MMP2
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15313914
|
EGR1
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11830539
|
EGFR
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
1845983
|
F2R
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16580177
9924018
|
MAPK3
|
ARRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16580177
9924018
|
RAF1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
PRKCD
|
ADCY5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17185372
|
CALM3
|
CAMK2D
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20668654
|
CALM1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12799359
11988487
|
AR
|
CALM1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16619263
20610535
|
CALM1
|
ADCY8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16258073
10075700
|
CALM1
|
CAMK2D
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20668654
|
LPAR3
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12531543
31160049
|
CALM2
|
CAMK2D
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20668654
|
CYSLTR2
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
28298427
20167430
|
GLP1R
|
ARRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18445652
0710402105
|
GAL
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
AVP
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9756892
8621513
|
CHRM3
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
28298427
20167430
|
MC5R
|
GNAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
31160049
20371771
|
ADORA2A
|
GNAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8995267
6162091
|
ARRB1
|
GNAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23353685
|
DRD1
|
GNAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
1832710
2898118
|
GNAS
|
ADCY4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9228084
21406690
|
GNAS
|
ADCY3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9228084
21406690
|
RAF1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19197339
7014125
|
EGR1
|
SPP1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20417179
19557503
|
EGR1
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
17011549
12890669
|
ESR2
|
SPP1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10428965
17562975
|
CAMK2A
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
ESR2
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16549430
17261755
|
MAP2K1
|
ELK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10716983
10997882
|
CEBPB
|
GHRHR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15299028
22074460
|
CALCA
|
CALCR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
6148938
1331173
|
GNA11
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16268778
18515384
|
PIK3CA
|
GNAQ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
16268778
18515384
|
GNA11
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15313914
|
GNAQ
|
AGTR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219925
17498700
|
GNA11
|
GNAQ
|
â—¼ GTPASE_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
8073283
7937899
|
ADRA1B
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9481484
31160049
|
ADRA1A
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
31160049
1334487
|
GALR2
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
31160049
9685625
|
CRHR1
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10598591
22869609
|
CHRM3
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
31160049
7629074
|
EDNRA
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15475516
31160049
|
HTR6
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12650852
31160049
|
CCKAR
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
31160049
11313903
|
F2RL1
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9349532
31160049
|
GNRH1
|
CAMK2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12810529
|
CAMK2A
|
ADCY3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
9768837
8798667
|
AR
|
RXFP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20610535
20154177
|
AR
|
ADORA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20610535
16987234
|
AR
|
CHRM5
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11884637
20610535
|
AR
|
GHRHR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
1428232
19533338
|
AR
|
ESR2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11371645
20610535
|
AR
|
F2R
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20610535
15629896
|
AR
|
ADM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16376459
20610535
|
AR
|
ADRA1D
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20610535
16964290
|
AR
|
ADRB2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9855630
20610535
|
AR
|
F2R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15629896
|
AR
|
MMP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16888681
|
EDNRA
|
ARRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19202075
0807158106
|
ADRB2
|
ARRB2
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
23208550
8428323
|
MAPK10
|
ARRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19782076
7263131
|
EDNRA
|
ARRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19202075
0807158106
|
ARRB1
|
AGTR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5219925
17498700
|
ARRB1
|
AGTR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11579203
17498700
|
ARRB1
|
ADRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
16407241
11171997
|
CHRM1
|
GNA11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
14976183
12200418
|
ADRB2
|
CCKBR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
28298427
20167430
|
CAMK2D
|
CAMK2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20668654
1000426
|
GCG
|
GIPR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0706404104
17715056
|
DRD4
|
ADRA1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22723743
1001347
|
DRD4
|
ADRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
22723743
1001347
|
DRD4
|
ADRA1B
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
22723743
1001347
|
DRD4
|
ADRB1
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
22723743
1001347
|
GABBR2
|
GABBR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5218685
16724110
|
BDKRB1
|
GABBR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
28298427
20167430
|
GNRH1
|
CAMK2B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12810529
|
BDKRB2
|
AGTR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
28298427
20167430
|
NPBWR2
|
NPW
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12719537
7590751
|
GHSR
|
GHRL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
10604470
11322507
|
F2RL2
|
F2R
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
17376866
0700763104
|
CTSG
|
F2R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
10978167
|
F2RL1
|
ADCY2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
28298427
20167430
|
CTSG
|
F2RL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
10978167
|
APLNR
|
APLN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
8294032
9792798
|
AGT
|
AGTR2
|
â—¼ UP_REGULATES
|
✅
|
+
|
0.81
|
0.81
|
Signor
|
16597412
|
ATF4
|
CEBPB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
20102225
11018027
|
AKT3
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
EDNRB
|
EDN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
16713569
12972292
23597562
|
CALCRL
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
828.0
|
0.82
|
STRING
|
36370105
|
GNA11
|
EDNRA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
16189514
10789830
|
GABRA1
|
GABRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
833.0
|
0.83
|
STRING
|
36370105
|
CALM3
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
GCG
|
GCGR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
AGTR1
|
ARRB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
11579203
17498700
15611106
|
EDN1
|
EDNRA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
16189514
10770212
16713569
7509919
23597562
|
CALM1
|
CAMK2D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
843.0
|
0.84
|
STRING
|
36370105
|
CALM1
|
CAMK2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
844.0
|
0.84
|
STRING
|
36370105
|
GAL
|
GALR2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.84
|
0.84
|
Signor
|
10601261
|
CALM1
|
CAMK2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
846.0
|
0.84
|
STRING
|
36370105
|
AGT
|
AGTR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
846.0
|
0.84
|
STRING
|
36370105
|
CGA
|
FSHR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
AKT2
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28514442
12149249
9736715
12176337
11445557
33961781
14500673
11278835
11546794
|
GLP1R
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
856.0
|
0.85
|
STRING
|
36370105
|
GCGR
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
859.0
|
0.86
|
STRING
|
36370105
|
ARRB2
|
DRD2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
32450252
21256133
25162404
|
FSHR
|
FSHB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
22802634
15662415
10395410
|
EGFR
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24658140
25402006
31980649
|
EGFR
|
ARRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
24658140
25402006
31980649
|
AKT1
|
AR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
870.0
|
0.87
|
STRING
|
36370105
|
CACNA1S
|
CALM3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
CACNA1S
|
CALM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
CACNA1S
|
CALM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
CALCA
|
CALCRL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
CALM1
|
EGFR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
CAMK2D
|
CAMK2G
|
â—¼ PHYSICAL_INTERACTION
|
|
|
878.0
|
0.87
|
STRING
|
36370105
|
CEBPB
|
EGR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
22260630
12947119
|
TRPC1
|
TRPC4
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
12032305
12857742
|
ADRB1
|
ARRB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
10862778
18787115
|
AKT1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
AKT1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
ELK1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
882.0
|
0.88
|
STRING
|
36370105
|
EGFR
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24658140
25402006
31980649
|
EGFR
|
ARRB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24658140
25402006
31980649
|
ADRB2
|
ARRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
892.0
|
0.89
|
STRING
|
36370105
|
GABRA1
|
GABRB3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
GABRA1
|
GABRG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
898.0
|
0.89
|
STRING
|
36370105
|
MAPK3
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
AR
|
PRKCD
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17553165
17178875
|
PRKCD
|
ADCY7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17185372
12454008
|
ATF4
|
CEBPB
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16026328
|
AR
|
CRH
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
16446741
|
CALM3
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9859994
2550447
19608982
|
CALM3
|
ADCY1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
2022671
7685187
8417150
|
CALM3
|
TRPC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11983166
11290752
12601176
|
CALM1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9859994
2550447
19608982
|
CALM1
|
TRPC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11983166
11290752
12601176
|
CALM1
|
CAMK2G
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10860555
20668654
|
CALM1
|
ADCY1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
2022671
7685187
8417150
|
CALM2
|
ADCY1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
2022671
7685187
8417150
|
CALM2
|
TRPC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11983166
11290752
12601176
|
CALM2
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9859994
2550447
19608982
|
GIP
|
GIPR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
15655707
17715056
12627975
8795084
7589426
|
CTSG
|
C3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
24315997
1861080
|
GNAS
|
ADORA2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
ACSN
|
17371980
17909080
18758473
|
GNAS
|
ADORA2A
|
â—¼ SHARES_COMPLEX
|
|
|
3.0
|
0.9
|
ACSN
|
17371980
17909080
18758473
|
GNAS
|
ADCY6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9228084
21406690
|
GNAS
|
ADCY8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9228084
21406690
32196115
|
GNAS
|
ADCY9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9228084
21406690
32196115
|
GNAS
|
ADCY7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9228084
21406690
32196115
|
AKT1
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
25241761
28628118
10576742
19197339
19058874
28205554
|
EGR1
|
CACNA1H
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22431737
23929524
|
EGR1
|
CHRNA7
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
9254668
10693923
24412748
|
EGR1
|
AR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15517885
12890669
|
CEBPB
|
CALCA
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19261615
18650268
22905241
|
CEBPB
|
CSH2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10855690
|
CEBPB
|
AVP
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
8466483
15123720
11414683
|
IAPP
|
CALCR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
1331173
9620797
2608057
|
AGTR1
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17498700
31160049
11313903
|
CAMK2A
|
OPRM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10908300
|
CAMK2A
|
GABBR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
20643921
|
AR
|
GNRH1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19680559
15744016
24914937
|
ADRB2
|
ARRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
23208550
24658140
17148612
24561123
27226565
|
ARRB2
|
ARRB1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
24069330
17353931
33961781
17620599
|
EDNRA
|
GNA11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
16189514
7882989
10789830
|
ESR2
|
ADORA1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19376833
|
AGT
|
CTSG
|
â—¼ CLEAVAGE
|
✅
|
|
3.0
|
0.9
|
Reactome
|
6807977
9570564
20889553
|
CTSG
|
AGT
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11747312
10899625
|
F2RL2
|
F2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
873923
8615752
10079109
|
F2
|
F2RL1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
873923
8615752
10079109
|
F2RL2
|
F2
|
â—¼ CLEAVAGE
|
✅
|
|
3.0
|
0.9
|
Reactome
|
9618465
9087410
1672265
|
F2
|
F2RL3
|
â—¼ CLEAVAGE
|
✅
|
|
3.0
|
0.9
|
Reactome
|
9618465
9087410
1672265
|
GLP2R
|
GCG
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
9990065
10322410
15471943
|
PRLHR
|
PRLH
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
9607765
10498338
8666380
|
CALM3
|
CAMK2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
912.0
|
0.91
|
STRING
|
36370105
|
CALM2
|
CAMK2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
912.0
|
0.91
|
STRING
|
36370105
|
CALM2
|
CAMK2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
CALM3
|
CAMK2A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
CALM3
|
CACNA1C
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
8087759
20953164
|
AKT1
|
ARRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
18191226
19122674
19262695
|
LEPR
|
LEP
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.92
|
0.92
|
HIPPIE
|
22405007
9786864
33961781
8608603
|
ADM
|
CALCRL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
928.0
|
0.92
|
STRING
|
36370105
|
GIP
|
GIPR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
F2
|
F2R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
ARRB2
|
AGTR1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.94
|
0.94
|
HIPPIE
|
11226259
11279203
15611106
28298427
|
ADCYAP1
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
ADCY9
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
CALM3
|
CAMK2D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
CALM2
|
CAMK2D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
FSHB
|
FSHR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
947.0
|
0.94
|
STRING
|
36370105
|
F2
|
F2RL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
952.0
|
0.95
|
STRING
|
36370105
|
F2
|
F2RL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
952.0
|
0.95
|
STRING
|
36370105
|
CACNA1C
|
CALM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
953.0
|
0.95
|
STRING
|
36370105
|
CACNA1C
|
CALM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
953.0
|
0.95
|
STRING
|
36370105
|
CAMK2A
|
CAMK2B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
956.0
|
0.95
|
STRING
|
36370105
|
CSH1
|
CSH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
957.0
|
0.95
|
STRING
|
36370105
|
RAF1
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
7014125
19197339
|
CAMK2B
|
CAMK2D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
961.0
|
0.96
|
STRING
|
36370105
|
MAP2K1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
CAMK2A
|
CAMK2D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
969.0
|
0.97
|
STRING
|
36370105
|
MAP2K1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
971.0
|
0.97
|
STRING
|
36370105
|
GH1
|
GHR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
CGA
|
FSHB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
CACNA1C
|
CALM3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
GABBR1
|
GABBR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
990.0
|
0.99
|
STRING
|
36370105
|
EGR1
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16750517
15863471
23763269
16170359
11830539
17230532
|
AR
|
EGFR
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
15305378
19318561
21613411
19258514
15650253
17242169
18692155
15288768
11556855
20610535
|
CAMK2G
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
3138233
10347170
16799092
1309762
7805884
7505275
92065884
15302935
|
CAMK2A
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
17389395
17081983
3138233
20166139
10347170
15901825
16799092
18691976
8226933
20068231
1309762
7805884
92065884
1956339
7505275
18669648
15302935
|
MAPK3
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
1651322
17081983
3138233
15901825
16785992
1939237
91332050
27531070
17570479
2543683
2115882
34086370
17192257
1651323
15302935
|
PRKCD
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
30.0
|
1.0
|
Omnipath
|
11447289
8321321
11313945
12040186
15302935
6321473
1860884
6090944
19568798
14585353
17496910
21386996
2984676
11940581
85012702
19615955
2987962
12845332
3379075
15567848
16488589
17956904
|
AR
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
18358509
12534934
22260327
15288768
18951974
|
PTK2B
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
14963038
11274221
16713569
10777553
|
PRKCG
|
EGFR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
17496910
11940581
21386996
11447289
19615955
16488589
6321473
8321321
12845332
11313945
12040186
19568798
15567848
14585353
|
EGFR
|
CALM1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
41.0
|
1.0
|
Omnipath
|
17145710
19901323
20029029
12359306
16497976
25402006
17389395
18578522
16799092
20068231
3415247
7925415
18669648
12153558
24658140
17287340
14960328
18707149
17016520
|
EGFR
|
CALM2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
31.0
|
1.0
|
Omnipath
|
19901323
20029029
16497976
15592455
25402006
17389395
18578522
16799092
20068231
7925415
3415247
8639568
18669648
12153558
24658140
17287340
2843348
14960328
15212693
18707149
17016520
|
EGFR
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12556561
15531749
|
EGFR
|
CALM3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
30.0
|
1.0
|
Omnipath
|
19901323
20029029
16497976
15592455
25402006
17389395
18578522
16799092
20068231
7925415
3415247
8639568
18669648
12153558
24658140
17287340
2843348
14960328
18707149
17016520
|
RAF1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
ELK1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
Reactome
|
8386592
11145955
7588619
7889942
|
MAP2K1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
106.0
|
1.0
|
Omnipath
|
9694850
17081983
11319218
18799465
17389395
9447970
15342917
8226933
15851026
12270934
12644307
11242034
1381507
17906627
9677429
11986622
8376945
7992057
11948414
7687743
9731057
19197339
11704645
7565670
12750173
12932319
8626767
23331499
12048245
7559390
17272394
15811950
26987942
19494114
18669648
18691976
17192257
8388392
7898932
16464493
19369195
12920017
15466214
19690332
11134045
19534553
10995751
7867743
8223433
8248196
10567369
19933846
17563371
1518847
11730323
18983981
16186792
16135787
15951569
19058874
15212693
10748187
9560161
9925641
9733512
18083107
11104681
9006895
17569879
21071413
7731720
1330321
93330262
19541618
15466476
12925710
11971971
11136732
11118451
10746662
|
MAPK13
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
12738796
18039929
11274345
15187187
|
MAPK3
|
CEBPB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
16009338
12213825
8384717
10995751
12048245
15878863
19327116
19443782
15212693
15367685
|
MAPK3
|
ELK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
64.0
|
1.0
|
Omnipath
|
17145710
9130707
20506250
15547943
20371703
7618106
7601337
12697810
12473660
23331499
8007980
16291755
16393692
16998585
18988627
17255949
8208531
15014501
15187187
8586671
19541618
11145955
25241761
19565474
11309409
8887554
17052211
15277685
18334532
15782123
8548291
14499342
9927426
7889942
8262053
8386592
10716983
12665513
15967991
8477450
12947314
15212693
11274345
|
MAPK3
|
ARRB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
25.0
|
1.0
|
Omnipath
|
19651622
19153083
18767875
17322306
15456867
10347142
20068231
19413330
9388255
|
MAPK3
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
14654779
23331499
19541618
18691976
16407412
19933846
9446616
9922370
15664191
18988627
|
PRKCD
|
ADRA2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11732925
|
PRKCD
|
BDKRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
11517230
|
PRKCD
|
ADRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
11809767
11146000
1848190
8083204
|
PRKCD
|
C5AR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
17145764
12464600
10636859
|
ESR2
|
CRH
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
18597742
8408641
17947358
12161509
15564578
|
CRH
|
CRHR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
8536644
8243338
23504413
11123370
|
CRH
|
CRHR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
52.0
|
1.0
|
Omnipath
|
8612563
8536644
19124613
7477349
11416224
9178757
7692441
9851694
20966082
11123370
9326293
10598591
18801728
|
CALM3
|
CAMK2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
3006921
17353931
20668654
|
CALM1
|
CDC42
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
22944912
21299499
21730051
9199170
|
CALM1
|
CAMK2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17145710
3006921
17353931
20668654
|
CCK
|
CCKAR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
31.0
|
1.0
|
Omnipath
|
10368033
9006937
10595537
11300760
10400673
9603948
|
CCK
|
CCKBR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
50.0
|
1.0
|
Omnipath
|
10368033
12695525
10438490
8349705
15001692
15520004
7681836
23597562
15068617
|
CALM2
|
CAMK2A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
3006921
17353931
20668654
|
GIP
|
GIPR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
12627975
26572091
17715056
8795084
15655707
7589426
15655705
|
GNA11
|
CYSLTR2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
10191087
3086311
16754659
1905813
8664309
|
GNAQ
|
CYSLTR2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
10191087
3086311
16754659
1905813
8664309
|
GCG
|
GLP1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
18248821
11116211
15528268
7937318
8404634
|
GALR3
|
GAL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
9832121
9722565
1710578
1722333
7524088
9685625
|
GALR2
|
GAL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
9832121
9722565
1710578
1722333
7524088
9685625
|
GAL
|
GALR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
9832121
9722565
1710578
1722333
7524088
9685625
|
GAL
|
GALR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
34.0
|
1.0
|
Omnipath
|
9832121
11600206
9880084
9480833
10601261
9685625
|
GAL
|
GALR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
55.0
|
1.0
|
Omnipath
|
9808667
11481429
10689365
11600206
9168941
7524088
9880084
9685625
8617199
|
GAL
|
GALR3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
9832121
9880084
9722565
|
CEBPB
|
C3
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
25617152
22171262
21308746
18247123
10594926
|
C3
|
C3AR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
8702752
11342658
8765043
20527893
9476119
|
GCG
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
15569269
8405712
19859570
17306374
17900700
|
ADORA2B
|
GNAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
2553705
3127824
9651336
12106601
12860470
|
ADORA2B
|
GNAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
2553705
3127824
9651336
12106601
12860470
|
ADRB2
|
GNAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12036966
15782186
23798571
6149763
|
GNAS
|
ADCY2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
9228084
9395396
1719547
9268375
21406690
|
GNAS
|
ADCY1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
9228084
6935665
210183
17652154
2022671
21406690
32196115
|
GNAS
|
ADCY5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
9228084
9748257
9268375
21406690
|
AKT1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
51.0
|
1.0
|
Omnipath
|
19197339
11971957
18767875
20230923
10576742
20068231
17570479
16189514
18669648
25241761
18691976
10576741
10618391
20688159
21745501
12087097
12801936
12048182
22798428
16854453
19058874
11997508
|
PRKCG
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
8288587
17053865
|
RAF1
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
143.0
|
1.0
|
Omnipath
|
10757792
18337766
18799465
15342917
23728975
26496610
15866172
17053865
11242034
9351825
9677429
8157000
7992057
11948414
11604401
16129686
10677502
12695496
19197339
7565670
12750173
7936666
1326789
19219045
23331499
18556463
10976102
18988627
15485920
15175348
18691976
16407412
10409742
9311917
17192257
7898932
8621729
23934108
11684694
21336309
7624324
12920017
11948406
15466214
11042690
12907640
9032297
27169363
12876277
8933152
8223433
8248196
8131746
12594221
10969079
10567369
17979178
17724343
24746704
19058874
10958680
8090753
21071413
7731720
7873542
1330321
8503013
16093354
19541618
8394352
15466476
25155755
11136732
9069260
94178255
8607979
10327068
10359597
8039496
20212043
|
PLG
|
F2R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10978167
|
PLG
|
F2RL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
12604689
10978167
9020112
|
ELK1
|
EGR1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
21791614
17967787
22593802
23059951
12374773
10194767
21257751
19417216
11739517
16840354
10329706
18814180
18434015
15449318
|
AKT1
|
MMP2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
20.0
|
1.0
|
ACSN
|
17409395
17680028
18471976
19440036
19930715
19945467
20214616
20398329
20609352
21084277
22131018
23572150
23589069
24030100
25136802
26597054
27328425
27510662
27572739
29556339
|
AR
|
AKT1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
20589722
11278645
17896924
18687691
22740037
12621049
12063252
22970326
|
PIK3CA
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
25793261
19117013
21041639
24950409
21816939
|
AKT1
|
AKT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
11546794
14500673
12176337
11445557
9736715
12149249
11278835
|
AKT1
|
AR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
30.0
|
1.0
|
Omnipath
|
17470458
18349820
29861848
16210317
21601007
17570479
11404460
22155408
12621049
14555644
11156376
|
AKT1
|
ADRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
11809767
9032240
|
MAPK13
|
ELK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15187187
19436832
15140942
20506250
21614932
16393692
11274345
|
MAPK10
|
ELK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
19436832
20506250
16393692
8654373
20028971
11274345
|
TRPC4
|
TRPC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
19307462
16418302
17416589
22534489
22144671
19812031
16270640
12377790
16818374
12032305
17892531
12857742
11301024
|
TRPC1
|
TRPC4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
19307462
16418302
17416589
22534489
22144671
19812031
16270640
12377790
16818374
12032305
17892531
12857742
11301024
|
CEBPB
|
ADRA1D
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
16431954
10796884
10051504
10871045
11058951
11481261
|
CEBPB
|
GH1
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
17129742
12213825
15860545
20228168
11414683
18180320
21292824
17110376
10531366
|
CEBPB
|
ADM
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12630823
9480831
|
CAMK2A
|
CEBPB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
1314426
|
GCG
|
GCGR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
22863277
4305077
8382034
12529935
|
CALCB
|
CALCRL
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
2177866
8626685
2985435
6609312
14722252
|
CALCRL
|
ADM2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
8387282
11693189
10217420
9620797
14615490
|
CALCA
|
CALCRL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
32.0
|
1.0
|
Omnipath
|
17145710
11693189
8626685
3001670
16293613
12234182
14668209
23597562
10347248
9620797
|
ADM2
|
CALCRL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
21658025
14615490
|
ADM
|
CALCRL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
11693189
10347248
9620797
|
CALCB
|
CALCRL
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
11693189
8626685
3001670
12196113
12234182
14668209
10347248
9620797
|
ADCYAP1
|
ADCYAP1R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
39.0
|
1.0
|
Omnipath
|
8703026
16930633
12488235
10583729
11931347
21350482
10100920
17470806
8253796
|
ADM
|
CALCR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
10781016
12565884
15692146
|
CALCA
|
CALCR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
48.0
|
1.0
|
Omnipath
|
14722252
9487987
7588285
11033437
2158663
1331173
11023820
26125036
10342886
6148938
15692146
12565884
|
ADM2
|
CALCR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
21658025
15692146
|
CALCB
|
CALCR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
14722252
9487987
7588285
11033437
2158663
11023820
10342886
15692146
12565884
|
IAPP
|
CALCR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
9487987
24169554
10342886
12529937
|
OPRM1
|
GNAQ
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9544801
16415903
11786497
10215864
|
GNAQ
|
CYSLTR1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
10191087
3086311
16754659
1905813
8664309
|
CHRM1
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
3110621
1341877
8576109
31160049
|
BDKRB1
|
GNAQ
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
12130679
11379050
31160049
11713280
|
MAP2K1
|
ARRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
28169830
11226259
|
AR
|
MMP2
|
â—¼ TRANSCRIPTIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
18612129
16888681
20610535
|
ARRB2
|
MAPK10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
19782076
11090355
18408005
11356842
|
ARRB2
|
ADRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
23208550
17148612
17666399
24658140
27226565
2163110
24561123
22364396
|
ARRB1
|
MAPK10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
19782076
11356842
19879840
|
GNA11
|
OPRM1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
9544801
16415903
11786497
10215864
|
GNA11
|
CYSLTR1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
10191087
3086311
16754659
1905813
8664309
|
AGT
|
AGTR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
12006574
21464395
10193788
10993080
16189514
15930094
9797979
16597412
17346243
|
AGT
|
AGTR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
35.0
|
1.0
|
Omnipath
|
2775266
21464395
8315512
21542804
17138938
8185599
15930094
9797979
8242249
7850406
|
F2
|
F2R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
28.0
|
1.0
|
Omnipath
|
9058715
10978167
15707890
10644723
14652070
11356985
23450633
18250335
12563219
22972936
|
F2
|
F2RL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
10978167
1135698510978160
11356985
|
F2
|
F2RL3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
1273221212732210
12732212
22318735
|
F2
|
F2RL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
11356985
12732212
1135698512732210
|
GCG
|
GLP2R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
24990862
11738243
9990065
|
FSHB
|
FSHR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
15662415
17145710
2126341
10395410
|
CGA
|
LHCGR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
10342833
12727981
1922095
|
CGA
|
FSHR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15662415
2126341
12374801
30910395
|
C5
|
C5AR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
35.0
|
1.0
|
Omnipath
|
9881961
11773063
9553099
15661745
10602324
1847994
|
GH2
|
GHR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
2387255
1955498
|
GH1
|
GHR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
33.0
|
1.0
|
Omnipath
|
2825030
8943276
17500058
1549776
9353194
26713839
1935820
31279174
9030599
23331499
7862673
7691587
19927328
10551877
21889455
9571026
3349036
2387255
31100495
29145629
24280222
24243840
|
LEP
|
LEPR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
9463481
22405007
12226096
23331499
9207021
9218470
8608603
9786864
|
PTH2R
|
PTH2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
12559132
3616618
6950381
12098667
8732687
8386612
8397094
8770894
8082781
7797535
|
PTH2
|
PTH2R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
10854439
11602681
11861531
|
UCN2
|
CRHR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15450949
|
UCN2
|
CRHR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
11226328
11416224
11329063
15450949
|
KNG1
|
BDKRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
18127230
3366244
8063797
1314587
|
KNG1
|
BDKRB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
18127230
3366244
8063797
1314587
|
KNG1
|
BDKRB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
9313952
8856107
8735629
9111052
8063797
10422787
|
KNG1
|
BDKRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
9203620
8063797
8302267
28966616
|
EDN1
|
EDNRB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
1710450
1719979
8440682
2649896
|
EDN2
|
EDNRB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
1710450
1719979
8440682
2649896
|
EDN1
|
EDNRB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
12972292
16597412
16713569
15629009
8440682
|
EDN3
|
EDNRB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
8460684
8086489
8904635
11982704
8001160
15629009
8440682
7524189
|
NPW
|
NPBWR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
12130646
12401809
12719537
|
NPW
|
NPBWR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
12130646
12401809
|
EDN1
|
EDNRA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
22.0
|
1.0
|
Omnipath
|
90829707
6479761
9082970
7509919
16597412
16713569
23597562
15629009
8440682
7647976
10770212
|
GALP
|
GALR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
10689365
1068936515944000
15944009
23233848
|
PPY
|
NPY1R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
1317848
3202875
7592911
7592910
6373251
6589611
10461880
|
EDN3
|
EDNRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
1710450
1719979
8440682
2649896
|
EDN2
|
EDNRA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
1710450
1719979
8440682
2649896
|
EDN2
|
EDNRA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
2175397
9082970
15629009
8440682
7647976
|
CORT
|
SSTR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
35.0
|
1.0
|
Omnipath
|
15333679
11011067
9125122
9650799
9205124
10598788
|
CORT
|
GHSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12161511
1122773711227730
11227737
|
AVP
|
AVPR1B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
2991279
4065330
8106369
7929452
|
AVP
|
AVPR1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
2991279
4065330
8106369
7929452
|
AVP
|
AVPR1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
79.0
|
1.0
|
Omnipath
|
15084136
9334232
10519430
12446593
10780976
9884074
1560825
9322919
9264324
9459574
9864265
8106369
10866830
|
AVP
|
AVPR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
73.0
|
1.0
|
Omnipath
|
15084136
10519430
12446593
10780976
9884074
1560825
9322919
11012895
9264324
7774575
11857925
9459574
9864265
|
AVP
|
AVPR1B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
66.0
|
1.0
|
Omnipath
|
15084136
10519430
12446593
10780976
9884074
9322919
9264324
9459574
16158071
7929452
9864265
|
GHRL
|
GHSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
45.0
|
1.0
|
Omnipath
|
29233536
12907757
21402696
11314756
11227737
10628755
10604470
15905359
15070777
|
CAMK2G
|
ADCY3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
9768837
8798667
|
PNOC
|
OPRL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
49.0
|
1.0
|
Omnipath
|
7481766
9413015
12070757
11097863
22827708
12967935
23597562
10692489
16189514
9353393
10369464
8849681
|
GHRH
|
GHRHR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
1333056
26917260
7680413
76804131333056
|
PRLH
|
PRLHR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
10475064
9607765
11030716
12606605
|
APLN
|
APLNR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
10617103
12939143
11336787
10802050
10777510
12603839
16189514
9792798
15341513
|
TAC4
|
TACR1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
11786503
11062498
15224188
|
APELA
|
APLNR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
29357134
25995451
25639753
29079036
28137936
26611206
28663440
24316148
|
SPX
|
GALR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
31730796
30305242
24517231
|
SPX
|
GALR3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
30305242
24517231
|
RLN2
|
RXFP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
11809971
12506116
22973049
15649866
18434306
|
RLN1
|
RXFP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
11809971
16411781
|
GALP
|
GALR3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9832121
983212115944009
15944009
|
GALP
|
GALR2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
9832121
20880399
10601261
15944009
23233848
|