Protein list:

Seperate proteins by space | Example

Select nodes using shift click or drag to add to this list
Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
Graph tools:

Note this may take some time with > 30 proteins
Filter Graph:

0.5
Layout:
  🔂

Click a node or edge for more data...
Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
LGR5 RNF43 â—¼   PHYSICAL_INTERACTION 800.0 0.8 STRING 36370105
TCF4 LGR5 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21436631
RSPO1 RNF43 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 23756651 29405118
LGR5 RSPO1 â—¼   PHYSICAL_INTERACTION 803.0 0.8 STRING 36370105
LGR5 RSPO2 â—¼   PHYSICAL_INTERACTION 849.0 0.84 STRING 36370105
RSPO1 ZNRF3 â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
ZNRF3 RSPO1 â—¼   PHYSICAL_INTERACTION 0.9 0.9 HIPPIE 24165923 25504990 29752411 24050775 22575959
ZNRF3 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 23151663 22575959 36131013
FZD5 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12857724 18077588
LRP6 RNF43 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23847203 20495530 22575959
RNF43 RSPO1 â—¼   PHYSICAL_INTERACTION 905.0 0.9 STRING 36370105
LGR5 ZNRF3 â—¼   PHYSICAL_INTERACTION 927.0 0.92 STRING 36370105
RSPO2 ZNRF3 â—¼   PHYSICAL_INTERACTION 987.0 0.98 STRING 36370105
RSPO1 ZNRF3 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 15.0 1.0 Omnipath 24165923 25504990 23151663 24349440 22575959 29405118 24050775
RSPO2 LGR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 29769720 2169364621693640 21693646
RSPO3 LGR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 21693640 29769720 21693646 29405118
LGR5 RSPO3 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 16357527 17400545 22575959 21909076 21727895 16109882 21693646 17804805
RSPO1 LGR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24349440 2169364621693640 21693646
RSPO4 LGR5 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 2169364621693640 21693646
LGR5 RSPO4 â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 16357527 17400545 22575959 21909076 21727895 16109882 21693646 17804805
RSPO1 LRP6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 17804805 17976036 18400942