|
IRF9
|
STAT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
918.0
|
0.91
|
STRING
|
36370105
|
TNFRSF1A
|
TRADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.92
|
STRING
|
36370105
|
TBK1
|
IRF3
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
17599067
5220070
|
TBK1
|
IRF3
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.92
|
0.92
|
mint
|
6948053
18583960
|
TBK1
|
IRF3
|
â—¼ COLOCALIZATION
|
✅
|
|
0.92
|
0.92
|
mint
|
17599067
5220070
|
TNFSF10
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
10894160
5212774
|
TNFSF10
|
CASP8
|
â—¼ COLOCALIZATION
|
✅
|
|
0.92
|
0.92
|
mint
|
8429107
23678861
|
NXF1
|
NXT2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
28514442
16189514
16713569
33961781
11073998
|
EP300
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
MYD88
|
TLR4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
922.0
|
0.92
|
STRING
|
36370105
|
MAP2K2
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
CASP8
|
FAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
CREBBP
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
MAVS
|
TRAF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
NUP98
|
XPO1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
PIK3CB
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
CREBBP
|
STAT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
936.0
|
0.93
|
STRING
|
36370105
|
PIK3CB
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
938.0
|
0.93
|
STRING
|
36370105
|
MYD88
|
IRF7
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
15361868
16484229
|
TBK1
|
TRAF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
PIK3CA
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
IFNAR1
|
IFNAR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
944.0
|
0.94
|
STRING
|
36370105
|
EP300
|
SMAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
HLA-DMA
|
HLA-DRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
PIK3CB
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
947.0
|
0.94
|
STRING
|
36370105
|
ACTG1
|
ACTB
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
8153045
21516116
|
TRAF3
|
MAVS
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
27348524
27980081
32366851
32324863
29125880
22792062
22022264
30267576
22079989
31806368
20080758
21200404
22908223
30527812
33608556
31390091
26221961
24622840
16858409
33582548
19419966
22901541
32511263
19893624
26519536
23545497
33411856
|
TNFSF10
|
TNFRSF10B
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
5211930
10542098
|
IL12A
|
IL12B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
951.0
|
0.95
|
STRING
|
36370105
|
CCND3
|
CDK6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
957.0
|
0.95
|
STRING
|
36370105
|
MAP2K2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
CASP9
|
APAF1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
5221774
9390557
|
FAS
|
FADD
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
5219431
17159907
|
TRADD
|
FADD
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
24686082
32296183
12107169
12796506
8681376
21724995
12911633
23955153
11112409
16919273
8565075
30561431
10911999
|
FAS
|
FADD
|
â—¼ COLOCALIZATION
|
✅
|
|
0.96
|
0.96
|
mint
|
16498403
5218359
|
RAF1
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
7014125
19197339
|
NUP98
|
NXF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
961.0
|
0.96
|
STRING
|
36370105
|
HLA-DRA
|
HLA-DRB5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
962.0
|
0.96
|
STRING
|
36370105
|
MAP2K1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
IKBKB
|
NFKB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
HLA-DMB
|
HLA-DRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
CHUK
|
NFKB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
965.0
|
0.96
|
STRING
|
36370105
|
IFNA2
|
IFNAR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
967.0
|
0.96
|
STRING
|
36370105
|
PIK3R1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
20018188
7383613
|
CDK6
|
CCND3
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
8153045
21516116
|
CDK6
|
CCND3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
28514442
16189514
25416956
33854235
14681455
21516116
32296183
17517622
9716181
11360184
30217970
23602568
15232106
26264872
27107012
32707033
16782892
16713569
8114739
29997244
32814053
33961781
26186194
|
NFKBIA
|
IKBKB
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.97
|
0.97
|
mint
|
8209688
16126728
506093200
|
TLR4
|
MYD88
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
17126326
15107846
10952994
17258210
18221795
20048342
15728506
33052227
12646618
11743586
21911421
21829704
|
NXF1
|
NXT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
28514442
11256625
16189514
25416956
16713569
17978099
11583626
23299939
16314397
33961781
29395067
11073998
26344197
|
MAP2K1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
971.0
|
0.97
|
STRING
|
36370105
|
CREBBP
|
STAT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
IFNAR1
|
TYK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
IFNA2
|
IFNAR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
MAP2K1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
TNFRSF10A
|
TNFSF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
CASP1
|
PYCARD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
HLA-DMA
|
HLA-DMB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
IKBKG
|
IKBKB
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
5219009
16938294
|
IKBKB
|
IKBKG
|
â—¼ PHOSPHORYLATION
|
✅
|
|
0.98
|
0.98
|
mint
|
8209688
16126728
506093200
|
CASP8
|
FADD
|
â—¼ COLOCALIZATION
|
✅
|
|
0.98
|
0.98
|
mint
|
5219431
17159907
|
CDK4
|
CCND3
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
8153045
21516116
|
TNFRSF10B
|
TNFSF10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
MAP2K2
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
984.0
|
0.98
|
STRING
|
36370105
|
PIK3CD
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
APAF1
|
CASP9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
NFKB1
|
NFKBIA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
PIK3CA
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
FADD
|
CASP8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
21785459
23142077
21988832
23972990
17290218
24098568
14681455
20103630
33469115
18485876
22274400
22864571
25043603
27560715
25939870
29795330
19524512
17159907
30561431
27552911
19176810
15659383
9343261
22179575
22173242
25911380
27321185
8681376
15280356
21737330
26437781
31046799
21458669
12702723
11717445
21737329
19060883
21525013
23429285
20448643
12107169
17047155
9228018
12887920
29497034
12911633
14612908
23955153
33961781
20829884
26972597
21620750
|
CCND3
|
CDK4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
28514442
16189514
25416956
21988832
33854235
9106657
14681455
21516116
23880157
16985050
32296183
10342870
26496610
19237555
9716181
11360184
30217970
15232106
14641107
25910212
27107012
16782892
33961781
26186194
11896535
|
CCND3
|
CDK4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
991.0
|
0.99
|
STRING
|
36370105
|
HLA-DRA
|
HLA-DRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
IRAK4
|
MYD88
|
â—¼ PHYSICAL_INTERACTION
|
|
|
993.0
|
0.99
|
STRING
|
36370105
|
HLA-DQA1
|
HLA-DQB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
IKBKG
|
NFKBIA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
NUP98
|
RAE1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
CHUK
|
NFKBIA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
NXF1
|
NXT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
IKBKB
|
NFKBIA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
CHUK
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
IKBKB
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
NFKBIA
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
CYCS
|
APAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
11753565
10393175
10364241
15829969
16977332
15907471
10722681
9390557
10578178
16713569
9267021
12147322
10206961
10329646
11112785
10940292
|
CASP3
|
APAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12874265
21827945
11550094
|
APAF1
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
63.0
|
1.0
|
Omnipath
|
17145710
15829969
15024710
9390557
19494828
11113115
10617566
9539746
10364241
10722681
27476169
21060833
19118655
20829884
16977332
10329646
15210107
10393175
16352606
11242052
14555243
10376594
12773388
10206961
19337385
10428850
9488720
19788417
15262985
9922454
21827945
10749135
9651578
19698783
12792650
9837928
11227497
|
BID
|
BAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
17145710
23782464
17289999
11175253
10950869
12624108
23604079
12242151
|
BAK1
|
VDAC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
9843949
10365962
10639121
|
BAK1
|
BAX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
15901672
11571294
16189514
16439990
|
BAK1
|
CYCS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
11447222
11175253
11326099
12232790
11741880
|
PYCARD
|
BAX
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
14730312
19062087
19104081
19968986
26885855
27048821
27066895
27984721
|
NFKB1
|
BAX
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
6.0
|
1.0
|
ACSN
|
12676992
15613549
21725609
23178297
23572150
7834749
|
STAT1
|
BAX
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17346710
19801665
20567883
|
RELA
|
BAX
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
18034190
18158998
20056115
|
BID
|
BAX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
20956295
17289999
25241761
19968986
15574335
10629050
19062087
10949027
12242151
23374347
14730312
17520191
8918887
|
AKT1
|
BAX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
26763134
14766748
15642728
17525161
|
PYCARD
|
BAX
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
16964285
19062087
14730312
19968986
|
BAX
|
VDAC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
16189514
10365962
9843949
12767928
|
BAX
|
CYCS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9461218
10629050
20709625
9843949
11326099
12232790
|
CASP3
|
BID
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
9727492
10364179
10805722
11832478
11085742
11085743
|
CASP8
|
BID
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
9727492
10364179
10805722
11832478
12196516
18458084
9727491
11085742
11085743
12097160
9873064
|
CASP1
|
BID
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11085743
9727491
|
CASP8
|
CASP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
15755874
17179148
9501089
9950028
18669646
23308069
10988287
18458084
16964285
9885230
9765224
11437602
15014070
21295084
8962078
9208847
|
CASP9
|
CASP3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
10708865
9390557
10508159
11230124
18723680
15657060
16977332
15507451
1067155
9708736
25241761
8900201
11242052
9765224
17437405
19788417
9812896
12620238
15941357
12181739
19465923
12792650
15725726
|
CASP3
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
9367996
11741536
|
CASP3
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
17544405
12124386
10579725
|
CASP9
|
CYCS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9390557
25313070
20462491
27697150
|
MAP2K2
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
12792650
18669648
|
AKT1
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
42.0
|
1.0
|
Omnipath
|
11756412
11923280
16697215
20398329
18372248
15004527
15808505
20138985
20214616
15703181
17570479
28177918
18840507
15169778
11714830
10949026
16341064
11715018
18636226
10529400
9812896
17680028
19440551
10722653
20832730
18570873
17052453
|
AKT2
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
9812896
15004527
|
AKT3
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
9812896
|
CYCS
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
19788417
16977332
9390557
16713569
12147322
12773388
10329646
12792650
15210107
|
MAPK3
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
38.0
|
1.0
|
Omnipath
|
15547943
20080742
29416675
12040186
15173823
12697810
11940578
19081073
19586613
16227978
12738796
16039586
17466630
17255949
18669648
15187187
19016842
19541618
19091303
19565474
17052211
18039929
18775330
10601235
12792650
11431469
|
MAP2K1
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
12792650
18669648
|
MAPK1
|
CASP9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
44.0
|
1.0
|
Omnipath
|
15547943
20080742
12040186
18083711
15173823
12697810
11940578
19081073
19586613
16227978
12738796
16039586
17466630
17255949
18669648
16888006
15187187
19016842
19541618
19091303
19565474
17052211
18039929
18775330
10601235
12792650
11431469
|
STAT1
|
EP300
|
â—¼ PHYSICAL_INTERACTION
|
|
|
22.0
|
1.0
|
ACSN
|
10918613
11134049
11830590
12193701
12223527
12796776
12811837
12967644
14607900
14764699
15265520
15814715
17016554
17513775
17559085
17689680
18272812
19833085
21263073
21930765
25960930
8683106
|
STAT1
|
EP300
|
â—¼ PROTEIN_INTERACTION
|
|
|
22.0
|
1.0
|
ACSN
|
10918613
11134049
11830590
12193701
12223527
12796776
12811837
12967644
14607900
14764699
15265520
15814715
17016554
17513775
17559085
17689680
18272812
19833085
21263073
21930765
25960930
8683106
|
IFNG
|
EP300
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
31.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11870632
11964313
12413632
12818165
14607900
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
1825141
18272812
19833085
20038811
20819927
21149606
21411734
24658051
26755705
2965306
6425450
9834059
9864217
|
AKT2
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17964260
16926151
|
AKT1
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
17623675
18182168
16926151
20333651
19158375
17964260
17570479
11116148
25904863
21901101
23275565
16024795
|
IRF3
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
9463386
9488451
11940575
9660935
21903422
10024886
11314014
|
MAPK1
|
EP300
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17623675
24530506
|
EP300
|
MITF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9660747
|
EP300
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
19608861
25400040
11567019
12419806
17617622
11533489
20333651
12456660
15152190
16846590
9096323
20064247
16382138
16713569
15171256
16135789
|
EP300
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
9843571
19419955
22033265
9679056
21269274
|
EP300
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
9843571
11134049
12743039
15133024
15824515
15623506
16876108
21567395
16109717
17074756
20564330
10497242
15588252
17469184
15345715
11058129
10575014
16862174
|
IFNG
|
ICAM1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
31.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11870632
11964313
12413632
12818165
14607900
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
1825141
18272812
19833085
20038811
20819927
21149606
21411734
24658051
26755705
2965306
6425450
9834059
9864217
|
IL18
|
ICAM1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
10.0
|
1.0
|
ACSN
|
10679398
11592085
14504095
14662834
15099563
15802534
26885855
27048821
27066895
9469432
|
RELA
|
ICAM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
55.0
|
1.0
|
Omnipath
|
10926553
7822333
9192770
9831247
7957928
15996193
22337883
19074768
16778171
9188493
16317091
17121934
18928584
15843586
22001597
9056676
18285351
16385502
10946302
15946255
20103608
10738944
15800027
22708120
23238746
22901690
9888295
11877286
7659084
17855547
10553096
10092659
9733827
11401521
11463837
9916895
20173029
10837365
16455661
19351910
20823682
12691701
16105834
12490396
17537731
22345292
10228026
16453001
19278584
|
JUN
|
ICAM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11356008
12832416
9218873
20459645
|
NFKB1
|
ICAM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
38.0
|
1.0
|
Omnipath
|
10926553
15480988
9192770
7957928
11198351
19074768
9188493
16317091
17121934
18928584
15843586
22001597
9056676
18285351
16385502
10946302
20103608
10738944
15800027
22708120
9888295
11877286
17855547
10553096
10092659
9733827
11401521
11463837
9916895
20173029
10837365
12691701
16105834
12490396
16453001
|
STAT1
|
ICAM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
11641425
19122651
9888295
9353323
11278281
12651068
7957928
23347335
10830295
22951020
9990314
|
TLR4
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12692549
15210742
14530355
17526488
17047224
14703513
19656901
17823124
23453971
|
TLR3
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12692549
15210742
16306936
16281057
14530355
17526488
17047224
14703513
23453971
|
TRAF3
|
IKBKE
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12692549
15210742
16306936
16281057
14530355
17526488
17047224
14703513
23453971
|
IKBKE
|
TICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12692549
15210742
16306936
16281057
14530355
17526488
17047224
14703513
23453971
|
IFIH1
|
IKBKE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
16177806
17020950
15210742
15210743
16306936
16127453
12702806
16858409
|
MAVS
|
IKBKE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
17145710
15210743
16127453
19153231
17020950
25636800
15210742
16306936
12702806
16177806
27419230
36056146
19546225
19380491
16858409
21200404
24706939
18207245
17468758
17327220
|
TICAM1
|
IKBKE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
14739303
16410796
12692549
16281057
|
TBK1
|
IKBKE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
17599067
16177806
15210742
15210743
16306936
16127453
17468758
12702806
18353649
17327220
16858409
|
TRAF3
|
IKBKE
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
16177806
15210742
15210743
16306936
16127453
17468758
12702806
17327220
16858409
24763515
|
IKBKE
|
IRF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
32.0
|
1.0
|
Omnipath
|
16127453
19153231
12692549
24722368
15210742
20532218
12702806
16380379
14703513
29800227
14679297
17706453
24396068
18440553
16281057
16625202
9463386
18818105
16199137
9566918
15695821
14739303
21138416
17526488
15212693
16914100
|
IKBKE
|
IRF7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
16625202
25225665
9786932
15210742
22787218
10893229
26712804
16127453
12702806
16380379
15367631
12692549
17706453
16199137
16914100
|
IKBKE
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
24065129
17502367
24416652
29186193
24058806
22520844
|
IKBKE
|
TBK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
17599067
16177806
15210742
15210743
16306936
16127453
17468758
12702806
17327220
24622840
16858409
|
IKBKE
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
28317833
12842894
16046471
20188669
15128824
17561400
17003035
30223576
15485852
10521409
15489227
15849198
16407239
26025205
15212693
12767944
|
IKBKE
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
31.0
|
1.0
|
Omnipath
|
10783893
18794072
8657102
8601309
15939554
12138192
10329681
10882136
9721103
12403772
21171089
16888014
15879144
20717897
16007147
7796813
11815618
10421793
25133483
21872579
10398585
16199137
|
TICAM1
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
TLR3
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
TLR4
|
IKBKG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
IKBKG
|
CHUK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
17.0
|
1.0
|
ACSN
|
11340079
12133805
12799363
15199157
15485931
16818229
17363905
17485448
17693255
18716620
20138012
20300203
20531300
21217011
22435554
23430059
28462531
|
IKBKG
|
CHUK
|
â—¼ SHARES_COMPLEX
|
|
|
17.0
|
1.0
|
ACSN
|
11340079
12133805
12799363
15199157
15485931
16818229
17363905
17485448
17693255
18716620
20138012
20300203
20531300
21217011
22435554
23430059
28462531
|
RELA
|
IKBKG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
NFKBIB
|
IKBKG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
NFKBIA
|
IKBKG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
NFKB1
|
IKBKG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
TRADD
|
IKBKG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
57.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
11438547
11460167
11875494
12646658
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
28574505
8910423
9488730
|
FADD
|
IKBKG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
57.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
11438547
11460167
11875494
12646658
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
28574505
8910423
9488730
|
TNF
|
IKBKG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
84.0
|
1.0
|
ACSN
|
10542212
10754326
10820262
10925299
10952726
11112697
11274345
11280761
11438547
11460167
11875494
12133805
12433365
12646658
12811837
12907458
1431106
14607933
14625680
14660645
15099563
15199157
15465827
15485931
15536066
15592525
15644117
15699106
15749903
16243976
16413922
16713974
16818229
16878026
16970925
17237376
17254973
17301840
17363905
17404308
17462996
17485448
17693255
17916596
18264787
18345002
18633355
18641653
18716620
19392652
19411070
20038811
20138012
20184663
20300203
20435894
21133840
21217011
21232017
21411734
21807870
21826665
22435554
22955274
23086447
23170255
23390297
23422957
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
2649237
28462531
7594497
8910423
9743347
|
IKBKG
|
NFKBIA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
17.0
|
1.0
|
ACSN
|
11340079
12133805
12799363
15199157
15485931
16818229
17363905
17485448
17693255
18716620
20138012
20300203
20531300
21217011
22435554
23430059
28462531
|
IKBKG
|
RELA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
38.0
|
1.0
|
ACSN
|
11280761
11438547
11460167
12133805
12811837
14660645
15145317
15199157
15485931
15536066
15573129
16818229
16970925
17237376
17254973
17301840
17363905
17485448
17693255
18264787
18716620
19833085
20138012
20300203
21133840
21217011
21232017
21807870
22435554
23086447
23422957
23430059
24378531
24699077
24766893
24958845
2649237
28462531
|
TNF
|
IKBKG
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
84.0
|
1.0
|
ACSN
|
10542212
10754326
10820262
10925299
10952726
11112697
11274345
11280761
11438547
11460167
11875494
12133805
12433365
12646658
12811837
12907458
1431106
14607933
14625680
14660645
15099563
15199157
15465827
15485931
15536066
15592525
15644117
15699106
15749903
16243976
16413922
16713974
16818229
16878026
16970925
17237376
17254973
17301840
17363905
17404308
17462996
17485448
17693255
17916596
18264787
18345002
18633355
18641653
18716620
19392652
19411070
20038811
20138012
20184663
20300203
20435894
21133840
21217011
21232017
21411734
21807870
21826665
22435554
22955274
23086447
23170255
23390297
23422957
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
2649237
28462531
7594497
8910423
9743347
|
IKBKG
|
IL6
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
38.0
|
1.0
|
ACSN
|
10542212
10754326
10952726
11875494
12133805
12907458
14660645
15199157
15465827
15485931
15536066
15644117
15749903
16243976
16413922
16818229
16878026
16970925
17237376
17254973
17363905
17404308
17485448
17693255
18716620
20138012
20300203
21217011
21807870
22435554
23086447
23390297
23422957
23430059
2649237
28462531
7594497
9743347
|
IKBKG
|
STAT1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
38.0
|
1.0
|
ACSN
|
11280761
11438547
11460167
12133805
12811837
14660645
15145317
15199157
15485931
15536066
15573129
16818229
16970925
17237376
17254973
17301840
17363905
17485448
17693255
18264787
18716620
19833085
20138012
20300203
21133840
21217011
21232017
21807870
22435554
23086447
23422957
23430059
24378531
24699077
24766893
24958845
2649237
28462531
|
NFKB1
|
IKBKG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14743216
|
AKT1
|
IKBKG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
20837477
20098747
17660512
|
TNFRSF1A
|
IKBKG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
16189514
10755617
|
IKBKG
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
42.0
|
1.0
|
Omnipath
|
17145710
7862124
11087742
10602462
16818647
8657102
16965765
22435544
11064457
24369075
10880512
7739562
14743216
16319058
7878466
16126728
10329646
15836773
16177806
21217772
16153868
10195894
12514169
18617513
15371334
16493424
17706453
15145317
10723801
15870263
7796813
17468758
16603398
17965022
11830587
|
IKBKG
|
NFKBIB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17145710
15836773
14743216
15145317
17072322
10723801
|
IKBKG
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
150.0
|
1.0
|
Omnipath
|
17145710
16938294
20932476
35339487
18266324
16260493
27929056
25979343
19666608
26496610
12133833
12192055
9751060
21423167
19706536
15836773
17561400
22099304
23986494
19959994
15327770
25400026
24266532
18450452
12657630
20434986
11583588
20200955
20300203
21903422
22990857
14743216
20167598
20098747
16126728
19656241
25852190
16906147
10195894
17000764
18329793
16186825
16547522
16611882
18037881
10968790
16497931
25286246
18462684
18207244
16603398
17965022
17977820
24240172
17568778
15084594
16129692
23506214
16319058
23123196
18949366
15218526
22605335
20368414
10837071
19820708
10980203
23131831
17363973
15214841
25304104
16493424
15184390
15691841
11864612
15802604
17693255
21455180
11865184
20211142
11971985
16970925
24469399
24618592
12486103
11057907
24369075
19365808
18583959
27426725
12612076
19422324
10094049
23109003
21803029
12459277
21640763
16285893
18266467
12709429
15620648
17072322
19815509
15749833
|
IKBKG
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
74.0
|
1.0
|
Omnipath
|
17145710
17485448
16938294
11865184
11877453
16970925
22435554
17244613
17568778
17363905
16818229
15084594
15485931
24369075
20300203
21217011
12799363
23180781
14743216
16319058
21703539
19666608
20098747
12612076
16126728
15218526
23430059
9751060
20138012
18716620
20368414
10837071
25355947
15836773
23109003
20531300
17702576
17363973
15214841
12459277
17561400
21640763
16285893
28462531
12709429
10968790
15199157
26192618
12133805
16497931
11864612
17693255
17072322
11340079
|
IKBKG
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14743216
|
RELA
|
IL1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
27371733
21131967
23195252
17612514
27076634
21106671
|
JUN
|
IL1A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19299558
8688489
|
TLR4
|
IRF7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
14517278
15210742
14703513
9566918
17823124
17157040
|
TRAF3
|
IRF7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15210742
16281057
14703513
9566918
17157040
|
TLR3
|
IRF7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15210742
16281057
14703513
9566918
17157040
|
TICAM1
|
IRF7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15210742
16281057
14703513
9566918
17157040
|
RELA
|
IRF7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15265881
16982926
11877397
|
NFKB1
|
IRF7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15265881
16982926
11877397
|
STAT1
|
IRF7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
22951020
11877397
16628196
22252317
12768031
15767254
15664995
|
IRF7
|
IFNA14
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10938111
19349300
15699120
11303025
|
IRF7
|
IFNA13
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
21670437
10933732
12077266
11473119
17785777
9877175
10938111
19798431
11303025
12242290
16612387
16251417
21940674
15265881
12138184
16175599
19349300
10692430
27012395
11162841
17702615
|
IRF7
|
IFNA4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
10938111
11884139
9786932
19557165
16014964
16380379
17785777
9877175
24185615
10692430
|
IRF7
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
22547704
24532789
12604599
15355347
16186222
12915551
16014964
22065573
19176627
23906644
17785777
22698399
17236232
9877175
10938111
11303025
19557165
21994549
10848607
20637800
19349300
14729983
10692430
20581830
11846976
20483755
12821121
19570869
|
IRF7
|
CXCL10
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23405030
20483755
16253303
24701034
|
IRF7
|
IFNA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10938111
11473119
19349300
17236232
10692430
|
TBK1
|
IRF7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
16625202
17599067
9786932
15210742
22787218
26712804
16127453
12702806
15367631
12692549
16380379
17706453
16199137
16914100
|
RAF1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
MAPK1
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
MAPK1
|
SMAD3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10197981
16156666
27153775
29577978
|
MAP2K2
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
68.0
|
1.0
|
Omnipath
|
21675959
11704645
9694850
17081983
7565670
12750173
19690332
12932319
11823456
18799465
15592455
11337027
18083107
21365009
12788955
11134045
19219045
17389395
9447970
15342917
23331499
19534553
17569879
7559390
23047924
8226933
8223433
17272394
15851026
15811950
19494114
18988627
18669648
11549292
23519423
19541618
18691976
1381507
16293107
17906627
11986622
19933846
8376945
19053285
16094384
11971971
17192257
11136732
11948414
8388392
7898932
9731057
11730323
18039929
11118451
19369195
12920017
15951569
15466214
10746662
|
PRKCA
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11704645
12598525
19074803
8903320
9160888
|
MAP2K1
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
149.0
|
1.0
|
Omnipath
|
21675959
9694850
17081983
10757792
11319218
18799465
15592455
12788955
19415658
12697810
17389395
9447970
15342917
8226933
15851026
12270934
12644307
17255949
10998418
11242034
1378617
1381507
17906627
11986622
8376945
8157000
7992057
11948414
9731057
19651622
11251083
11266467
18707149
14743221
11279118
11704645
12750173
12932319
16497976
11337027
23331499
12048245
7559390
17272394
15811950
19494114
18669648
18691976
11741894
15972258
19053285
16094384
17192257
7898932
24623782
9166761
19369195
21336309
12920017
15466214
17016520
19901323
1712480
19690332
11823456
9032297
11134045
12876277
19534553
10995751
20068231
21506533
8223433
8248196
16153436
12594221
10567369
19933846
17563371
11730323
29175850
11352917
16135787
15951569
19058874
15212693
23241949
9560161
91184134
18083107
16887817
18578522
17569879
21071413
9148935
18452278
1330321
8670897
19541618
10777511
15935618
12925710
11971971
9765155
11136732
11118451
12082107
12952943
10746662
21768338
|
MAPK1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12975377
23602568
16424009
19058874
23397142
21707490
|
MAPK1
|
JUN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
8072547
11313929
15378002
12531896
12853483
23720779
9662434
1496019
17570479
1922387
11278277
11739718
16023596
20086174
25557171
7737130
26755651
8224842
14676207
17920329
25201974
9022811
22327296
18650425
8137421
18443042
12881422
18572021
17001009
33767435
7744008
23616010
26745678
14617628
11432833
16819515
22606284
12040039
|
MAPK1
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12801888
|
MAPK1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
17081983
18767875
15849194
19690332
11409918
14654779
23331499
23180781
8226933
20068231
18988627
21917714
18669648
19541618
18691976
16407412
19933846
9922370
15664191
8388392
19651622
10801873
8349614
18775330
9604935
|
MAPK1
|
EIF2AK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17404396
9528799
|
MAPK1
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
53.0
|
1.0
|
Omnipath
|
19218245
18032789
18729074
16156666
19914161
23331499
19914168
24080014
8226933
14512875
15520018
20736297
26497676
12193595
26297431
18988627
8388392
10197981
15241418
18775330
9604935
9380693
|
MAPK1
|
MITF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
21887372
10952390
16162175
29121864
9440696
10673502
12819038
20701798
27428965
16246839
|
MAPK1
|
PML
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
22935031
29416846
23293771
23316480
15093545
|
MAPK1
|
CIITA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
15210796
17095509
18245089
|
MAPK1
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
24342355
17290218
|
MAPK1
|
TNFRSF1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
10702263
11606045
|
MAPK1
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15073167
16888388
16691505
|
RAF1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
MAPK3
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
MAPK3
|
SMAD3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
10197981
16156666
27153775
29577978
|
MAP2K2
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
101.0
|
1.0
|
Omnipath
|
19901323
17081983
11704645
9694850
12750173
1411546
19690332
12932319
18799465
16497976
18083107
11134045
8626767
9006895
17389395
19219045
15342917
9447970
16887817
23331499
17569879
7867743
7559390
21071413
19534553
8226933
20068231
8223433
17272394
93330262
15851026
15811950
26987942
18988627
19494114
18669648
19541618
11242034
15466476
18691976
1381507
17906627
11986622
19933846
8376945
11971971
17192257
11136732
11948414
7898932
7687743
9731057
19651622
11730323
16464493
18983981
11251083
11118451
15580310
19369195
18707149
12920017
15951569
15466214
10746662
15212693
|
PRKCA
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11704645
12598525
19074803
8903320
9160888
|
MAP2K1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
106.0
|
1.0
|
Omnipath
|
9694850
17081983
11319218
18799465
17389395
9447970
15342917
8226933
15851026
12270934
12644307
11242034
1381507
17906627
9677429
11986622
8376945
7992057
11948414
7687743
9731057
19197339
11704645
7565670
12750173
12932319
8626767
23331499
12048245
7559390
17272394
15811950
26987942
19494114
18669648
18691976
17192257
8388392
7898932
16464493
19369195
12920017
15466214
19690332
11134045
19534553
10995751
7867743
8223433
8248196
10567369
19933846
17563371
1518847
11730323
18983981
16186792
16135787
15951569
19058874
15212693
10748187
9560161
9925641
9733512
18083107
11104681
9006895
17569879
21071413
7731720
1330321
93330262
19541618
15466476
12925710
11971971
11136732
11118451
10746662
|
MAPK3
|
CIITA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
26181363
17095509
20538595
18245089
15210796
|
MAPK3
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
28115363
12801888
|
MAPK3
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
23331499
10197981
15241418
24080014
18775330
8226933
16156666
9604935
12193595
8388392
|
MAPK3
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
24342355
17290218
26036637
29233910
24484936
20937773
|
MAPK3
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
14654779
23331499
19541618
18691976
16407412
19933846
9446616
9922370
15664191
18988627
|
PIK3CA
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
NCK1
|
PIK3R1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
52.0
|
1.0
|
ACSN
|
10022831
10086337
10567412
10811803
10849428
10982827
11166270
11447289
11449354
11532940
11777939
11960372
12175651
12393695
12629515
12640133
13678960
15099563
15111329
15501236
15520864
15567848
15573129
15574420
16002046
16076871
16572188
16582911
16887996
17086423
17496910
17673906
17883421
19414323
19449109
21372296
21378271
22064427
22461508
23390297
23896411
24217602
24346288
24670066
25922287
26201938
26552706
8551221
8837607
9157999
9570538
9753319
|
JAK1
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
9774657
15021914
7544789
|
JAK2
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8702385
12706299
16135792
17474147
|
PIK3R1
|
FASLG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11741599
25241761
19807924
|
PIK3R1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10527852
16799564
19442713
|
PIK3R1
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
8596638
25241761
20713702
27107012
11733063
21825134
32814053
26496610
8139559
14729945
10358930
14665640
|
PIK3R1
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
9113989
8596638
21827948
12147247
11733063
22020336
24165795
31031754
14665640
|
PML
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
21071413
15356634
16189514
18988627
|
PYCARD
|
NLRP3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
ACSN
|
11989976
17959595
19104081
20385749
23202296
23702978
26885855
27048821
27066895
27439607
27984721
|
PYCARD
|
NLRP3
|
â—¼ SHARES_COMPLEX
|
|
|
11.0
|
1.0
|
ACSN
|
11989976
17959595
19104081
20385749
23202296
23702978
26885855
27048821
27066895
27439607
27984721
|
IRAK4
|
PYCARD
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
MYD88
|
PYCARD
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
PYCARD
|
IL1B
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
19104081
20385749
23202296
26885855
27048821
27066895
27439607
27984721
|
PYCARD
|
NLRP3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11989976
17959595
19104081
20385749
23202296
23702978
26885855
27048821
27066895
27439607
27984721
|
CASP1
|
PYCARD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
24630722
25605870
12191486
15383541
11051551
11967258
11536016
24803432
21385879
26121674
11432859
12019269
16585594
19337385
14634131
|
RAE1
|
NUP98
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
19615732
26186194
18832153
35096974
16036565
10209021
15851029
17172455
24927547
20498086
21467841
888800000819
|
TNF
|
TRAF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
7639698
25152365
19815541
8702708
7544915
|
TNF
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
33.0
|
1.0
|
ACSN
|
11112697
11274345
11279185
12531547
12646658
1330325
1431106
14607933
14625680
15099563
15310755
15699106
17916596
18633355
19411070
20038811
20184663
21133840
21411734
21826665
21920725
22955274
23170255
23430059
23510023
23567181
23769623
24092389
26201938
26801188
28765050
8663014
8910423
|
TNF
|
TRADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
65.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11279185
11280761
11438547
11460167
11875494
12531547
12646658
12811837
1330325
1431106
14607933
14625680
14660645
14730360
15099563
15310755
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
21920725
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26801188
26972597
28574505
28765050
8663014
8910423
9488730
|
TNF
|
FADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
57.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
11438547
11460167
11875494
12646658
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
28574505
8910423
9488730
|
TNF
|
TNFRSF1A
|
â—¼ PROTEIN_INTERACTION
|
|
|
33.0
|
1.0
|
ACSN
|
11112697
11274345
11279185
12531547
12646658
1330325
1431106
14607933
14625680
15099563
15310755
15699106
17916596
18633355
19411070
20038811
20184663
21133840
21411734
21826665
21920725
22955274
23170255
23430059
23510023
23567181
23769623
24092389
26201938
26801188
28765050
8663014
8910423
|
TNF
|
TRADD
|
â—¼ SHARES_COMPLEX
|
|
|
65.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11279185
11280761
11438547
11460167
11875494
12531547
12646658
12811837
1330325
1431106
14607933
14625680
14660645
14730360
15099563
15310755
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
21920725
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26801188
26972597
28574505
28765050
8663014
8910423
9488730
|
TNF
|
FADD
|
â—¼ SHARES_COMPLEX
|
|
|
57.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
11438547
11460167
11875494
12646658
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
28574505
8910423
9488730
|
STAT1
|
TNF
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
46.0
|
1.0
|
ACSN
|
10485906
10754326
10820262
10952726
11134049
11399519
11830590
11875494
11964313
12193701
12223527
12433365
12796776
12811837
12907458
12967644
14607900
14607933
14660645
14764699
15465827
15644117
15699106
15814715
16127449
16878026
17016554
17260466
17404308
17485448
17513775
17559085
17689680
18272812
18345002
19833085
19879327
21097505
21263073
21930765
23390297
25960930
6357187
7594497
8683106
8871614
|
TNF
|
TRADD
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
65.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11279185
11280761
11438547
11460167
11875494
12531547
12646658
12811837
1330325
1431106
14607933
14625680
14660645
14730360
15099563
15310755
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
21920725
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26801188
26972597
28574505
28765050
8663014
8910423
9488730
|
TYK2
|
TNF
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
IL6
|
TNF
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
JAK2
|
TNF
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
JAK1
|
TNF
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
NFKB1
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
74.0
|
1.0
|
Omnipath
|
17513725
12058956
24337575
12657243
17704137
12471036
17707233
7624137
11259437
12686724
16433741
26114754
20237317
7876168
16707469
12117498
14976218
10485496
15465827
8622636
15812247
21138578
18990758
10748079
15013838
15749903
16916598
17646159
10754326
16040075
10837498
18285351
11675405
11739517
15743782
20066113
20617556
17085785
8530146
8805669
10919279
14960579
1740105
10963848
16055086
9742085
17292554
10553096
11312646
15543947
17442180
16285952
10079106
11297551
10551799
10201927
12907458
8679226
9281604
22782967
8219230
11749970
9916895
11094063
11490006
7895918
1618817
16483936
18057724
20722069
16569682
9452482
17407192
17082635
|
JUN
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
42.0
|
1.0
|
Omnipath
|
12759366
11087751
7935377
21059644
16881863
24548427
12509451
9826775
10318823
8998076
18408586
15546613
20164416
7896795
9211933
10952728
9566900
23583459
10748079
24009130
10954918
10754326
9813054
10837498
9988757
11739517
16365438
19285436
16199883
8816436
10551799
8552071
9160673
11490006
21098092
16483936
10688670
10913190
16888805
9030359
25567680
9760243
|
RELA
|
TNF
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
136.0
|
1.0
|
Omnipath
|
26596471
17707233
20817730
12686724
27075886
21765477
21537341
19530226
17390058
18077329
15064230
20617556
8805669
17351769
23335080
21573233
17292554
16285952
9916895
11749970
7895918
17496784
12628924
23857586
12657243
15857826
12471036
11259437
16433741
9831247
20237317
15465827
26023919
22661093
10748079
15013838
17350185
10754326
15470505
11827962
20139176
26408955
22901690
18772140
21108432
22742857
23195252
18362169
24012417
11312646
17442180
9281604
10079106
11297551
15081318
22718766
24908318
8219230
26004152
11094063
11490006
9916692
16483936
18057724
16569682
22138107
18467438
20547752
22723832
19846753
17407192
20221401
19854828
20534538
7876168
16707469
12117498
20544543
23178569
15812247
21138578
12610112
25888873
16916598
16040075
28039105
14749357
20066113
19285436
25161822
22388040
14960579
20195282
16199883
15543947
23971673
10551799
11290773
22798670
22021035
20722069
20221720
27338466
19385047
12058956
26997758
25690886
7624137
20686703
26114754
14976218
10485496
17607667
8622636
11007957
18285351
10837498
11739517
18719026
17268554
17085785
17142966
10963848
9742085
23042817
27534992
10553096
26516703
20696864
10201927
16850160
8679226
21098092
20097764
9129150
17082635
|
TNF
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
39.0
|
1.0
|
Omnipath
|
15192014
27329558
22240205
15833743
19351843
28187781
15841081
28107185
28373828
26999213
24386331
24957606
26179215
21572963
18258304
28317833
29441018
10722927
19596989
28423685
12881425
25118327
24036851
28089769
21904602
24141032
10938077
30201812
20691659
24166907
19789307
19393267
22768286
26310932
19411070
23789107
28790310
29708974
20507904
|
TNF
|
TNFRSF1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
98.0
|
1.0
|
Omnipath
|
17145710
19084540
8288897
11448951
23746843
22801493
14732063
2848815
9568681
2158863
8182064
9488135
23070005
20080539
11239407
26670046
14743216
21724995
21133840
24070898
25911380
7852363
2170974
17151142
26186194
27560715
25241761
23032187
24726327
20103630
8805640
11502070
19442713
3034874
23955153
18067990
22099304
15485837
22675546
12753742
1310388
12887920
19287455
10634209
2170559
1331108
24980434
22028622
|
TNF
|
TRADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
17145710
12887920
19287455
15485837
32196115
|
TNF
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
19053972
24083678
25215581
29088783
24386331
25888769
20460401
16866128
19934328
9363938
24349153
|
TRADD
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
60.0
|
1.0
|
ACSN
|
10465784
11112697
11274345
11279185
11668179
12048245
12531547
12556535
12646658
12655147
12738796
1330325
1431106
14607933
14625680
14730360
15099563
15170913
15310755
15592525
15699106
17462996
17496911
17916596
18633355
18641653
18855897
19392652
19411070
19524513
19632174
20038811
20184663
21133840
21232017
21411734
21614932
21826665
21920725
22955274
23010170
23070005
23170255
23430059
23510023
23567181
23769623
23850759
24092389
24378531
26201938
26587781
26653790
26801188
28574505
28765050
8663014
8910423
9379049
9582321
|
TRADD
|
TNFRSF1A
|
â—¼ SHARES_COMPLEX
|
|
|
60.0
|
1.0
|
ACSN
|
10465784
11112697
11274345
11279185
11668179
12048245
12531547
12556535
12646658
12655147
12738796
1330325
1431106
14607933
14625680
14730360
15099563
15170913
15310755
15592525
15699106
17462996
17496911
17916596
18633355
18641653
18855897
19392652
19411070
19524513
19632174
20038811
20184663
21133840
21232017
21411734
21614932
21826665
21920725
22955274
23010170
23070005
23170255
23430059
23510023
23567181
23769623
23850759
24092389
24378531
26201938
26587781
26653790
26801188
28574505
28765050
8663014
8910423
9379049
9582321
|
TRADD
|
TNFRSF1A
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
60.0
|
1.0
|
ACSN
|
10465784
11112697
11274345
11279185
11668179
12048245
12531547
12556535
12646658
12655147
12738796
1330325
1431106
14607933
14625680
14730360
15099563
15170913
15310755
15592525
15699106
17462996
17496911
17916596
18633355
18641653
18855897
19392652
19411070
19524513
19632174
20038811
20184663
21133840
21232017
21411734
21614932
21826665
21920725
22955274
23010170
23070005
23170255
23430059
23510023
23567181
23769623
23850759
24092389
24378531
26201938
26587781
26653790
26801188
28574505
28765050
8663014
8910423
9379049
9582321
|
TNFRSF1A
|
TRADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
72.0
|
1.0
|
Omnipath
|
17145710
8565075
8943045
11934887
8612133
9915703
11684708
8621670
9430227
19641494
27552911
16611992
21760970
11821416
10187805
21724995
12721308
21741934
21232017
10795740
21119000
15310755
11502070
15115707
23955153
18776134
18939944
9916731
9129204
9082980
15485837
15173123
22297296
15357952
24130170
12887920
10634209
24758719
19524513
15465831
7758105
11035039
8791485
15725726
|
TNFRSF1A
|
FADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21760970
15357952
15033800
21741934
9129204
|
TNFRSF1A
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15357952
12887920
21741934
8875942
15725726
|
TNFRSF1A
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23815148
21724995
10795740
24323043
10755617
|
TRAF3
|
IRF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15210742
16281057
14703513
9566918
17157040
|
TLR4
|
IRF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
14517278
15210742
14703513
9566918
17823124
17157040
|
TLR3
|
IRF3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15210742
16281057
14703513
9566918
17157040
|
SMAD3
|
IRF3
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
25.0
|
1.0
|
ACSN
|
10925299
11074002
11279127
11399519
11792802
11875494
12193690
12702545
12809600
15265520
15644117
16127449
16179589
16713975
17260466
17689680
18768831
21042762
21614932
22331441
23390297
6357187
8515656
8871614
9389648
|
SMAD4
|
IRF3
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
25.0
|
1.0
|
ACSN
|
10925299
11074002
11279127
11399519
11792802
11875494
12193690
12702545
12809600
15265520
15644117
16127449
16179589
16713975
17260466
17689680
18768831
21042762
21614932
22331441
23390297
6357187
8515656
8871614
9389648
|
IRF3
|
IFNA2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10938111
11473119
12821121
19349300
24185615
10692430
|
IRF3
|
IFNA4
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
11846978
11884139
12242290
9786932
9707562
12821121
16380379
17785777
9446577
10692430
|
IRF3
|
IFNA5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
20638368
19349300
18851954
12242290
|
IRF3
|
CXCL10
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
16253303
19541850
23405030
20483755
18691624
16490936
12821121
24257594
|
IRF3
|
IFNA13
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
15741273
15331713
10048763
10933732
11473119
8524823
9891032
17785777
19193793
9877175
22593165
10938111
11303025
12242290
21795596
24278020
23028052
19349300
10692430
27012395
11162841
24535579
12821121
16641293
20047764
|
IRF3
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
84.0
|
1.0
|
Omnipath
|
19108859
22911767
20453844
22684309
15857993
17540767
16699525
9891032
24185615
12885884
16125763
19349300
20581830
11846976
20610716
16954376
23911869
9707562
12821121
18851954
26483348
23096996
12604599
12829834
22065573
19176627
9649509
20375222
24180280
27481269
18539711
21492741
19570869
20048166
16641293
20304918
15955070
25531393
18641315
19153231
24257594
20130065
16186222
15699120
12077266
17785777
17243100
22285490
9877175
11303025
22417706
23843640
21148557
18225953
17692882
21281747
11222729
9541017
20660350
21228327
17652396
18614628
19541850
20083668
24532789
22902624
18272195
17079289
21632562
17079305
17496231
22083261
10938111
19846511
10848607
17845078
9446577
10692430
18309294
20483755
17947522
24656046
17296604
|
IKBKB
|
IRF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
25070846
20604809
9566918
14703513
19153595
27992402
18272581
16914100
|
MAVS
|
IRF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17020950
25636800
21903422
16153868
22750291
|
TICAM1
|
IRF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14739303
12471095
16281057
|
TBK1
|
IRF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
90.0
|
1.0
|
Omnipath
|
24549848
18583960
22072751
16380379
26811330
16127453
17618271
23478265
19153231
12692549
28618271
17599067
22388039
15841462
25636800
21903422
15210742
33990776
20532218
16699525
20170763
30842273
12702806
16306043
17018283
20628368
16914100
33411856
23746807
28159912
16394098
18356163
22904301
34379517
22810896
14703513
22750291
27548204
29800227
22079989
24056301
14679297
17706453
20511230
24396068
19211767
18440553
16281057
12524442
16625202
9463386
19893624
18636086
15749911
18818105
27125670
24807708
15695821
9566918
30496178
17526488
19656901
23028469
32351706
24371060
15367631
16199137
25803835
24622840
16155125
|
IRF3
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
59.0
|
1.0
|
Omnipath
|
10521456
17138826
19218087
10082512
15582653
21903422
17015689
23746807
23824799
16154084
15502848
25002588
9660935
14668346
17761676
12473110
20581830
9488451
25733689
18309294
9566918
10024886
17126870
16155125
15107417
17296604
11314014
|
CCND3
|
CDK6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
17517622
8114739
26186194
27107012
23602568
10477583
16782892
21516116
25416956
29997244
31515488
32814053
15232106
32296183
11360184
16713569
9716181
|
MYD88
|
CCL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
STAT1
|
CCL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
46.0
|
1.0
|
ACSN
|
10485906
10754326
10820262
10952726
11134049
11399519
11830590
11875494
11964313
12193701
12223527
12433365
12796776
12811837
12907458
12967644
14607900
14607933
14660645
14764699
15465827
15644117
15699106
15814715
16127449
16878026
17016554
17260466
17404308
17485448
17513775
17559085
17689680
18272812
18345002
19833085
19879327
21097505
21263073
21930765
23390297
25960930
6357187
7594497
8683106
8871614
|
IRAK4
|
CCL2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
RELA
|
CCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
60.0
|
1.0
|
Omnipath
|
24337575
10644332
22189654
18226221
20038977
8630731
12488502
19738286
22189669
14976218
19371341
12540607
24260304
11716760
21138578
8617886
12218154
14631383
20952659
17452470
16325549
10744656
15223809
10530453
11006087
16040075
16730843
23583295
24063814
27076634
10987310
16206198
9388261
10614622
18353872
16166627
16829531
16818736
10636866
20195282
10469356
17507908
12647268
12682245
21106671
24550391
16764699
17932106
25108845
20200316
15950427
24634218
9174597
23198981
11949945
9916692
17537731
22723832
|
JUN
|
CCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
19162185
18024959
18443042
14752027
22674286
23583295
19299558
12667961
10918580
19371341
26554515
|
STAT1
|
CCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17255531
19915063
17167270
7561042
9558097
19404962
|
NFKB1
|
CCL2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
32.0
|
1.0
|
Omnipath
|
10644332
22189654
20038977
11512674
8630731
12488502
12540607
11716760
8617886
12218154
14631383
16325549
10744656
10530453
11006087
16040075
10987310
16206198
9388261
10614622
16818736
10636866
10469356
17507908
12647268
16764699
25108845
20200316
15950427
20579762
11949945
|
MYD88
|
SOCS3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
IRAK4
|
SOCS3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
STAT1
|
SOCS3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
19122651
15339920
10359822
19115200
19643666
14742442
17091494
12639901
17558387
|
JAK1
|
SOCS3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
25682267
10950967
16459330
10707961
10373548
|
SOCS3
|
JAK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
10882725
10421843
23331499
10514492
19543316
21071413
29752723
10551777
24438103
24354892
11314018
15514089
24600449
22342841
18988627
9344848
|
IFNA6
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA6
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA14
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA14
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
TLR4
|
FADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21737330
15814722
19278658
12620240
20308068
12181749
|
TLR3
|
FADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
22421964
21737330
15814722
19278658
12620240
20308068
12181749
|
CASP8
|
FADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
FADD
|
FASLG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
11003656
11274345
1134007
11583996
12215447
12702723
12724420
14744430
15592525
15760909
16406523
16498403
16940415
17462996
18545270
18641653
19392652
19427028
19498109
19524512
19524513
19597341
19632174
19838173
20452955
20531300
21133840
21232017
22421439
22427918
23010170
23069999
23073834
23377657
23850759
24366341
24378531
26024392
26587781
26653790
26853145
26900751
26972597
27558815
27984721
28498367
28574505
28645028
9184224
9217161
9488730
9759866
|
FADD
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
ACSN
|
11003656
15325588
17462996
20531300
23725295
24070470
26587781
26972597
28574505
9488730
|
FADD
|
TRADD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
57.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
11438547
11460167
11875494
12646658
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
28574505
8910423
9488730
|
FADD
|
TICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
22421964
21737330
15814722
19278658
12620240
20308068
12181749
|
FADD
|
FAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
52.0
|
1.0
|
ACSN
|
11003656
11274345
1134007
11583996
12215447
12702723
12724420
14744430
15592525
15760909
16406523
16498403
16940415
17462996
18545270
18641653
19392652
19427028
19498109
19524512
19524513
19597341
19632174
19838173
20452955
20531300
21133840
21232017
22421439
22427918
23010170
23069999
23073834
23377657
23850759
24366341
24378531
26024392
26587781
26653790
26853145
26900751
26972597
27558815
27984721
28498367
28574505
28645028
9184224
9217161
9488730
9759866
|
FADD
|
CASP8
|
â—¼ SHARES_COMPLEX
|
|
|
10.0
|
1.0
|
ACSN
|
11003656
15325588
17462996
20531300
23725295
24070470
26587781
26972597
28574505
9488730
|
FADD
|
TRADD
|
â—¼ SHARES_COMPLEX
|
|
|
57.0
|
1.0
|
ACSN
|
10925299
11003656
11112697
11274345
11280761
11438547
11460167
11875494
12646658
12811837
1431106
14607933
14625680
14660645
14730360
15099563
15592525
15699106
16713974
17301840
17462996
17916596
18264787
18633355
18641653
19392652
19411070
19524513
19632174
20038811
20184663
20435894
20531300
21133840
21232017
21411734
21826665
22955274
23010170
23170255
23430059
23508573
23510023
23567181
23769623
23850759
24092389
24378531
24699077
24958845
26201938
26587781
26653790
26972597
28574505
8910423
9488730
|
FADD
|
FAS
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
11003656
11274345
1134007
11583996
12215447
12702723
12724420
14744430
15592525
15760909
16406523
16498403
16940415
17462996
18545270
18641653
19392652
19427028
19498109
19524512
19524513
19597341
19632174
19838173
20452955
20531300
21133840
21232017
22421439
22427918
23010170
23069999
23073834
23377657
23850759
24366341
24378531
26024392
26587781
26653790
26853145
26900751
26972597
27558815
27984721
28498367
28574505
28645028
9184224
9217161
9488730
9759866
|
FADD
|
FASLG
|
â—¼ SHARES_COMPLEX
|
|
|
52.0
|
1.0
|
ACSN
|
11003656
11274345
1134007
11583996
12215447
12702723
12724420
14744430
15592525
15760909
16406523
16498403
16940415
17462996
18545270
18641653
19392652
19427028
19498109
19524512
19524513
19597341
19632174
19838173
20452955
20531300
21133840
21232017
22421439
22427918
23010170
23069999
23073834
23377657
23850759
24366341
24378531
26024392
26587781
26653790
26853145
26900751
26972597
27558815
27984721
28498367
28574505
28645028
9184224
9217161
9488730
9759866
|
TNFRSF10B
|
FADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
11376335
15173180
9430228
12721308
10894160
14585074
16189514
9430227
15452120
|
STAT1
|
FADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10848577
|
TNFRSF10A
|
FADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
11376335
9430228
10894161
10894160
14585074
16189514
9430227
15452120
|
TRADD
|
FADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
29.0
|
1.0
|
Omnipath
|
8565075
14744432
12911633
21760970
9430228
21724995
21741934
12796506
10911999
20203691
23955153
32296183
12107169
11112409
11464215
8681376
12887920
24686082
21183682
18545270
|
MYD88
|
FADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21988832
10880445
17785432
16189514
11828002
|
FAS
|
FADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
62.0
|
1.0
|
Omnipath
|
22864571
8521815
11717445
21713032
16762833
23606538
8967952
20935634
7538907
21803845
9325248
19118384
12721308
21959933
18328427
16189514
25563855
10196099
17159907
27321185
26186194
25241761
9880544
16498403
21625644
9082980
12107169
15659383
15993755
21382479
7536190
11464215
26942442
11035039
15725726
16410793
|
FADD
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
82.0
|
1.0
|
Omnipath
|
22864571
17145710
11717445
19524512
34591612
15280356
17047155
27552911
12911633
25043603
21458669
11788820
19176810
21525013
21988832
22179575
25939870
12702723
21737330
21741934
26437781
25911380
9228018
21785459
20829884
23972990
21620750
12220669
9774341
17159907
10521396
27321185
17290218
27560715
20103630
24098568
20203691
14612908
8681377
18485876
12107169
15659383
22421964
20448643
9343261
20125124
8681376
12887920
19060883
21737329
23142077
22173242
26972597
22274400
19935698
16410793
|
FADD
|
MYD88
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
21988832
10880445
17785432
16189514
11828002
|
NFKB1
|
NFKBIA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
1829648
21725609
23178297
23572150
8096091
|
IKBKB
|
NFKBIA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
RELA
|
NFKBIA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
18204072
17876798
24083678
15499023
25759022
23422506
12859951
7775482
11744993
22723832
23450368
11060311
12885753
18981184
9250151
|
NFKB1
|
NFKBIA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
17876798
15499023
17709515
7775482
11744993
10454561
11060311
12885753
9250151
|
NFKB1
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
61.0
|
1.0
|
Omnipath
|
17145710
25609649
7862124
1340770
16210649
16970925
21719482
9738011
9865693
10497169
8657102
9572494
9315679
21988832
8887676
10329681
1829648
14743216
17003112
11313474
20558726
26496610
7867065
7891711
10837071
7831327
15836773
26186194
11571291
15214841
17561400
16846590
9566883
8096091
15371334
7479976
11020244
9426183
16493424
15145317
8631829
20237821
20980497
16513645
9597130
7479848
7739549
7628694
10655476
|
TBK1
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
25.0
|
1.0
|
Omnipath
|
10783893
9721103
16007147
12138192
7796813
12403772
10990461
10421793
11815618
8657102
10398585
8601309
|
RELA
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
134.0
|
1.0
|
Omnipath
|
17145710
15657065
11801607
25609694
15226358
17003112
9057089
26496610
19219072
23850221
7831327
12927781
16683270
17301240
17561400
9566883
10391945
8887633
16209943
21719482
10066434
8657102
10581242
29734393
21988832
12419806
14743216
16105840
15671248
9751059
9990853
25759022
10498867
8246997
7878004
11020244
9426183
15845455
26476452
23563313
16951195
25520503
9694722
11287411
10329681
15799966
17612295
24457201
10085161
10837071
10969074
11571291
9573251
15214841
16846590
20065107
7479976
24248593
8887627
15145317
16493424
9135156
24634218
7479848
15024091
14636585
26463447
7862124
1340770
22081069
8139561
27923823
16970925
9738011
9865693
9572494
11231305
14685242
20797629
11313474
16226509
14690596
22022389
21217772
26186194
30213788
15371334
8978697
20980497
7739549
7628694
|
EIF2AK2
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
24.0
|
1.0
|
Omnipath
|
9721103
16007147
12138192
10723127
7796813
12403772
8657102
10398585
8601309
9214631
|
CHUK
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
113.0
|
1.0
|
Omnipath
|
17145710
15922746
11087742
18074035
12626540
11527961
9244310
11809792
15836773
16177806
9721103
18501560
11923072
17706453
9509763
10723801
11858955
10421793
25133483
10398585
9346484
9346241
21765415
8657102
16737960
9315679
9252186
21490922
16219905
14743216
20484017
10329646
18922877
10882136
16153868
10195894
14751757
16007147
7796813
17053167
9632633
15856023
17965022
10783893
10602462
23602409
27682876
10469655
16965765
15084594
16493072
11095741
12138192
10723127
15210742
10329681
7878466
26930276
9914500
9520446
12514169
12403772
10527519
15145317
16493424
9135156
16023083
12637324
10593898
14636585
9214631
7862124
10074115
15389589
12486103
9891086
8601309
10880512
7739562
16286467
17379600
23109003
9689078
15371334
10733566
29145629
11042193
23970940
10085062
17468758
|
IKBKB
|
NFKBIA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
164.0
|
1.0
|
Omnipath
|
18593939
17145710
18375836
11087742
16793322
11527961
28086098
21232017
12429743
21423167
17693123
21399639
15836773
16177806
9721103
29139553
9271416
17561400
11923072
10889159
17706453
10723801
12791687
11858955
22037600
16365431
10421793
25133483
10398585
9346484
9346241
11158290
18539148
23328071
15574499
21765415
16818647
8657102
18202307
16737960
9315679
21490922
9252186
20001801
15919917
16495515
11368781
16291755
24386391
14743216
25759022
10329646
10882136
16153868
10195894
14751757
18981174
10807933
16007147
7796813
9632633
15856023
17965022
25753787
10783893
10602462
27682876
16965765
15084594
19196987
17322026
12138192
10723127
15210742
16319058
15217903
15218526
7878466
9914500
17367806
9520446
15214841
16846590
12514169
18657515
12403772
10527519
15145317
16888014
16493424
17047224
9135156
15024091
16023083
10593898
14636585
22579987
9214631
24911653
7862124
10320352
16970925
23707515
9346485
12949498
17363905
12486103
9891086
8601309
10880512
7739562
16286467
23109003
9689078
25595906
15371334
16285893
11356195
29145629
23970940
10085062
11815618
17468758
17615396
24586253
17072322
|
STAT1
|
STAT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
20.0
|
1.0
|
ACSN
|
11134049
11830590
12193701
12223527
12796776
12811837
12967644
14607900
14764699
15814715
17016554
17513775
17559085
17689680
18272812
19833085
21263073
21930765
25960930
8683106
|
STAT1
|
STAT2
|
â—¼ SHARES_COMPLEX
|
|
|
20.0
|
1.0
|
ACSN
|
11134049
11830590
12193701
12223527
12796776
12811837
12967644
14607900
14764699
15814715
17016554
17513775
17559085
17689680
18272812
19833085
21263073
21930765
25960930
8683106
|
JAK1
|
STAT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10426994
11907067
12244150
12811837
15536084
16081783
16713974
16785506
19833085
20856220
21840487
23124025
24751819
7512720
7521688
|
JAK2
|
STAT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
17.0
|
1.0
|
ACSN
|
11015446
11306493
11777960
11867689
12393492
12811837
14610620
19833085
20406969
20805416
21765015
22323450
22869907
23046136
24030977
24091328
27216177
|
IFNAR2
|
STAT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
IFNGR1
|
STAT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
IFNAR1
|
STAT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
IFNGR2
|
STAT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
TYK2
|
STAT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
IFNG
|
STAT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
69.0
|
1.0
|
ACSN
|
10485906
10754326
10820262
10952726
11134049
11399519
11489965
11579131
11777960
11830590
11870632
11875494
11964313
12193701
12223527
12413632
12433365
12796776
12811837
12818165
12907458
12967644
14607900
14607933
14660645
14764699
15465827
15634932
15644117
15699106
15778339
15811952
15814715
16127449
16286920
16424049
16713974
16878026
17016554
17260466
17404308
17485448
17513775
17559085
17689680
1825141
18272812
18345002
19833085
19879327
20038811
20819927
21097505
21149606
21263073
21411734
21930765
23390297
24658051
25960930
26755705
2965306
6357187
6425450
7594497
8683106
8871614
9834059
9864217
|
STAT1
|
MYD88
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
46.0
|
1.0
|
ACSN
|
10485906
10754326
10820262
10952726
11134049
11399519
11830590
11875494
11964313
12193701
12223527
12433365
12796776
12811837
12907458
12967644
14607900
14607933
14660645
14764699
15465827
15644117
15699106
15814715
16127449
16878026
17016554
17260466
17404308
17485448
17513775
17559085
17689680
18272812
18345002
19833085
19879327
21097505
21263073
21930765
23390297
25960930
6357187
7594497
8683106
8871614
|
STAT1
|
CIITA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
46.0
|
1.0
|
ACSN
|
10485906
10754326
10820262
10952726
11134049
11399519
11830590
11875494
11964313
12193701
12223527
12433365
12796776
12811837
12907458
12967644
14607900
14607933
14660645
14764699
15465827
15644117
15699106
15814715
16127449
16878026
17016554
17260466
17404308
17485448
17513775
17559085
17689680
18272812
18345002
19833085
19879327
21097505
21263073
21930765
23390297
25960930
6357187
7594497
8683106
8871614
|
IFNG
|
STAT1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
69.0
|
1.0
|
ACSN
|
10485906
10754326
10820262
10952726
11134049
11399519
11489965
11579131
11777960
11830590
11870632
11875494
11964313
12193701
12223527
12413632
12433365
12796776
12811837
12818165
12907458
12967644
14607900
14607933
14660645
14764699
15465827
15634932
15644117
15699106
15778339
15811952
15814715
16127449
16286920
16424049
16713974
16878026
17016554
17260466
17404308
17485448
17513775
17559085
17689680
1825141
18272812
18345002
19833085
19879327
20038811
20819927
21097505
21149606
21263073
21411734
21930765
23390297
24658051
25960930
26755705
2965306
6357187
6425450
7594497
8683106
8871614
9834059
9864217
|
STAT1
|
TRIM25
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17069755
|
STAT1
|
IL12A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19029990
19164128
21987655
20709027
|
STAT1
|
FAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11309387
19262492
16317104
14602726
22805310
|
STAT1
|
IFNG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
70.0
|
1.0
|
Omnipath
|
12759422
14735146
26170288
8823363
1833631
8647290
7619083
11416037
12130529
16162660
21178011
9218597
12493643
17283162
15217838
10830295
24200694
7957928
19476491
9271410
19262492
7565811
9880553
17878383
9748323
21039465
17016440
10881178
21530491
17270146
12052885
15055356
10201928
18616672
13678429
19124156
9491997
24478085
8509377
8990168
12893768
16380218
23740952
17105733
16195385
23419754
19935876
7796811
17558024
19929594
10713330
23645984
9548487
11390994
12223098
15931263
17689680
18802113
18787082
10440232
20004484
10373559
10585866
10707961
12403783
23582260
10982806
9059994
16785492
22767256
|
STAT1
|
IFNA13
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
42.0
|
1.0
|
Omnipath
|
11244574
9325014
11909852
15714000
1833631
14978477
12356687
8454630
17617740
20585034
22589541
8683106
1756724
22252317
11566724
11591697
11972347
18616672
19135978
8509377
10586107
20526365
15664995
8444884
17050680
18562017
7796811
18778729
1315834
17374731
22479354
10406469
21659501
8805641
18024894
19561067
8034722
15467722
23598529
17689680
12748307
|
STAT1
|
IL6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
8683127
24242046
23675777
19703987
7619083
18616672
24012417
20693420
|
STAT1
|
CXCL10
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
15006601
25199798
22022583
23153456
23740952
9690917
9858321
24127910
12754213
19479051
20585034
20833730
17558387
19136629
28262979
|
STAT1
|
CIITA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
12847226
10202014
10652022
11981818
15247301
8759739
11464288
19029990
12052885
9551976
9491997
18601229
15297606
11397960
9858567
21576360
17346795
|
STAT1
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
9325014
18035482
19096445
17374731
22479354
24478085
15194680
16020513
10321980
|
TYK2
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
68.0
|
1.0
|
Omnipath
|
11839738
10918587
15261459
8232552
7543024
15322115
23331499
8780896
10435617
24243840
11294897
7690989
14764663
18988627
12637327
11438544
10748192
14565860
7657660
12817007
23257612
29145629
9355737
11152457
23124025
18389480
10982844
7592750
|
JAK2
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
81.0
|
1.0
|
Omnipath
|
11839738
10918587
7888666
20353823
7543024
15322115
25950470
23331499
21071413
14978237
11294897
7690989
7504785
18988627
12637327
25535282
11438544
21576360
10748192
7657660
12817007
14984365
7504784
21207025
9355737
11152457
7615558
19834108
15284024
10982844
7592750
19787091
|
JAK1
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
132.0
|
1.0
|
Omnipath
|
35317858
11839738
10918587
15261459
34950606
11306517
8756628
12244150
8156998
9535918
10748192
7657660
12817007
23257612
27774606
25297818
22306691
8631301
7510216
14963018
15284024
24243840
7592750
10851062
11823427
23331499
7532278
11418623
11722592
18988627
12637327
27387064
8662591
10022928
19088846
32953130
7796299
7504784
23124025
19787091
24058793
20169197
7543024
15322115
18941194
19534553
15978943
14978237
11294897
14764663
21429244
14565860
34228987
25386349
18989459
34521819
9020188
19535621
10982844
21576360
12759422
18508557
8232552
12093291
12040185
20006573
8662795
7690989
20087684
11438544
20035788
11972023
29145629
9355737
11152457
12517932
18389480
|
IFNGR1
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
10848598
23285134
28143527
24608040
24366643
7514165
27378243
8156998
8605876
8662591
15780933
8910398
28445952
24443556
24777831
26113305
22162832
15494521
7615558
|
IFNG
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
29796172
23285134
18566411
28430601
28143527
24366643
24608040
17947699
25950470
19846878
27378243
18950705
27570112
15051500
17986321
26467650
23657944
20087684
9649436
22823229
14517275
22178447
22425562
23352233
23562842
28445952
11960596
17997851
24443556
26934444
24777831
11972023
12725866
26113305
22162832
29925830
10707961
23840250
25753288
9454765
|
STAT2
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
10490982
8621447
24065129
17923090
15978943
1502203
10446176
9724754
14722125
21178011
15825084
21268015
12048190
8605877
|
EIF2AK2
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23597922
9135145
11278865
16516295
10637230
|
IFNB1
|
STAT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
23933255
22816309
22194884
17488182
12068083
25885435
26353965
25892232
19174562
|
STAT1
|
IRF9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
29145629
7537377
9242679
23331499
8621447
24065129
17923090
8943351
12590259
17351669
|
STAT1
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
15695802
10848577
9773981
8848048
9037008
16481475
15894584
8986769
|
STAT1
|
CASP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17339457
17085014
|
SMAD3
|
SMAD4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
SMAD4
|
SMAD3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
72.0
|
1.0
|
ACSN
|
10454538
10925299
10964912
11007770
11013125
11013220
11074002
11114293
11224571
11279127
11283613
11283614
11376132
11399519
11792802
11875494
12193690
12545156
12702545
12809600
14976548
15001984
15095404
15155580
15265520
15644117
16127449
16179589
16713975
16831886
17018611
17055429
17260466
17550342
17563753
17689680
17705132
18353785
18768831
18832382
19208835
19597490
19815509
19901969
20027199
20713526
20731704
21041997
21042762
21098712
21252118
21317430
21577210
21614932
2191300
22331441
22514743
22652804
23140366
23338822
23390297
23784029
23869868
25374926
6357187
8515656
8871614
8893010
9312026
9389648
9618481
9670020
|
SMAD4
|
SMAD3
|
â—¼ PROTEIN_INTERACTION
|
|
|
72.0
|
1.0
|
ACSN
|
10454538
10925299
10964912
11007770
11013125
11013220
11074002
11114293
11224571
11279127
11283613
11283614
11376132
11399519
11792802
11875494
12193690
12545156
12702545
12809600
14976548
15001984
15095404
15155580
15265520
15644117
16127449
16179589
16713975
16831886
17018611
17055429
17260466
17550342
17563753
17689680
17705132
18353785
18768831
18832382
19208835
19597490
19815509
19901969
20027199
20713526
20731704
21041997
21042762
21098712
21252118
21317430
21577210
21614932
2191300
22331441
22514743
22652804
23140366
23338822
23390297
23784029
23869868
25374926
6357187
8515656
8871614
8893010
9312026
9389648
9618481
9670020
|
SMAD4
|
IFNG
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
25.0
|
1.0
|
ACSN
|
10925299
11074002
11279127
11399519
11792802
11875494
12193690
12702545
12809600
15265520
15644117
16127449
16179589
16713975
17260466
17689680
18768831
21042762
21614932
22331441
23390297
6357187
8515656
8871614
9389648
|
SMAD4
|
SMAD3
|
â—¼ LOCALISATION
|
✅
|
|
72.0
|
1.0
|
ACSN
|
10454538
10925299
10964912
11007770
11013125
11013220
11074002
11114293
11224571
11279127
11283613
11283614
11376132
11399519
11792802
11875494
12193690
12545156
12702545
12809600
14976548
15001984
15095404
15155580
15265520
15644117
16127449
16179589
16713975
16831886
17018611
17055429
17260466
17550342
17563753
17689680
17705132
18353785
18768831
18832382
19208835
19597490
19815509
19901969
20027199
20713526
20731704
21041997
21042762
21098712
21252118
21317430
21577210
21614932
2191300
22331441
22514743
22652804
23140366
23338822
23390297
23784029
23869868
25374926
6357187
8515656
8871614
8893010
9312026
9389648
9618481
9670020
|
SMAD3
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
104.0
|
1.0
|
Omnipath
|
25609649
9843571
15084259
20211142
21532621
24584437
18729074
23788427
12419246
18923419
9892009
19768112
10531362
15231748
9679060
12167862
21988832
12150994
23331499
12543979
18568018
21071413
19135894
15467747
25502805
9732876
11927552
16189514
12917407
25514493
15350224
10995777
18988627
10092624
12732634
25910212
10878024
9111321
20564330
27107012
9311995
12957874
20142324
11114293
32296183
15588252
15761153
24157709
26555259
29892012
17469184
22442258
16714330
21597466
15922743
22045334
17591701
24382352
22310290
19139564
19917253
29997244
31515488
28115363
10942775
21297662
17283070
12794086
|
JUN
|
SMAD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
10220381
9312063
9732876
|
IFNB1
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
15312780
9121453
10395669
9334213
15778442
12842042
17969444
|
IFNAR1
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15312780
8943354
18508557
15449939
17969444
16171819
|
IFNG
|
JAK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
Reactome
|
16467876
7617032
7673114
12438563
10986460
7615558
1396683
8550631
|
JAK1
|
IFNAR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
JAK1
|
TYK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
85.0
|
1.0
|
ACSN
|
10433356
10485906
10542212
10623821
11160275
11207245
11306493
11371360
11698286
11867689
11870632
11875494
11964292
12223527
12401408
12496409
12754507
12811837
12818165
1439146
14607900
14610620
14657224
14764699
15099563
15282297
15356132
15573129
15579430
15864272
16200688
16243976
16413922
16424049
16713974
17404308
17485448
17513775
18209571
18250477
1825141
18451175
18555777
18555778
19581928
19833085
20138012
20184663
20406969
20510870
20856220
21097505
21115385
21191065
21220452
21469115
21840487
21930765
21930769
22595692
23034983
23124025
23390297
23567181
24011634
24030977
24091328
24346288
24418198
25002027
25582338
26201938
26268945
26755705
27216177
27557510
2965306
7512720
7521688
7543512
7590867
8837607
9535722
9834059
9845545
|
JAK1
|
IFNGR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK1
|
JAK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
92.0
|
1.0
|
ACSN
|
10485906
11160275
11306493
11371360
11489965
11579131
11777960
11867689
11870632
11964313
12223527
12401408
12413632
12496409
12754507
12811837
12818165
1439146
14607900
14610620
14657224
15099563
15356132
15573129
15634932
15778339
15811952
15814715
16243976
16286920
16413922
16424049
16713974
17016554
17404308
17485448
17559085
17683974
18209571
18250477
1825141
18272812
18451175
18555777
18555778
19581928
19833085
20038811
20138012
20184663
20237318
20406969
20510870
20581311
20819927
20856220
21097505
21115385
21149606
21411734
21469115
21840487
22595692
22754783
23034983
23124025
23390297
23567181
24011634
24030977
24091328
24346288
24418198
24658051
25002027
25582338
26201938
26268945
26755705
27216177
27557510
2965306
6425450
7512720
7521688
7543512
7590867
8837607
9535722
9834059
9845545
9864217
|
JAK1
|
IL6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
JAK1
|
IFNAR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
JAK1
|
IFNG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK1
|
IFNGR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK1
|
JAK2
|
â—¼ SHARES_COMPLEX
|
|
|
92.0
|
1.0
|
ACSN
|
10485906
11160275
11306493
11371360
11489965
11579131
11777960
11867689
11870632
11964313
12223527
12401408
12413632
12496409
12754507
12811837
12818165
1439146
14607900
14610620
14657224
15099563
15356132
15573129
15634932
15778339
15811952
15814715
16243976
16286920
16413922
16424049
16713974
17016554
17404308
17485448
17559085
17683974
18209571
18250477
1825141
18272812
18451175
18555777
18555778
19581928
19833085
20038811
20138012
20184663
20237318
20406969
20510870
20581311
20819927
20856220
21097505
21115385
21149606
21411734
21469115
21840487
22595692
22754783
23034983
23124025
23390297
23567181
24011634
24030977
24091328
24346288
24418198
24658051
25002027
25582338
26201938
26268945
26755705
27216177
27557510
2965306
6425450
7512720
7521688
7543512
7590867
8837607
9535722
9834059
9845545
9864217
|
JAK1
|
IFNG
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK1
|
IFNAR1
|
â—¼ SHARES_COMPLEX
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
JAK1
|
TYK2
|
â—¼ SHARES_COMPLEX
|
|
|
85.0
|
1.0
|
ACSN
|
10433356
10485906
10542212
10623821
11160275
11207245
11306493
11371360
11698286
11867689
11870632
11875494
11964292
12223527
12401408
12496409
12754507
12811837
12818165
1439146
14607900
14610620
14657224
14764699
15099563
15282297
15356132
15573129
15579430
15864272
16200688
16243976
16413922
16424049
16713974
17404308
17485448
17513775
18209571
18250477
1825141
18451175
18555777
18555778
19581928
19833085
20138012
20184663
20406969
20510870
20856220
21097505
21115385
21191065
21220452
21469115
21840487
21930765
21930769
22595692
23034983
23124025
23390297
23567181
24011634
24030977
24091328
24346288
24418198
25002027
25582338
26201938
26268945
26755705
27216177
27557510
2965306
7512720
7521688
7543512
7590867
8837607
9535722
9834059
9845545
|
JAK1
|
IFNAR2
|
â—¼ SHARES_COMPLEX
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
JAK1
|
IL6
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
JAK1
|
IFNGR1
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK1
|
IFNGR2
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK1
|
IL6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
JAK1
|
IL18
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
32.0
|
1.0
|
ACSN
|
10485906
11160275
11371360
11867689
11870632
12223527
12401408
12496409
12818165
14610620
16243976
16413922
17404308
17485448
18250477
1825141
19833085
20184663
20406969
20510870
20856220
21469115
21840487
23124025
23390297
24030977
24091328
27216177
2965306
7512720
7521688
9834059
|
IFNAR2
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9334213
23331499
7988557
12133952
23180781
16710296
18988627
|
IFNAR1
|
JAK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
8943354
18508557
8232552
17351669
8524272
7526154
9334213
23331499
10542297
11694501
10982844
15449939
15312780
8702790
8621447
17969444
8605876
10022928
15120645
16171819
29145629
8197134
16987978
24243840
|
JAK1
|
TYK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
8702790
19901323
7504784
7589562
15659558
30029643
|
JAK1
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9774657
15021914
|
JAK1
|
STAT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
29145629
23331499
10542297
24243840
8197134
10022928
7532278
18508557
16987978
8232552
9020188
12040185
8605876
18988627
10982844
25386349
|
JAK1
|
IFNGR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
12133952
8232552
8550631
8156998
7796299
7615558
8649432
19041276
|
CDK4
|
SMAD3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
10197981
12193595
15241418
16156666
|
IL18
|
SMAD3
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
10.0
|
1.0
|
ACSN
|
10679398
11592085
14504095
14662834
15099563
15802534
26885855
27048821
27066895
9469432
|
SMAD3
|
IFNG
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
25.0
|
1.0
|
ACSN
|
10925299
11074002
11279127
11399519
11792802
11875494
12193690
12702545
12809600
15265520
15644117
16127449
16179589
16713975
17260466
17689680
18768831
21042762
21614932
22331441
23390297
6357187
8515656
8871614
9389648
|
SMAD3
|
IL6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
14754879
12672795
18804287
12853969
|
AKT1
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
25241761
15104092
16362038
21071413
18988627
26297431
15048128
|
CREBBP
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
15849193
10497242
15467747
18003620
9679056
15990875
15750622
19589780
17074756
17283070
9679060
|
CDK4
|
SMAD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
34.0
|
1.0
|
Omnipath
|
34003249
10197981
15241418
25241761
19920136
15520018
20068231
17099224
16156666
16189514
19413330
14512875
12193595
33051597
19114991
|
SMAD3
|
JUN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
23331499
9732876
10220381
11306568
21829441
10903323
|
MYD88
|
IRAK4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
37.0
|
1.0
|
ACSN
|
10679398
11274345
11592085
11964313
12620219
12682231
12907458
14504095
14607900
14660645
14662834
15099563
15749884
15749903
15802534
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
18977329
19161412
20547845
21372296
21826665
23508573
23681101
23811849
26885855
27048821
27066895
9469432
9743347
|
IRAK4
|
TLR7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
18794297
20485341
16286015
11960013
12297423
|
IRAK4
|
IL18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
18.0
|
1.0
|
ACSN
|
10679398
11274345
11592085
12620219
12682231
14504095
14660645
14662834
15099563
15802534
16878026
17704786
23681101
23811849
26885855
27048821
27066895
9469432
|
MYD88
|
IRAK4
|
â—¼ SHARES_COMPLEX
|
|
|
37.0
|
1.0
|
ACSN
|
10679398
11274345
11592085
11964313
12620219
12682231
12907458
14504095
14607900
14660645
14662834
15099563
15749884
15749903
15802534
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
18977329
19161412
20547845
21372296
21826665
23508573
23681101
23811849
26885855
27048821
27066895
9469432
9743347
|
IRAK4
|
IL18
|
â—¼ SHARES_COMPLEX
|
|
|
18.0
|
1.0
|
ACSN
|
10679398
11274345
11592085
12620219
12682231
14504095
14660645
14662834
15099563
15802534
16878026
17704786
23681101
23811849
26885855
27048821
27066895
9469432
|
IRAK4
|
IL6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
IRAK4
|
CXCL10
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
IRAK4
|
NLRP3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
MYD88
|
IRAK4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
36.0
|
1.0
|
Omnipath
|
20485341
15084582
19167362
12150927
17486091
26871637
25502805
24316379
16189514
18221795
15905496
25910212
12538665
16410796
22011580
12860405
12297423
32296183
17507369
11960013
24735611
20966070
17548806
31515488
|
MYD88
|
TLR7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
9430229
15361868
19079358
15492225
12447442
|
MYD88
|
IL18
|
â—¼ PHYSICAL_INTERACTION
|
|
|
18.0
|
1.0
|
ACSN
|
10679398
11274345
11592085
12620219
12682231
14504095
14660645
14662834
15099563
15802534
16878026
17704786
23681101
23811849
26885855
27048821
27066895
9469432
|
MYD88
|
IL18
|
â—¼ SHARES_COMPLEX
|
|
|
18.0
|
1.0
|
ACSN
|
10679398
11274345
11592085
12620219
12682231
14504095
14660645
14662834
15099563
15802534
16878026
17704786
23681101
23811849
26885855
27048821
27066895
9469432
|
IFNG
|
MYD88
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
31.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11870632
11964313
12413632
12818165
14607900
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
1825141
18272812
19833085
20038811
20819927
21149606
21411734
24658051
26755705
2965306
6425450
9834059
9864217
|
MYD88
|
IL6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
MYD88
|
NLRP3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
MYD88
|
CXCL10
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
25.0
|
1.0
|
ACSN
|
11274345
11964313
12620219
12682231
12907458
14607900
14660645
15749884
15749903
16127449
16243976
16413922
16713974
16878026
17404308
17485448
17704786
18633355
20547845
21372296
21826665
23508573
23681101
23811849
9743347
|
TLR7
|
MYD88
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
16482509
12791976
16410796
|
TLR4
|
MYD88
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
25.0
|
1.0
|
Omnipath
|
22664090
19717524
20048342
21911421
9625770
17228323
17258210
11743586
15107846
15728506
12888566
21829704
18221795
10952994
17635639
17126326
12646618
|
IFNG
|
IFNGR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK2
|
IFNGR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
IFNGR1
|
IFNGR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
42.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
22003200
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK2
|
IFNGR1
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
IFNG
|
IFNGR1
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
IFNGR1
|
IFNGR2
|
â—¼ SHARES_COMPLEX
|
|
|
42.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
22003200
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
IFNG
|
IFNGR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
60.0
|
1.0
|
Omnipath
|
17145710
16110316
12915721
12438563
7514165
15530433
23331499
16237089
23898330
9111318
15143187
16467876
10986460
18988627
1396683
8550631
20304997
11250200
10860730
12165521
29145629
10811850
7617032
18591661
8631301
7615558
7510216
7673114
|
IFNGR1
|
JAK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
11438544
15864272
17063185
23898330
12040185
7499845
|
JAK2
|
IFNG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
IFNG
|
IFNGR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK2
|
IFNG
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
IFNG
|
IFNGR2
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
TICAM1
|
IFNG
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11672593
11964313
12032143
12811837
15644117
16306937
16917499
17114424
20154735
20547845
23508573
|
IFNG
|
RELA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
48.0
|
1.0
|
ACSN
|
10485906
10679398
11489965
11579131
11777960
11870632
11964313
12133954
12413632
12759422
12818165
14607900
14668329
15079071
15536066
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17145890
17404308
17550372
17559085
1825141
18272812
19171876
19833085
20038811
20138012
20819927
21149606
21224476
21411734
23430059
24658051
26755705
2965306
6425450
8383323
8580069
8641346
9743347
9834059
9864217
|
IFNG
|
TLR4
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11672593
11777960
11870632
11964313
12032143
12413632
12811837
12818165
14607900
15634932
15644117
15778339
15811952
15814715
16286920
16306937
16424049
16713974
16917499
17016554
17114424
17559085
1825141
18272812
19833085
20038811
20154735
20547845
20819927
21149606
21411734
23508573
24658051
26755705
2965306
6425450
9834059
9864217
|
NFKB1
|
IFNG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
12759422
21642544
21243522
9374532
10227974
16481345
17556653
19732956
21224476
14662860
12757742
18690006
17407192
|
RELA
|
IFNG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
17035338
12759422
12105194
21243522
9374532
10227974
20643337
19929594
19732956
21224476
23195252
23667107
12842891
14662860
12757742
18690006
17407192
10075983
|
JUN
|
IFNG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
20006311
22123848
14734615
15187132
11943142
20304822
17556653
1314139
17105733
22413812
19265145
11801649
16713974
7759501
12836278
15522880
12626576
9558063
8756632
18641343
22351517
|
IFNG
|
IFNGR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
31.0
|
1.0
|
Omnipath
|
12915721
7673114
7514165
12438563
15530433
23331499
16237089
9111318
15143187
16467876
10986460
18988627
1396683
8550631
29145629
10811850
7617032
18591661
8631301
7615558
7510216
20304997
|
JAK2
|
IFNGR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK2
|
IL6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
JAK2
|
TYK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
73.0
|
1.0
|
ACSN
|
10485906
10807786
11160275
11306493
11371360
11867689
11870632
12223527
12244147
12372421
12401408
12496409
12754507
12818165
1439146
14610620
14657224
15099563
15356132
15546391
15573129
16243976
16413922
17404308
17485448
18209571
18250477
1825141
18451175
18555777
18555778
19581928
19833085
20138012
20184663
20406969
20510870
20856220
21042762
21097505
21115385
21469115
21840487
22077060
22595692
23034983
23124025
23390297
23567181
24011634
24030977
24091328
24204259
24346288
24418198
25002027
25582338
26201938
26268945
26755705
27216177
27557510
2965306
7512720
7521688
7543512
7590867
8683106
8700208
8837607
9535722
9834059
9845545
|
JAK2
|
IL6
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
JAK2
|
TYK2
|
â—¼ SHARES_COMPLEX
|
|
|
73.0
|
1.0
|
ACSN
|
10485906
10807786
11160275
11306493
11371360
11867689
11870632
12223527
12244147
12372421
12401408
12496409
12754507
12818165
1439146
14610620
14657224
15099563
15356132
15546391
15573129
16243976
16413922
17404308
17485448
18209571
18250477
1825141
18451175
18555777
18555778
19581928
19833085
20138012
20184663
20406969
20510870
20856220
21042762
21097505
21115385
21469115
21840487
22077060
22595692
23034983
23124025
23390297
23567181
24011634
24030977
24091328
24204259
24346288
24418198
25002027
25582338
26201938
26268945
26755705
27216177
27557510
2965306
7512720
7521688
7543512
7590867
8683106
8700208
8837607
9535722
9834059
9845545
|
JAK2
|
IFNGR2
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10485906
11489965
11579131
11777960
11867689
11870632
11964313
12413632
12811837
12818165
14607900
14610620
15634932
15778339
15811952
15814715
16286920
16424049
16713974
17016554
17559085
17683974
1825141
18272812
19833085
20038811
20406969
20819927
21149606
21411734
21840487
24091328
24658051
26755705
27216177
2965306
6425450
7512720
7521688
9834059
9864217
|
JAK2
|
IL18
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
32.0
|
1.0
|
ACSN
|
10485906
11160275
11371360
11867689
11870632
12223527
12401408
12496409
12818165
14610620
16243976
16413922
17404308
17485448
18250477
1825141
19833085
20184663
20406969
20510870
20856220
21469115
21840487
23124025
23390297
24030977
24091328
27216177
2965306
7512720
7521688
9834059
|
JAK2
|
IL6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
IL1B
|
JAK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10198225
7528775
9038232
8943050
9454765
7594594
|
IFNGR2
|
JAK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
7901766
23331499
23898330
7514165
16381926
|
JAK2
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
11134016
8876196
9689060
10205168
|
IFNB1
|
TYK2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15312780
8943354
18508557
15449939
17969444
16171819
|
TYK2
|
IL6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
TYK2
|
IFNAR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
TYK2
|
IFNAR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
TYK2
|
IFNAR1
|
â—¼ SHARES_COMPLEX
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
TYK2
|
IL6
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
TYK2
|
IFNAR2
|
â—¼ SHARES_COMPLEX
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
TYK2
|
IL18
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
31.0
|
1.0
|
ACSN
|
11160275
11371360
11867689
11870632
12223527
12401408
12496409
12818165
14610620
16243976
16413922
17404308
17485448
18250477
1825141
19833085
20184663
20406969
20856220
21115385
21840487
23124025
23390297
24030977
24091328
27216177
2965306
7512720
7521688
7543512
9834059
|
TYK2
|
IL6
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
35.0
|
1.0
|
ACSN
|
11306493
11867689
12754507
1439146
14610620
15099563
15356132
15573129
18209571
18555777
18555778
19581928
19833085
20138012
20406969
21115385
21840487
23034983
23567181
24011634
24091328
24346288
24418198
25002027
25582338
26201938
26268945
27216177
27557510
7512720
7521688
7543512
7590867
8837607
9845545
|
IL1B
|
TYK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10198225
7528775
9038232
8943050
9454765
7594594
|
IFNAR2
|
TYK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23331499
12960323
12040185
18988627
|
TYK2
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
45.0
|
1.0
|
Omnipath
|
9677371
8524272
24704786
14647450
7526154
16551269
21949722
23223197
16189514
9121453
8702790
9461596
8605876
7559568
12220192
21994561
15337770
8700538
20937132
8628273
18166147
95059042
9733772
10523853
|
TYK2
|
STAT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
8943354
18508557
8232552
17351669
12040185
7526154
9334213
23331499
10542297
24243840
23223197
11694501
15449939
18988627
15312780
8702790
8621447
17969444
8605876
10022928
32953130
21994561
1638633
16171819
29145629
18989459
34521819
8197134
16987978
10982844
8605877
|
RELA
|
CCL5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
12820969
11478739
17510282
19786024
12050170
21138578
12122011
19828633
18367595
22030901
18502824
16707500
10926836
11413310
20663893
22388040
15144466
9120310
12603855
26096887
11259372
21189258
12388374
15972972
11389171
25523420
18525004
|
JUN
|
CCL5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
11413310
10760799
19828633
10075858
20862675
26096887
7513046
|
NFKB1
|
CCL5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
12820969
11413310
11478739
12122011
17065335
17510282
11700023
15144466
19786024
16707500
21189258
12388374
15972972
9120310
11389171
12050170
11259372
|
RELA
|
IL6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
114.0
|
1.0
|
Omnipath
|
26596471
19124729
10373597
9523851
23595969
28270510
21537341
17982049
15226358
18243142
12200447
20371366
24664372
23874122
14532843
18942706
10975857
21278793
10469356
22547075
17490702
11459775
23335080
10569191
19707556
19687301
7499267
8290595
23857586
24676671
18061164
11058167
12887736
15013753
15158360
22661093
20935672
20511231
17350185
10903137
16112536
27413250
21810609
16984731
16166627
18469854
12881425
24012417
23386688
22105366
8752656
12176740
27371733
22578249
18057724
20351184
10329846
19164127
10542237
11564778
20221401
15517885
19122653
20534538
7876168
27211851
9516466
18996370
8824277
18310089
21104991
25888873
12359431
11327783
20066113
20100571
19703987
19469019
21106671
16960103
18502099
16043358
21996739
20650996
22021035
11120852
12672795
12058956
18483242
22189669
14976218
17495236
11007957
21131967
11975924
27337441
9182853
10963848
17040605
11504280
15756023
10823821
17932106
19966855
20696864
12177065
8679226
9199307
17196927
20457835
21098092
17532054
|
JUN
|
IL6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
26513016
10542237
21069809
15389813
15158360
20225236
12667961
20371366
20511231
20862675
8453101
10202034
18502099
10037779
8830832
19687301
21098092
25567680
20351184
17341596
11120852
21312239
24676671
|
NFKB1
|
IL6
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
71.0
|
1.0
|
Omnipath
|
17513725
18061164
12058956
24337575
19124729
15611045
11058167
9523851
15517885
12887736
15158360
7876168
17495236
25549935
17982049
15241416
18243142
9516466
2405250
18996370
8824277
18310089
24664372
15749903
10903137
16112536
14532843
11327783
18942706
11975924
20066113
16984731
10975857
11160296
19703987
22895549
10963848
10469356
22547075
17040605
11459775
17490702
19469019
8247545
11504280
15756023
10569191
10823821
20696864
12907458
19707556
16043358
11035101
12176740
11302724
8679226
8725624
22578249
8752656
17196927
17532054
12727841
18057724
7499267
10329846
9199307
9502421
19164127
11120852
24676671
11098847
|
JUN
|
RAF1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
11274345
12738796
17439715
18039929
26587781
8545107
|
AKT1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
51.0
|
1.0
|
Omnipath
|
19197339
11971957
18767875
20230923
10576742
20068231
17570479
16189514
18669648
25241761
18691976
10576741
10618391
20688159
21745501
12087097
12801936
12048182
22798428
16854453
19058874
11997508
|
PRKCB
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8288587
1386920
12917261
22826029
|
PRKCA
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
1386920
23331499
9447975
8321321
12551925
8288587
7935389
12917261
9922370
15664191
93309588
1437148
|
RAF1
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
7565670
12750173
18799465
16364241
11909642
19219045
21988832
23331499
15342917
8933152
9671314
8393135
9808624
8223433
16189514
18988627
18669648
19541618
16293107
10969079
10567369
8157000
11136732
11948414
7898932
9069260
18039929
19369195
8607979
10327068
17116858
24746704
12920017
16129686
19058874
15466214
|
RAF1
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
143.0
|
1.0
|
Omnipath
|
10757792
18337766
18799465
15342917
23728975
26496610
15866172
17053865
11242034
9351825
9677429
8157000
7992057
11948414
11604401
16129686
10677502
12695496
19197339
7565670
12750173
7936666
1326789
19219045
23331499
18556463
10976102
18988627
15485920
15175348
18691976
16407412
10409742
9311917
17192257
7898932
8621729
23934108
11684694
21336309
7624324
12920017
11948406
15466214
11042690
12907640
9032297
27169363
12876277
8933152
8223433
8248196
8131746
12594221
10969079
10567369
17979178
17724343
24746704
19058874
10958680
8090753
21071413
7731720
7873542
1330321
8503013
16093354
19541618
8394352
15466476
25155755
11136732
9069260
94178255
8607979
10327068
10359597
8039496
20212043
|
RELA
|
CXCL8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
7.0
|
1.0
|
ACSN
|
15079071
15536066
17550372
19171876
23430059
8383323
9743347
|
JUN
|
CXCL8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
18684922
16701870
24048734
14686613
24284797
15057743
12643600
17197543
11864912
10817569
12218154
22031759
17586662
10969814
19064995
12716652
27856305
25582859
17471497
22095787
16818736
23176534
14670967
18435575
16846747
19734226
16299055
14612204
18772138
19132242
12209633
15939312
16834785
11399048
11120852
25567680
|
RELA
|
CXCL8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
129.0
|
1.0
|
Omnipath
|
12820969
24337575
15289496
9405619
9698090
20038977
15057743
21665565
24260304
10817569
14631383
10969814
15005855
19668231
16325549
19732956
8207232
18281166
27856305
23894194
9388261
26340924
10975857
10745031
20194077
10928981
16553947
17565687
16764699
22848596
15531761
16105834
16803583
9510190
15355994
18221537
12643600
20053934
11716760
8617886
12218154
12707271
23637609
27076634
8878392
17917246
12163591
16829531
16818736
14670967
12038622
15958549
18362169
8413215
19734226
23386688
11297551
15950427
17362989
16455661
27371733
11953364
8413306
18074095
11973337
18786178
19376732
19837667
17276517
15517885
11342414
18669446
7876168
15350531
14645117
22891766
18034886
11564889
12748173
17586662
18996370
15223809
17041011
12485925
16004996
15079071
21343296
26618242
18435575
17636245
22340043
19173296
24634218
11120852
10477716
21343177
12058956
17045242
19786024
24048734
24770886
10202011
18309103
11864912
21131967
19064995
10530453
12716652
16418726
28283022
18723827
17040605
21255844
15615716
17932106
19966855
20696864
15387324
21451502
15722553
15879558
12855659
12883201
15688424
18045535
10506755
|
NFKB1
|
CXCL8
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
75.0
|
1.0
|
Omnipath
|
9510190
12058956
11973337
18786178
17045242
15289496
16701870
19376732
19837667
9698090
17276517
11512674
19786024
20038977
10202011
15057743
15517885
12643600
11342414
7876168
15350531
18034886
11716760
11564889
11864912
12218154
12707271
10969814
12748173
14631383
16325549
17586662
18996370
19732956
17041011
10530453
18281166
12716652
16418726
12485925
16004996
9388261
8878392
17917246
10975857
10745031
10928981
16553947
16818736
14670967
18435575
12038622
15958549
17040605
8413215
21255844
22340043
1401924
9452482
16764699
11297551
15950427
15387324
15879558
16105834
11953364
15688424
18074095
8413306
11096450
16803583
10506755
11120852
10477716
|
JUN
|
TNFRSF10B
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
11274345
17439715
23430059
23850759
26587781
8545107
|
JUN
|
IL12B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15187114
15270850
14688340
25567680
11279072
|
JUN
|
IL1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
11306276
18566416
7935377
10226077
14686613
16365456
11145674
17283046
20463008
23608488
8133045
8798756
18789903
16729332
|
JUN
|
IL5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
11579103
12452838
10491186
17845581
9234684
7615560
8120390
17687519
7592673
16373364
|
JUN
|
FASLG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
18196534
9873041
9660938
14563113
9710625
11003676
19670268
10811113
9468493
15160330
15546613
12618758
11397794
10744679
|
JUN
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9660935
18035482
22065573
10848607
20048166
22083261
17376932
|
JUN
|
MMP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
19268464
15212943
14767528
19940138
11414701
15777790
20353950
17116726
16000878
|
JUN
|
FAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11733515
12963547
10903433
19670268
|
RELA
|
JUN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18174238
9468519
16713569
10488148
|
CREBBP
|
JUN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
8028671
10327051
2138276
9659924
9786917
16713569
17296604
8545107
18443043
16055710
|
JUN
|
CCND3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
18813803
19219074
16406505
16880536
16054035
19190345
17000779
17439715
8545107
16396903
11274345
20107231
|
FASLG
|
FAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
53.0
|
1.0
|
ACSN
|
11003656
11274345
1134007
11583996
12215447
12702723
12724420
14744430
15592525
15760909
16406523
16498403
16940415
17462996
18545270
18641653
19392652
19427028
19498109
19524512
19524513
19597341
19632174
19838173
20452955
20531300
21133840
21232017
22075988
22421439
22427918
23010170
23069999
23073834
23377657
23850759
24366341
24378531
26024392
26587781
26653790
26853145
26900751
26972597
27558815
27984721
28498367
28574505
28645028
9184224
9217161
9488730
9759866
|
FASLG
|
FAS
|
â—¼ SHARES_COMPLEX
|
|
|
53.0
|
1.0
|
ACSN
|
11003656
11274345
1134007
11583996
12215447
12702723
12724420
14744430
15592525
15760909
16406523
16498403
16940415
17462996
18545270
18641653
19392652
19427028
19498109
19524512
19524513
19597341
19632174
19838173
20452955
20531300
21133840
21232017
22075988
22421439
22427918
23010170
23069999
23073834
23377657
23850759
24366341
24378531
26024392
26587781
26653790
26853145
26900751
26972597
27558815
27984721
28498367
28574505
28645028
9184224
9217161
9488730
9759866
|
NFKB1
|
FASLG
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
14563113
12655294
15160330
16770006
10671224
|
FASLG
|
FAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
39.0
|
1.0
|
Omnipath
|
17145710
8521815
9126929
1375228
1713127
14965271
21803845
9039262
11239407
25241761
9228058
15659383
12753742
7505205
12887920
15725726
|
NFKB1
|
FAS
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
11473033
16317104
10022897
16784892
7528667
19628709
9733827
10871852
|
TNFRSF10B
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15024054
20696707
19278658
10837247
19416807
21235526
|
TRIM25
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
18761323
16618810
11717445
12884866
16585540
|
TLR3
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
Reactome
|
22421964
21737330
12752666
15814722
16115877
14739303
21737329
12181749
|
TLR4
|
CASP8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21737330
12752666
15814722
16115877
14739303
21737329
|
CASP8
|
IFIH1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
18761323
16618810
11717445
12884866
16585540
|
TNFSF10
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17145710
10894161
27821809
23678861
|
TRADD
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
17145710
15173123
20125124
12887920
10521396
20203691
21741934
14585074
17047155
22421964
19935698
11788820
|
TNFRSF10B
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17047155
12721308
12218097
22421964
|
TNFRSF10A
|
CASP8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
19427028
12218097
10894161
17047155
21785459
17898872
22421964
|
EIF2AK2
|
EIF2S1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
85.0
|
1.0
|
Omnipath
|
28167698
11432733
28781602
20685959
9335428
10504407
3352609
24178712
25687824
17290288
24706853
16288713
19043413
19259124
23399035
21738672
8626809
9431994
21899699
11985496
2912723
23259068
28670265
19364808
2116318
9819435
23706307
8099443
8096514
31226023
18096616
15550948
8099444
17372663
24335187
11337501
9930704
21377708
23056444
21418572
18971339
16179258
20149255
19583950
28623239
10542257
21368187
1677563
22174864
11452027
24909749
20040105
12737801
16179259
16289913
25521494
|
TLR4
|
CHUK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
CHUK
|
TICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
CHUK
|
TLR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
CHUK
|
RELA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
CHUK
|
NFKB1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
CHUK
|
NFKBIB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
AKT2
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
19609947
12048203
10485710
|
EIF2AK2
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10723127
10648614
|
AKT1
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
31.0
|
1.0
|
Omnipath
|
15710601
12048203
25241761
19442713
11278366
10485711
15800029
19609947
17570479
17660512
18515365
19088076
10485710
|
CHUK
|
CREBBP
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
21674813
17145710
14597638
17434128
22435559
12789342
27220480
|
CHUK
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
49.0
|
1.0
|
Omnipath
|
17145710
15611276
22110409
19609947
10521409
20863851
20051109
20363318
12767944
26999213
12842894
21903422
19110719
15858576
16382138
22155370
23894194
16046471
15128824
21569639
16846590
8246997
15485852
25341660
15494311
11983155
15980040
15489227
15849198
14636585
23343355
|
CHUK
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
91.0
|
1.0
|
Omnipath
|
9346484
24911653
20932476
28514442
11971985
16970925
12210728
9346485
17965022
16713569
12486103
9891086
15456791
11057907
20434986
16129692
16260493
21903422
21724995
16286467
14743216
16319058
18949366
10779355
25748427
25852190
12244103
11585904
9751060
15218526
10094049
10837071
9914500
21575199
9721103
25241761
10195894
9689078
15214841
21784860
17561400
21640763
16285893
10733566
16186825
16493424
10022904
12709429
12351658
10968790
12547194
15691841
15620648
15327770
11864612
11460167
14636585
17693255
17072322
9346241
|
CHUK
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
39.0
|
1.0
|
Omnipath
|
12482991
19442713
14743216
15494311
11976329
15489227
16382138
16713569
10022904
10469655
27554194
11158290
11297557
|
CHUK
|
NFKBIB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
32.0
|
1.0
|
Omnipath
|
17145710
8657102
15084594
9315679
9252186
14743216
9278383
9914500
15836773
9721103
23109003
9689078
15145317
10723801
29145629
9135156
10593898
14636585
17072322
29695914
|
NFKB1
|
RELA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
IKBKB
|
RELA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
RELA
|
IL12B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
27.0
|
1.0
|
Omnipath
|
12820969
14688340
20221401
11058167
10657616
10940886
19122653
18690006
11792125
19624579
17982049
9464836
17924060
7565674
14976188
15251981
12077291
17579043
24012417
19299558
16166378
12517966
17635610
24184907
15270850
20876114
9808189
|
RELA
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
20186924
18031796
20649564
|
RELA
|
TNFRSF10B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18523266
18599488
19351839
|
RELA
|
IL1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
48.0
|
1.0
|
Omnipath
|
26596471
27338466
11114294
8413223
20975042
17707233
23383347
11058167
12686724
16433741
23667107
15382119
19122653
24009751
27211851
18566416
15292915
20617571
23056550
12517972
18285351
19843519
22267743
15812237
25161822
22388040
8021507
9878621
14960579
10963848
23195252
11395507
27534992
9058643
15543947
19846753
20696864
8679226
24908318
28389361
27371733
15972680
20336759
10080875
17082635
|
RELA
|
CCL11
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
22254182
18714023
15531761
16604092
11076795
15972682
10586089
14660485
16428072
|
RELA
|
NFKB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
16778171
20427719
23362108
16513645
1740105
20596645
16513841
19469019
8454856
21420936
16135789
9417120
|
RELA
|
IL12A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
14568984
17982049
17579043
20876114
19122653
22070873
18690006
19164128
19185846
|
RELA
|
IFNA13
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
7957928
15331713
9446577
8035474
|
RELA
|
CXCL10
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
23932714
20164184
15226358
16253303
25199798
16982926
19342664
10756005
23740952
17449583
16818736
19929594
22030901
19479051
24257594
21249144
24701034
20833730
|
RELA
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
23932714
15955070
22547704
19570999
10074115
21209118
17079305
7799921
17496231
15699120
12077266
8035474
17785777
12005436
24185615
10848607
16125763
9446577
20855868
24656046
23857586
|
NFKB1
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
88.0
|
1.0
|
Omnipath
|
17145710
16209943
25609649
8428580
12947093
16970925
17072323
2050119
15657065
21270162
11976329
16793322
21544861
22261743
8657102
9824778
11880271
9450761
17962807
21988832
25355951
9722548
18215660
14743216
15799966
10799898
16105840
15218526
8798655
14690596
22139845
22808155
11571291
17072327
16740634
10498867
8255759
8246997
15214841
16846590
15371334
16285893
17072322
17855547
18321863
16493424
7479976
15145317
17561400
20110362
9426183
23687337
12414801
11970949
20154269
20237821
24175631
24634218
34100597
14645533
17982102
21763497
16204234
9437432
20547752
15818410
7628694
|
CREBBP
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
42.0
|
1.0
|
Omnipath
|
10542243
14597638
18241676
17138826
15140884
9096323
16713569
12456660
10454579
16382138
19608861
9806899
25314079
11931769
12163591
12881425
9659924
15171256
9548485
16291753
17362989
25733689
17434128
15334063
15806143
10235267
17296604
|
IKBKB
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
135.0
|
1.0
|
Omnipath
|
15280197
17785205
27329558
22110409
22753932
22205033
21765477
15611068
18519641
15858576
25241761
33579825
23536830
28122346
19393267
34556881
24442433
14560022
15192014
21242976
16840782
19609947
33789981
10521409
26826124
21492457
19110719
23303310
16105840
22212641
26587973
34219129
15210811
16046471
11359840
27626700
15128824
28416608
17178723
21674813
17362989
28737909
19377466
15980040
16407239
15849198
20507904
26082493
15557193
34082140
21798539
26267322
29363544
12767944
20224721
26307684
12842894
17108032
26170389
24336331
27315556
31980577
11259436
34380537
20872791
21674474
15465828
15994321
17548605
26603838
16148147
25136068
33914760
26569329
22234699
17012367
14636585
22039465
32123095
15212693
27466442
33883226
15611276
22081069
19197368
17070014
20051109
26693062
14963024
33971703
28381553
33459422
27244888
18544167
18922932
20188669
15485852
20696864
22689577
17982102
20410276
15489227
|
TBK1
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
12842894
17562815
15128824
15485852
10521409
15489227
15849198
14560022
19958770
12767944
|
IL1B
|
RELA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
25606026
26999213
22240205
23666959
19197368
25306394
24009751
|
RELA
|
NFKBIB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
42.0
|
1.0
|
Omnipath
|
22081069
10497169
12672800
21988832
14685242
14743216
16189514
16226509
26186194
11571291
10498867
15371334
8816457
8887627
15145317
9135156
16513645
9597130
14636585
|
CASP1
|
IL18
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22270365
17039247
15326478
9121587
9334240
|
IFNB1
|
IFNAR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
15312780
9121453
10395669
9334213
15778442
12842042
17969444
|
IFNAR2
|
IFNAR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
IFNAR2
|
IFNAR1
|
â—¼ SHARES_COMPLEX
|
|
|
16.0
|
1.0
|
ACSN
|
11207245
11698286
11964292
12811837
14610620
14764699
15864272
17513775
19833085
21115385
21840487
21930765
21930769
7512720
7521688
7543512
|
IFNA5
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10395669
|
IFNA4
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA2
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
10395669
10339405
21854986
18027911
10984492
17001036
11888273
|
IFNA7
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA10
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNB1
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
8181059
10395669
7623815
11278538
1127853810395660
|
IFNA13
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
8181059
10395669
11278538
11698684
21856167
|
IFNA16
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA17
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
7623815
21856167
|
IRF9
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17923090
18456457
|
IFNA21
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA8
|
IFNAR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10395669
8969169
|
IFNAR2
|
STAT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
12220192
17923090
11786546
9121453
18456457
|
TLR4
|
IKBKB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
TLR4
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12692549
15210742
14530355
17526488
17047224
14703513
19656901
17823124
23453971
|
TLR4
|
TICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
ACSN
|
11672593
11964313
12032143
12811837
15644117
16306937
16917499
17114424
20154735
20547845
23508573
|
TLR4
|
TICAM1
|
â—¼ PROTEIN_INTERACTION
|
|
|
11.0
|
1.0
|
ACSN
|
11672593
11964313
12032143
12811837
15644117
16306937
16917499
17114424
20154735
20547845
23508573
|
TLR4
|
TRAF3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11672593
11964313
12032143
12811837
15644117
16306937
16917499
17114424
20154735
20547845
23508573
|
CREBBP
|
STAT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17923090
28707474
10464260
8848048
|
NFKB1
|
CXCL10
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
20164184
16253303
17274000
20579762
16982926
19342664
10756005
16818736
19929594
19479051
21249144
24701034
|
TNFRSF10A
|
TRADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9430228
9430227
|
TNFRSF10B
|
TRADD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9430228
9430227
|
IFNB1
|
STAT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
15312780
9121453
10395669
9334213
15778442
12842042
17969444
|
STAT2
|
IRF9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
29145629
7537377
9242679
23331499
8621447
24065129
17923090
21903422
15978943
8943351
12590259
17351669
21178011
21268015
|
PLG
|
F2RL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
12604689
10978167
9020112
|
NLRP3
|
IL1B
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
19104081
20385749
23202296
26885855
27048821
27066895
27439607
27984721
|
NFKB1
|
IL1B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
8413223
17707233
11058167
12686724
16433741
18285351
8021507
9878621
14960579
10963848
9058643
15543947
20696864
8679226
11035101
15972680
20336759
18772363
10080875
17082635
|
CASP1
|
IL1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
1919001
7642516
7797510
17039247
28147281
8999548
19439663
9121587
|
AKT1
|
MMP2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
17409395
17680028
18471976
19440036
19930715
19945467
20214616
20398329
20609352
21084277
22131018
23572150
23589069
24030100
25136802
26597054
27328425
27510662
27572739
29556339
|
PIK3CA
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
25793261
19117013
21041639
24950409
21816939
|
TBK1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
21329883
21464307
21106850
|
AKT1
|
AKT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
11546794
14500673
12176337
11445557
9736715
12149249
11278835
|
AKT1
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15184909
25241761
22689577
15856005
10485711
17660512
|
IKBKB
|
NFKB1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
NFKB1
|
IL12A
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
14568984
11602633
17982049
17579043
15871905
18690006
19164128
|
NFKB1
|
IL12B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
14688340
11058167
10657616
10940886
18690006
11792125
17982049
9464836
17924060
7565674
14976188
9234715
12077291
9497375
17579043
19299558
22427889
16166378
15270850
9808189
|
NFKB1
|
IFNB1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
15955070
17079305
7799921
17496231
15699120
10074115
20855868
24656046
10848607
12077266
8035474
17785777
20048166
21209118
16125763
12005436
22427889
21343618
|
NFKB1
|
IFNA13
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
7957928
15331713
8035474
|
NFKB1
|
CCL11
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
16604092
11076795
15972682
10586089
14660485
|
NFKB1
|
TNFRSF10B
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18523266
18599488
19351839
|
NFKBIB
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
17145710
15836773
11571291
16513645
9597130
23109003
14743216
12670396
10497169
15371334
7867065
8816457
15145317
15084594
|
IKBKB
|
NFKB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
57.0
|
1.0
|
Omnipath
|
31598684
11976329
16713569
10469655
29485707
26999213
12842894
10835356
27187478
27402796
18782567
27554194
12482991
25241761
10022904
15199157
19519322
15489227
19250910
15212693
11158290
11297557
|
CCND3
|
CDK4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
11896535
25416956
16985050
34591612
21988832
14597415
17517622
16782892
10342870
21516116
23880157
15232106
16189514
11360184
26496610
25910212
26186194
27107012
10477583
19237555
32296183
14641107
9106657
9508775
31515488
9716181
|
IKBKB
|
TLR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
IKBKB
|
TICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15064760
15814722
16115877
16603398
16547522
|
IKBKB
|
NFKBIB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
9315679
9914500
9721103
10593898
9135156
|
TBK1
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
10783893
21903422
21138416
10195894
14743216
16207722
10022904
14560022
|
MAVS
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
17145710
16177806
16153868
21903422
17468758
18207245
|
IKBKB
|
NFKBIB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
39.0
|
1.0
|
Omnipath
|
17145710
10320352
9346485
8657102
15084594
9315679
10723127
14743216
28086098
15218526
9278383
11470788
9914500
15836773
9721103
23109003
9689078
15145317
9520401
10723801
17047224
29145629
9135156
10593898
14636585
9346484
17072322
9346241
|
TRAF3
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12692549
15210742
16306936
16281057
14530355
17526488
17047224
14703513
23453971
|
TICAM1
|
TRAF3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11672593
11964313
12032143
12811837
15644117
16306937
16917499
17114424
20154735
20547845
23508573
|
TICAM1
|
TRAF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
17327220
16306937
16306936
17991829
18450748
24577058
20418377
|
MAVS
|
TRAF3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
22901541
19893624
17020950
18818105
21200404
16306936
18207245
19546225
22844514
22792062
19193783
34610835
16858409
|
TRAF3
|
TBK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
27135603
15210743
16127453
15210742
16306936
12702806
23986588
22792062
16177806
20389019
17991829
20174559
16858409
23717208
34084167
22330071
17468758
17327220
24622840
|
IFNB1
|
IFNAR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15312780
8943354
18508557
15449939
17969444
16171819
|
IFNA13
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
7932753
23331499
8181059
11698684
21856167
|
IFNB1
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
23331499
8181059
1834641
10049744
7592797
7623815
11278538
18988627
29311663
112785381834641
|
IFNA7
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA4
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA10
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA16
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA2
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
7592797
9334213
1834641
|
IFNA17
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
7623815
21856167
|
IFNA21
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
IFNA8
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
7592797
21856167
|
IFNA5
|
IFNAR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
21856167
|
TLR3
|
TICAM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
14517278
12539043
12242293
12855817
14982987
12609980
|
TLR3
|
TICAM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
12471095
12539043
15932500
16410796
14982987
14751757
14519765
|
TICAM1
|
TBK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
20200155
19416887
21903422
14530355
14739303
16410796
19656901
20418377
29018427
16281057
|
HLA-DRA
|
HLA-DOA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DRA
|
HLA-DOB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DRA
|
HLA-DMA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
CIITA
|
HLA-DRA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10886240
11889043
11429551
9300692
9600954
|
NUP98
|
NXF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
22334672
10668806
16713569
|
PIK3R3
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
8596638
22402981
9415396
11733063
26496610
25814554
|
PIK3R3
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
8596638
22402981
11733063
25814554
|
TLR3
|
TBK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
9.0
|
1.0
|
Reactome
|
12692549
15210742
16306936
16281057
14530355
17526488
17047224
14703513
23453971
|
IFIH1
|
TBK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
16177806
17020950
15210742
15210743
16306936
16127453
12702806
16858409
|
MAVS
|
TBK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
21813773
15210743
16127453
33372174
17020950
25636800
21903422
15210742
16753195
16306936
12702806
24643253
16177806
27419230
16153868
16858409
29743353
17468758
17327220
|
IFIH1
|
MAVS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
19416887
22301138
17600090
17020950
19052324
21903422
16410796
16785313
16713980
23499489
16127453
33372174
16125763
|
HLA-DQA1
|
HLA-DMA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DPA1
|
HLA-DMA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DQA2
|
HLA-DMA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
DNAJC3
|
EIF2AK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
25329545
9447982
8576172
|
MITF
|
TPSD1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18284417
20513998
11157480
11741327
|
TNFSF10
|
TNFRSF10B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
50.0
|
1.0
|
Omnipath
|
22266862
14585074
21459798
19427028
15538968
9325248
10894161
11239407
16189514
12628743
21525171
23678861
10549288
20103630
11094155
16227629
10542098
10894160
22585859
21822306
9242610
9311998
15766588
20097879
|
TNFRSF10A
|
TNFRSF10B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9430228
16319225
|
IRF9
|
IFNA13
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
20403236
9186002
22252317
15145216
22626811
8864350
|
TNFSF10
|
TNFRSF10A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
9314565
9613612
14585074
19427028
15538968
9325248
10894161
11239407
16189514
12628743
10549288
20103630
10894160
9082980
9242610
9311998
15766588
9430226
|
HLA-DQA1
|
HLA-DMB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DQA1
|
HLA-DOA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DQA1
|
HLA-DOB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DQA2
|
HLA-DOA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DQA2
|
HLA-DOB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DQA2
|
HLA-DMB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
CIITA
|
HLA-DMB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11889043
9300700
7495736
9600954
11332992
|
IL12A
|
IL12B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17145710
10779781
10899108
8943050
7527811
|
HLA-DOB
|
HLA-DPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DOA
|
HLA-DPA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|
HLA-DPA1
|
HLA-DMB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
9606180
7481823
9075930
9311912
7667286
8046351
10631952
|