Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
CYCS APAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9267021 5221616
EIF2AK3 APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16595687
E2F3 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18469863 12527885
E2F3 ATM â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12527885 18319725
ERBB4 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18676864
ETS1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17590421 10698492
HSP90AA1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18266962
E2F2 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11559537 18319725
BCL2 CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16713569 10622714
HLA-DMB CD74 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 2391366 8574855
GADD45B CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10973963
E2F2 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7958836
HDAC1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17980157 18319725
E2F1 E2F2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15014447 18319725
DNAJC3 EIF2AK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25329545 12446838
EIF2AK3 BIRC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19029953
HSP90AA1 FASN â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8204010 21360678
IRF7 IFNA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19349300 12242290
IRF3 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17035306 20483755
CALM3 CAMK2D â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20668654
CCR2 CD81 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 28298427 20167430
HEY2 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10692439
FGFR3 GPSM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14667819 5216829
CFB C3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 809512 279011
CFD C3 â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 809512 279011
PSME2 PSME1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
CD3E CD247 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 8520027 9850860
GNAS ADCY4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9228084 21406690
IFNGR1 IFNG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 376230 7617032
IFNGR1 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR1 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNG CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNG CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
CIR1 HDAC1 â—¼   COLOCALIZATION 2.0 0.8 intact 6548441 9874765
IRF5 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18332133 12138184
IFNGR2 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
IFNGR2 CAMK2A â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
FGFR3 PSME1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CISH GHR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12586763 10585430
GNAI1 GNG2 â—¼   PROXIMITY 2.0 0.8 intact 8189321 21552208
F2R GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22318735 31160049
F2RL3 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17158345 31160049
CXCL11 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22633458 15178708
CHD4 GSTT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
E2F3 CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8618861 10733529
EGLN2 EPAS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12788921 15474027
GNA12 BTK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11742120 9796816
CFD CFB â—¼   CLEAVAGE ✅ 2.0 0.8 Reactome 809512 279011
BCAP31 FDPS â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
APC BTRC â—¼   PHYSICAL_INTERACTION 806.0 0.8 STRING 36370105
CDK1 CCNA1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 7799941 1628647 14681455 8565853 16009130
DDB1 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 34026424 25189618 24249678 26679995
BIRC2 E2F1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 28542143 30359437 21653699
EPAS1 EGLN2 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 23275444 17353276 15474027
BIRC2 BTK â—¼   PHYSICAL_INTERACTION 816.0 0.81 STRING 36370105
CD81 GNAI1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32900848 30024968
C3 CFD â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
AP1G2 AP1S1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16713569 9733768
ATM CHEK1 â—¼   PHOSPHORYLATION ✅ + 0.82 0.82 Signor 20068082
CCR5 CCL4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 9334377 10477718 10498628 8663314 23597562 12427015 9468473
AP1B1 AP1G2 â—¼   PHYSICAL_INTERACTION 0.83 0.83 HuRI 32296183
CDK1 CDC25C â—¼   PHOSPHORYLATION ✅ + 0.83 0.83 Signor 8119945
CDC25C CDK1 â—¼   DEPHOSPHORYLATION ✅ + 0.83 0.83 Signor 19574738
ATP6V0D1 ATP6V1A â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
E2F1 E2F3 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 35140242 24981860 20106982
CDC42 EPHA2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 31871319 28628118 28205554
AP1M2 AP1S1 â—¼   PHYSICAL_INTERACTION 842.0 0.84 STRING 36370105
CUL4B HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 34026424 25189618
HEY2 HDAC1 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16189514 11486045
APAF1 CYCS â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
APC CDC42 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17145773 21311754
CD81 GNAI2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 32900848 30024968
CHEK1 DDB1 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
GNAI1 GNAI2 â—¼   PHYSICAL_INTERACTION 861.0 0.86 STRING 36370105
CCNA1 CDK1 â—¼   PHYSICAL_INTERACTION 868.0 0.86 STRING 36370105
IRF5 IRF3 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 16189514 11303025 12138184
HRAS BRAF â—¼   PHYSICAL_INTERACTION ✅ 0.87 0.87 mint 34591642
HRAS BRAF â—¼   PROXIMITY ✅ 0.87 0.87 mint 30194290
PSME1 PSME2 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
ACVR2B BMP2 â—¼   PHYSICAL_INTERACTION 871.0 0.87 STRING 36370105
GNAI2 GNG2 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
AP1M1 CTLA4 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11583591 9812899
CCNA1 E2F1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16774918 10022926
E2F1 HDAC1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10734134 9468140 17980157 26468294 9468139
IRF7 IRF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18641315 11162841
AP1B1 AP1G2 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 32296183 33961781
HDAC1 CHD4 â—¼   PHYSICAL_INTERACTION ✅ 0.88 0.88 mint 26949739
BLNK BTK â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
CKS2 CDK1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 26496610 23602568 33961781 26186194 19786724 25852190 32707033 26344197 18471975
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
GHR CISH â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10585430 12586763 25505247
AP1M2 AP1G2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 33961781 26186194
EPAS1 EGLN1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 19208626 23275444 19147576 31763849 16407130 15474027 30487161 17353276
EPAS1 ARNT â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 24981860
AP1B1 ATM â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9707615 10608806
E2F1 ATM â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22832221 23993922 12527885
BAK1 AIFM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12232790 23003569
E2F1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11559537 18319725 11704823
CHEK1 BRCA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18317453 24627786
CHEK1 E2F3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19917728
CTLA4 CD80 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11279502 20587542 21982860 7545666
CUL4B DDB1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19651607 33969670 33357448 28225217 24292684 25189618 21145461 18593899 26496610 16678110 16964240 33536335 27113764 29499938 30898011 28886238 29738775 17392787 29846670 22939629 22038470 34026424 16949367 31911655 28446751 17041588 23238014 31973889 16861906 33961781 30945288 26344197 32140073
E2F1 CYP27B1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12629508
E2F3 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14576826 10766737 18319725
EFNA5 EPHA2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 20228801 20505120 9245480 33961781
HRAS HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16024644 15118125 15284455
IRF3 IRF7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20483755 15367631 15664995
C1QC C1QA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14681455 21054788 12960167 28325905
C1QA C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
GPSM3 GNAI1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 14656218 33961781 25416956
C1QC C1S â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10904115 15388251 761607
C1QC C2 â—¼   CLEAVAGE ✅ 3.0 0.9 Reactome 6019133 12396008 10925294
PSME2 PSME1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 32296183 8663520 16189514 9346951 22863883 33961781 19017543 22939629 9325261
GNAS ADCY6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9228084 21406690
GNAS ADCY9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9228084 21406690 32196115
GNAS ADCY7 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9228084 21406690 32196115
EIF4E ETS1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 15563472 9155017 9878069
CHD4 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 25247294 32744500 21258344 11102443 28977666 9885572 26496610 20585571 10220385 22075476 21670149 22939629 23752268 27616479 9790534 9804427 26949739 20693977 33961781 24981860 12920132 26344197
CD28 CD80 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 2164219 7964482 21982860 1847722 7545666
FGF9 FGFR3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 14613973 8576175 10574949
GNG2 BTK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11742120 11698416 7567982
EPAS1 ARNT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23434853 15192019 16181639 9079689 19845609 23275444 33591636 26160453 19129502 32461361 14668441 24981860 11018023 23796364
AP1B1 AP1M2 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
EGLN1 EPAS1 â—¼   PHYSICAL_INTERACTION 906.0 0.9 STRING 36370105
AP1M2 AP1S1 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 28514442 10535737 16189514 33961781 26186194
CALM3 CAMK2A â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
CD247 CD3E â—¼   PHYSICAL_INTERACTION 923.0 0.92 STRING 36370105
ADCY9 GNAS â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
AP1M1 AP1S1 â—¼   PHYSICAL_INTERACTION 942.0 0.94 STRING 36370105
CALM3 CAMK2D â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
CHD4 HDAC1 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
AP1B1 AP1M1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
CD80 CTLA4 â—¼   PHYSICAL_INTERACTION 950.0 0.95 STRING 36370105
AP1B1 AP1S1 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
C3 CR1 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
GNAS GNG2 â—¼   PHYSICAL_INTERACTION 955.0 0.95 STRING 36370105
BRAF HRAS â—¼   PHYSICAL_INTERACTION 956.0 0.95 STRING 36370105
AP1G1 AP1B1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10535737 10747088 9733768 7593184 23415225 11409905 33961781 22939629 26344197
AP1B1 AP1M1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 7593184 22939629 33961781 26344197
AP1B1 AP1S1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 22939629 33961781 24843023 26344197
AP1M2 AP1G1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 28514442 10535737 16189514 33961781 26186194 26344197
AP1G1 AP1M1 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10535737 10747088 7593184 22939629 26344197
C1QA C1QC â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
FGB FGG â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
AP1B1 AP1G1 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
AP1M2 AP1B1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 10535737 33961781 26186194 26344197
CAMK2A CAMK2D â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
BLNK BTK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 21482705 12093870 10498607 16969585 10556826 21822214
AP1G1 AP1M2 â—¼   PHYSICAL_INTERACTION 970.0 0.97 STRING 36370105
GH1 GHR â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
CDC25C CHEK1 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
AP1G1 AP1S1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
AP1G1 AP1M1 â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
EFNA5 EPHA2 â—¼   PHYSICAL_INTERACTION 976.0 0.97 STRING 36370105
C3 CFB â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
AP1G1 AP1S1 â—¼   PROTEIN_INTERACTION 0.98 0.98 HIPPIE 10535737 16189514 10747088 9733768 7593184 15758025 22939629 26344197
GNAI1 GNG2 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
FGA FGB â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
FGA FGG â—¼   PHYSICAL_INTERACTION 986.0 0.98 STRING 36370105
GNB3 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG5 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
CDK1 CKS2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
CUL4B DDB1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
EIF2B4 EIF2B5 â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ARNT EPAS1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
GNB3 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
CXCL11 ACKR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 29386406 29180449 27875312 24218476 22633458 16940167 20161793
E2F1 APAF1 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11389439 11559530 11591730 15279786 17218262 17303408 17660363 18590585 7575488
E2F1 APAF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 12766778 18524851 18951482 17600109 18093951 15972851 18056406 12149244 11389439
CYCS APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 11753565 10393175 10364241 15829969 16977332 15907471 10722681 9390557 10578178 16713569 9267021 12147322 10206961 10329646 11112785 10940292
E2F1 APAF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11559530 12149244 18319725 11591730 11389439
ATM CHEK1 â—¼   ENZYMATIC_REACTION ✅ 54.0 1.0 ACSN 11331603 11438669 11804596 11877377 12086603 12556884 12607003 14988723 15136767 15140942 15175241 15459660 15485915 15798197 15867354 15964794 16163361 16332722 16581787 16713580 16731533 16805667 16858402 17102137 17116885 17296725 17303408 17384638 17582221 17713585 18006705 18048416 18469862 18511906 18583988 18716619 18756267 18995830 19151707 19282663 19342888 19357644 19490890 19622404 19788416 19793801 19793861 19841479 20019063 20051983 21376743 23847781 9168117 9858600
ATM E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 20972224 11459832 27679857 15494392 15140942 27028861 21543892 27025900 20860841 24741006 17570479 25101673 28812991 15838517 22174788
ATM CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 69.0 1.0 Omnipath 29774099 20976184 26683224 25663895 12676583 17303408 14657349 29167438 27545311 10859164 19056039 15485915 28808226 12588868 16163361 15650047 12676962 17570479 14988723 14681223 26516160 10608806 26069190 29741650 12676925 23847781 17118344 11252893 20376879 15964794 15149599 18691976 19059218 20068082 15707391 12607003 25450480 17525332 11553781 19646247 15870257 15459660 20798862 19716789 11877377 12660173 11390642 15674326 16782033 28396830 28228262 12446774 15533933 15212693 29555944
BCL2 BAK1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 BAK1 â—¼   PROTEIN_INTERACTION 8.0 1.0 ACSN 11704864 17446862 22039431 23064052 23377657 23430059 23850759 8929532
BCL2 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 17145710 9463381 14980220 11206074 17289999 26004684 11728179 20836993 19168699
BAK1 CYCS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11447222 11175253 11326099 12232790 11741880
E2F1 BCL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17404573 11559537 12679318
BCAP31 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9334338 17145710
CDK1 BCL2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 24097825 24677263 23638364 19917720 27231850 11774038 11326318 10766756
AP1G1 CD74 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
CD74 HLA-DMB â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
CD74 AP1M1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
CD74 AP1B1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
CD74 AP1M2 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
CD74 AP1S1 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 10480952 7650016 7592972 10593899 14731593 2121367 9497313 8939989
CD74 HLA-DOA â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 9606180 7481823 9075930 9311912 7667286 8046351 10631952
FLT3LG CD74 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10477595 14670306 15749884 16418395 16713974 17404308 20547845 25215878 8920882 9268501
HMGB1 CD74 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26618107 27048821 27192565
CDK1 GADD45A â—¼   PHYSICAL_INTERACTION 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17660363 18414028 18543256 18590585 18995830 19004803 19652693 19686080 23485469 7575488
CDK1 GADD45A â—¼   SHARES_COMPLEX 22.0 1.0 ACSN 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17660363 18414028 18543256 18590585 18995830 19004803 19652693 19686080 23485469 7575488
CDK1 E2F1 â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 14551205 15279786 17218262 17303408 17660363 18414028 18590585 7575488
CDK1 CDC25C â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 1075565 12124778 14551205 14614141 15242590 15279786 15375219 15377654 15485915 15917306 16713580 16818604 17303408 17568790 17596790 17660363 18073536 18414028 18543256 18590585 18786381 18995830 19652693 19686080 7575488 9892021
E2F1 CDK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15510213 7623816 14618416 12760745 11799067 8137237 12629169 17108174
GADD45A CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 18942077 10362260 10973963 12124778 16189514
E2F2 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15510213 18319725
E2F3 CDK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15510213 10733529 18319725
CDK1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 20798862 19837665 18691976 21765472 21907702 29092815 18983824 16629900 22686412 24242917
CDK1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 7575488 18590585 17303408 8087847 27175585 17570479 17660363 15279786
CDK1 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17349584 17110335 17303408 18073536 1075565 11836499 15279786 8348613 7575488 20668692 24710276 9733650 12036951 20068231 8440392 12742231 32075732 16189514 9141461 16123593 18669648 19652693 18590585 9585407 12814430 10864927 10373560 18691976 11313986 12124778 18786381 17660363 18272572 8119945 15917306 27038604 9268380 17596790 28396830 17568790 19350548 16964243 10037602 18212344 12478465 12766774
E2F1 CHEK1 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 10884389 12496474 15220350 15279786 17218262 17303408 17660363 18590585 18660752 19525936 20376879 7575488
CHEK1 CDC25C â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 15459660 15798197 17102137 17116885 17296725 17384638 17568790 17582221 18677104 19793801 20126263
E2F1 CHEK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 7575488 18590585 20376879 17303408 18660752 19525936 17660363 15220350 15279786
CHEK1 CDC25C â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 102.0 1.0 Omnipath 29774099 17145710 10391675 18321553 29425806 10214922 20716119 18677104 20860841 15798197 19793801 11836499 10681541 21152443 12505356 27603133 24505404 11333986 9836640 11551930 17097061 23880065 15736430 26485758 11240139 9889122 20068231 17116885 12742231 28442587 17582221 20126263 14681223 9278511 17384638 15629715 12814430 11313986 11741534 20068082 24079846 26542114 9278512 9659898 15705874 11027648 24525428 9914179 10557092 15459660 10676638 9810229 15150265 10209160 17296725 15296723 25512053 12399544 21035467 9543386 9744884 19490919 28396830 17102137 17568790 16488126 16330544 12478465
CSNK2A2 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 19651622 19415658 17081983 20166139 18767875 11602581 20068231 18452278 17570479 17287340 19413330 18669648
CSNK2A2 EIF2B5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11500362 18669648
CD80 CTLA4 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26405600 7512027 7523569 9359474
CTLA4 CD28 â—¼   DOWN_REGULATES ✅ - 12.0 1.0 ACSN 10921877 11093160 12370081 16227604 16885030 16916641 18292600 19890961 21159657 21376459 22116087 22437870
CD80 CTLA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 17145710 21530327 21422170 17953528 22437870 11279501 23954143 11279502 20587542 31757674 7545666 10583602 21982860
E2F3 E2F1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14576826 7958836 12063292
E2F1 IRF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19826915 24535579 22464952 21225257
CCNA1 E2F1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 17660363 15840440 16135794 18590585 7575488 17303408 9736735 15133492 15558010 15123636 9556498 10022926 16213134 11980909 16123593 11739724 15279786
EFNA5 EPHA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 20228801 9245480 24003208 15114347 22570727 11114742 9330863 20505120
EPHA2 CLDN4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16236711
HMGB1 BTK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21873236 11544529 22454496 16439361 15944945 12724322 17726518
IFNG HMGB1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 10485906 11489965 11579131 11777960 11870632 11964313 12413632 12818165 14607900 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 1825141 18272812 19833085 20038811 20819927 21149606 21411734 24658051 26755705 2965306 6425450 9834059 9864217
HMGB1 CCL4 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10952726 11672593 12646658 12803886 15802534 16267105 16327802 19931333 21372296 22842346 26618107 27048821 27192565
ETS1 HMOX1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15590657 20348279 16310515 10022513
IRF7 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 21670437 10933732 12077266 11473119 17785777 9877175 10938111 19798431 11303025 12242290 16612387 16251417 21940674 15265881 12138184 16175599 19349300 10692430 27012395 11162841 17702615
IRF3 IFNA5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20638368 19349300 18851954 12242290
IRF3 IFNA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 15741273 15331713 10048763 10933732 11473119 8524823 9891032 17785777 19193793 9877175 22593165 10938111 11303025 12242290 21795596 24278020 23028052 19349300 10692430 27012395 11162841 24535579 12821121 16641293 20047764
BMP7 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9748228 23331499 16446785
CALM3 CAMK2A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 3006921 17353931 20668654
CCL4 CCR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 10498628 16298345 8663314 10477718 9468473 20219869 23597562 10699158 9334377 9790730 16467191 22633458 12427015 12964882
GPSM3 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 14656218 22843681 32296183 25416956
C3 CR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 10382758 2551147 9988761 2141838
HLA-G CD247 â—¼   PHYSICAL_INTERACTION 29.0 1.0 ACSN 10562324 10925299 11353765 11385609 11438547 11489965 11513144 11875494 11994457 12055234 12731048 12811837 15081523 15778339 16287995 16713974 17100877 20435894 20814939 21059766 22267813 23414611 23508573 24378531 8478617 9603467 9625766 9738502 9751747
HLA-G CD247 â—¼   SHARES_COMPLEX 29.0 1.0 ACSN 10562324 10925299 11353765 11385609 11438547 11489965 11513144 11875494 11994457 12055234 12731048 12811837 15081523 15778339 16287995 16713974 17100877 20435894 20814939 21059766 22267813 23414611 23508573 24378531 8478617 9603467 9625766 9738502 9751747
HLA-G CD247 â—¼   DOWN_REGULATES ✅ - 29.0 1.0 ACSN 10562324 10925299 11353765 11385609 11438547 11489965 11513144 11875494 11994457 12055234 12731048 12811837 15081523 15778339 16287995 16713974 17100877 20435894 20814939 21059766 22267813 23414611 23508573 24378531 8478617 9603467 9625766 9738502 9751747
IFNG IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 IFNGR2 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 IFNGR2 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 60.0 1.0 Omnipath 17145710 16110316 12915721 12438563 7514165 15530433 23331499 16237089 23898330 9111318 15143187 16467876 10986460 18988627 1396683 8550631 20304997 11250200 10860730 12165521 29145629 10811850 7617032 18591661 8631301 7615558 7510216 7673114
IFNG IFNGR2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNG IFNGR2 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
CLEC2B IFNG â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11265639 12731048 12740575 15972651 17057721 20663776 20814939 21149606 23609447
HLA-G IFNG â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10925299 11438547 11489965 11513144 11875494 11994457 12055234 12811837 15081523 15778339 16287995 16713974 17100877 20435894 23414611 23508573 24378531 9625766 9751747
IFNG IFNGR2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 12915721 7673114 7514165 12438563 15530433 23331499 16237089 9111318 15143187 16467876 10986460 18988627 1396683 8550631 29145629 10811850 7617032 18591661 8631301 7615558 7510216 20304997
HRAS BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17145710 7706312 14970219 18567582 12932319 8073291 1386920 23331499 8601312 9154803 18988627 8668348 21779497 19541618 19933846 17563371 18098337 16803888 26165597 24441586 16135787 12917261 15710605 10545207
GLUL GLUD1 â—¼   PHYSICAL_INTERACTION 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL GLUD1 â—¼   SHARES_COMPLEX 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
GLUL GLUD1 â—¼   ENZYMATIC_REACTION ✅ 31.0 1.0 ACSN 11274345 16469705 17603935 18641653 19037093 19498109 19524512 19524513 19632174 20823910 20861672 21133840 21232017 22265414 22421439 23010170 23073834 23627914 24366341 26024392 26587781 26653790 26807733 26853145 26900751 27558815 27833036 27959630 28498367 28574505 28645028
FLT3LG CD80 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10477595 14670306 15749884 16418395 16713974 17404308 20547845 25215878 8920882 9268501
CD80 CD28 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11964292 12810107 14764699 15197224 17513775 17629517 18585785 20231889 22437870 23390297 25215878 25582338 26405600 7512027 7523569 9359474
CD80 CD28 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 21530327 7964482 22437870 2164219 1847722 23954143 15610849 7545666 21982860 21487479
ETS1 ANGPT2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 18720385 15003510 17287278
CAMK2A ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 25024220 12475968 25117710 20435626
ARNT ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17615296 9157999 9278421 11708773 16716598 12080085 10403805 16887934 15181457 7539918 12490555 1823643 12829734 13130303 15451019 9746763 8943284 15111329 9159130 11566883 21041997
FGF9 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 23331499 16597617 25772309 8576175 10574949 8663044 15231666
CCR5 GNAI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
GNAI2 ADCY6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933
CCR5 GNAI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 10508237 23109003 17084806 18538863 10644702 16183910 15337520 15251452
GNAI1 ADCY6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933
EPAS1 EGLN1 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 5.0 1.0 Reactome 12615973 12788921 19208626 18337469 18184961
EGLN1 EPAS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12788921 30487161 16407130 23275444 19147576 17353276 19208626 15474027
EGLN2 EPAS1 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 4.0 1.0 Reactome 12615973 18184961 12788921 19208626
BMP2 ACVR2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 23331499 20385559 16446785 28977600 15064755 18988627 17295905
GDF1 ACVR2B â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 15485907 21229555 21356369 15150278 15531507
FGA BTK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21873236 11544529 22454496 16439361 15944945 12724322 17726518
FGB BTK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21873236 11544529 22454496 16439361 15944945 12724322 17726518
FGG BTK â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 21873236 11544529 22454496 16439361 15944945 12724322 17726518
ELOC EPAS1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
GH1 GHR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 33.0 1.0 Omnipath 2825030 8943276 17500058 1549776 9353194 26713839 1935820 31279174 9030599 23331499 7862673 7691587 19927328 10551877 21889455 9571026 3349036 2387255 31100495 29145629 24280222 24243840
F2R GNA12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8290554 16189514 31160049 22972936