Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
ABL1 CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10601328 19564926
ABL1 DAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
ABL1 ARHGEF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 CTNNA2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10601328 19564926
ABL1 SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
ABL1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11753601 9916993
GRB2 BAD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
BCL2L11 BAD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7034061 19427863
MAPK9 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14673001 17555943
IKBKB BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23332762
BCL2L1 BAK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
BCL2L1 BAK1 â—¼   PROXIMITY 2.0 0.8 intact 29997244 20178071
BCL2L11 BAX â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7034061 19427863
FOXO1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15817464 15632117
STAT3 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17089128 20422978
BCL2L11 BAX â—¼   PROXIMITY 2.0 0.8 intact 7034061 19427863
STAT6 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12023955 11369758
FOS BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16911523
FOXO1 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15059979 10871843
BCL2L1 MAPK8 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 15733859 5217553
STAT3 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11994401
PRKACA BCL2L11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21151042 8142029
FASLG BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15659383 25241761
DCC CASP9 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0901767106 19721007
CASP9 BIRC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11024045 5213055
NKX3-1 CASP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15705778 24252419
FOXO1 CASP9 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19050291 20200974
RARA CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16166294
FGFR3 CDK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SKP2 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16376880 5218183
FGFR3 CDKN1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
CDKN1A CCND3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
SMARCA4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414052
PLCG2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31575057
PPARG CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15041706
PLCG1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 31575057
CDKN1A POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16678112
ESR1 CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18563714
STAT3 CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25453873 28072604
ESR1 CXCL12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16912174
EPAS1 EGLN3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20061373 15156561
RUNX1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16917507 5218981
NFKB1 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
STAT6 EP300 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 8415882 23461825
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
ESR1 EP300 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16704985 11279135
EP300 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20660371 19102934
EP300 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22000024 19419955
EP300 RELA â—¼   ACETYLATION ✅ 2.0 0.8 intact 5214468 11533489
MAPK3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 24530506
TADA3 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11707411 16713569
FOXO1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16670091 19289458
FOXO1 DAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12351634
FOXO1 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17873901
FOXO1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15688035 16100571
CREBBP FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10973497
FOXO1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 25510553 19049975
FLT3LG GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19438505 23168613
JAK2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9209406 8400282
PLCG2 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SP1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SMARCC1 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
SMARCD3 GRB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 SMARCC2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 GSTM3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 IL2RG â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 CAMK2D â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
GRB2 ARHGEF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
GRB2 DAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5216105 12577067
MAPK3 GRB2 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7739560 8816480
MAPK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8994038
FGFR1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9480847 16713569
HSP90AA1 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
HSP90AA1 TRAF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
STAT5B HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19014541 22552610
HSP90AA1 DAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16551624
PRKCG KEAP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12198130
F2R MAPK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
FOS MAPK1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7588633 12134156
ESR1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23250869 22430216
FGF2 MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9490736 12750158
HGF MAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
MAPK1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
MAPK1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15778365
F2R MAPK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16580177 9924018
FOS MAPK3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 7588633 12134156
HGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16397249 17667909
EGF MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17081983 16024629
MAPK3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16888388 16691505
NKX3-1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20530667 12173040
ETS1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 11424091
FOS MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10348347 12173040
CSNK1A1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19759023
RPS6KB1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20657550
MDM2 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21988832 23839035
MSH6 MSH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548274 9774676
MSH3 MSH2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6548274 9774676
PLCG1 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6805619 9020117
MAPK8 PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033842 16982329
HGF PIK3R1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10871282 10648629
PIK3R1 ARHGEF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 FLT3LG â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 19438505 11027663
PIK3R1 PLCG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 GNAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16268778 18515384
PIK3R1 JAK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PIK3R1 NTRK1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6730539 8226808
NTRK1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8226808 8384556
EGF PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 19531499
GNG4 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23109003 17169327
IL2RG PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10421845
PIK3R1 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7642542 16982329
PIK3R1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25814554 15021914
SP1 POLK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17099721
SMARCA2 SMARCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10078207 16713569
SMARCA4 SMARCC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10078207 16713569
SMARCC1 IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
SP1 SMARCC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16288722 15187086
HGF STAT3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 9094433 9440692
PDGFRB STAT3 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 ACSN 17145802 17496910
RELA STAT3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 25040843
STAT3 PGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23042533
STAT3 NDUFA13 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21827581 12628925
STAT3 EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23991099
STAT3 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22218594
STAT3 BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16048438
STAT3 F2R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23504318
STAT3 DAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 24217921 23438478
PDGFRB STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17496910 9484840
KITLG STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11071637 24116056
STAT3 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12393476
ELOC CUL2 â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 5219492 17183367
CUL2 ELOC â—¼   PHYSICAL_INTERACTION ✅ 0.8 0.8 mint 19327355 7014028
TRAF1 BCAS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
LPAR3 GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12531543 31160049
LPAR3 GNA13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22863277 15856019
PRKACA ITGAV â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
MAPK8 CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 7033842 16982329
PDGFRB CRK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 10733900 6731185
CRK SP1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
CRK ARHGEF11 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
BCR CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8978305 21602891
HGF PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10521801 16782899
PTEN PDGFRB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16456542 5218301
LRP6 PDGFRB â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 21245321 1019443108
PDGFRB JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8657151 9484840
ITGB1 CCNE2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 000924 30021884
ARHGEF11 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
FGF19 PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
BCR PLCG1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15050920 10579907
PLCG1 ALK â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 18097461 9819383
PLCG1 AGTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 9516477 6730883
PLCG1 IL3RA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17474147 8109998
PLCG1 FGF23 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16844695 10652257
PLCG1 KIT â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 6730376 7537096
PAX8 SMAD4 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
SMAD4 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 10199400 11427533
FOS SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11854297
SMAD4 RUNX1T1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21540640
CREBBP SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 9679056 9679060
SMAD4 DAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11740493
SMAD4 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9679056 9679060
IFNGR1 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
GLI2 IFNGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14691458
JAK2 PIK3CB â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11598010 12506011
JAK2 STAT6 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15261459 23124025
JAK2 PLCG2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15644415 8034732
JAK2 IL12A â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 22306691 12829785
JAK2 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
JAK2 PRKACA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
STAT5B JAK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17255200 11682625
IL2RG JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8041779 24608040
RELA PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14729949
CDC42 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16381926
PTEN SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12804776
FZD4 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 27096005 19388021
DVL1 ROCK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15121866 23331499
SP1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 12847090 5216518
NFKB1 HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11931769 5215238
RELA HDAC1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11931769 5215238
RELA HDAC1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23027620
PPARG HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21151932 16431920
RUNX1T1 NCOR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18952841 0802696105
PPARD CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20592029 19395102
SP1 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19120021
ESR1 HES1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18414489 19039095
HES1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14614508
MAPK8 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15659383 25241761
DAPK1 PAPSS2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
TPM3 CHUK â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
CHUK IKBKB â—¼   PHYSICAL_INTERACTION 2.0 0.8 ACSN 12799363 23430059
CHUK IKBKB â—¼   PROTEIN_INTERACTION 2.0 0.8 ACSN 12799363 23430059
FGFR3 RELA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
RELA KITLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19197368 14563684
RELA F2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11463837 19351910
RELA BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17350185
RELA PPARD â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 14708613
RELA EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20495570
RELA CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18425349
RELA IKBKB â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 12842894 5216511
FOS RELA â—¼   PROXIMITY 2.0 0.8 intact 18172215 0705181105
RELA FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 10488148
RELA PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 10542237 16189514
IL2RG IL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
IL2RG STAT5B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8709637 7489741
ESR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 16144913
PPARG IL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 19307774 11093153
ESR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23331499 16144913
NFKB1 IL15 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21343618 10906187
JAK3 IL2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15178252 16477002
ESR1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
NFKB1 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12456660 16135789
STAT6 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15145939 10373589
CREBBP ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12573436
CREBBP ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8941362
IL3 PRKACA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
RUNX1 IL3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9036972
NFKB2 SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 20513428 16902410
DCC CDC42 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
CDC42 PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11817894 15788770
CDC42 RPS6KB1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5214238 11438723
CDC42 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11438723
GLI2 CSNK1A1 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 17283082 16611981
GLI2 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18710724 20934421
GLI2 FGF19 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15614767 18279667
GLI2 HHIP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16571352 19574535
SP1 EPAS1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17024177 5219187
SP1 IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12576336 14568984
SP1 ETS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12706891 8247540
SP1 AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12032593
SP1 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16516150 15818598
SP1 NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7541912
SP1 F2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12911579
SP1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21411747 17350185
SP1 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15158147 19302822
RARA ETS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11327309
ETS1 CSF3R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7964503
FOS ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16189514 8557686
IFNGR2 CAMK2D â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 15322115 11972023
EPAS1 FGF2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17324924 18625704
FGF19 FGFR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0907812106 19706524
RARA FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19546303 9507016
MITF FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14737107
STAT6 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18342537 11922943
PPARA FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17360982 18754816
FOS NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20188076
RUNX1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19686049
NFKB1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17350185
NFKB1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21790895
NFKB1 BIRC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 9294162 9733516
CDK4 CCND2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 20156660 27107012
FGFR3 PPARA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
TXN2 TXNRD2 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 2.0 0.8 Reactome 17707404 9923614
IKBKB NFKB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 14743216 5216883
JAK3 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 12207328 26758199
RUNX1 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16287839 14747476
RUNX1 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23487742 17283131
RUNX1 CSF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15676205
ITGA2B PTK2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11476890 16919435
GNB3 GNAQ â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
GNAQ GNB2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 25675501 15889144
IL5 PRKACA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
PRKACA IL3RA â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 10477722 10949031
NCOA2 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11923473 23936147
PRKACA PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 8657310 9660757
STAT5B CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11160217 12586844
ESR1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11060032 21610700
NFKB2 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18504428
CCND3 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16609025
GNAQ AGTR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 5219925 17498700
EDNRA GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15475516 31160049
GNAQ PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
GNAQ PLCB3 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
MITF BRAF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 23831555 16001072
ARNT ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 17991765
ESR1 NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20623181
ESR1 SLC2A1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14605097
NTRK1 SHC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11791173 9507002
NTRK1 SHC2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12006576 9507002
NFKB2 IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 17982049 17579043
CSNK1A1 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15747065
RXRG RARA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16189514 5217968
RARA LAMB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 2556699 8645318
RARA CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18829110 23062266
PRKCG RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8145770 10608897
PPARA AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15067378 20613959
LEF1 MITF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10747853 12048204
IL7R STAT5B â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8709637 7489741
ALK JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11850821
RXRG PPARA â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 16169070 5217955
STAT5B JAK3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 8709637 7489741
ELOC NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 22001063
PLCB3 PLCB1 â—¼   PHOSPHOLIPASE ✅ 2.0 0.8 Reactome 11015615 2841328
CRK GRB2 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
MAPK8 MAPK9 â—¼   PHYSICAL_INTERACTION 805.0 0.8 STRING 36370105
LRP5 AXIN1 â—¼   RELOCALIZATION ✅ - 0.8 0.8 Signor 11336703
EP300 FOXO1 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
FGFR1 PIK3R1 â—¼   PHYSICAL_INTERACTION 808.0 0.8 STRING 36370105
CDKN1A CCNE1 â—¼   PHYSICAL_INTERACTION ✅ 0.81 0.81 mint 16765349 5218735
NFKB1 EP300 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11739381 23811396 14662860 12471036 20065107 22013068 12960163
EP300 PPARD â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 16930961 10567538 18797151
EP300 HDAC1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 14968110 30110629 22778253 16787918 33742100 18722353 22731250
FGFR1 CRK â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 10464310 25241761
PPARD NCOR1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 11903058 11867749 21775429 15001550
PPARG SP1 â—¼   PROTEIN_INTERACTION 0.81 0.81 HIPPIE 18509005 24735796 20360975 22282354 18310298
CREBBP FGFR1 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
PDGFRB PTEN â—¼   PHYSICAL_INTERACTION 811.0 0.81 STRING 36370105
PTEN PTK2 â—¼   DEPHOSPHORYLATION ✅ - 0.81 0.81 Signor 10400703
LRP6 AXIN1 â—¼   RELOCALIZATION ✅ - 0.81 0.81 Signor 18632848
CREBBP FOXO1 â—¼   PHYSICAL_INTERACTION 817.0 0.81 STRING 36370105
BAD BAX â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19427863 17274640
CDK2 TPM3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21319273 26496610
ROCK2 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30413785 33742100
EPAS1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23275444 15261140 22807441 25689462
IL3RA GRB2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17474147 7523859
ESR1 MSH6 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16260778 31527615
RBX1 ELOC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 33504946 12149480
GNAI3 GNB2 â—¼   PHYSICAL_INTERACTION 819.0 0.82 STRING 36370105
ESR1 GSTM3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23576398 31527615
DVL1 SMAD4 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 12650946
JAK2 AGTR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 7746328 11152457
PPARG RARA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 32296183 32929351
ROCK2 ROCK1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
SP1 EPAS1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22402494 17024177
FOS ESR1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 17317669 25303530
CDK4 JAK3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
PPARA RXRG â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 16169070 22205725
EPAS1 ARNT2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23275444 20211142
PPARD RXRG â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 15604093 22205725
ARID1B SMARCD3 â—¼   PHYSICAL_INTERACTION 822.0 0.82 STRING 36370105
GRB2 PDGFRB â—¼   PHYSICAL_INTERACTION 824.0 0.82 STRING 36370105
GNAQ PLCB3 â—¼   PHYSICAL_INTERACTION 826.0 0.82 STRING 36370105
SHC3 GRB2 â—¼   RELOCALIZATION ✅ + 0.82 0.82 Signor 16829981
ABL1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 829.0 0.83 STRING 36370105
CCND3 CDK2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 16782892 33854235 26496610 9716181 33961781 26186194 23455922
PPARD MDM2 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
IFNA5 IFNA6 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
BCR KIT â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 8757502 25241761
BIRC5 CDK4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 10713676 16189514
FOS MITF â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 16189514 9918847
SHC3 NTRK1 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 25921289 9507002
JAK3 ALK â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 14968112 11850821
IFNA5 IFNA4 â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
RELA STAT3 â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
ESR1 NCOA2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 0.83 0.83 Signor 11477071
BRAF MAPK1 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
CREBBP NCOA6 â—¼   PHYSICAL_INTERACTION 836.0 0.83 STRING 36370105
EP300 FOS â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 19064921 21937452 11287611 24069158
FOXO1 SKP2 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
SP1 STAT3 â—¼   PHYSICAL_INTERACTION 839.0 0.84 STRING 36370105
TADA3 RARA â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 20413580 12235159
SMAD4 SKP2 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 16865698 15314162
CCNE1 CDK4 â—¼   PROTEIN_INTERACTION 0.84 0.84 HIPPIE 9716181 28628118 28205554
ALK GRB2 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
CSF1R PIK3R1 â—¼   PHYSICAL_INTERACTION 840.0 0.84 STRING 36370105
PPARG SP1 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
ETS1 RUNX1 â—¼   PHYSICAL_INTERACTION 843.0 0.84 STRING 36370105
HDAC1 STAT3 â—¼   PHYSICAL_INTERACTION 845.0 0.84 STRING 36370105
JAK2 STAT5B â—¼   PHOSPHORYLATION ✅ + 0.84 0.84 Signor 9575217
CDKN1A EP300 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
SMARCA4 SP1 â—¼   PHYSICAL_INTERACTION 846.0 0.84 STRING 36370105
BCAS2 TXN2 â—¼   PHYSICAL_INTERACTION 0.84 0.84 HuRI 32296183
IKBKB NFKB1 â—¼   PHOSPHORYLATION ✅ - 0.84 0.84 Signor 11158290
ITGAV ITGB1 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
IL12B IL23R â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
STAT2 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15154850 10464260 18678383
RUNX1 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 14752096 16917507
PAX8 EP300 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 10924503 35140242
SP1 STAT3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 17471507 24396070 21184768 16931573
HDAC1 STAT3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15653507 22750444 15870198 22116549
CRK BCR â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8943292 8978305 19380743
PLCG1 PDGFRB â—¼   PHYSICAL_INTERACTION ✅ 0.85 0.85 mint 6730306 1396585
KIT JAK2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 8611693 7527392 9355737
ETS1 NFKB2 â—¼   PHYSICAL_INTERACTION 849.0 0.85 STRING 36370105
RARA NCOA2 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 16713569 9430642 12503607 12612084 9192892 20543827
EP300 FOS â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
FGF2 FGFR3 â—¼   PHYSICAL_INTERACTION 850.0 0.85 STRING 36370105
BAK1 BID â—¼   PHYSICAL_INTERACTION 853.0 0.85 STRING 36370105
HDAC1 RUNX1 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
NCOA6 RARA â—¼   PHYSICAL_INTERACTION 856.0 0.85 STRING 36370105
CHUK RELA â—¼   PHOSPHORYLATION ✅ + 0.85 0.85 Signor 10521409
KIT ABL1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 12374739 24728074
EPAS1 EGLN3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 17684156 17353276 15474027 23275444
SMAD4 EP300 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9679056 25514493 18215124 9843571 14612423 10887155 22033265
EP300 FOXO1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 15890677 24419059 25609649 18786403 11896584
EP300 NCOA2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10490106 9920895 15731352 20448036
EP300 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10205054 15653507 16713569 33531691 26504087 18782771 30110629 11923478 15735682 15649887 33742100 22116549
PIK3R1 GRB2 â—¼   PHYSICAL_INTERACTION ✅ 0.86 0.86 mint 5220480 7642581
FGFR3 GRB2 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9045692 26344197
ESR1 STAT3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 23874500 11429412
PLCG1 ALK â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11888936 9819383 14968112 9174053
HDAC1 PPARD â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 18037904 11867749 16189514
HEY1 HES1 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 27129302 26068074 19802006 33961781
CREBBP ETS1 â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
FGFR1 FGF4 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 11486033 10748122 14613973
ELK1 MAPK8 â—¼   PHYSICAL_INTERACTION 859.0 0.86 STRING 36370105
ESR1 RARA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 9717844 25303530 25604459
NCOA2 ARNT â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26350169 12024042
AXIN1 CSNK1A1 â—¼   PHYSICAL_INTERACTION 860.0 0.86 STRING 36370105
NCOR1 PPARD â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CREBBP STAT6 â—¼   PHYSICAL_INTERACTION 865.0 0.86 STRING 36370105
CREBBP MDM2 â—¼   PHYSICAL_INTERACTION 866.0 0.86 STRING 36370105
CDC42 PIK3R1 â—¼   PHYSICAL_INTERACTION 867.0 0.86 STRING 36370105
CCND2 CDK2 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 9840943 28514442 33854235 33961781 26186194 23455922 9178893
GSTM3 GSTM4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 25416956 33961781 26186194
ESR1 SP1 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 10681512 17656465 17312152 16651265 18765668 10446910 15084343 16439465 15637147 19652226 15705965 15987735 9611253 15557281 9328340
GSTM5 GSTM4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 32296183 33961781 26186194
ARNT2 TRAF4 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 33961781 24722188
FOXO1 PRKACA â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
NCOR1 RUNX1T1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
GSTM4 GSTM5 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CDKN1A MDM2 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
EP300 STAT3 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
NCOA2 RXRG â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
CDKN1A STAT3 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
IKBKB KEAP1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
ALK PLCG1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
EP300 NFKB1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
EP300 MDM2 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
RELA SP1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ETS1 FOXO1 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
PIK3R1 PTK2 â—¼   PHYSICAL_INTERACTION 875.0 0.87 STRING 36370105
KEAP1 RBX1 â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
CHUK CREBBP â—¼   PHYSICAL_INTERACTION 876.0 0.87 STRING 36370105
IFNA14 IFNA6 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
ESR1 HDAC1 â—¼   PHYSICAL_INTERACTION 877.0 0.87 STRING 36370105
EP300 PPARG â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ESR1 NCOA6 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
SMARCA2 SMARCA4 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
PDGFRB PLCG1 â—¼   PHOSPHORYLATION ✅ + 0.87 0.87 Signor 7535778
PTEN PTK2 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
HDAC1 RUNX1T1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CHUK RELA â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
CREBBP ESR1 â—¼   PHYSICAL_INTERACTION 878.0 0.87 STRING 36370105
ABL1 PLCG1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 10708759 1383690 17474147
BIRC5 CASP9 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11024045 11069302 16189514 25241761
SP1 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15647279 19062177 10651903 11517158 23714681 10899165 16478997 11030335 24530506 34252870 28425985 31536933 32115405 17623675 10362258 16734381 17906698 22415975 12200149
SKP2 EP300 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 22770219 18243116 26593157
EP300 PPARA â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 9407140 10336495 18797151
NCOA6 PPARG â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 15604093 19596656 24368734 10788465 11877444 19047629
TADA3 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 12034840 31527615 18089809 20413580
PLD1 CDC42 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 31871319 10747870
IL15 IL2RG â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16189514 8178155 10903799 8568232 9371812
SP1 NFKB1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 18083845 16740634 33572115 7933095
FGF2 FGFR3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 14613973 9045692 10574949
FOS RUNX1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 11641401 11274169
RAC3 ESR1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 16331275 21217774
HDAC1 SMARCA4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
GSTM3 GSTM4 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
NTRK1 PLCG1 â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
RARA RXRG â—¼   PHYSICAL_INTERACTION 880.0 0.88 STRING 36370105
GRB2 PTK2 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
KIT PLCG1 â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
IKBKB RELA â—¼   PHYSICAL_INTERACTION 881.0 0.88 STRING 36370105
BCR GRB2 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
ELK1 MAPK3 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
CRK PIK3R1 â—¼   PHYSICAL_INTERACTION 882.0 0.88 STRING 36370105
EP300 SMAD4 â—¼   PHYSICAL_INTERACTION 883.0 0.88 STRING 36370105
ABL1 PIK3R1 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
CSF1R GRB2 â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
JAK2 STAT3 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
ABL1 GRB2 â—¼   PHYSICAL_INTERACTION 886.0 0.88 STRING 36370105
MAPK1 MAPK3 â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
GRB2 KIT â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
ESR1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
NTRK1 ABL1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10708759 10679771
CASP9 DCC â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11248093 16537496 19721007
EP300 STAT6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10454341 17237818 23461825
FOXO1 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22266855 11435445 11353774
NTRK1 GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11733534 25921289 10748052
CSF3R GRB2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9824671 14557262 17001306
CDK4 HSP90AA1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
MAPK1 STAT3 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
MDM2 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12897156 11178989 16713569 10766163 17545634 31012223
RARA NCOA6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10823961 16713569 10866662 11158331 10567404
NCOA6 ESR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10866662 16794079 10567404 10681503 11773444 26487511
KIT PIK3R1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
RBX1 SKP2 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 29499133 18826954 34237211 18667692 19112177 19398581 18239684 33961781 30349055 33504946 11245432 23770852
JAK2 STAT3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10925297 11294897 15156153 30413785 15284024 11350938 12626508 12576423 11940572 10918587 12244095 8626374 9211920 19834108 26775640 14551213 27351213 23838182
SP1 SMAD4 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 10878024 18215124 21297662 16714330 11114293 22033265
AXIN1 LRP6 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22682247 19107203 23959799 24976009 28966723 16890161 20128690 23892894
IL3RA IL3 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 9278420 7957082 8649415
SKP2 CCNE1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 11237742 22959436 10790373
RARA SP1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 18270252 10361124 19401466 16713569
FGF23 FGFR1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 22393163 27879395 19966287 17086194
PLCB1 GNAQ â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 16754659 12193606 11753430
MITF LEF1 â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 12048204 12032083
EPAS1 ARNT â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 24981860
CDKN1A SKP2 â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
CDK4 CDKN2B â—¼   PHYSICAL_INTERACTION 892.0 0.89 STRING 36370105
BAK1 BCL2L11 â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
CREBBP RELA â—¼   ACETYLATION ✅ + 0.89 0.89 Signor 16382138
IL15 IL2RG â—¼   PHYSICAL_INTERACTION 893.0 0.89 STRING 36370105
HDAC1 NFKB1 â—¼   PHYSICAL_INTERACTION 894.0 0.89 STRING 36370105
HDAC1 RELA â—¼   PHYSICAL_INTERACTION 895.0 0.89 STRING 36370105
BIRC3 CASP9 â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
NCOR1 PPARA â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
NFKB2 RELA â—¼   PHYSICAL_INTERACTION 896.0 0.89 STRING 36370105
ABL1 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23950177 16713569 17474147 14725908 9407116 9516488 8194526 19380743 19823681 7926767 16955467
ABL1 BCR â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12543778 1712671 8112292 21653319 11780146
ABL1 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16702947 25624478 12110584
MAPK3 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19777442 10597268 12566304
MAPK1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 8929531 10597268 12566304
BCL2L11 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22492984 12242151
BAX BCL2L11 â—¼   PHYSICAL_INTERACTION 899.0 0.9 STRING 36370105
BAX BID â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25241761 15574335 20956295 23374347 17289999
ETS1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 17213822
SMAD4 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15886208 16603637 18620728
STAT5B BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20585448 11756417 22729867
CASP9 BIRC3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16701639 25241761 21988832 16339151 9545235 15069192
SKP2 CDK2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 16189514 9858587 9636170 25852190 23455922 10559858 19270695 26496610 23602568 16979657 10386600 19686743 15355997 20160477 18604603 22770219 33422522 33961781 26186194 7553852
CDK2 EP300 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 33961781 26186194 10330164 23455922
MITF CDK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19067971 15607961 1999537
CDK2 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11598016 19450264
HSP90AA1 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 15664193 9844631 20018861
MSH2 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
GNB2 CDKN1A â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ETS1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18955504 12740370
HES1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19541765 19321451 11809764
RUNX1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10617663 23487742 23150456
EP300 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15154850 20234175 16713569 11070080 9809062 28196907 15013777
EP300 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 17468099 10944516 14701856 11287611 19596656 32603375 11877444 12040021 10075656 30595551 22787115 12479814
EP300 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19887647 11782371 12738788 25728767 11867769 12479814 23065768 15308690 20388208 14761960 22227247 8799122 20348541 23403292 12714702 11581164 16713569 19838210 18765668 16645043 30418174 12574227
MDM2 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 9809062 11070080 16713569
EP300 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12573436 10999956
FOXO1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12391153 15613482
FOXO1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 19470765 15632117 22468883
PIK3CB GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11002419 10995764 10448070
CDC42 GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
PDGFA GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 7935391 8388543 9739761
ITGA2B GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 12005431 9566877 7997267
KITLG GRB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8950973 16129412 10377264
KIT GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 24728074 7523859 17452978 17904548 10377264 8950973 10022833 7523381 12444928 8647802
JAK2 GRB2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 7500025 17474147 8536716 8950973
SHC3 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16729043 12242309 16829981
STAT3 HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9880553 10440232 23228483
HSP90AA1 BIRC5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 14614132 15894266 15218035
BRAF MAPK1 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
MAPK1 NCOA6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11301320 11773444
BRAF MAPK3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 27503831 16939974 9560161
BRAF MAPK3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 16508002 14654779 19933846
FGF2 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9490736 29436393 12750158
MAPK3 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 12819038 10841026
HDAC1 MDM2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15640443 33985974 12426395 30818224
NCOA2 MSH6 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14662770 10454563 11747826
NKX3-1 HDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 16697957
PDGFA PIK3R1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PIK3R1 ALK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11280786 11110708 18097461
SP1 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16814105 19464346 17376651
RBX1 CUL2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 19327355 17183367 12149480 15448697 10230407 12481031 29547696 32296183 11861641 15601820 30349055 22405651 25540389 10579999 19250909 21822215 21778237 29958295 22863883 33961781 33504946 28591624 17132228
SMARCA4 LEF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 19571879 11532957 21654818
KITLG STAT3 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11494148 10358045 9355737
NFKB1 STAT3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12057007 25241761 16713569
STAT3 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21546410
STAT3 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24287565 12147685
STAT3 CCNE1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22583478 19049964 19010822
CREBBP STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15649887 11773079
PLD1 PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 8024366 19323535 7215275
GSTM3 GSTM5 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 25416956 33961781 26186194
ITGA2B CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 16581250 10777559 12640026
PDGFA CRK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 10508235 9546424 9739761
CRK KIT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9092574 24728074 9233773 12878163
PDGFRB PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
ITGB1 LAMB1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11964076 16413178 16581764
LAMB1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10842354
COL4A1 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8223488
LAMC2 ITGB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10842354
EGF PLCG1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 8940074 1672440 10473558
PLCG1 FGFR1 â—¼   PHYSICAL_INTERACTION ✅ 0.9 0.9 mint 8321198 6730542
FGFR1 PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 12601080 1689310 1656221 25241761 23063561 8321198 9660748 20932831 18022941 19665973 15117958
NTRK1 PLCG1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 25921289 9856458 1715690 8384556 10092678 1400471 10708759
FGFR1 PLCG1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
PLCG1 FGFR1 â—¼   PROXIMITY ✅ 0.9 0.9 mint 8019672 20932831
EGF PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23613900 17081983 16525023
SP1 SMAD4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21421563
SMAD4 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12429655 22710759 19419955
SP1 IFNGR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11477089 17339358
JAK2 IL12B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
JAK2 IL3 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
JAK2 IL3RA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
JAK2 IL5 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 2681215 1400495 1396555
CSF3R JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23331499 7775438 11812652
JAK2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10925297 9553131
RUNX1 HDAC1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18316480 10617663 22777353
ESR1 HDAC1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 17312152 31527615 24051437 33731348 14722073 21182205 15557281 18451880 14506733 15140878
HDAC1 SP1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 15647279 20072153 19062177 11909966 17894944 21636851 18003922 12176973 11896613 15557281 10409740 11517158 15713621 12665570 15722551 17906119 16478997 18850004 16121030 16883603 12091390 15155736 18948152 18059533 16713569 20385359 15528196 16734381 12200149 12847090
NCOR1 PPARA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11903058 10336495 16713569 15870285 19955185 21775429 18292238
NCOR1 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11903058 17468099 10339548 30575522 15681609 15604093 19596656 22078880 35140242 11877444 16127449 30595551 23703729 21775429
NCOR1 RARA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 9531570 19377461 10336495 16606617 25303530 21988832 27107012 9121466 10882117 15604093 16469706 30532072 18978041 15336696 7566114 9486655 20543827
NCOR1 ESR1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16713569 24051437 12145334 16469706 17400812 12738788 21182203
NCOR1 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 22395773 20462215
PPARA CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16220077 15120605 10988245
NFKB2 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15079071 8413215 8413306
PTK2 HES1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 intact 21900206 2001699 8089645
ETS1 CHUK â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15469934
RELA EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15964798 21912613 23383347
RELA IL7R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18226221
RELA PPARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 20054868 10542237
RELA AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10628750 8833654 8613256
RELA NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9058597
NCOA2 PPARG â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11500849 23178929 15026545 10944516 19596656 11877444 17513608
PPARD PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20097210 10991946 20176998
PPARG FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 10678274 23657115 18059282
IL12A IL12RB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
IL12B IL12RB2 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 18389480 7638186 7528775
RARA CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23321499 16417649 21110951
NCOA2 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14966289 11747826 16613851
FGFR1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25241761 15929978
CREBBP NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12789342 16835236
SP1 IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8454603 23226269
PRKACA LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 21262972 18981475 21406690
JAK3 STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23109003 11406370 12495636
GLI2 PRKACA â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 17283082 19056373 16611981
SP1 F2R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9494121 12975361
SP1 NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20427719 20538607 9151857
SP1 LRP5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20141633
SP1 MAPK8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 14561739 16452190 9295358
SP1 NTRK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19656944 19643914 21123453
SP1 EDNRB â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 16921166 16623715
ETS1 BMP4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19431154 15695386
ETS1 JAK3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12794134
FGFR1 FGF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10748122 16829530 9174056 19627396 7520751 23597563 15096041 10950949 11030354 7730326 8609172 21693575 17086194 23597562 10574979 1697263 10490103 1722683 11786412 26267536 15548653 14505356 22539306 1709094 8868466 19696444 8692946 18199118 14613973
FOS PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10535756 1331087 1663213
NFKB1 AGT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10628750 8613256
NFKB1 CDK4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 24296733 18425349
NFKB1 NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9058597
KITLG STAT5B â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11494148 10358045 9355737
IKBKB NFKB2 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 Reactome 10723127 17047224 27701768
BIRC3 TRAF1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11907583 25241761 16713569 30948266 9384571 25996949 33961781 23524849
GNA13 ARHGEF11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11799111 10026210
GNGT2 GNB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 8636150 19168127 19376773
ESR1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11457657 10949931 17068199
RARA CCND3 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 16189514 16713569 12482873
AGTR1 GNAQ â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17498700 31160049 11313903
STAT5B ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11731618 11682625
ESR1 RPS6KB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 22286763 21292829 18414489
GNA13 ARHGEF1 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11313914 15951850 22661716
RARA MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15246741 10415749 1682056
PDGFA PIK3CB â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 2466336 1374684 9739761
PIK3CB ALK â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 11280786 11110708 18097461
IL7R STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 20974963 7719938
JAK3 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23109003 11406370 12495636
EPAS1 ARNT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23434853 15192019 16181639 9079689 19845609 23275444 33591636 26160453 19129502 32461361 14668441 24981860 11018023 23796364
IL12B IL12A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 10899108 10779781 7527811
PAX8 F2R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18632625
GNG4 PLCB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 23109003 17675482 17169327
EP300 HDAC1 â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
BAX BID â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
ESR1 SP1 â—¼   PHYSICAL_INTERACTION 901.0 0.9 STRING 36370105
SMARCC1 SMARCC2 â—¼   PHYSICAL_INTERACTION 902.0 0.9 STRING 36370105
CCND2 CDK2 â—¼   PHYSICAL_INTERACTION 903.0 0.9 STRING 36370105
CCND3 CDK2 â—¼   PHYSICAL_INTERACTION 904.0 0.9 STRING 36370105
GRB2 PIK3R1 â—¼   PHYSICAL_INTERACTION 908.0 0.9 STRING 36370105
PLCG1 JAK2 â—¼   PROTEIN_INTERACTION 0.91 0.91 HIPPIE 17474147 14978237
CCND2 CDKN1A â—¼   PHYSICAL_INTERACTION 910.0 0.91 STRING 36370105
CDK2 SKP2 â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
BAX BCL2L1 â—¼   PHYSICAL_INTERACTION 913.0 0.91 STRING 36370105
MSH3 MSH6 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
AXIN1 LRP6 â—¼   PHYSICAL_INTERACTION 916.0 0.91 STRING 36370105
EP300 SP1 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
GRB2 BCR â—¼   PHYSICAL_INTERACTION ✅ 0.92 0.92 mint 5214841 11726515
JAK3 IL2RG â—¼   PROTEIN_INTERACTION 0.92 0.92 HIPPIE 7973658 16189514 27742835 7973659
SMARCC1 SMARCD3 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
HDAC1 SP1 â—¼   PHYSICAL_INTERACTION 920.0 0.92 STRING 36370105
BCL2L1 BID â—¼   PHYSICAL_INTERACTION 921.0 0.92 STRING 36370105
EP300 RELA â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
CREBBP RELA â—¼   PHYSICAL_INTERACTION 924.0 0.92 STRING 36370105
PDGFRB PIK3R1 â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
JAK2 STAT5B â—¼   PHYSICAL_INTERACTION 926.0 0.92 STRING 36370105
GSTM3 GSTM5 â—¼   PHYSICAL_INTERACTION 0.92 0.92 HuRI 32296183
SMARCC1 SMARCA4 â—¼   PHYSICAL_INTERACTION ✅ 0.93 0.93 mint 24981860
CHUK NFKB2 â—¼   PHYSICAL_INTERACTION 929.0 0.93 STRING 36370105
CCND3 CDKN1A â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
EP300 ESR1 â—¼   PHYSICAL_INTERACTION 930.0 0.93 STRING 36370105
HHIP SHH â—¼   PHYSICAL_INTERACTION 931.0 0.93 STRING 36370105
GNB3 GNGT2 â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
F2 F2R â—¼   PHYSICAL_INTERACTION 932.0 0.93 STRING 36370105
BAD BCL2L1 â—¼   PHYSICAL_INTERACTION 933.0 0.93 STRING 36370105
ELK1 MAPK1 â—¼   PHYSICAL_INTERACTION 935.0 0.93 STRING 36370105
CREBBP STAT2 â—¼   PHYSICAL_INTERACTION 936.0 0.93 STRING 36370105
BAX BCL2L11 â—¼   PROXIMITY ✅ 0.94 0.94 mint 7034061 19427863
SHH HHIP â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 10050855 19561609
ARID1B SMARCC2 â—¼   PHYSICAL_INTERACTION 943.0 0.94 STRING 36370105
ARID1B SMARCC1 â—¼   PHYSICAL_INTERACTION 945.0 0.94 STRING 36370105
ARID1B SMARCA2 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
PIK3CB PIK3R1 â—¼   PHYSICAL_INTERACTION 947.0 0.94 STRING 36370105
CDKN1A CCND2 â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 16765349 5218735
PIK3R1 PDGFRB â—¼   PHYSICAL_INTERACTION ✅ 0.95 0.95 mint 7536927 6730373
IL2RG IL2 â—¼   PROTEIN_INTERACTION 0.95 0.95 HIPPIE 16477002 8049354 11418623 8006584 10662798 22446627
CCND2 CDK4 â—¼   PHYSICAL_INTERACTION 949.0 0.95 STRING 36370105
IL12A IL12B â—¼   PHYSICAL_INTERACTION 951.0 0.95 STRING 36370105
SMARCC2 SMARCD3 â—¼   PHYSICAL_INTERACTION 952.0 0.95 STRING 36370105
CCNE2 CDKN1A â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
NCOA2 PPARG â—¼   PHYSICAL_INTERACTION 954.0 0.95 STRING 36370105
ARID1B SMARCA4 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CDK2 CDKN1A â—¼   PHOSPHORYLATION ✅ - 0.95 0.95 Signor 15964852
SMARCA2 SMARCD3 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
FGF2 FGFR1 â—¼   PHYSICAL_INTERACTION 957.0 0.95 STRING 36370105
CDK2 CCNE1 â—¼   PHOSPHORYLATION ✅ - 0.96 0.96 Signor 19561641
CSF1R GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 10025673 8262059 7597091 9380408 9178909
PLCG1 GRB2 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 16713569 7629168 7516467 9020117 21706016 10940929 16038803 9281317
NCOA2 RARA â—¼   PHYSICAL_INTERACTION 961.0 0.96 STRING 36370105
SMARCA4 SMARCD3 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
FGF23 FGFR1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
IKBKB NFKB1 â—¼   PHYSICAL_INTERACTION 963.0 0.96 STRING 36370105
CCNE1 CDKN1A â—¼   PHYSICAL_INTERACTION 964.0 0.96 STRING 36370105
CHUK NFKB1 â—¼   PHYSICAL_INTERACTION 965.0 0.96 STRING 36370105
ABL1 CRK â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 31980649 9747873 11380621 15696159 8875975 9480911 21602891 18835194 18619508 12384576 8194526 11956190 19380743 24412932 9642287 17474147 8978305 12097319 17515907 33961781 12198159 7926767
CCNE2 CDK2 â—¼   PHYSICAL_INTERACTION 969.0 0.97 STRING 36370105
CCNE2 CDK2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15232106 9840943 28514442 24358021 9858585 26496610 14681455 25852190 9840927 33961781 26186194 23602568 23455922
BCR GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 8112292 11726515 15143164 9747873 10887132 8995379 8955135 9174058 14725908 21706016 33961781 19380743 32203420 9178913 7529874
CRK GRB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 8810325 10962563 8662907 19380743 10970810
MSH3 MSH2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 16025128 8942985 10029069 8805365 14657349 33961781 9774676 22939629 22179786 19377479
CUL2 ELOC â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 19327355 17183367 24076655 19339690 15966899 23563313 9447969 15601820 10449727 26735018 25661653 11384984 31444342 24981860 21145461 9122164 30166453 29991678
PLCG1 KIT â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25241761 24728074 16713569 7536744 11071635 7537096 14647465
HDAC1 NFKB1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 25241761 12972430 17962807 24448807 11931769 14678988 16319923 17827154
NFKB1 NFKB2 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 14743216 27609421 21988832 17962807 15169888 35140242 25609649 15660126
CDKN2B CDK4 â—¼   PHYSICAL_INTERACTION ✅ 0.97 0.97 mint 21900206 2001699 8089645
NCOA2 ESR1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 14766010 12612084 11250900 12837248 17697320 11376110 9430642 11265755 20348541 19460354 18499756 12630920 12714702 9192892 15657427 11014206 16645043 11937504 12554772 26487511 9774463
SMARCA2 SMARCC2 â—¼   PHYSICAL_INTERACTION 971.0 0.97 STRING 36370105
BCL2L1 BCL2L11 â—¼   PHYSICAL_INTERACTION 973.0 0.97 STRING 36370105
SMARCA2 SMARCC1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
BIRC3 TRAF1 â—¼   PHYSICAL_INTERACTION 974.0 0.97 STRING 36370105
CREBBP PPARG â—¼   PHYSICAL_INTERACTION 975.0 0.97 STRING 36370105
PDGFRB PLCG1 â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
NCOR1 PPARG â—¼   PHYSICAL_INTERACTION 977.0 0.97 STRING 36370105
ABL1 CRK â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
FGFR1 PLCG1 â—¼   PHYSICAL_INTERACTION 978.0 0.97 STRING 36370105
BCL2L1 BAD â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 11583631 5214629
CDKN1A CDK2 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 16765349 5218735
CDK4 CCND3 â—¼   PHYSICAL_INTERACTION ✅ 0.98 0.98 mint 8153045 21516116
BAK1 BCL2L1 â—¼   PHYSICAL_INTERACTION 982.0 0.98 STRING 36370105
NCOR1 RARA â—¼   PHYSICAL_INTERACTION 983.0 0.98 STRING 36370105
CDK4 CDKN1A â—¼   PHYSICAL_INTERACTION 985.0 0.98 STRING 36370105
CDK2 CCNE1 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 28137908 16431923 29439025 9891079 18559665 33854235 11940657 15004009 17431037 17361108 33854239 14681455 17254967 8867812 23853094 10827081 10330164 8662825 25852190 15557281 9192873 23455922 21092281 14536078 21372285 21241890 19631451 16223725 26496610 1388288 9716181 9472014 15980415 14701826 23602568 8978686 11433299 11132966 24771265 12839982 20587660 19470470 10359664 15514162 17970072 9840943 25728284 9660939 8647086 24358021 7799941 12529437 8756624 33961781 15670215 26186194 20837141 12800980
MSH6 MSH2 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 19377479 25241761 10783165 8942985 9428522 10029069 26496610 10856833 14657349 10748159 33961781 9774676 22939629 26344197 15064730
CCND2 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 16189514 14681455 32296183 9325318 11360184 30217970 28205554 15169570 10022865 17873913 25910212 27107012 28628118 33961781 26186194 11896535 9178893 11971966
CCND3 CDK4 â—¼   PROTEIN_INTERACTION 0.99 0.99 HIPPIE 28514442 16189514 25416956 21988832 33854235 9106657 14681455 21516116 23880157 16985050 32296183 10342870 26496610 19237555 9716181 11360184 30217970 15232106 14641107 25910212 27107012 16782892 33961781 26186194 11896535
ESR1 NCOA2 â—¼   PHYSICAL_INTERACTION 989.0 0.99 STRING 36370105
CCND3 CDK4 â—¼   PHYSICAL_INTERACTION 991.0 0.99 STRING 36370105
CUL2 RBX1 â—¼   PHYSICAL_INTERACTION 992.0 0.99 STRING 36370105
GNB3 GNG13 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB3 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG7 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNGT2 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG12 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG3 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
GNB2 GNG4 â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
SMARCA4 SMARCC2 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
SMARCA4 SMARCC1 â—¼   PHYSICAL_INTERACTION 995.0 0.99 STRING 36370105
ARNT EPAS1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
CDK2 CDKN1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB2 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
GNB3 GNG2 â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ABL1 CRK â—¼   ENZYMATIC_REACTION ✅ 6.0 1.0 ACSN 10837221 15459660 18835194 21051857 21199784 21435002
NTRK1 ABL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10708759 10679771
ABL1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 100.0 1.0 Omnipath 8978305 9747873 9480991 19426560 17081983 23124138 16522685 16713569 20841568 18768933 8875975 25860930 21779437 19534553 16187300 17515907 21602891 16267043 20068231 10592173 17570479 8194526 7926767 11080615 25381819 12198159 9642287 15696159 18619508 18835194 11956190 22848689 11314030 9480911 19001122 19402756 20697350 12384576 24412932 7542925 11380621 12799422 19380743 12955086 17474147 17016520
ABL1 BCR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 9407116 10405761 12522270 11780146 8622703 9178913 1712671 12124177 7529874 9467953 8955135 20841568 8112292 16912036 12543778 11376433
ABL1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 22553782 24974292 29066624 15657060 20841568 28177918
ABL1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 16705159 15923602 15793561 25821558 9111318 15143187 16705160 11593427 20841568
ABL1 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8940193 20841568
ABL1 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 26721416 27618557 24868554 21715626 30903103 22590567
ABL1 PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 14993293 19275932 20841568
ABL1 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 32.0 1.0 Omnipath 23331499 12110584 20651945 29065514 22352870 16702947 25973395 27626309 21081495 27956626 20841568 14757045 19738896 15212693 28690977
ABL1 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8940193 20841568
ABL1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 11726515 16713569 20841568 8596638 16955467 10592173 8647802 8194526 7926767 14725908 23950177 8112292 9407116 23181695 19380743 17474147 9516488 19823681
ABL1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 10708759 19290927 12652307 1383690 16525023 8657103 20841568 17474147
ABL1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 20841568 20101225 30692633
ABL1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 8940193 16846476 20841568
ABL1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 30323259 25368164 26385316
MAPK8 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 11983683 12189144 14673001 16166315 15526032 29795446 15907327 14967141 15725726 17555943
RPS6KB1 BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 15280015 10611223 12954615 9346240 11493700 10230394 10558990 8929531 9381178 19641507 17270021 10837486
PRKACA BAD â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 49.0 1.0 Omnipath 11983683 10880354 20166139 9346240 11493700 9381178 18794113 12931191 15280015 10230394 10558990 8929531 18669648 10837473 10837486 10611223 12954615 10949026 10851172 15123689 18707149 16403219 17270021
BAD BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 79.0 1.0 Omnipath 9305851 22705850 9389483 11483855 16697956 19667065 18628207 11907096 25416956 10620799 31467278 32814053 20837658 9388232 11077446 21988832 26871637 11206074 8929531 16189514 7834748 19427857 12115603 11494146 26186194 15694340 25241761 23109003 20603619 32296183 15705582 15131699 29997244 9372935 11583631 31515488 9824152
BID BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 23782464 17289999 11175253 10950869 12624108 23604079 12242151
BCL2L1 BAK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 35.0 1.0 Omnipath 22705850 9463381 22516262 31467278 32814053 9020082 23680104 34098062 18178565 15901672 16189514 17446862 20836993 23055042 19060904 17289999 32296183 10085290 14596824 15292519 29997244 31515488 11175750 9027312
BAK1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15901672 11571294 16189514 16439990
BCL2L11 BAX â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 10198631 12419244 15486085 15724238 23430059 23850759 9430630
NFKB1 BAX â—¼   DOWN_REGULATES ✅ - 6.0 1.0 ACSN 12676992 15613549 21725609 23178297 23572150 7834749
SP1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11278953 10510469 11748232
RELA BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18034190 18158998 20056115
NKX3-1 BAX â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12203124 17213822 19801665 8183578 21594902 17486276 23291169 19266349 19242108 19054058 19136938
BID BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 20956295 17289999 25241761 19968986 15574335 10629050 19062087 10949027 12242151 23374347 14730312 17520191 8918887
MAPK8 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15525785 18471544 16709574
BCL2L1 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 59.0 1.0 Omnipath 22705850 18981409 21458670 28202514 11283018 17525735 29749471 21567405 9388232 18547146 19074440 16151013 21199865 18178565 26496610 16189514 15486085 26186194 17289999 9111042 12419244 25241761 14963330 12853473 9742125 9153240 19427863 21852238 14766748 21671007 15131699 9670005 8596636 24814347 9824152 9027312
BCL2L11 BAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 22492984 26186194 17289999 12419244 11301022 12198137 17525735 21199865 18948948 23235460 11997495 15486085 12242151 23374347 19427863 15721256
RELA BCL2L1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15079071 15536066 17550372 19171876 23430059 8383323 9743347
NKX3-1 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22869582 19439449 23677993 21354697 11450946 16316993 16214938
RELA BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10925251 17673602 14978135 20585448 15231833 14739605 10585435 20066113 16904634 9439816 10733571 15756023 15986355 21722408 12226754 15856023 16453001 18223231 19706766
NFKB1 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 10925251 17673602 12176906 11992002 14978135 15231833 14739605 10585435 20066113 16904634 9439816 18222423 10733571 15756023 15986355 12226754 15856023 16453001 11756417 18223231
STAT3 BCL2L1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 15805299 20067773 15184887 15469392 16651438 11369651 16912181 17880940 16384639 21344490 20069389 18222423 21172343 21184768 21435102 18544087 18790750 20654581 11850821
MAPK8 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 10617621 25241761 15733859 12633850 18471544
STAT5B BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10428780 19211554 10435632 10428030 11756417
BCL2L11 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 34.0 1.0 Omnipath 17145710 16697956 9430630 17525735 22516262 18498746 10198631 21199865 20836993 26186194 15694340 17289999 27013495 32296183 23245996 11859372 19427863 21671007 14596824 9731710 16260615
NFKB1 BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10428780 19211554 10435632 10428030 11756417
BID BCL2L1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 19.0 1.0 Omnipath 9727492 19074440 16697956 15694340 17289999 25241761 22464442 14963330 16189514 27159560 24814347 15574335
BCL2L1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16189514 25241761 9539746
CUL2 BCL2L11 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258
RBX1 BCL2L11 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17884153 18420585 18931676 19622404 19622774 19686080 19809470 19847258
FOXO1 BCL2L11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17702754 16006742 12913110 16123151 19690465 19757185
MAPK8 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 15486195 14555991 18691976 22071694 12591950 15470142 18174237 18498746 12818176
MAPK9 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 15486195 14555991 18691976 18174237 12591950 15470142 12818176
MAPK3 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 15486195 25915848 17604722 14555991 28474232 19150432 18174237 12646560 12818176 15486085 15212693 14681225
MAPK1 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 15486195 17604722 14555991 28474232 19150432 12646560 16282323 12818176 17570479 15486085 15212693
MAPK10 BCL2L11 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 15486195 14555991 18691976 12591950 15470142 18498746 12818176
CSNK1A1 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11583622 12598529 20356928
MAPK8 BID â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 18594987 25326334 25077544 27374471
BIRC5 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 11069302 25241761 11024045 16189514 12773388 10329646 15210107
PRKACA CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 29352269 15703181
BIRC3 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 16339151 21988832 9990849 15069192 25241761 9545235 16701639
MAPK3 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 38.0 1.0 Omnipath 15547943 20080742 29416675 12040186 15173823 12697810 11940578 19081073 19586613 16227978 12738796 16039586 17466630 17255949 18669648 15187187 19016842 19541618 19091303 19565474 17052211 18039929 18775330 10601235 12792650 11431469
MAPK1 CASP9 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 44.0 1.0 Omnipath 15547943 20080742 12040186 18083711 15173823 12697810 11940578 19081073 19586613 16227978 12738796 16039586 17466630 17255949 18669648 16888006 15187187 19016842 19541618 19091303 19565474 17052211 18039929 18775330 10601235 12792650 11431469
CCNE1 CDK2 â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
MAPK1 CDK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10962581 12359725
CDK2 SKP2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 7553852 20160477 23602568 25271736 18239684 28446188 23226679 10386600 19270695 26496610 16189514 25852190 26186194 25788262 9858587 22770219 15355997 10559858 23807222 22311674 16979657 9636170 19686743 19270694 18604603 23455922
CDK2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 94.0 1.0 Omnipath 23443559 23455922 10878006 20100570 23602568 15964852 20839231 25416956 23737759 9840943 18850315 11302688 20519948 24358021 19440234 15557281 9472014 9658399 16962592 9736735 12949733 8641969 10022118 15890360 12839982 16765349 17418410 15647383 10874474 15232106 17570479 17698606 12361598 26496610 9632134 24419005 12417722 16189514 26186194 20587660 25241761 8622677 9660939 25483090 12800980 20102411 10918595 12058028 12144826 8242751 9464540 9858587 29899857 23007395 11477082 9218599 12383116 25463440 12730199 8756624 9284049 9380407 9546435 24218572 16964243 15212693 13678583
CDK2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 21106439 19652536 7575488 18590585 17522590 17303408 27035875 19473886 24948874 15677884 15279786 23029264 19124971 17660363 17038621 20148668
CDK2 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 25914884 17570479 16046550 17015473
CDK2 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 10428798 22431515 23390529 17570479 23770852
CDK2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 50.0 1.0 Omnipath 17145710 16223725 21092281 15004009 10962581 9840943 8643455 24358021 8861947 21372285 17570479 11237742 10330164 22558078 10652300 19561641 10477583 18691976 23853094 12144826 10500095 1388288 10827081 17970072 28137908 19470470 8756624 10809788 14536078 15364936
NCOR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 22253232 20466759 20696891 24821728 24821727
FOS CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 12705898 12087103 14755691 16141357 10891399 11789587 21864583
RELA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18954936 22305266 23037503 18269916
SMAD4 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10878024 9618481 9865717 11786386 9307274 24052079 12429655 10962574 10415848
HDAC1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12665570 19182791 15130752 18210215 16287849 17172847
FOXO1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17609436 23574718 23918930 24769335
RARA CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10356361 24821728 21383775
STAT3 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23178160 19372587 15286705 18320073 15063116 16923815 9694869 22328012 12438313 11773079 20654581 10023678 19329556 21184768 11114718
ESR1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15557281 16628468 20696891 16847062 12151347 11517191 15378598 11274368 16469747 17681750 20301197 22787161 23349794
EP300 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10362258 15509808 21858218 22000024 21245169
PPARG CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19551868 19103521 19208833 16985067 18509005 15041706 15345676 16091736
SP1 CDKN1A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 101.0 1.0 Omnipath 9580699 15978937 15557281 11064455 16103879 19584258 20301197 20935676 15961274 15361832 11274368 11842244 15489892 15302882 10212208 12796485 23184467 14529564 12806965 9819384 10321829 10649433 12434298 18270969 18850004 16081043 9183012 21858218 10809237 9618481 16298343 11574165 10362258 11384995 15659839 14744793 10030670 17090534 10733944 19318349 12665570 18202149 17516505 15033443 22001409 17885207 10485470 9553133 15345676 15694838 22427654 17556661 10506225 23066038 15979845 18636159 14527674 24821727 15899840 14755691 12151347 24589735 18210215 23877711 11953011 21311948 15528212 15790310 10878024 22132221 12782287 12773551 8995437 21184768 12379120 17026958 24451377 10601254 8557703 16810128 16533812 7499379 10625687 15389873 16706751 12727210 21325288 16818630 18419600 15041706 23235480 19244234 15694666 23329847 18509005
DAPK3 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 12431783 17855660 11756412 11779850 15001356
SKP2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 32035614 25241761 23261596 17679094 15998794 17477906 19686743 16376880 15980415 18794347 13678583
MDM2 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17373842 25241761 20086099 14633995 14761977 20308078
MAPK1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 20519948 19364816 28368408
RBX1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 11278750 15340381 12820959 15688063 18381890 19440234
MAPK8 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 12730199 15964852 17325029 19664994 12058028 11779850 17570479 20519948 16964243 18669648
SMAD4 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 9618481 17550342 12545156 11013220 15155580 11074002
SP1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 17026958 9389648 9618481 17550342 12545156 11013220 15155580 11074002
FOXO1 CDKN1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15084259 19380174 21708191 15084260 21613825 17940099 11154281
CDKN1A CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 23443559 26186194 25241761 27107012 8756624 15169570 25416956 16765349 31515488 16189514 32296183
CDKN1A CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 22.0 1.0 Omnipath 21988832 23443559 26186194 25241761 27107012 8756624 25416956 16328436 31515488 16189514 15232106 32296183 23880157 26496610 9716181
CDKN1A STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 25241761 16189514 10764767
CDKN1A CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 17145710 23443559 26186194 28514442 9840927 9840943 15232106 26496610 24358021
CDKN1A CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 30.0 1.0 Omnipath 17145710 23443559 31831640 21988832 9472014 17293600 11438644 9380407 12839982 16765349 9632134 25241761 8891332 9660939 8242751 9218599 11477082 8756624 8662825 8637717 9716181 13678583
CDKN1A CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 23443559 15169570 18850315 9658399 16962592 15232106 9632134 16189514 8622677 15695403 20102411 8242751 9464540 23007395 7626805 9106657 12383116 30193583 17556661 23543736 8756624
HGF CXCL12 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12649206 15059978 16212809 17145802 18633355 19631971 22763439 23402812 23667593 26366398 26819959 27474009 28475121 9242465
SP1 CXCL12 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15808852 23246486 21465475 19745163 23098564
EPAS1 EGLN3 â—¼   OXIDOREDUCTASE_ACTIVITY_ELECTRON_TRANSFER ✅ 5.0 1.0 Reactome 12615973 12788921 19208626 18337469 18184961
EGLN3 EPAS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12788921 23275444 17684156 17353276 15474027
MAPK1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17623675 24530506
EP300 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9660747
EP300 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 19608861 25400040 11567019 12419806 17617622 11533489 20333651 12456660 15152190 16846590 9096323 20064247 16382138 16713569 15171256 16135789
EP300 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 25.0 1.0 Omnipath 18782771 15509516 8756628 10205054 7530500 15653507 15735682 19506034 16285960 16713569 11322950 7499365 15649887 9590694
EP300 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 9843571 19419955 22033265 9679056 21269274
EP300 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15731352 20448036 10490106 9920895
EP300 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17306568 17666529 23343194 21285352 15576399 21151179 22761862 22290435 16039586 19619488 19623618 17143292
EP300 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11509556 15145939 10454341
SKP2 FOXO1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11516665 12820959 15071497 15147722 15340381 15459660 15668399 15688063 18931676 19622404 19686080
FOXO1 IL7R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21532575 19285438 19136962 18978794
FOXO1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16006742 15632117 12482965 19690465 14576824 12172378
CSNK1A1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 13.0 1.0 Omnipath 14710188 16511445 21233202 7641885 11980723 11311120 15121840 19188143
PPARA FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 16985262 18391971
ESR1 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 17145710 18391971 22266855 11435445 11353774
STK4 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 19221179 18786403 21245099 21320536 22898666 29896440 18394876
SKP2 FOXO1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15340381 17522590 15147722 17646672 12820959 15668399 11516665 15071497 15688063
FOXO1 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10783894 20673124 11094066 10102273 15668399 17646672 11994454
FOXO1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16670091 12966085 17317207
FOXO1 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 10454538 11283614 9308237 17936558 19380174 10783894 11283613 17873901 20673124 11094066 15668399 17646672 21708191 15084260 21613825 17940099 11994454 11154281
FGFR1 GRB2 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 17505008 18757403 21666749 11689702 11739186 18381441 19809159 21160078 14534538 15448205
FGF19 GRB2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
STAT5B GRB2 â—¼   PHYSICAL_INTERACTION 14.0 1.0 Reactome 16627759 22411868 11090077 26515730 20111072 15498859 10698507 12468433 12796379 30552988 23103841 31066629 15003515 17356133
GRB2 BRAF â—¼   PHYSICAL_INTERACTION 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
GRB2 CRK â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 FGF23 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
GRB2 PLCG1 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 PLCG1 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 BRAF â—¼   SHARES_COMPLEX 48.0 1.0 ACSN 10086337 10567412 10811803 10843677 10982827 11023813 11034387 11062502 11385609 11447289 11777939 11907067 12040186 12175651 12419216 12640133 12782630 14585353 14764585 15169888 15536084 15547943 15567848 15574420 15735649 15863030 16102570 16227978 16488589 16582911 16887996 17178906 17395718 17496910 17613518 17673906 19449109 19541618 19565474 19568798 19615955 21102635 22435554 24027568 26552706 7510700 8551221 9510155
GRB2 CRK â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
FOS GRB2 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11274345 12738796 15067049 16393692 16394015 18039929 19667062 21385848 22634314 23430059 9064320
GRB2 PLCG2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10072481 10086337 10567412 10781611 10811803 10982827 11169415 11447289 11777939 12175651 12640133 14764585 15567848 15574420 16102570 16329184 16582911 16887996 17496910 17673906 19449109 19494291 19909365 23620508 25137453 26552706 7523143 7890616 8551221 8649391 8976179 9489702 9535722
GRB2 PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
GRB2 PLCG1 â—¼   ENZYMATIC_REACTION ✅ 51.0 1.0 ACSN 10072481 10086337 10209041 10567412 10781611 10811803 10925299 10982827 11169415 11447289 11532940 11777939 11994416 12175651 12640133 1281218 12845332 14764585 15214048 15567848 15574420 16102570 16329184 16582911 16887996 1712101 17397400 17496910 17673906 19449109 19494291 19909365 23523669 23620508 24584707 25137453 2536067 25456276 25960930 26552706 7523143 7682895 7890616 8226994 8551221 8649391 8976179 8995379 9489702 9535722 9846483
GRB2 CXCL8 â—¼   ENZYMATIC_REACTION ✅ 24.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11283723 11447289 11449354 11777939 12175651 12393695 12640133 15520864 15567848 15574420 16076871 16582911 16887996 17496910 17673906 19223473 19449109 26552706 8551221
GRB2 ITGB1 â—¼   ENZYMATIC_REACTION ✅ 26.0 1.0 ACSN 10086337 10426994 10567412 10811803 10982827 11447289 11777939 11777960 11907067 12175651 12640133 15536084 15567848 15574420 16339513 16582911 16713974 16887996 17070508 17100878 17496910 17673906 18490724 19449109 26552706 8551221
PTEN GRB2 â—¼   REGULATES ✅ 15.0 1.0 ACSN 10648629 10753747 11747822 12040186 15584861 15721744 16288286 16982858 17218262 19847259 22179046 22465479 23732914 24254977 25364523
PDGFRB GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7935391 16713569 7486683
PTEN GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
NTRK1 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733534 10748052
EGF GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17081983 19531499 17673906 10973965
CSF1R GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9178909 9380408 10025673 8262059
KIT GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 24728074 8950973 7523381 10022833 7523859 8647802 16713569 17452978 17904548 10377264
JAK2 GRB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8536716 8950973 7500025 17474147 19273609
GRB2 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 10806474 12558988 8649427 8816475 11119718 16298995 7597091 7997267 9148935 12110680 12005431 10085298 16713569 10749687 10354709 21900206
GRB2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9281317 15953601 7629168 9020117 16713569 10940929
HSP90AA1 PLCG1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 17177598 16187797 15284455 16953218 17712310
NFKB1 HSP90AA1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 ACSN 17724475 21725609 23178297 23572150
PRKCG HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 26804907 24117238
PPARA HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16189514 12482853 12962497
STAT3 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 18266962 16189514 12559950
RBX1 KEAP1 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
RBX1 KEAP1 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 11900249 12648680 12820959 15340381 15459660 15688063 15703371 16697054 17312394 17884153 18931676 19560419 19622404 19686080 19809470 19818716 19847258 23030059 23850759
KEAP1 IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 27387502 20600852 19818716 25926686 24127568 24322982
ELK1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 8386592 11145955 7588619 7889942
FGFR3 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGFR1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
FGF19 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
ETS1 MAPK1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 8552081 10358095 20534573 11782450 15572696
MAPK1 RBX1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 31434245 22955283 12748172 16009132
MAPK1 FGF23 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
SP1 MAPK1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12220517 16797880 20506264 20121399 20882567 18372343 10727414 21170990 17889508
MAPK1 MAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12975377 23602568 16424009 19058874 23397142 21707490
MAPK1 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 21494553 21449613 25241761 16045329 23991633 20361728 11570862 22521293 11948414
MAPK1 DAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 15616583
MAPK1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 25409419 11733495 16574647 9099735 9030579 15507114 26670611 17570479 17998334 18596912
MAPK1 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 56.0 1.0 Omnipath 17145710 9130707 20506250 15547943 12551925 19690332 9763608 12697810 8007980 16291755 11279280 16393692 17255949 8208531 15014501 10637505 15187187 8586671 19541618 11145955 19565474 11309409 8887554 17052211 9501095 18334532 15782123 8548291 9927426 21655091 7889942 8262053 15655247 8386592 10716983 12665513 15967991 10644696 8477450 12947314 11274345
MAPK1 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 19318349 20882567 16377629 18775330 8226933 14744793 16079281 11904305 9604935 15212693 14593115 8388392
MAPK1 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12801888
MAPK1 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 27342992 23405013
MAPK1 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 12054624 15547943 20080742 14967450 12040186 15173823 12697810 11940578 7545671 16227978 21035469 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 19085255 11279232 9271440 18039929 18775330 11705993 10601235 12792650 11431469
MAPK1 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 59.0 1.0 Omnipath 18448488 19413330 11335711 9343414 15465816 25584415 12576423 11350938 20068231 12681450 12763138 9872331 11780390 18491316 18669648 11404481 10521505 18691976 20058876 15979846 14551213 10446219
MAPK1 RUNX1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16046550 17015473
MAPK1 PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11287604 11481231
MAPK1 TPR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12594221 18794356 22028470
MAPK1 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 21887372 10952390 16162175 29121864 9440696 10673502 12819038 20701798 27428965 16246839
MAPK1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 15655247 10949034 15528270 18372406 15461668 12118371 12466266 7495695 17615152 15059947 16076840 7491495 12093745 10409727 9528769 7838153
MAPK1 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 14654779 21478863 19541618 16508002 19710016 19933846 15664191 29335436 8621729
MAPK1 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 12134156 20506250 15547943 8248197 7816602 15084594 12697810 8226933 20068231 18452278 12738796 16393692 17255949 17439715 15187187 19541618 23109003 19565474 17722974 17052211 7588633 8545107 16055710 8388392 18039929 12972619 18775330 21098038 9604935 11274345
MAPK1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15073167 16888388 16691505
MAPK1 PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10187842
MAPK1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 18039929 19541618 21965663 20974802 19565474 15547943 12063245 12738796 11226259
FGF19 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
ELK1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 8386592 11145955 7588619 7889942
FGFR1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
ETS1 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 8552081 10358095 20534573 11782450 15572696
FGFR3 MAPK3 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 FGF23 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 19652666 12419216 18452557 12974390
MAPK3 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 40.0 1.0 Omnipath 32205409 20150555 21983342 11904305 14593115 18199680 8226933 14744793 16079281 19318349 20882567 22266860 28574228 21097497 8388392 32615164 16377629 19245816 18775330 9604935 15212693
MAPK3 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17018293 12134156 20506250 15547943 7816602 15084594 12697810 8226933 12738796 16393692 17255949 17439715 15187187 19541618 23109003 19565474 17722974 17052211 7588633 8545107 16055710 8388392 18039929 12972619 18775330 26725323 21098038 9604935 11274345
MAPK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 73.0 1.0 Omnipath 18448488 19413330 11335711 9343414 23331499 15465816 25584415 12576423 11350938 20068231 12681450 10417333 12763138 9872331 18988627 11780390 18491316 18669648 11404481 10521505 18691976 19723038 20058876 14551213 10446219
MAPK3 PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11287604 11481231
MAPK3 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 64.0 1.0 Omnipath 17145710 9130707 20506250 15547943 20371703 7618106 7601337 12697810 12473660 23331499 8007980 16291755 16393692 16998585 18988627 17255949 8208531 15014501 15187187 8586671 19541618 11145955 25241761 19565474 11309409 8887554 17052211 15277685 18334532 15782123 8548291 14499342 9927426 7889942 8262053 8386592 10716983 12665513 15967991 8477450 12947314 15212693 11274345
MAPK3 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 15547943 20080742 14967450 12040186 15173823 12697810 11940578 16227978 12738796 16039586 9722592 17255949 15774499 15187187 19541618 19091303 19565474 17052211 11279232 9271440 18039929 18775330 10601235 12792650 11431469
MAPK3 DAPK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 17145710 25241761 15616583 26769850
MAPK3 ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8761310 23331499 12048211 11948414
MAPK3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10949034 18372406 15461668 9528769 12118371 14680484 17615152 15059947 16076840 7491495 12093745 15212693 15528270 7838153
MAPK3 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 27342992 23405013 18411303
MAPK3 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 17496910 18039929 19541618 21965663 20974802 19565474 15547943 12063245 12738796 11226259
MAPK3 BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 16.0 1.0 Omnipath 14654779 21478863 19541618 21135229 16508002 19933846 15664191 8621729
MAPK3 SMAD4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 28115363 12801888
MAPK3 PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10187842
MAPK3 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 18596912 11733495
HDAC1 MDM2 â—¼   PHYSICAL_INTERACTION 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   SHARES_COMPLEX 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
HDAC1 MDM2 â—¼   DOWN_REGULATES ✅ - 51.0 1.0 ACSN 10721693 11283614 11715018 11779693 11923280 12545156 12668723 14761977 15024084 15140942 15151915 15155580 15169778 15465827 15574337 15876864 16232121 17055429 17110379 17158541 17508028 17550342 17823410 19448627 19459846 20027199 20066118 20182602 20457558 20506250 20679392 20713526 20818389 21234400 21336307 21340684 21483453 21518799 21733352 21764762 2191300 21919891 22102694 22370643 22754780 22796940 23140366 23869868 6396087 9450543 9618481
ESR1 MDM2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 12897156 17166846 12750288 8324731 22787161 21169420 19578757
DAPK3 MDM2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15001356 11504915
MSH2 MSH3 â—¼   PHYSICAL_INTERACTION 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
MSH2 MSH6 â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 11307145 11948476 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 16879101 17129768 17303408 17395641 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261 23507534
MSH2 MSH6 â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 11307145 11948476 12556884 12947387 15136767 15703371 16332722 16612326 16697054 16713580 16858402 16879101 17129768 17303408 17395641 18157157 18406444 18543256 19151707 19473888 19595721 19596235 19596236 19847258 20478261 23507534
MSH2 MSH3 â—¼   SHARES_COMPLEX 20.0 1.0 ACSN 10882712 12947387 15703371 16612326 16697054 17036055 18157157 18406444 18469862 19473888 19595721 19596235 19596236 19686080 19772495 19805513 19847258 20478261 20655466 22101340
FGF19 PIK3R1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
FGFR3 PIK3R1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
PIK3R1 FGF23 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11353842 9632781 14534538 9182757
CRK PIK3R1 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10086337 10567412 10811803 10849428 10982827 11335727 11447289 11449354 11532940 11777939 12175651 12393695 12640133 15308668 15567848 15574420 16000375 16076871 16530705 16582911 16887996 17496910 17673906 18835194 19449109 19454690 22064427 22464172 24217602 25922287 26552706 8551221
STAT3 PIK3R1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11733515 24218138 23963458 15793565 16293640
KIT PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 9092574 17496910 1382595 11071635 25241761 24728074 7509796 7537096 12878163 10022833 16713569 7520444 17452978 9233773
JAK2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8702385 12706299 16135792 17474147
CDC42 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7629060 8034624 9381982
PTK2 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10806474 8649427 7537275 10973983 12554777 16713569 9416004 19889638
PTEN PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 16288286 10648629 17218262 12040186 15584861
IL7R PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9233603 7522165
PDGFRB PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 10752619 8564419 1372092 7486683 7692233 7536927 16713569 11710529 8382612 8086421 11896612 8670861 8388538 9153411 1330535 17496910 1314164 16135792 7680644 19864249 10697503 15377662
ESR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11029009 11689445 16169518 23065768 16713569
CRK PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10962563 35044719 25241761 19380743 12878163 25814554 11418612
FGFR1 PIK3R1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17496910 18412956 25241761 15117958
PIK3R1 FASLG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11741599 25241761 19807924
PIK3R1 CDC42 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 7629060 8034624 9381982
PIK3R1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 10962563 35044719 25241761 19380743 12878163 25814554 11418612
PIK3R1 PIK3CB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8596638 25241761 20713702 27107012 11733063 21825134 32814053 26496610 8139559 14729945 10358930 14665640
PIK3R1 PLCG2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17474147 25241761
GLI2 RBX1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 Reactome 15198976 19852954 20360384 21878643 19684112 9874371 16651542 15115751 19955409 20154143 20487519 20014402 20956384 19818708 16740475 24072710 14528312 23955340
NFKB1 RBX1 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
GLI3 RBX1 â—¼   PHYSICAL_INTERACTION 18.0 1.0 Reactome 15198976 19852954 20360384 21878643 19684112 9874371 16651542 15115751 19955409 20154143 20487519 20014402 20956384 19818708 16740475 24072710 14528312 23955340
RBX1 SKP2 â—¼   PHYSICAL_INTERACTION 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
RBX1 EPAS1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
RBX1 RELA â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9990852 10514433 9859996 9990853 7628694
RBX1 CUL2 â—¼   PHYSICAL_INTERACTION 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 CUL2 â—¼   SHARES_COMPLEX 21.0 1.0 ACSN 10973499 11900249 12351678 12648680 12820959 15340381 15459660 15652751 15688063 15703371 15721254 16697054 17884153 18420585 18931676 18985005 19622404 19622774 19686080 19809470 19847258
RBX1 SKP2 â—¼   SHARES_COMPLEX 17.0 1.0 ACSN 11900249 12648680 12820959 15071497 15147722 15340381 15459660 15688063 15703371 16697054 17884153 18931676 19270156 19622404 19686080 19809470 19847258
RBX1 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
RBX1 CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
SMARCA4 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9099865 18451880 11003650
SMARCA4 SMARCC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17145710 10078207 12917342 23540691 9891079 28420882
IL2RG STAT3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
KIT STAT3 â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT3 STAT5B â—¼   PHYSICAL_INTERACTION 11.0 1.0 Reactome 23073628 15790786 11369651 15007386 12481435 15526160 28403213 10358045 28192400 17546049 9355737
STAT3 JAK3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 11418623 12517932 12244150 27774606 12093291 12759422
FLT3LG STAT3 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10477595 14670306 15749884 16418395 16713974 17404308 20547845 25215878 8920882 9268501
IL15 STAT3 â—¼   ENZYMATIC_REACTION ✅ 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
IL2RG STAT3 â—¼   ENZYMATIC_REACTION ✅ 15.0 1.0 ACSN 10426994 11907067 12244150 12811837 15536084 16081783 16713974 16785506 19833085 20856220 21840487 23124025 24751819 7512720 7521688
JAK2 STAT3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 11867689 14610620 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
CSF3R STAT3 â—¼   ENZYMATIC_REACTION ✅ 12.0 1.0 ACSN 11867689 14610620 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
STAT3 FGF2 â—¼   ENZYMATIC_REACTION ✅ 33.0 1.0 ACSN 10347215 11875494 12193690 12223527 12907458 14607900 14670306 15218058 15356132 15465827 15573129 16418395 17404308 18776941 19380816 20093776 20237412 20406969 20435894 20580461 20581311 21372296 21765015 21840487 22461508 23124025 23390297 23454751 23953057 24857661 27216177 28186502 7543512
STAT3 FOS â—¼   UP_REGULATES ✅ + 38.0 1.0 ACSN 10347215 11528470 12223527 13130303 14607900 14670306 15218058 15356132 15573129 15810077 16418395 16716598 16831886 17403902 18297062 18776941 18832382 19380816 19412634 20093776 20237412 20406969 20581311 21317430 21840487 21883379 22006115 22943793 22945800 23124025 23454751 23953057 24857661 27216177 28186502 7543512 7768934 9278421
STAT3 CCND3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16084951 18310224 15184887
STAT3 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 17204573 14737107 12640143 12600988 11685114 8071311 15040450 16293640
STAT3 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 14647442 18835816 16407846 11278729 23954444 17967179 12168776
STAT3 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 19880237 26512963 15184887 15469392 16651438 18242580 16397018 21344490 20826784 24431073 15077160 12393476 19284568 17880940 17533050 17932422 22984561
ALK STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 17145710 10918587 9305919 8272872 12626508 16084951 15592455 23331499 12576423 11350938 11294897 14968112 12244095 9083098 8626374 9566874 11940572 11429593 14551213 11850821 15212693 9582023
MAPK8 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 66.0 1.0 Omnipath 23255093 17502367 21702955 19413330 11335711 9343414 23331499 15465816 12576423 11350938 20068231 12763138 9872331 18491316 18669648 10521505 18691976 20058876 15979846 14551213 10446219
JAK3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 23331499 10037026 23109003 11406370 12495636 16189514 12207328 10825200 12934099 18988627 30029643
MAPK9 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 20871632 18691976
JAK2 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 167.0 1.0 Omnipath 10918587 8272872 16319070 18718905 15592455 34066153 23166634 33986510 17389395 29162862 29449694 33512408 21098725 9083098 17565041 27748760 27344175 34031055 29290793 21285325 33846242 33774038 9566874 25962054 20826784 14551213 26188635 26008966 15284024 26175413 21481791 33774344 26307676 9305919 10925297 15615703 12626508 16497976 32087696 16469875 31914141 23331499 11350938 28978186 16306356 33824475 18988627 17401459 19147545 15151905 12637586 34433042 8626374 15950906 27181202 24793791 20455003 21575192 32094172 15322111 17016520 34247191 19901323 12626585 27086926 21166956 23906537 31976162 9211920 12576423 22306293 10207096 12075083 11294897 26787900 12244095 14701810 33909625 11803465 17360477 28827891 33820781 19159681 18939995 11445068 27941883 11429593 30054295 26675255 11850821 9582023 34067421 34707127 15786731 25986861 27351213 34118143 15077188 26699492 12595539 21071413 18498667 22153071 15156153 33513694 25915428 11940572 12529382 18525315 24501689 33839684 24316223 19834108 9575217
FGFR3 STAT3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 54.0 1.0 Omnipath 19901323 10918587 9305919 8272872 12626508 16497976 15592455 17389395 12576423 11350938 11294897 12244095 9083098 8626374 9566874 11940572 11429593 14551213 11850821 17016520 9582023
STAT3 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19345327 12057007 23335796 16713569 18448488
TADA3 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12034840 20413580 18089809 16713569
CUL2 EPAS1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
GNAI3 ADCY6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 23109003 15539636 7935349 16460834 11376933
FGF16 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16597617 25772309
FGF16 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16597617 25772309
ITGAV CRK â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 10837075 11146654 14697347 15031725 18353785 22035837 22470492 9295024 9763615
SP1 ITGAV â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10504395 23319049 12136940 23345412
COL4A1 ITGAV â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14610079
ITGAV PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 17.0 1.0 Omnipath 19889638 12844492 23397142 10545505 7657702 8636223 10022831 19339212 11927607 19161977 16919435 7529872 11553709 8755653 7512751
HGF CRK â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 10871282 12138161 11146548 10753869 10618718
PDGFRB CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 23331499 19426560 10733900 16713569 27686861
NTRK1 CRK â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7657647 8552402 12446789 7509449
CRK MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 25241761 11432831 10592173 16713569 16982329
CRK PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 29.0 1.0 Omnipath 7561682 25814554 12370821 20068231 11602246 10085298 12615911 7509446 7529876 17016520 11314030
FGF2 HGF â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11874475 18232728 18633355 18776941 19508171 19631971 21098712 22652804 23123598 25374926 9242465
SP1 HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9223667 17967179 12482909
PPARG HGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22472882 24569592 16291834 11292834
PDGFA PDGFRB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15207812 25737405 7679113
PDGFRB PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 34.0 1.0 Omnipath 17081983 7486683 2472219 16126727 15592455 7535778 16713569 23331499 1689310 11896612 15641795 16153436 16038803 23063561 1708307 7682059 15144186 12601080 1396585 8885868 8657103 8443409 23397142 15212693
PDGFRB PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10806474 20802513 16713569
ITGB1 PTK2 â—¼   ENZYMATIC_REACTION ✅ 14.0 1.0 ACSN 12731048 18037882 19161977 19454690 19487819 20644254 20814939 22067905 22470492 24202395 9003039 9456329 9763606 9973479
ITGB1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 8649427 21909923 8878413 10545505 7657702 9003039 19339212 19487819 19161977 16189514 16919435 7529872 19889638
PLCG1 FGFR3 â—¼   PHYSICAL_INTERACTION 7.0 1.0 Reactome 19147536 16091734 10652257 10918587 19749790 18337450 16844695
FGFR3 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17496910 12601080 17081983 16038803 1689310 1708307 7682059 15144186 8885868 16126727 15592455 8657103 16153436
JAK2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17474147 14978237
PRKACA PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 1370476 2479646
ALK PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 11888936 23331499 14968112 9174053
NTRK1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 10708759 23331499 1400471 8552402 9856458 21071413 8384556 10092678 25921289 18988627 1715690
FGFR1 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 32.0 1.0 Omnipath 17081983 20932831 1656221 16126727 15592455 9660748 19665973 7991458 1689310 8321198 8050374 16153436 17496910 25241761 16038803 10459043 23063561 1708307 7682059 15144186 12601080 9052794 8885868 8657103 15212693
PTK2 PLCG1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8660853 26278977 10430888 23397142
SMAD4 SP1 â—¼   PHYSICAL_INTERACTION 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 SP1 â—¼   SHARES_COMPLEX 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 GLI2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD4 FGF2 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD4 SP1 â—¼   ENZYMATIC_REACTION ✅ 47.0 1.0 ACSN 10454538 10964912 11007770 11013125 11013220 11074002 11114293 11279127 11283613 11283614 11376132 11792802 12545156 12702545 12809600 15001984 15095404 15155580 15265520 16179589 16713975 17055429 17550342 17705132 18353785 18768831 19815509 19901969 20027199 20713526 21042762 21098712 21252118 21614932 2191300 22331441 22652804 23140366 23338822 23784029 23869868 25374926 8515656 9312026 9389648 9618481 9670020
SMAD4 ETS1 â—¼   ENZYMATIC_REACTION ✅ 20.0 1.0 ACSN 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 8515656 9389648
SMAD4 HEY1 â—¼   UP_REGULATES ✅ + 22.0 1.0 ACSN 11074002 11279127 11792802 12702545 12809600 14976548 15265520 16179589 16713975 16831886 18768831 18832382 19208835 19597490 20731704 21042762 21317430 21614932 22331441 8515656 8893010 9389648
SMAD4 PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 21836474 21926264 16580992 12524424
SMAD4 LEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 10890911 21071413 18988627
SMAD4 FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 23331499 9732876 10942775
SMAD4 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 11013220 10454538 9670020 11283613 11074002 11283614
JAK2 IFNGR1 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 IFNGR2 â—¼   PHYSICAL_INTERACTION 42.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 IFNGR1 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 IFNGR2 â—¼   SHARES_COMPLEX 42.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 22003200 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
IFNGR1 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 23331499 11438544 15864272 17063185 23898330 12040185 7499845
JAK2 IFNGR2 â—¼   PHYSICAL_INTERACTION 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 CSF3R â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK2 IL2RG â—¼   PHYSICAL_INTERACTION 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
JAK2 IL12RB2 â—¼   PHYSICAL_INTERACTION 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 IL2RG â—¼   SHARES_COMPLEX 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
JAK2 IFNGR2 â—¼   SHARES_COMPLEX 41.0 1.0 ACSN 10485906 11489965 11579131 11777960 11867689 11870632 11964313 12413632 12811837 12818165 14607900 14610620 15634932 15778339 15811952 15814715 16286920 16424049 16713974 17016554 17559085 17683974 1825141 18272812 19833085 20038811 20406969 20819927 21149606 21411734 21840487 24091328 24658051 26755705 27216177 2965306 6425450 7512720 7521688 9834059 9864217
JAK2 CSF3R â—¼   SHARES_COMPLEX 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK2 IL12RB2 â—¼   SHARES_COMPLEX 18.0 1.0 ACSN 10807786 11867689 12244147 12372421 14610620 15546391 19833085 20406969 21042762 21115385 22077060 24091328 24204259 27216177 7543512 8683106 8700208 9834059
JAK2 CSF3R â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 11867689 14610620 18400509 19833085 20237318 20406969 20581311 21840487 22754783 24091328 27216177 7512720 7521688
JAK2 STAT6 â—¼   ENZYMATIC_REACTION ✅ 17.0 1.0 ACSN 11015446 11306493 11777960 11867689 12393492 12811837 14610620 19833085 20406969 20805416 21765015 22323450 22869907 23046136 24030977 24091328 27216177
KIT JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 8611693 7527392 15526160 9355737
IFNGR2 JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7901766 23331499 23898330 7514165 16381926
IL3RA JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 23331499 15988755 17312100 15795318
IL23R JAK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18988627 23331499 12023369
JAK2 ARHGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 25981295 20098430
JAK2 STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 23331499 9047382 21071413 12538627 26959975 24354892 16306356 18988627 12456798 9575217 11682625
JAK2 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9852261 23331499 18852293 22992805
ROCK1 PTEN â—¼   ENZYMATIC_REACTION ✅ 8.0 1.0 ACSN 10652353 11698448 12194823 12778124 19349987 20008297 22074495 27785353
PPARG PTEN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 18065496 16775433 16425225 23867870 20198337 11378386
ROCK2 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20008297 20351293 15793569 21642958
ROCK1 PTEN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 20008297 22074495 24867289 15793569 21642958 26460959 20351293
PTEN PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 9616126 15717329 10427092 23109003 10400703 10592173 9927060 23397142 11857088
DVL1 AXIN1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11336703 17529994 18077588 17569865
AXIN1 DVL1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
AXIN1 DVL1 â—¼   SHARES_COMPLEX 6.0 1.0 ACSN 10428961 16288291 16940750 19751508 22270359 8666229
CHUK AXIN1 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 11955436 11967263 12051714 12799363 23430059 7542250 8666229
CSNK1A1 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 11487578 11955436 11884395 12554650 8638126 19244247 15327768 10581160 10421629 12051714 17318175
LRP6 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 20128690 23331499 8666229 12897152 10428961 24976009 16890161 18632848 22682247 23959799 16340998 18988627 19107203
LRP5 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23331499 8666229 11336703 10428961 18632848 21071413 19075000
DVL1 AXIN1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 18.0 1.0 Omnipath 12556519 11278246 10862053 10330403 10330181 10428961 9482734 10196136 11027605 18339531
DVL1 LRP6 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
DVL1 FZD1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 17234765 18077588 14636582 22411803
GNB2 DVL1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 19561403
HDAC1 NCOR1 â—¼   PHYSICAL_INTERACTION 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 NCOR1 â—¼   SHARES_COMPLEX 4.0 1.0 ACSN 15465827 16127449 21234400 22796940
HDAC1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21655924 23242655 18316616 20101232
HDAC1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 11564889 11931769 16483679 30670829 16325585 16713569 17183360 21983014
HDAC1 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20081843 21234400
KIT KITLG â—¼   PHYSICAL_INTERACTION 15.0 1.0 ACSN 12490555 14623871 15099563 15337769 16510505 16831886 17093497 17550342 18524989 18633355 18832382 20731704 21199805 21317430 22406545
KIT KITLG â—¼   PROTEIN_INTERACTION 15.0 1.0 ACSN 12490555 14623871 15099563 15337769 16510505 16831886 17093497 17550342 18524989 18633355 18832382 20731704 21199805 21317430 22406545
SP1 KIT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 24008320 20833840 9834219
MITF KIT â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1999537 19067971 11174389 11076759 19937254
KITLG KIT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 38.0 1.0 Omnipath 17662946 1698556 7680037 12036870 7536489 25717186 26358753 17259966 1375232
KIT STAT5B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10358045
PPARG NCOR1 â—¼   PHYSICAL_INTERACTION 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
PPARG NCOR1 â—¼   SHARES_COMPLEX 11.0 1.0 ACSN 11399519 11875494 15644117 16127449 17260466 17681149 17689680 21234400 23390297 6357187 8871614
NCOR1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 20462215 17400812 12392082 10612426
NCOR1 PPARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 11.0 1.0 Omnipath 15870285 19955185 18292238 11903058 16713569 10336495 21775429
NCOR1 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 15175761 11877444 15604093 16127449 11903058 22078880 23703729 9121466 21775429 17468099
NCOR1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 16469706 12738788 12145334 17400812 16713569 21182203
RELA CXCL8 â—¼   ENZYMATIC_REACTION ✅ 7.0 1.0 ACSN 15079071 15536066 17550372 19171876 23430059 8383323 9743347
PPARG CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 19395102 18485432 20107546 20554962 16303327 20889551 15331599 12695526 15720834
RELA CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 129.0 1.0 Omnipath 12820969 24337575 15289496 9405619 9698090 20038977 15057743 21665565 24260304 10817569 14631383 10969814 15005855 19668231 16325549 19732956 8207232 18281166 27856305 23894194 9388261 26340924 10975857 10745031 20194077 10928981 16553947 17565687 16764699 22848596 15531761 16105834 16803583 9510190 15355994 18221537 12643600 20053934 11716760 8617886 12218154 12707271 23637609 27076634 8878392 17917246 12163591 16829531 16818736 14670967 12038622 15958549 18362169 8413215 19734226 23386688 11297551 15950427 17362989 16455661 27371733 11953364 8413306 18074095 11973337 18786178 19376732 19837667 17276517 15517885 11342414 18669446 7876168 15350531 14645117 22891766 18034886 11564889 12748173 17586662 18996370 15223809 17041011 12485925 16004996 15079071 21343296 26618242 18435575 17636245 22340043 19173296 24634218 11120852 10477716 21343177 12058956 17045242 19786024 24048734 24770886 10202011 18309103 11864912 21131967 19064995 10530453 12716652 16418726 28283022 18723827 17040605 21255844 15615716 17932106 19966855 20696864 15387324 21451502 15722553 15879558 12855659 12883201 15688424 18045535 10506755
FOS CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11973337 18317936 12218154 22095787 12748173 10969814 15005855 17586662 16818736 24048734 14686613 16846747 15057743 15615716 8999951 25567680 19173296
ESR1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 15208657 16029657 19440537 14991571 18669446 17932106
NFKB1 CXCL8 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 9510190 12058956 11973337 18786178 17045242 15289496 16701870 19376732 19837667 9698090 17276517 11512674 19786024 20038977 10202011 15057743 15517885 12643600 11342414 7876168 15350531 18034886 11716760 11564889 11864912 12218154 12707271 10969814 12748173 14631383 16325549 17586662 18996370 19732956 17041011 10530453 18281166 12716652 16418726 12485925 16004996 9388261 8878392 17917246 10975857 10745031 10928981 16553947 16818736 14670967 18435575 12038622 15958549 17040605 8413215 21255844 22340043 1401924 9452482 16764699 11297551 15950427 15387324 15879558 16105834 11953364 15688424 18074095 8413306 11096450 16803583 10506755 11120852 10477716
NFKB1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17553314 20126979 14739605 23838170
RELA BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17553314 20126979 14739605
LEF1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17005722 19620402 11517919 16288908 17063141
SP1 BIRC5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 17350596 17876054 21131823 18175117 20660371 22334592 22734486 21433308 22773958 21093004 19120021 17124180
NFKB1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 14563113 12655294 15160330 16770006 10671224
SP1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10075666 20617570 11254710 11053446 14563113 10754388 18293083 15659839 11970950 12655294 17192273 11745351 15173177 15004200 10671224
ETS1 FASLG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20617570 11970950
DAPK1 DAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 15611134 15367680 18239682
CHUK RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
CHUK NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
CHUK TRAF4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 22547678
CHUK CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 21674813 17145710 14597638 17434128 22435559 12789342 27220480
CHUK RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 49.0 1.0 Omnipath 17145710 15611276 22110409 19609947 10521409 20863851 20051109 20363318 12767944 26999213 12842894 21903422 19110719 15858576 16382138 22155370 23894194 16046471 15128824 21569639 16846590 8246997 15485852 25341660 15494311 11983155 15980040 15489227 15849198 14636585 23343355
CHUK IKBKB â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 91.0 1.0 Omnipath 9346484 24911653 20932476 28514442 11971985 16970925 12210728 9346485 17965022 16713569 12486103 9891086 15456791 11057907 20434986 16129692 16260493 21903422 21724995 16286467 14743216 16319058 18949366 10779355 25748427 25852190 12244103 11585904 9751060 15218526 10094049 10837071 9914500 21575199 9721103 25241761 10195894 9689078 15214841 21784860 17561400 21640763 16285893 10733566 16186825 16493424 10022904 12709429 12351658 10968790 12547194 15691841 15620648 15327770 11864612 11460167 14636585 17693255 17072322 9346241
CHUK NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 39.0 1.0 Omnipath 12482991 19442713 14743216 15494311 11976329 15489227 16382138 16713569 10022904 10469655 27554194 11158290 11297557
CHUK NFKB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 17145710 16970925 11520989 15310758 16793322 28829404 12387745 26999213 18617892 14743216 15218526 15140882 15214841 17561400 15084608 15371334 16285893 22388891 15145317 29907126 26462035 11239468 17072322
NFKB1 RELA â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
PRKACA RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
IKBKB RELA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
RELA IL2 â—¼   ENZYMATIC_REACTION ✅ 16.0 1.0 ACSN 10679398 12133954 12759422 14668329 15079071 15536066 17145890 17404308 17550372 19171876 20138012 21224476 23430059 8383323 8580069 9743347
SP1 RELA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 7636984 8450395 9151857 20538607 11964305
RELA IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 27.0 1.0 Omnipath 12820969 14688340 20221401 11058167 10657616 10940886 19122653 18690006 11792125 19624579 17982049 9464836 17924060 7565674 14976188 15251981 12077291 17579043 24012417 19299558 16166378 12517966 17635610 24184907 15270850 20876114 9808189
RELA IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 7623820 8814256 22427656 9417120 9605137 15477007 9111330 21832163 9135552 8383323 8934574 11035116 7730629 16275766 9737979 19968887 28199730 1604322 15585831 8977179 12027419 18045535 18207244 17179947 23578476 15710339 9233628 11145913
RELA NFKB2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 9056676 9528780 15755876 7541912
RELA TRAF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 19343319 17673602 14991743 19383900 17018379 9733827 9733516 10823821 11297551
RELA BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 18.0 1.0 Omnipath 15231833 15050749 19343319 17673602 18226221 23250755 17000776 11880364 21279667 21765477 10733571 18566231 12010810 15723831 10823821 11297551 16291753
RELA NFKB1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 16778171 20427719 23362108 16513645 1740105 20596645 16513841 19469019 8454856 21420936 16135789 9417120
RELA IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 14568984 17982049 17579043 20876114 19122653 22070873 18690006 19164128 19185846
NFKB1 RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 88.0 1.0 Omnipath 17145710 16209943 25609649 8428580 12947093 16970925 17072323 2050119 15657065 21270162 11976329 16793322 21544861 22261743 8657102 9824778 11880271 9450761 17962807 21988832 25355951 9722548 18215660 14743216 15799966 10799898 16105840 15218526 8798655 14690596 22139845 22808155 11571291 17072327 16740634 10498867 8255759 8246997 15214841 16846590 15371334 16285893 17072322 17855547 18321863 16493424 7479976 15145317 17561400 20110362 9426183 23687337 12414801 11970949 20154269 20237821 24175631 24634218 34100597 14645533 17982102 21763497 16204234 9437432 20547752 15818410 7628694
CREBBP RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 42.0 1.0 Omnipath 10542243 14597638 18241676 17138826 15140884 9096323 16713569 12456660 10454579 16382138 19608861 9806899 25314079 11931769 12163591 12881425 9659924 15171256 9548485 16291753 17362989 25733689 17434128 15334063 15806143 10235267 17296604
IKBKB RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 135.0 1.0 Omnipath 15280197 17785205 27329558 22110409 22753932 22205033 21765477 15611068 18519641 15858576 25241761 33579825 23536830 28122346 19393267 34556881 24442433 14560022 15192014 21242976 16840782 19609947 33789981 10521409 26826124 21492457 19110719 23303310 16105840 22212641 26587973 34219129 15210811 16046471 11359840 27626700 15128824 28416608 17178723 21674813 17362989 28737909 19377466 15980040 16407239 15849198 20507904 26082493 15557193 34082140 21798539 26267322 29363544 12767944 20224721 26307684 12842894 17108032 26170389 24336331 27315556 31980577 11259436 34380537 20872791 21674474 15465828 15994321 17548605 26603838 16148147 25136068 33914760 26569329 22234699 17012367 14636585 22039465 32123095 15212693 27466442 33883226 15611276 22081069 19197368 17070014 20051109 26693062 14963024 33971703 28381553 33459422 27244888 18544167 18922932 20188669 15485852 20696864 22689577 17982102 20410276 15489227
PRKACA RELA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 11931769 15833743 9150141 17959673 9660950 16135789 12628924
RELA SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12055073 7933095 10671503 20861353
IL2 IL2RG â—¼   PHYSICAL_INTERACTION 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RG IL15 â—¼   PHYSICAL_INTERACTION 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
IL2RG STAT6 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9651359 7796300 23124025 15805299 8085155
IL2 IL2RG â—¼   SHARES_COMPLEX 26.0 1.0 ACSN 10807786 10820393 10849428 12095053 15289500 15563472 16212621 16799562 17371980 1825141 18758473 19528259 19833085 20856220 21840487 22224781 23124025 23650441 24829413 26755705 2965306 6164929 7512720 7521688 8683106 9625766
IL2RG IL15 â—¼   SHARES_COMPLEX 19.0 1.0 ACSN 10820393 12811837 14607946 16212621 16815076 17398124 17459805 19833085 19913445 20007590 20856220 21307131 21840487 23124025 24829413 25582338 7512720 7521688 7523571
IL2RG STAT6 â—¼   ENZYMATIC_REACTION ✅ 32.0 1.0 ACSN 10485906 11160275 11371360 11867689 11870632 12223527 12401408 12496409 12818165 14610620 16243976 16413922 17404308 17485448 18250477 1825141 19833085 20184663 20406969 20510870 20856220 21469115 21840487 23124025 23390297 24030977 24091328 27216177 2965306 7512720 7521688 9834059
IL2 IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 53.0 1.0 Omnipath 15265897 16477002 10807786 19528259 19833085 7521688 17371980 8049354 15563472 18758473 10662798 15289500 23331499 26755705 8683106 23180781 12095053 11418623 6164929 9625766 24829413 1825141 8006584 16799562 7829965 8568232 10820393 7512720 23650441 20856220 7681595 10849428 22224781 1631559 16212621 21840487 26192618 2965306 8260650 23124025
IL15 IL2RG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 8568232 9371812 15265897 1526589 10903799 8026467 19710453 11418623 16189514 8178155 78568232
IL2RG JAK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 23331499 7973658 7973659 18445337 10856136 16189514 10629052 15621723 7973657
PPARG STAT6 â—¼   PHYSICAL_INTERACTION 10.0 1.0 ACSN 10432118 10485906 12223527 12244147 14610620 15634881 17681149 21093321 23124025 24204259
PPARG STAT6 â—¼   PROTEIN_INTERACTION 10.0 1.0 ACSN 10432118 10485906 12223527 12244147 14610620 15634881 17681149 21093321 23124025 24204259
PPARG STAT6 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 10432118 10485906 12223527 12244147 14610620 15634881 17681149 21093321 23124025 24204259
PPARA PPARG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 12941763 16226723 20706641 17261671 18769491
PPARG MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19046432 19296842 11869069 15090544
PPARG SP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16269451 15111490 15908479 11777901
PPARG IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 19217272 16611855 10671476 15187132 11726648 19712756
PPARG AGTR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 20890053 11416035 11409645 16938288 22282354
NCOA2 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23331499 11500849 9238002 17513608 21071413 15026545 18988627 18584035 10944516
MAPK8 PPARG â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 9030579
PPARG RXRG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 12615696 16189514 18988627 15130092
IL15 IL12RB2 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 7523571
IL15 IL2 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 7523571
IL15 SP1 â—¼   ENZYMATIC_REACTION ✅ 13.0 1.0 ACSN 10426994 10952726 11907067 14607946 15536084 16713974 17398124 17459805 19913445 20007590 21307131 25582338 7523571
IL2 IL12RB2 â—¼   ENZYMATIC_REACTION ✅ 21.0 1.0 ACSN 10807786 11280761 11460167 14660645 15289500 15563472 17301840 1825141 18264787 18758473 19528259 21133840 21232017 22224781 23650441 24699077 24958845 26755705 2965306 6164929 9625766
IL12A IL12RB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11086056 943050 8943050
IL12B IL12RB2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 11086056 8943050 1108605611940480 11940489
ETS1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 7876544 9780181 24019486
NFKB1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 26.0 1.0 Omnipath 17641034 1777483 7623820 7744006 8834450 15477007 8254209 9111330 9135552 8383323 11035116 7730629 15079071 2848811 9737979 1707162 19968887 7957556 1604322 8977179 12027419 17491020 18207244 8814256 9233628 11145913
RUNX1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 17466384 22253733 17377532 21292764
SP1 IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 10656874 12560487 9175624 9756940 8814256
FOS IL2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 20557936 8893011 11260070 11685114 8397339 1737937 9605137 9590239 11262396 7989759 1916630 8473495 10601992 8114694 22474330 18725523 9233628 11385624 2518655 15170389 8468462 7565732 12432566 8660843 7739550 1305903 20680391 19181930
ARNT CREBBP â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 11959990 11063749 7836384 11959977 9632793 17804822 9822602 10202154
CREBBP LEF1 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 10769018 11050151 18160704 15060161 11973335 10775268
SP1 CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 23297421 20096088 9765204 21191649 21464950 12200429 20130956 12169688 15576380 15184875 15713621 18571793
NCOA2 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 17145710 15657427 15987788 9192892 9430642
CREBBP STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 11509556 15695802 11574547 10454341
CREBBP ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 9192902 18765668 16417649 11113179 8616895 11782371 14766010 17400812
CREBBP NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17145710 15657427 15987788 9192892 9430642
CREBBP STAT2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 17923090 28707474 10464260 8848048
IL3 IL3RA â—¼   PHYSICAL_INTERACTION 13.0 1.0 ACSN 11698286 12393492 15034038 15549123 15573129 17200410 18633355 22323450 23026134 23046136 23125331 23762788 24778133
IL3 IL3RA â—¼   SHARES_COMPLEX 13.0 1.0 ACSN 11698286 12393492 15034038 15549123 15573129 17200410 18633355 22323450 23026134 23046136 23125331 23762788 24778133
RUNX1 IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 11997340 9036972 20506188 15735013 10023677 8180380
ETS1 IL3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 8704203 12387738 25861992
IL3 IL3RA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 23331499 11700046 8649415 9278420 7957082 1465408
CCNE2 SKP2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 16209941 10375532 15199159 11231585
SP1 SKP2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16969077 16883603 19329185
SKP2 CCNE1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 11237742 12648680 11900249 16697054 18931676 19809470 15459660
SKP2 CCNE2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 19847258 19686080 19270156 17884153 19622404 15703371 12648680 11900249 16697054 18931676 19809470 15459660
LRP6 FZD1 â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 11448771 11029007 15459103 12205098 22000856 22653731 11357136 15084453 23256519 23791946
CSNK1A1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 25301071 23331499 21887268 16890161 27821587 14731402 24794231 25735981 20229235 16341017
CDC42 MAPK8 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 25241761 12213839 25284480 18426980 10930450
ROCK1 PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 9182576 22348083 16254240 15247219 16760434 10744763 17745990 7529876 12960434
ROCK1 DAPK3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15611134 25769953 17158456 16325270 20854903 18239682
SHH HHIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 1005085510050850 19561609 10050855
GLI3 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 21234400 20562908 9216996 19032343 12435627 16406505 19114989 16880536 16054035 11001584 17000779 16169709 16413481 15087129 16396903 19809516 20107231
CSNK1A1 GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 21233202 7641885 16611981 17419683 21536646 19797085 18455992 16371461
PRKACA GLI2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 16611981 20027184 16885213 17419683 19056373 19996099
GLI2 HHIP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 24.0 1.0 Omnipath 18813803 16880536 19190345 18698484 15087129 17845852 19049965 11001584 20107231 20712011 15520176 16406505 17000779 16413481 16571352 16396903 9609833 18497536 14555646 9216996 11493558 15140221 16054035 20143239
ESR1 EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 10894157 15075211 20889718 8770893 19423651
SP1 IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16518544 20121399 15270850 19134014
SP1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16740727 7585542 15831516 9626663
SP1 PDGFA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 15297375 9453298 9321833 9351401 22964636 7499234 10364563 11823426
SP1 CCND2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 11160217 9339900 19753117
SP1 PRKACA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 12759366 16574895 16790435 9458366 9415398 12169688 10949931 12694408 11562358
SP1 ESR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 12237165 19351845 11345900 21235772 23209644 12429135 18006846 10982795 22622808 15691879 21191649
SP1 AGTR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 19129260 23475749 11416035 18443233 11072083 11779634 22282354 15507319
SP1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17626239 10082538 9528985
SP1 CDKN2B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10649433 16298343 11804592 11013220 20121949 7592908 21872590
SP1 PRKCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 19145069 11327698 12105191 11578973 12727210 17257588 15533438 18295514 11336542 9756852 17509747 20092859 12694408 19464346 11060301 15380450
SP1 CTH â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22360859 22244329 16230075 21659522
MAPK8 SP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 28831131 22266860 18199680 19245816 25398907 17570479
SP1 CDKN2B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 9389648 11013220 10454538 9670020 11283613 11074002 11283614
ETS1 MMP1 â—¼   UP_REGULATES ✅ + 27.0 1.0 ACSN 10048576 15001984 15003528 15111329 15181457 16079281 16391805 16556862 16682805 17615296 17872466 18337545 19208835 19564415 20589835 21041997 21081489 21317430 22439866 22608498 23691193 24376839 7512751 7528107 8844971 9157999 9811054
ETS1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 9349499 8262053 1722028
ETS1 IL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 17845581 25861992 10212281 16373364
ETS1 MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 23060436 21244711 20826544 15247905 11829472 17283078 16278291 11556732 17214640 15972796 16317516 10949659 11830328 9178763 16569638
ARNT ETS1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17615296 9157999 9278421 11708773 16716598 12080085 10403805 16887934 15181457 7539918 12490555 1823643 12829734 13130303 15451019 9746763 8943284 15111329 9159130 11566883 21041997
ETS1 MMP1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10048576 16391805 17615296 15111329 9157999 19208835 21081489 21041997 15181457
FGF2 FGFR1 â—¼   ENZYMATIC_REACTION ✅ 11.0 1.0 ACSN 11874475 18232728 18633355 18776941 19508171 19631971 21098712 22652804 23123598 25374926 9242465
FGF2 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 22298955 16597617 866304410574949 9045692 15780951 10574949 8663044 25772309
FGF2 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 41.0 1.0 Omnipath 17145710 15096041 8868466 10490103 16597617 11030354 23597562 1722683 14613973 17086194 14505356 9174056 7730326 25772309 11786412 16829530 10950949 23597563 10574979 26267536
FGFR1 FGF23 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 1379698 16507368 8622701 11294897 17086194
FGF23 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 27879395 19966287 16597617 16081635 22393163 25772309
FGF5 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 16597617 83868288386828 8386828 25772309
FGF19 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22442730 16597617 25772309
FGF18 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10751172 16597617 25772309
FGF20 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 31276493 16597617 25772309
FGF17 FGFR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 10751172 16597617 25772309
ESR1 FOS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 8114761 9528985 18414489 10037443 21813366 11726205
FOS IL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 15271374 12452838 17845581 16373364
FOS MMP1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11665970 19028685 9334186 16380175 10914841 15090544 20463008 15467742 10684971
FOS NQO1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 8375015 8065332 8962164 9058597 8004128
FOS PRKCG â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 8917435 11698596 7942278 8504741
FOS IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19285436 15187114 15270850 14688340 25567680
PRKACA FOS â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 9920881 20068231 18452278 8248197 1545828
IKBKB NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 9315679 9914500 9721103 10593898 9135156
PRKACA NFKB1 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17462920 12628924 19197368 19122653 18385332
NFKB1 BIRC3 â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 ACSN 21725609 23178297 23572150 9294162 9733516
NFKB1 BIRC3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15231833 15050749 19343319 17673602 17000776 11880364 10733571 9733516 18566231 12010810 15723831 10823821 11297551
NFKB1 IL12A â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 14568984 11602633 17982049 17579043 15871905 18690006 19164128
NFKB1 IL12B â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 20.0 1.0 Omnipath 14688340 11058167 10657616 10940886 18690006 11792125 17982049 9464836 17924060 7565674 14976188 9234715 12077291 9497375 17579043 19299558 22427889 16166378 15270850 9808189
NFKB1 TRAF1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 19343319 17673602 14991743 17018379 9733827 9733516 10823821 11297551
IKBKB NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 57.0 1.0 Omnipath 31598684 11976329 16713569 10469655 29485707 26999213 12842894 10835356 27187478 27402796 18782567 27554194 12482991 25241761 10022904 15199157 19519322 15489227 19250910 15212693 11158290 11297557
PRKACA NFKB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 19531803 12947093 17959673 15642694 15197457
CDKN2B CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 21.0 1.0 Omnipath 25910212 23455922 26186194 23602568 7478582 19447967 16169070 31515488 16189514 32296183 26496610 9111314 9042862 9163429 21900206
CCND3 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 43.0 1.0 Omnipath 11896535 25416956 16985050 34591612 21988832 14597415 17517622 16782892 10342870 21516116 23880157 15232106 16189514 11360184 26496610 25910212 26186194 27107012 10477583 19237555 32296183 14641107 9106657 9508775 31515488 9716181
CCND2 CDK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 25910212 17517622 27107012 11896535 10477583 9325318 31515488 16189514 32296183
FGF17 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 10751172 16597617 25772309
FGF20 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16597617 25772309
FGF23 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 16597617 12032146 25772309
FGF18 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15781473 10751172 16597617 1578147310751170 25772309
FGF19 FGFR3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 16597617 25772309
MAPK8 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 27.0 1.0 Omnipath 8846788 20506250 8654373 20028971 23331499 17875713 16393692 10637505 26538579 8586671 9501095 26370088 7889942 19436832 7651411 11274345
MAPK9 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 9130707 20506250 8846788 8654373 20028971 17875713 16393692 26538579 11145955 11309409 8887554 26370088 8548291 15782123 8262053 19436832 12665513 12947314 11274345
MAPK10 ELK1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19436832 20506250 16393692 8654373 20028971 11274345
STAT6 JAK3 â—¼   PHYSICAL_INTERACTION 5.0 1.0 Reactome 9651359 7796300 23124025 15805299 8085155
STAT6 IL5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20608912 21276008 11120785 16393972
MAPK8 STAT6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21123173
RUNX1 CSF1R â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 16007221 17589498 9209363 8577711 8585955
DCC PTK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 15494733 29479476 20434207 15494734
GNA13 ARHGEF12 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12515866 11094164 12024019
ESR1 GNG2 â—¼   PHYSICAL_INTERACTION 4.0 1.0 Reactome 11689445 27288742 11369763 25587652
GNB2 PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 1465133 9307019 8387502 1465134 8306983
GLI3 PRKACA â—¼   ENZYMATIC_REACTION ✅ 5.0 1.0 Reactome 17283082 16705181 20154143 16371461 16611981
PRKACA GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 9.0 1.0 Omnipath 16481469 23331499 20027184 17419683 10693759 19996099
PRKACA ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 22266331 9891036 15193262
PRKACA BRAF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 11510412 10931830
PRKACA GNA13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 12399457
PRKACA PLCB3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 28615442 9660757 10893237
PRKACA RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 16769902 7476969 20215566
LEF1 CCND2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
LEF1 CCND3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 10.0 1.0 Omnipath 17666529 23343194 21285352 18974774 22761862 22290435 16039586 19619488 19623618 17143292
GNAQ PLCB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 11753430 1309799 12193606 16754659 8245028 8387502 1322796 1846707
ESR1 RARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 8300756 8912864 8732679 11038749 15831516 15870697 10076999 9626663 18414489
RPS6KB1 ESR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 29128895 23242584 22114931 23460185 19925796 19112174 7838153
ESR1 NCOA2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 18499756 9192892 9430642 11014206 19460354 15657427 23331499 11477071 26487511 16645043 12612084 20348541 12630920 14766010 17697320 11937504 12714702 12554772 9774463
ESR1 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 23331499 17641689 15831516 9717844 9841885
MAPK8 RPS6KB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 21988832 17570479 11279232 23816567
BCR STAT5B â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 21330321 14660670 17698633 10935490
F2R GNA13 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 8290554 20223821 10922491 16189514 22318735 22972936 21331223
GNA13 ARHGEF1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 14607242 9641916 9641915 16189514 12681510
MAPK8 STK4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 27042197 20028971
MAPK8 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10383391 15657432 21272161
GLI3 CSNK1A1 â—¼   ENZYMATIC_REACTION ✅ 4.0 1.0 Reactome 16371461 20154143 21921029 16705181
CSNK1A1 GLI3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 21233202 7641885 16611981 21536646 19797085 18455992 16371461 11955435
NCOA2 RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12612084 20543827 23331499 9192892 9430642 16713569 12503607
RXRG RARA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 22.0 1.0 Omnipath 21988832 25910212 25303530 23331499 20211142 15604093 21071413 10529278 21516116 25416956 31515488 16189514 32296183 16713569 18988627 29892012
AGT AGTR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 23.0 1.0 Omnipath 12006574 21464395 10193788 10993080 16189514 15930094 9797979 16597412 17346243
LEF1 MITF â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12032083 12048204
JAK3 IL7R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 15996891 20167604 7481769 27423467 10781830 22551764
JAK3 ALK â—¼   PHYSICAL_INTERACTION 10.0 1.0 Reactome 16939498 16153455 18097461 15317731 16825495 11850821 19459784 16170336 12934099 16871283
ALK SHC3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12185581 23331499
PPARD PPARA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 18445701 19483106 11867749 16288226
PPARA RXRG â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 22205725 23331499 16169070 15130092
F2 F2R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 28.0 1.0 Omnipath 9058715 10978167 15707890 10644723 14652070 11356985 23450633 18250335 12563219 22972936
ELOC EPAS1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
IL12A IL12B â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 17145710 10779781 10899108 8943050 7527811
IL12B IL23R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 12023369 17587057
DLL4 NOTCH4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 19.0 1.0 Omnipath 23331499 1621980212814940 12814948 10837027 16219802 18988627 22353464