Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
BACH1 NQO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15734732
NFE2L2 DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22691366 14978030
DDIT3 ATF3 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
EP300 PARP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16204234
HSP90AA1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
HIF1A HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14726529 20068160
MAPK3 PARP1 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 0508606103 16627622
PPP1CA MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12624094 12840032
PARP1 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18314489
JUN BATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12087103
RBM48 VIM â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
VIM MAFG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
VIM CHD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 15383276 5217202
HIF1A JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15794924 19828020
NFE2L2 NFE2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24613345 15790560
NFE2L2 CYP2E1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19671018 23400918
NFE2L2 ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24509533 19864258
MAF NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18694732
HIF1A CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17382325 5219810
HSP90AB1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
NFE2L3 NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15385560
MAFG CHD3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
MED31 MAFG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HOXD12 MAFF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11036080
PRRX1 MAFF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11036080
RBM48 MAFG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
HOXD12 MAFG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11036080
PRRX1 MAFG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11036080
BACH1 MAFG â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
HIF1A HSP90AB1 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
EP300 PARP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 18280497 16204234 19622798 12960163 24636898 33742100
JUN ATF3 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 10327051 6546308
BATF3 BACH1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
PARP1 JUN â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 24636898 25609649
JUN CHD3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21196933 25609649
DDIT3 BACH1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23661758 20102225
CCD67 JUN â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CCD67 MAFF â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
CCD67 MAFG â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
NF2L3 NFE2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 23661758 20102225
DDIT3 NFIL3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16189514 23661758 20102225
BATF3 JUN â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
BATF3 ATF3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 23661758 20211142 12805554 20102225
HIF1A JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25879517 19738058 11739718
BACH2 BATF3 â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
BACH2 MAFG â—¼   PHYSICAL_INTERACTION 0.87 0.87 HuRI 32296183
ATF3 DDIT3 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
BACH1 MAFF â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 23661758 26496610 33961781 26186194
DDIT3 BATF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32296183 25416956 23661758 20211142 20102225
BACH2 MAFF â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 26186194 23661758
NF2L3 MAFF â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 33961781 26186194 23661758
CREBBP JUN â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
JUN DDIT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10523647 23661758
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
BATF3 BACH2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32296183 33961781 23661758
MAFG NFE2L2 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
NF2L3 MAFG â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33961781 23661758 20102225
NFE2 MAFG â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16189514 9166829 9150357 20102225
MAFF NFE2L2 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
BACH1 NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19897490 15734732
ATF3 DDIT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 31467278 23661758 20211142 26264872 29997244 32814053 33961781 8622660 20102225 27107012
JUN DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19299913 22622069 12069855
EP300 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27956703 21268080 21937452 24069158 11689449 14630807 11980644 10327051 12437352 12471036 24636898
MAPK3 PPP1CA â—¼   DEPHOSPHORYLATION ✅ 3.0 0.9 intact 211739200 12840032 8214413
BATF3 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 23661758 10878360 33961781 25609649 20102225
JUN NF2L2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32911434 20232342 12805554 9872330 20194533
NFE2L2 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17313370 18241676 18199529
HIF1A MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17335808 18588890 20102637
HIF1A NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9486205 7500013 7508926
MAFF NF2L2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32911434 23737527 23661758 12490281 33961781 26186194
MAFG NF2L2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 16189514 24140708 23737527 25416956 11013233 21988832 23661758 32911434 18692475 22942279 9150357
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
HIF1A HSP90AA1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ATF3 JUN â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
MAFG NFE2L1 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
BACH2 MAFG â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 32296183 33961781 23661758
NFE2L2 MAFG â—¼   PHYSICAL_INTERACTION ✅ 0.94 0.94 mint 34591642
BACH1 MAFG â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 19011633 23661758 25219500 26496610 33961781 20102225
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
MAFF NF2L1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 23661758 33961781 26186194 8932385
MAFG NF2L1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16189514 31467278 23661758 9421508 9150357 20102225 8932385
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
ATF3 JUN â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 8649793 23661758 26496610 10327051 8622660 1827203 25609649 20102225 14667575 20304822
CREBBP HIF1A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
BACH1 HMOX1 â—¼   DOWN_REGULATES ✅ - 4.0 1.0 ACSN 10821856 10874044 12356737 12511571
BACH1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 23.0 1.0 Omnipath 12511571 17942419 22107958 20083128 14747657 18550526 20501657 23737527 17257585 12356737 18771089 22698995 20345481 14580148 23479260 19439223 22735309 17409198 21982894 15233805 20643109 21555518
BACH1 HMOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 12356737 10874044 10821856 12511571
ATF3 DDIT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9343434 14729979 22753726 10085237
MAFG EP300 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 22965115 32649885 32303435 22789539 21775727 12234984 32582032 33859744
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
NFE2L2 HMOX1 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19747488 23850759
HMOX1 NOS2 â—¼   DOWN_REGULATES ✅ - 10.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17689680 22461508 23390297 6357187 8871614
NFE2L2 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 72.0 1.0 Omnipath 24211276 21382013 23000247 21908612 17942419 18381655 31257023 12745069 22107958 18586007 23904790 24434148 21622983 21808062 22245129 16951197 22370642 23571756 24844779 21658364 11274184 20083128 14747657 15870071 17313370 24759106 20558128 14688281 23525690 21597468 22541814 21443188 21635873 18704831 22521774 16407140 22793650 18006113 22459801 24035498 24140584 23413426 22901690 18771089 24755082 20345481 16551619 23294286 23046979 15122755 16945925 23347118 23738042 21037234 23479260 19056485 19679681 22484158 18202225 24024136 16480751 19931411 20402460 17408602 21982894 25337552 24503931 19454702 23826208 20643109 18567745
JUN HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8774698 24755082 8872603 20486760 20833713 18689604
HIF1A HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11592948 19828020 20819234 17389506 10600883 11356853 15805230 18799519 17122584 17996129 20526373 15050899 20833713 14970910 19254160
NFE2L2 HMOX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10874044 18241676 12356737 18535259 12511571 10821856
MAPK3 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10551817 18519666 24099156
MAPK3 NOS2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17804409
JUN VIM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 7986748 14654785 2922288 16831196
JUN ATF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8576171 21304988 14667575 10979959 22870894
JUN NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11035254 8375015 8065332 20833713 9058597 8004128
JUN MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 22437631 10913304 20463008 20225236 10206959 16707434 20648623 9178763 15027120 19708869 10914841 15090544 14550555 9923649 11156425 9334186 8798622 16317516 19028685 11259586 16380175 12871225 15467742 10995748 21640141 16569638
JUN NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17105733 17940019 16421203 18596035 11254551 14962367 14686613 16771680 9776360 12788789 12020969
ATF3 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10327051 25609649 1827203 14667575 20102225 23661758 8622660 20304822 8649793
CREBBP JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8028671 10327051 2138276 9659924 9786917 16713569 17296604 8545107 18443043 16055710
JUN ATF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10327051 25609649 1827203 14667575 20102225 23661758 8622660 20304822 8649793
NFE2L2 NQO1 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 10441483 10821856 10874044 11279008 11909699 12356737 12511571 15521073 16219762 17512463 18761713 19027064 19747488 23850759
NFE2L2 NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 39.0 1.0 Omnipath 18039655 21569840 21382013 23000247 20599494 20309604 19007787 18028974 20623181 8962164 21622983 21638050 22245129 22302369 12947090 16948474 11013233 22521774 22154326 11035254 14510636 21926171 22459801 23413426 15385560 15574414 17360324 22911891 19897490 15734732 23738042 24024136 12149651 22346778 21843634 16785233 21097520
CREBBP NFE2L2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 21196497 11683914 11154691
NFE2L2 NQO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18535259 18241676
MAFG CREBBP â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 22965115 32649885 32303435 22789539 21775727 12234984 32582032 33859744
HIF1A CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12542982 20547241 17452336 15907483 19489936 15342390 15184875
HIF1A NOS2 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A NOS2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 25156364 9486205 16306444 20079239 16325051 11325839 10679484 12154035 9115299 18339887
MAFG NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12149651 11013233 15574414