DDIT4
|
TSC2
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
2.0
|
0.8
|
ACSN
|
18198340
19557001
|
DDIT4
|
TSC1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
2.0
|
0.8
|
ACSN
|
18198340
19557001
|
DVL2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20156660
27107012
|
LPIN1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
PIK3CA
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
GRB10
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
GRB2
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
20156660
27107012
|
MAPK3
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
MAPK1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8994038
|
RAF1
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK1
|
RPS6KA2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12832467
16626623
|
MAPK1
|
RPS6KA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12832467
16626623
|
MAPK1
|
RPS6KA3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12832467
16626623
|
MAPK1
|
MAP2K1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
23241949
8412360
|
RPS6KA1
|
MAPK1
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
29997244
20178071
|
PRKCB
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8903320
10327068
|
RAF1
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20674547
15664191
|
MAPK3
|
RPS6KA1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12832467
16626623
|
MAPK3
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
MAPK3
|
RPS6KA2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12832467
16626623
|
MAPK3
|
RPS6KA3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12832467
16626623
|
MAPK3
|
IRS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
7739560
8816480
|
PRKCB
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8903320
10327068
|
MLST8
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12087098
9465032
|
MTOR
|
PDPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5214238
11438723
|
MTOR
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5214238
11438723
|
SGK1
|
MTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
20338997
18925875
|
EIF4E
|
MTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12150926
15809305
|
AKT1
|
MTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
17611497
18954143
|
MTOR
|
EIF4EBP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12150926
15809305
|
MTOR
|
RPS6KA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15060135
|
MTOR
|
CLIP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12231510
|
PIK3R1
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.8
|
0.8
|
mint
|
6730400
7589433
|
PIK3R1
|
SOS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PIK3R1
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17474147
8109998
|
PIK3R1
|
INSR
|
â—¼ PROXIMITY
|
|
|
2.0
|
0.8
|
intact
|
6731120
10500481
|
RRAGD
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
20006481
18497260
|
DEPDC5
|
SESN2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25819761
26449471
|
SESN2
|
KPTN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25819761
26449471
|
SESN2
|
ITFG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25819761
26449471
|
SESN2
|
KICS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
25819761
26449471
|
INS
|
SGK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
28106162
22842983
|
STRADA
|
CAB39L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
14517248
12805220
|
STRADB
|
CAB39L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
14517248
12805220
|
TNF
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
21887257
19287455
|
FZD7
|
WNT5A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
20457807
24865425
|
WNT8A
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
10097073
|
ATP6V1G1
|
ATP6V1E1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16169070
5217955
|
WNT9A
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23209147
15578921
|
WNT9A
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23209147
15578921
|
TSC2
|
TSC1
|
â—¼ COLOCALIZATION
|
|
|
2.0
|
0.8
|
intact
|
6547838
9580671
|
RPS6KA2
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15342917
|
TSC2
|
MAPKAP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
18411301
29497474
|
RICTOR
|
PRKCA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
18566587
6948588
|
PTEN
|
PDPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
11943559
23331499
|
PTEN
|
AKT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
10644997
|
RAF1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
19197339
7014125
|
HRAS
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
108050
32814053
|
HRAS
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
9069260
21779497
|
FZD4
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
27096005
19388021
|
FZD2
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23151663
19388021
|
FZD3
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
22944199
19388021
|
CHUK
|
IKBKB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
ACSN
|
12799363
23430059
|
CHUK
|
IKBKB
|
â—¼ PROTEIN_INTERACTION
|
|
|
2.0
|
0.8
|
ACSN
|
12799363
23430059
|
CHUK
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12351658
|
EIF4B
|
RPS6KA1
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
5218723
16763566
|
PDPK1
|
RHOA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12783890
10753910
|
DVL2
|
RHOA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
11779461
18162551
|
RHOA
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
15884057
11748077
|
LRP6
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
ACSN
|
16273260
23371553
|
LRP6
|
DVL2
|
â—¼ SHARES_COMPLEX
|
|
|
2.0
|
0.8
|
ACSN
|
16273260
23371553
|
WNT7A
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12857724
15578921
|
WNT10B
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23209147
15578921
|
WNT10B
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19008118
12055200
|
WNT6
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12857724
8717036
|
TBC1D7
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17658474
|
GSK3B
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
15972957
16959574
|
AKT2
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
12150915
12172553
|
AKT3
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
12150915
12172553
|
PDPK1
|
PRKCB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12840507
9889098
|
PDPK1
|
PRKCA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
2.0
|
0.8
|
Reactome
|
12840507
9889098
|
PDPK1
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
29312296
16207722
|
INS
|
IRS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9609109
15316008
|
PIK3R3
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
0611271104
17360667
|
IGF1R
|
GRB10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
6547677
9506989
|
IGF1R
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17496910
7541045
|
IGF1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19183465
12875741
|
IGF1
|
INSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23518924
32196115
|
RPS6KB1
|
AKT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
5214238
11438723
|
BRAF
|
PRKCA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16810323
5218785
|
PRKCA
|
RPS6KA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16810323
5218785
|
INSR
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
8567177
8385099
|
INS
|
GRB10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
12493740
14615605
|
PIK3CA
|
GRB10
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
31066629
23246379
|
LAMTOR2
|
ATP6V1B2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
25567906
1257132
|
RPS6KB2
|
RPS6
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
16810323
5218785
|
RPS6KA2
|
RPS6
|
â—¼ PHOSPHORYLATION
|
✅
|
|
2.0
|
0.8
|
intact
|
16810323
5218785
|
RPS6KA3
|
RPS6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
17360704
|
NPRL2
|
KICS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
29123071
28199306
|
NPRL2
|
ITFG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
29123071
28199306
|
NPRL2
|
KPTN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
29123071
28199306
|
PIK3CD
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
PIK3CA
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
RPS6KA2
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16810323
5218785
|
SLC38A9
|
LAMTOR5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
25561175
25567906
|
RRAGC
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
16189514
5217968
|
RRAGA
|
RNF152
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
21203937
25936802
|
LRP5
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
2.0
|
0.8
|
Omnipath
|
21606194
|
PIK3CD
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
9885561
10455108
|
FNIP1
|
FLCN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
17028174
0603781103
|
NPRL3
|
KPTN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
29123071
28199306
|
NPRL3
|
KICS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
29123071
28199306
|
NPRL3
|
ITFG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
29123071
28199306
|
PIK3R2
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
19531499
9651378
|
ATP6V1G2
|
ATP6V1E1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
intact
|
14667819
5216829
|
WNT5B
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
26849959
20093360
|
WNT9B
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23209147
15578921
|
WNT4
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23331499
14671310
|
WNT5A
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
2.0
|
0.8
|
Reactome
|
19910923
19582886
|
WNT2
|
FZD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
24032637
|
WNT2
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23209147
15578921
|
WNT2B
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23209147
15578921
|
WNT10B
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23209147
15578921
|
WNT6
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
23209147
15578921
|
WNT5B
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16273260
15578921
|
WNT11
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
2.0
|
0.8
|
Omnipath
|
16273260
15578921
|
WNT1
|
LRP6
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.8
|
0.8
|
Signor
|
21078818
|
SOS2
|
HRAS
|
â—¼ GTPASE_REACTION
|
✅
|
+
|
0.8
|
0.8
|
Signor
|
21779497
|
TBC1D7
|
TSC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
802.0
|
0.8
|
STRING
|
36370105
|
MLST8
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
803.0
|
0.8
|
STRING
|
36370105
|
MLST8
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
803.0
|
0.8
|
STRING
|
36370105
|
CAB39L
|
STK11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
805.0
|
0.8
|
STRING
|
36370105
|
IGF1R
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
806.0
|
0.8
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
807.0
|
0.8
|
STRING
|
36370105
|
IRS1
|
RPTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
16354680
19561084
30240640
|
EIF4E1B
|
EIF4EBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.81
|
0.81
|
HuRI
|
32296183
|
NPRL2
|
WDR59
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.81
|
0.81
|
HIPPIE
|
28199306
23723238
28199315
|
NRAS
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.81
|
0.81
|
mint
|
34591642
|
NRAS
|
BRAF
|
â—¼ PROXIMITY
|
✅
|
|
0.81
|
0.81
|
mint
|
30194290
|
RPS6
|
RPS6KB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
810.0
|
0.81
|
STRING
|
36370105
|
FLCN
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
814.0
|
0.81
|
STRING
|
36370105
|
FLCN
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
816.0
|
0.81
|
STRING
|
36370105
|
SEH1L
|
WDR59
|
â—¼ PHYSICAL_INTERACTION
|
|
|
816.0
|
0.81
|
STRING
|
36370105
|
LRP6
|
WNT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
817.0
|
0.81
|
STRING
|
36370105
|
DVL1
|
DVL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
817.0
|
0.81
|
STRING
|
36370105
|
BRAF
|
RPTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
31980649
|
SKP2
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
19270695
21358672
23911321
19270694
|
SKP2
|
WDR59
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
AKT3
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WDR59
|
GRB10
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WDR59
|
NPRL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
25263562
28199306
|
SZT2
|
NPRL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28199306
28199315
|
WNT7A
|
WNT5A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WNT7A
|
WNT7B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WNT16
|
WNT5A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WNT5A
|
WNT5B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
LPIN3
|
LPIN2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
LPIN3
|
LPIN1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
WNT16
|
WNT11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.82
|
0.82
|
HIPPIE
|
28514442
33961781
|
KRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
824.0
|
0.82
|
STRING
|
36370105
|
AKT1
|
GSK3B
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
0.82
|
0.82
|
Signor
|
15829723
|
AKT1
|
GSK3B
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.82
|
0.82
|
Signor
|
23552696
|
TSC2
|
MTOR
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
0.82
|
0.82
|
Signor
|
12271141
|
CAB39L
|
STRADA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
828.0
|
0.82
|
STRING
|
36370105
|
SOS1
|
KRAS
|
â—¼ GTPASE_REACTION
|
✅
|
+
|
0.82
|
0.82
|
Signor
|
25624485
|
PRR5L
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
17461779
18030348
|
TTI1
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
20810650
22544753
20427287
|
MTOR
|
SGK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
18570873
27451907
|
SEC13
|
SESN2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
TSC1
|
RHEB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
12820960
30514904
|
SEC13
|
WDR59
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
25263562
28199306
33961781
26186194
|
SEC13
|
WDR24
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
25263562
33961781
26186194
23723238
|
ITFG2
|
SZT2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
28199306
|
KPTN
|
SZT2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
28199306
|
WNT4
|
WNT5A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
WNT4
|
WNT7B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
WNT3A
|
WNT3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28514442
33961781
26186194
|
WDR59
|
SZT2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.83
|
0.83
|
HIPPIE
|
28199306
28199315
|
LRP6
|
WNT3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
833.0
|
0.83
|
STRING
|
36370105
|
MAPK3
|
RPS6KA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
834.0
|
0.83
|
STRING
|
36370105
|
RHEB
|
TSC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
834.0
|
0.83
|
STRING
|
36370105
|
RPTOR
|
ULK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
SESN2
|
WDR24
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
IGF1R
|
INS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
835.0
|
0.83
|
STRING
|
36370105
|
BRAF
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
836.0
|
0.83
|
STRING
|
36370105
|
MTOR
|
RPS6KB2
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.84
|
0.84
|
Signor
|
11733037
|
ULK1
|
RPTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
25686248
21795849
21460634
21460630
|
ULK1
|
SESN2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
25040165
29330382
|
AKT1
|
STK11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
28628118
24412244
28205554
|
AKT1
|
SKP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
839.0
|
0.84
|
STRING
|
36370105
|
LRP6
|
WNT3A
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
19910923
12897152
14739301
33961781
22726442
21944579
|
AKT1
|
IRS1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.84
|
0.84
|
HIPPIE
|
10497255
17640984
|
FZD8
|
WNT3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
839.0
|
0.84
|
STRING
|
36370105
|
FLCN
|
FNIP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
840.0
|
0.84
|
STRING
|
36370105
|
FNIP2
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
842.0
|
0.84
|
STRING
|
36370105
|
MTOR
|
ULK1
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.84
|
0.84
|
Signor
|
21460634
|
FLCN
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
842.0
|
0.84
|
STRING
|
36370105
|
NPRL3
|
WDR24
|
â—¼ PHYSICAL_INTERACTION
|
|
|
846.0
|
0.84
|
STRING
|
36370105
|
MAPK1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
ATP6V1D
|
ATP6V1G2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
NPRL3
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
KRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
847.0
|
0.84
|
STRING
|
36370105
|
RHEB
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
18550814
16098514
16915281
15854902
33157014
15772076
15878852
25351248
|
RPTOR
|
RRAGA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28514442
18497260
31601708
23184942
21816923
26582740
33961781
26186194
31601764
33157014
25561175
24337580
|
FZD8
|
WNT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
15454084
11448771
|
WNT1
|
LRP6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
11448771
11029007
|
PIK3CA
|
IRS1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.85
|
0.85
|
mint
|
34591642
|
AKT2
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28514442
12149249
9736715
12176337
11445557
33961781
14500673
11278835
11546794
|
WDR24
|
NPRL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
23723238
28199315
|
NPRL2
|
SZT2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.85
|
0.85
|
HIPPIE
|
28199306
28199315
|
MTOR
|
SGK1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.85
|
0.85
|
Signor
|
18570873
|
AKT1
|
PTEN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
852.0
|
0.85
|
STRING
|
36370105
|
WDR24
|
WDR59
|
â—¼ PHYSICAL_INTERACTION
|
|
|
852.0
|
0.85
|
STRING
|
36370105
|
IGF1R
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
854.0
|
0.85
|
STRING
|
36370105
|
IGF1R
|
IRS1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.85
|
0.85
|
Signor
|
17827393
|
KPTN
|
SZT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
856.0
|
0.85
|
STRING
|
36370105
|
RPTOR
|
RRAGD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
857.0
|
0.85
|
STRING
|
36370105
|
PIK3R1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.86
|
0.86
|
mint
|
5220480
7642581
|
PRR5
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
17461779
18505677
|
MTOR
|
MAPKAP1
|
â—¼ COLOCALIZATION
|
✅
|
|
0.86
|
0.86
|
mint
|
21045808
8088164
|
RPTOR
|
TELO2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
24036451
23263282
|
RPTOR
|
RRAGC
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
25567906
21981924
18497260
31601708
21816923
25446900
31601764
25561175
24337580
|
TSC2
|
GSK3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
16959574
12511557
|
AKT1
|
PTEN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
12297295
19903340
12077256
28628118
20605778
28205554
10866658
20596030
|
LRP6
|
FZD8
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
11448771
11029007
15908424
|
INSR
|
IGF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
26027733
8452530
|
AKT1
|
BRAF
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.86
|
0.86
|
HIPPIE
|
10869359
25241761
28628118
28205554
|
MAPK3
|
RPS6KA3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
861.0
|
0.86
|
STRING
|
36370105
|
MTOR
|
TTI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
IGF1R
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
DEPDC5
|
ITFG2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
ITFG2
|
SZT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
862.0
|
0.86
|
STRING
|
36370105
|
EIF4EBP1
|
MLST8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
867.0
|
0.86
|
STRING
|
36370105
|
FNIP1
|
FNIP2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
27353360
18403135
|
ULK1
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
25686248
23524951
29321306
21460630
|
TELO2
|
MTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
18160036
20801936
|
SESN2
|
NPRL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
25263562
28199315
|
HRAS
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.87
|
0.87
|
mint
|
34591642
|
HRAS
|
BRAF
|
â—¼ PROXIMITY
|
✅
|
|
0.87
|
0.87
|
mint
|
30194290
|
GRB10
|
IRS1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
8621530
12783867
|
NPRL2
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
869.0
|
0.87
|
STRING
|
36370105
|
KPTN
|
ITFG2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.87
|
0.87
|
HIPPIE
|
28514442
17353931
28199306
33961781
26186194
|
HRAS
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
871.0
|
0.87
|
STRING
|
36370105
|
AKT1
|
CHUK
|
â—¼ PHYSICAL_INTERACTION
|
|
|
872.0
|
0.87
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.87
|
0.87
|
Signor
|
21779497
|
DEPDC5
|
MIOS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
873.0
|
0.87
|
STRING
|
36370105
|
PIK3R2
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
874.0
|
0.87
|
STRING
|
36370105
|
MTOR
|
TELO2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
DEPDC5
|
SZT2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
875.0
|
0.87
|
STRING
|
36370105
|
PIK3R1
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
ITFG2
|
KPTN
|
â—¼ PHYSICAL_INTERACTION
|
|
|
876.0
|
0.87
|
STRING
|
36370105
|
HRAS
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
877.0
|
0.87
|
STRING
|
36370105
|
RRAGD
|
RPTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
26582740
24337580
18497260
22424946
|
WDR24
|
SESN2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
26586190
25263562
28199315
26449471
|
WDR59
|
SESN2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
25263562
26972053
28199315
|
BRAF
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
23153539
28514442
31980649
18332145
20141835
23934108
31015455
11325826
23680146
20130576
26466569
22169110
33961781
34017080
28806393
20212043
25155755
22605333
|
TSC1
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28628118
15342917
12167664
28205554
|
IGF1R
|
IRS1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
7559507
8776723
10082579
7541045
8530377
33991522
8895367
12220227
15629149
8662806
|
WDR24
|
SZT2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.88
|
0.88
|
HIPPIE
|
28199306
28199315
|
AKT1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
AKT1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
880.0
|
0.88
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1B2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
881.0
|
0.88
|
STRING
|
36370105
|
RICTOR
|
RPS6KB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
883.0
|
0.88
|
STRING
|
36370105
|
CHUK
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
INS
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
+
|
0.88
|
0.88
|
Signor
|
1851182
|
GRB10
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
884.0
|
0.88
|
STRING
|
36370105
|
MAPK1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
GRB10
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
MIOS
|
NPRL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
NPRL2
|
WDR59
|
â—¼ PHYSICAL_INTERACTION
|
|
|
887.0
|
0.88
|
STRING
|
36370105
|
FNIP2
|
FLCN
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
27353360
28656962
25126726
33137092
18403135
|
RPTOR
|
RRAGB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
889.0
|
0.89
|
STRING
|
36370105
|
PDPK1
|
SGK1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
17916563
16189514
10191262
17314099
10357815
12387817
|
ATP6V1E2
|
ATP6V1G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.89
|
0.89
|
HuRI
|
32296183
|
AKT1
|
TSC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
12438239
12150915
15342917
12167664
|
GRB10
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
9553107
10585452
|
DVL1
|
DVL2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24643799
28514442
20224554
33961781
26186194
31340145
|
DVL2
|
DVL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
24643799
31340145
33961781
28514442
|
GSK3B
|
LRP6
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
19107203
16890161
16365045
|
INS
|
INSR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
2550426
11278498
29512653
23302862
|
NPRL2
|
NPRL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
28199306
33961781
23723238
27684187
19521502
28199315
|
RRAGA
|
RRAGD
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28514442
16189514
26582740
33961781
26186194
28716898
11073942
25561175
22424946
|
WDR24
|
NPRL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.89
|
0.89
|
HIPPIE
|
28199306
25263562
23723238
28199315
|
IRS1
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
891.0
|
0.89
|
STRING
|
36370105
|
HRAS
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
MIOS
|
WDR59
|
â—¼ PHYSICAL_INTERACTION
|
|
|
893.0
|
0.89
|
STRING
|
36370105
|
AKT1
|
RICTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
894.0
|
0.89
|
STRING
|
36370105
|
INSR
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
895.0
|
0.89
|
STRING
|
36370105
|
IKBKB
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
896.0
|
0.89
|
STRING
|
36370105
|
MIOS
|
SEC13
|
â—¼ PHYSICAL_INTERACTION
|
|
|
898.0
|
0.89
|
STRING
|
36370105
|
CAB39
|
STK11
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28514442
19513107
25241761
26479318
14676191
15561763
20562859
31217475
31554794
33961781
15733851
25852190
32707033
|
PDPK1
|
DDIT4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
PIK3CD
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
PIK3CB
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
11002419
10995764
10448070
|
BRAF
|
MAPK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
16508002
14654779
19933846
|
MAPK1
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK1
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
SGK1
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19447520
|
RHOA
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10617617
9854026
12810709
|
LAMTOR3
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
11266467
9733512
|
MAPK1
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
15851026
17671177
|
BRAF
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
27503831
16939974
9560161
|
RPS6KA6
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
BRAF
|
MAPK3
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
16508002
14654779
19933846
|
MAPK3
|
MAP2K2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
MAPK3
|
MAP2K1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
10567369
19219045
8013650
|
RHOA
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10617617
9854026
12810709
|
MAPK3
|
STK11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
25846811
|
MTOR
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
MTOR
|
RPTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16847060
26522726
12604610
19619545
26348909
33378666
20169205
24036451
18570873
24516643
19299511
34031390
22424946
22356909
25940091
12719976
22544753
23263282
12150926
12665511
18505677
17277771
17461779
22493283
19114562
18722121
21071439
18030348
19446321
12718876
12747827
24375676
22258093
16837165
21045808
16962653
18955708
17565979
12408816
15467718
23953116
27043084
23911927
17043309
31601708
21177249
21614075
21795849
16631613
20381137
21321085
23297343
23872070
16354680
19875983
25446900
29059166
24337580
16603397
16183647
34171383
15066126
24403073
25332233
17386266
19145465
25007995
16798736
26678875
15268862
20427287
30865892
16919458
25273559
15459249
18519641
18504440
12150925
|
MTOR
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
25241761
18566587
25792870
15718470
14970221
24670654
10910062
18505677
29567957
22337773
21177249
26293922
19299511
18566586
30639242
21045808
11438723
22084251
23872070
21343617
22307628
|
PRKCA
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21474067
18851840
20027184
|
PRKAA1
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
14970221
|
RPS6KA6
|
FZD5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
RHEB
|
RPTOR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16631613
25446900
15854902
33157014
24337580
|
RPS6KA3
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
18722121
|
AKT2
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
17517883
18372248
17277771
|
PRKAA2
|
SESN2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
24366874
22363791
18692468
|
SESN2
|
PRKAA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
24366874
22363791
18692468
|
TTI1
|
TELO2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
20427287
20371770
20801936
22863883
20810650
|
WNT7A
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19497282
22944199
23290138
|
FZD7
|
DVL1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
14636582
22179044
19388021
|
PRKAA2
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21673972
|
RHEB
|
TSC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
12869586
12820960
30514904
12842888
17077083
15854902
12771962
|
AKT3
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
12150915
12167664
12172553
|
AKT1
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
25241761
28628118
10576742
19197339
19058874
28205554
|
RHEB
|
RAF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
16803888
19222999
9001246
15150271
15854902
|
DVL1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10428961
16914735
20837657
|
AKT3
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
19609947
|
PRKCB
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12070292
|
PRKCA
|
RHOA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
10592173
11284700
|
FZD5
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12857724
18077588
|
WNT2
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23209147
15578921
32196115
|
WNT9B
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
20093360
|
WNT2
|
FZD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
24032637
|
PDPK1
|
AKT1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
16189514
9368760
11825911
14500673
10698680
31467278
12149249
27563096
11313365
11278835
22569334
26264872
10226025
32876514
26256536
21775285
11438723
11445557
23397142
|
PDPK1
|
AKT2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
3.0
|
0.9
|
Reactome
|
9228007
9094314
15890450
|
PDPK1
|
PRKCG
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
15209375
17053865
|
MAP2K1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
11160134
|
IGF1R
|
IGF1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
26027733
21645859
8452530
|
AKT1
|
GSK3B
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
19713527
8524413
23824745
16009706
29464284
20856200
19995607
16123141
20682768
27563096
14645548
15688030
22337773
11035810
17428466
18505846
15470047
14701753
16282323
|
PRKCA
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
1386920
16810323
12917261
|
PRKCA
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
19836308
|
PRKCB
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
12070292
|
PIK3CA
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
21653832
16456001
10068651
|
AKT2
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
3.0
|
0.9
|
Omnipath
|
10869359
|
PRKCB
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
1386920
17570479
12917261
|
EIF4EBP1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
GSK3B
|
FZD5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
FLCN
|
FNIP1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
17028174
27353360
28656962
33137092
18403135
|
DVL3
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
intact
|
21900206
2001699
8089645
|
PIK3CB
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
21653832
16456001
10068651
|
PIK3R2
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
22402981
8596638
11733063
|
PIK3R2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
3.0
|
0.9
|
Reactome
|
21653832
16456001
10068651
|
SOS1
|
KRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25624485
23331499
16293107
|
WDR24
|
WDR59
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.9
|
0.9
|
HIPPIE
|
28199306
25263562
23723238
28199315
|
WNT8A
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
28733458
10097073
|
WNT9B
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
30978219
25892522
28733458
|
WNT3A
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
25425204
21078818
15578921
|
WNT3A
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
21078818
18212053
10601008
|
WNT8A
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23209147
15578921
32196115
|
WNT10B
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
3.0
|
0.9
|
Omnipath
|
23331499
11092808
12055200
|
MAPK1
|
RPS6KA3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
900.0
|
0.9
|
STRING
|
36370105
|
PDPK1
|
SGK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
903.0
|
0.9
|
STRING
|
36370105
|
SOS1
|
HRAS
|
â—¼ GTPASE_REACTION
|
✅
|
+
|
0.9
|
0.9
|
Signor
|
23132018
|
GRB2
|
SOS1
|
â—¼ RELOCALIZATION
|
✅
|
+
|
0.9
|
0.9
|
Signor
|
23452850
|
AKT1
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
905.0
|
0.9
|
STRING
|
36370105
|
MAPK1
|
RPS6KA2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
906.0
|
0.9
|
STRING
|
36370105
|
MTOR
|
AKT1S1
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.9
|
0.9
|
Signor
|
18372248
|
RPS6KB1
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
907.0
|
0.9
|
STRING
|
36370105
|
TSC1
|
RHEB
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
-
|
0.9
|
0.9
|
Signor
|
20006481
|
GRB2
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
908.0
|
0.9
|
STRING
|
36370105
|
GRB2
|
IRS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
912.0
|
0.91
|
STRING
|
36370105
|
LAMTOR1
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
LAMTOR4
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
MIOS
|
WDR24
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
RRAGA
|
RRAGB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
RRAGD
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
913.0
|
0.91
|
STRING
|
36370105
|
IRS1
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
914.0
|
0.91
|
STRING
|
36370105
|
LAMTOR5
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
915.0
|
0.91
|
STRING
|
36370105
|
CASTOR1
|
ZC2HC1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
0.91
|
0.91
|
HuRI
|
32296183
|
ATP6V1C2
|
ATP6V1D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
915.0
|
0.91
|
STRING
|
36370105
|
TSC2
|
RHEB
|
â—¼ GTPASE_REACTION
|
✅
|
-
|
0.91
|
0.91
|
Signor
|
15340059
|
LAMTOR4
|
RRAGD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
917.0
|
0.91
|
STRING
|
36370105
|
INSR
|
IRS1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.91
|
0.91
|
Signor
|
7651388
|
PIK3R1
|
IRS1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.92
|
0.92
|
mint
|
6731578
14632132
|
ATP6V1A
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.92
|
STRING
|
36370105
|
ATP6V1B2
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.92
|
STRING
|
36370105
|
LAMTOR5
|
RRAGD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
919.0
|
0.92
|
STRING
|
36370105
|
IRS1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1C1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
ATP6V1A
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
ATP6V1B2
|
LAMTOR1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
920.0
|
0.92
|
STRING
|
36370105
|
MTOR
|
AKT1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.92
|
0.92
|
Signor
|
21592956
|
INSR
|
IRS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
923.0
|
0.92
|
STRING
|
36370105
|
MAP2K2
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
EIF4E2
|
EIF4EBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
924.0
|
0.92
|
STRING
|
36370105
|
ATP6V1C2
|
ATP6V1F
|
â—¼ PHYSICAL_INTERACTION
|
|
|
928.0
|
0.92
|
STRING
|
36370105
|
ATP6V1B2
|
ATP6V1H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
928.0
|
0.92
|
STRING
|
36370105
|
SOS2
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.93
|
0.93
|
mint
|
5220477
7629138
|
NRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.93
|
0.93
|
mint
|
30194290
|
ATP6V1C2
|
ATP6V1E1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
ATP6V1B2
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
932.0
|
0.93
|
STRING
|
36370105
|
RPS6KB1
|
RPS6
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.93
|
0.93
|
Signor
|
15809305
|
BRAF
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
933.0
|
0.93
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1E2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
AKT1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
PIK3CB
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
934.0
|
0.93
|
STRING
|
36370105
|
BRAF
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
935.0
|
0.93
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
935.0
|
0.93
|
STRING
|
36370105
|
DEPDC5
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
936.0
|
0.93
|
STRING
|
36370105
|
ATP6V1C2
|
ATP6V1E2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
AKT1
|
PDPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
937.0
|
0.93
|
STRING
|
36370105
|
PIK3CB
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
938.0
|
0.93
|
STRING
|
36370105
|
SOS1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.94
|
0.94
|
mint
|
17084389
5219305
|
ATP6V1B1
|
ATP6V1G2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
939.0
|
0.94
|
STRING
|
36370105
|
NPRL3
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
939.0
|
0.94
|
STRING
|
36370105
|
ATP6V1B2
|
ATP6V1G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
940.0
|
0.94
|
STRING
|
36370105
|
ATP6V1C2
|
ATP6V1G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
940.0
|
0.94
|
STRING
|
36370105
|
ATP6V1C1
|
ATP6V1D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
ATP6V1C2
|
ATP6V1G2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1F
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1G2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
ATP6V1B2
|
ATP6V1C1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
ATP6V1B2
|
ATP6V1G2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
PIK3CA
|
PIK3R3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
ATP6V1C1
|
ATP6V1F
|
â—¼ PHYSICAL_INTERACTION
|
|
|
941.0
|
0.94
|
STRING
|
36370105
|
MTOR
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
943.0
|
0.94
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1C1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
944.0
|
0.94
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1F
|
â—¼ PHYSICAL_INTERACTION
|
|
|
944.0
|
0.94
|
STRING
|
36370105
|
DEPDC5
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
944.0
|
0.94
|
STRING
|
36370105
|
STK11
|
STRADA
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.94
|
0.94
|
Signor
|
12805220
|
ATP6V1B1
|
ATP6V1G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
NRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
IGF1
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
945.0
|
0.94
|
STRING
|
36370105
|
MTOR
|
ULK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
946.0
|
0.94
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1B1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
946.0
|
0.94
|
STRING
|
36370105
|
PIK3CB
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
947.0
|
0.94
|
STRING
|
36370105
|
NPRL2
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
948.0
|
0.94
|
STRING
|
36370105
|
BRAF
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
948.0
|
0.94
|
STRING
|
36370105
|
STRADA
|
STK11
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
5217549
15733851
|
DVL1
|
DVL3
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
32296183
10330181
|
LAMTOR3
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.95
|
0.95
|
mint
|
8153045
21516116
|
RRAGD
|
RRAGB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.95
|
0.95
|
HIPPIE
|
18497260
33961781
28716898
11073942
20381137
24337580
22424946
|
ATP6V1E1
|
ATP6V1G2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
950.0
|
0.95
|
STRING
|
36370105
|
RHEB
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
953.0
|
0.95
|
STRING
|
36370105
|
ATP6V1B2
|
ATP6V1C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
953.0
|
0.95
|
STRING
|
36370105
|
MIOS
|
SEH1L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
953.0
|
0.95
|
STRING
|
36370105
|
RRAGB
|
RRAGD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
953.0
|
0.95
|
STRING
|
36370105
|
ATP6V1C1
|
ATP6V1E1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
955.0
|
0.95
|
STRING
|
36370105
|
BRAF
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
956.0
|
0.95
|
STRING
|
36370105
|
MAP2K2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
BRAF
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
958.0
|
0.95
|
STRING
|
36370105
|
RAF1
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
8396417
22510884
|
RAF1
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.96
|
0.96
|
mint
|
7014125
19197339
|
RRAGC
|
RRAGB
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
25567906
21981924
33961781
28716898
11073942
20381137
25561175
24337580
22980980
22424946
|
RRAGC
|
RRAGA
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.96
|
0.96
|
HIPPIE
|
28514442
16189514
25567906
21981924
16713569
31601708
21816923
23184942
33961781
26186194
33157014
11073942
28716898
20381137
25561175
24337580
25936802
22424946
|
RPS6KB1
|
MTOR
|
â—¼ PHOSPHORYLATION
|
✅
|
-
|
0.96
|
0.96
|
Signor
|
15905173
|
MTOR
|
RPS6KB1
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.96
|
0.96
|
Signor
|
12782654
|
ATP6V1A
|
ATP6V1G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
960.0
|
0.96
|
STRING
|
36370105
|
MAP2K1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
963.0
|
0.96
|
STRING
|
36370105
|
FLCN
|
FNIP2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
966.0
|
0.96
|
STRING
|
36370105
|
ATP6V1D
|
ATP6V1G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
966.0
|
0.96
|
STRING
|
36370105
|
SOS1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
5220480
7642581
|
IRS1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
7488107
8388384
7486683
8810325
22974441
21706016
8491186
7629070
12173038
8536716
|
RICTOR
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
24036451
|
MTOR
|
RICTOR
|
â—¼ COLOCALIZATION
|
✅
|
|
0.97
|
0.97
|
mint
|
21045808
8088164
|
PIK3R1
|
PIK3CA
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.97
|
0.97
|
mint
|
20018188
7383613
|
TSC1
|
TSC2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
16464865
25263562
11290735
17077083
12511557
11741832
10807585
11175345
20166753
15342917
30514904
11741833
17658474
15963462
16339216
20169078
10585443
14551205
9580671
12167664
10915759
16424383
20412061
12869586
16636147
9809973
14651849
28561026
15851513
17693255
21134130
15340059
12176984
15851026
|
GRB10
|
IGF1R
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
18286479
8764099
9369444
12697834
8621530
8776723
9506989
19165858
|
GRB10
|
INSR
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.97
|
0.97
|
HIPPIE
|
10871840
9369444
12551896
8621530
7479769
9506989
12493740
19648926
9006901
15664450
|
ATP6V1B1
|
ATP6V1E1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
970.0
|
0.97
|
STRING
|
36370105
|
RHEB
|
TSC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
971.0
|
0.97
|
STRING
|
36370105
|
MAP2K1
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
971.0
|
0.97
|
STRING
|
36370105
|
GRB2
|
SOS2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
ATP6V1B1
|
ATP6V1D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
KRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
INS
|
INSR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
972.0
|
0.97
|
STRING
|
36370105
|
MTOR
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
IGF1
|
IGF1R
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1C2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
973.0
|
0.97
|
STRING
|
36370105
|
MAP2K1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
AKT1S1
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
974.0
|
0.97
|
STRING
|
36370105
|
AKT1S1
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
975.0
|
0.97
|
STRING
|
36370105
|
ATP6V1E1
|
ATP6V1G1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
976.0
|
0.97
|
STRING
|
36370105
|
SLC3A2
|
SLC7A5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
976.0
|
0.97
|
STRING
|
36370105
|
CAB39
|
STK11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
978.0
|
0.97
|
STRING
|
36370105
|
RPTOR
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
24036451
|
MTOR
|
RPTOR
|
â—¼ COLOCALIZATION
|
✅
|
|
0.98
|
0.98
|
mint
|
21045808
8088164
|
TELO2
|
TTI1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
979.0
|
0.98
|
STRING
|
36370105
|
EIF4EBP1
|
EIF4E
|
â—¼ PHYSICAL_INTERACTION
|
✅
|
|
0.98
|
0.98
|
mint
|
16504179
5218377
|
HRAS
|
RAF1
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
18273062
6540139
|
RAF1
|
HRAS
|
â—¼ PROXIMITY
|
✅
|
|
0.98
|
0.98
|
mint
|
18273062
6540139
|
DEPDC5
|
NPRL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
979.0
|
0.98
|
STRING
|
36370105
|
TBC1D7
|
TSC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
980.0
|
0.98
|
STRING
|
36370105
|
ATP6V1E1
|
ATP6V1H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
980.0
|
0.98
|
STRING
|
36370105
|
ATP6V1E1
|
ATP6V1F
|
â—¼ PHYSICAL_INTERACTION
|
|
|
980.0
|
0.98
|
STRING
|
36370105
|
MAPK1
|
RPS6KA1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
LAMTOR3
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
TSC1
|
TSC2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
LAMTOR3
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
981.0
|
0.98
|
STRING
|
36370105
|
ATP6V1B2
|
ATP6V1F
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
NPRL2
|
NPRL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
LAMTOR3
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
982.0
|
0.98
|
STRING
|
36370105
|
EIF4EBP1
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
IGF1R
|
IRS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
ATP6V1F
|
ATP6V1H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
983.0
|
0.98
|
STRING
|
36370105
|
MAP2K2
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
984.0
|
0.98
|
STRING
|
36370105
|
MAPKAP1
|
MLST8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
984.0
|
0.98
|
STRING
|
36370105
|
ATP6V1D
|
ATP6V1H
|
â—¼ PHYSICAL_INTERACTION
|
|
|
984.0
|
0.98
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1B2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
985.0
|
0.98
|
STRING
|
36370105
|
ATP6V1B2
|
ATP6V1E1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
985.0
|
0.98
|
STRING
|
36370105
|
PIK3CD
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
ATP6V1B2
|
ATP6V1D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
ATP6V1D
|
ATP6V1F
|
â—¼ PHYSICAL_INTERACTION
|
|
|
986.0
|
0.98
|
STRING
|
36370105
|
PIK3CA
|
PIK3R2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
987.0
|
0.98
|
STRING
|
36370105
|
MTOR
|
RPTOR
|
â—¼ PHOSPHORYLATION
|
✅
|
+
|
0.98
|
0.98
|
Signor
|
19346248
|
SOS2
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
28514442
31980649
32062451
21988832
17474147
14679214
21706016
7629138
33961781
20936779
10940929
19380743
32203420
|
HRAS
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
989.0
|
0.99
|
STRING
|
36370105
|
INSR
|
IRS1
|
â—¼ PROTEIN_INTERACTION
|
|
|
0.99
|
0.99
|
HIPPIE
|
11781100
25667086
16582879
17167487
7935368
10455177
11606564
7499194
15629149
8662806
8626379
|
LAMTOR2
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
MAPKAP1
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
MTOR
|
RPS6KB1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
DEPDC5
|
NPRL2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
LAMTOR2
|
RRAGB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
RRAGB
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
LAMTOR3
|
RRAGD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
992.0
|
0.99
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1E1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
993.0
|
0.99
|
STRING
|
36370105
|
LAMTOR5
|
RRAGB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
993.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
RRAGB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
993.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
RRAGD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
993.0
|
0.99
|
STRING
|
36370105
|
LAMTOR4
|
RRAGB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
993.0
|
0.99
|
STRING
|
36370105
|
LAMTOR3
|
RRAGB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
993.0
|
0.99
|
STRING
|
36370105
|
MTOR
|
RHEB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
BRAF
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
994.0
|
0.99
|
STRING
|
36370105
|
IRS1
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
EIF4EBP1
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
MAPKAP1
|
RICTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
SEC13
|
SEH1L
|
â—¼ PHYSICAL_INTERACTION
|
|
|
995.0
|
0.99
|
STRING
|
36370105
|
MLST8
|
MTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
ATP6V1A
|
ATP6V1D
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
EIF4E
|
EIF4EBP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
996.0
|
0.99
|
STRING
|
36370105
|
ATP6V1D
|
ATP6V1E1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
RRAGB
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
RRAGA
|
RRAGD
|
â—¼ PHYSICAL_INTERACTION
|
|
|
997.0
|
0.99
|
STRING
|
36370105
|
GRB2
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR2
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR4
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR5
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
RPTOR
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
LAMTOR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR3
|
LAMTOR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR4
|
LAMTOR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR2
|
LAMTOR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR5
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR5
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR5
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
LAMTOR4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR1
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR3
|
LAMTOR4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR2
|
LAMTOR4
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR4
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR4
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR4
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR2
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR2
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR2
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR2
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
RRAGA
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
LAMTOR3
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
RRAGC
|
SLC38A9
|
â—¼ PHYSICAL_INTERACTION
|
|
|
998.0
|
0.99
|
STRING
|
36370105
|
STK11
|
CAB39
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
15509864
18687677
19197243
19942859
20160076
20484410
23030059
8910387
|
CAB39
|
STRADA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
15509864
18687677
19197243
19942859
20160076
20484410
23030059
8910387
|
STK11
|
CAB39
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
15509864
18687677
19197243
19942859
20160076
20484410
23030059
8910387
|
CAB39
|
STRADA
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
15509864
18687677
19197243
19942859
20160076
20484410
23030059
8910387
|
IRS1
|
GRB2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
8316835
8810325
9832424
8621421
8530377
9852124
9003010
|
GRB2
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
48.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11023813
11034387
11062502
11385609
11447289
11777939
11907067
12040186
12175651
12419216
12640133
12782630
14585353
14764585
15169888
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17613518
17673906
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
9510155
|
GRB2
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
53.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
9069260
9510155
|
GRB2
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
54.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
8929532
9069260
9510155
|
SOS1
|
GRB2
|
â—¼ PROTEIN_INTERACTION
|
|
|
1.0
|
1.0
|
HIPPIE
|
28514442
16520382
31980649
32062451
8493579
21988832
14679214
7510700
7514169
21706016
10319320
32203420
9872323
9797459
34407391
16906159
10716926
12577067
8810325
7629168
11960376
7664271
8626525
15192046
7629138
11997436
8943292
10207103
8695800
10570290
10025673
8112292
11726515
8816480
20473329
7559490
7773779
9447984
19380743
7642581
7527391
9716598
9344843
10477741
16713569
19323566
7516467
17474147
9569023
8188688
16893902
11964172
9478994
33961781
8479541
28166272
9009162
|
GRB2
|
LAMTOR2
|
â—¼ SHARES_COMPLEX
|
|
|
53.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
9069260
9510155
|
GRB2
|
BRAF
|
â—¼ SHARES_COMPLEX
|
|
|
48.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11023813
11034387
11062502
11385609
11447289
11777939
11907067
12040186
12175651
12419216
12640133
12782630
14585353
14764585
15169888
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17613518
17673906
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
9510155
|
GRB2
|
RAF1
|
â—¼ SHARES_COMPLEX
|
|
|
54.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
8929532
9069260
9510155
|
HRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
KRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
IRS1
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
12.0
|
1.0
|
ACSN
|
10086337
10826997
12175651
12444011
12767520
16931767
17604717
19030972
21540285
22465479
24036369
8621421
|
NRAS
|
GRB2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
GRB2
|
PIK3R1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
32.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10849428
10982827
11335727
11447289
11449354
11532940
11777939
12175651
12393695
12640133
15308668
15567848
15574420
16000375
16076871
16530705
16582911
16887996
17496910
17673906
18835194
19449109
19454690
22064427
22464172
24217602
25922287
26552706
8551221
|
PTEN
|
GRB2
|
â—¼ REGULATES
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10648629
10753747
11747822
12040186
15584861
15721744
16288286
16982858
17218262
19847259
22179046
22465479
23732914
24254977
25364523
|
PTEN
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
16288286
10648629
17218262
12040186
15584861
|
IRS1
|
GRB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
8265614
7862167
11788580
8388384
8491186
8536716
7488107
7486683
10358772
10592173
8196603
12173038
12679424
8114695
11259577
8810325
|
GRB2
|
SOS2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
17145710
21988832
20936779
19531499
14764585
10940929
19380743
21706016
10359574
14679214
17474147
21779497
9199344
7629138
|
GRB2
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
145.0
|
1.0
|
Omnipath
|
9544989
9872323
7642581
15746962
11726515
8621483
23334917
16520382
11997436
21706016
10359574
8950973
7664271
16713569
16893902
16906159
21988832
19323566
9009162
10716926
11964172
7629168
9815779
10592173
9716598
8647802
28166272
7773778
7773779
18778683
8188688
10319320
8810325
9344843
23452850
11960376
8816480
10025673
7510700
8940013
12955078
9697839
12345678
10477741
8493579
8943292
12577067
7862167
9199344
8112292
7898932
10207103
8695800
19531499
10570290
7760801
20005866
19380743
9447984
8235613
8479540
7527391
14679214
8479541
17474147
7514169
7629138
|
GRB2
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17496910
16713569
17673906
11352655
|
NRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
HRAS
|
MAPK1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
MAPK1
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
MAPK1
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
MAPK1
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
MAP2K2
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
68.0
|
1.0
|
Omnipath
|
21675959
11704645
9694850
17081983
7565670
12750173
19690332
12932319
11823456
18799465
15592455
11337027
18083107
21365009
12788955
11134045
19219045
17389395
9447970
15342917
23331499
19534553
17569879
7559390
23047924
8226933
8223433
17272394
15851026
15811950
19494114
18988627
18669648
11549292
23519423
19541618
18691976
1381507
16293107
17906627
11986622
19933846
8376945
19053285
16094384
11971971
17192257
11136732
11948414
8388392
7898932
9731057
11730323
18039929
11118451
19369195
12920017
15951569
15466214
10746662
|
PRKCA
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11704645
12598525
19074803
8903320
9160888
|
MAP2K1
|
MAPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
149.0
|
1.0
|
Omnipath
|
21675959
9694850
17081983
10757792
11319218
18799465
15592455
12788955
19415658
12697810
17389395
9447970
15342917
8226933
15851026
12270934
12644307
17255949
10998418
11242034
1378617
1381507
17906627
11986622
8376945
8157000
7992057
11948414
9731057
19651622
11251083
11266467
18707149
14743221
11279118
11704645
12750173
12932319
16497976
11337027
23331499
12048245
7559390
17272394
15811950
19494114
18669648
18691976
11741894
15972258
19053285
16094384
17192257
7898932
24623782
9166761
19369195
21336309
12920017
15466214
17016520
19901323
1712480
19690332
11823456
9032297
11134045
12876277
19534553
10995751
20068231
21506533
8223433
8248196
16153436
12594221
10567369
19933846
17563371
11730323
29175850
11352917
16135787
15951569
19058874
15212693
23241949
9560161
91184134
18083107
16887817
18578522
17569879
21071413
9148935
18452278
1330321
8670897
19541618
10777511
15935618
12925710
11971971
9765155
11136732
11118451
12082107
12952943
10746662
21768338
|
MAPK1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12975377
23602568
16424009
19058874
23397142
21707490
|
MAPK1
|
RPS6KA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
8939914
12832467
9915826
17906627
32296183
19282669
|
MAPK1
|
RPS6KA3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
24.0
|
1.0
|
Omnipath
|
21988832
18156174
12016217
25241761
12832467
23602568
8939914
10480933
9915826
17906627
10980595
10856237
19282669
|
MAPK1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
16039586
28646232
18451303
|
MAPK1
|
RPS6KA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
60.0
|
1.0
|
Omnipath
|
17081983
32814053
20385094
11532940
7601337
23331499
15342917
8939914
21071413
23047924
20068231
11335727
9687510
12618428
18988627
18669648
23519423
23109003
18691976
12594221
9915826
17906627
8202512
9430688
19651622
12832467
11500364
14966081
29997244
25730857
8387505
10411321
18212344
|
MAPK1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
17081983
18767875
15849194
19690332
11409918
14654779
23331499
23180781
8226933
20068231
18988627
21917714
18669648
19541618
18691976
16407412
19933846
9922370
15664191
8388392
19651622
10801873
8349614
18775330
9604935
|
MAPK1
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
43.0
|
1.0
|
Omnipath
|
12054624
15547943
20080742
14967450
12040186
15173823
12697810
11940578
7545671
16227978
21035469
12738796
16039586
9722592
17255949
15774499
15187187
19541618
19091303
19565474
17052211
19085255
11279232
9271440
18039929
18775330
11705993
10601235
12792650
11431469
|
MAPK1
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
21071439
19339977
19864431
21325048
22493283
|
MAPK1
|
EIF4EBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
73.0
|
1.0
|
Omnipath
|
17081983
11691836
18767875
11553333
12665511
25702871
19413330
10405182
18187866
19664995
12747827
10942774
9092573
15051500
20068231
9465032
27387559
11410517
11777913
18669648
8083223
12105188
17386266
25762619
17287340
9405468
12588975
12370290
19651622
10779345
27402756
10364159
11799119
26170285
12912989
33658337
16339216
12759354
|
MAPK1
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
23331499
10197981
8816480
9922370
8626428
|
MAPK1
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
15342917
15851026
18794886
|
MAPK1
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
14.0
|
1.0
|
Omnipath
|
14654779
21478863
19541618
16508002
19710016
19933846
15664191
29335436
8621729
|
MAPK1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
37.0
|
1.0
|
Omnipath
|
15001544
17081983
18949383
16123357
27014871
16914728
17360977
16099428
30401435
16131083
17640984
12510059
15613682
21850561
14579029
20594869
8626671
9395471
19651622
15576463
22289259
14769130
16020478
17242212
|
MAPK1
|
TNFRSF1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
10702263
11606045
|
MAPK1
|
STK11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
25679014
25846811
|
MAPK1
|
GRB10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
15952796
18220336
18669648
20068231
|
MAPK1
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17496910
18039929
19541618
21965663
20974802
19565474
15547943
12063245
12738796
11226259
|
KRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
RAF1
|
MAPK3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
25435214
20179705
20141835
16364920
20130576
15035987
25907612
|
MAPK3
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
MAPK3
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
MAPK3
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
5.0
|
1.0
|
Reactome
|
11802164
15239952
21779496
11802165
15260967
|
LAMTOR3
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23331499
9733512
|
MAP2K2
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
101.0
|
1.0
|
Omnipath
|
19901323
17081983
11704645
9694850
12750173
1411546
19690332
12932319
18799465
16497976
18083107
11134045
8626767
9006895
17389395
19219045
15342917
9447970
16887817
23331499
17569879
7867743
7559390
21071413
19534553
8226933
20068231
8223433
17272394
93330262
15851026
15811950
26987942
18988627
19494114
18669648
19541618
11242034
15466476
18691976
1381507
17906627
11986622
19933846
8376945
11971971
17192257
11136732
11948414
7898932
7687743
9731057
19651622
11730323
16464493
18983981
11251083
11118451
15580310
19369195
18707149
12920017
15951569
15466214
10746662
15212693
|
PRKCA
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
11704645
12598525
19074803
8903320
9160888
|
MAP2K1
|
MAPK3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
106.0
|
1.0
|
Omnipath
|
9694850
17081983
11319218
18799465
17389395
9447970
15342917
8226933
15851026
12270934
12644307
11242034
1381507
17906627
9677429
11986622
8376945
7992057
11948414
7687743
9731057
19197339
11704645
7565670
12750173
12932319
8626767
23331499
12048245
7559390
17272394
15811950
26987942
19494114
18669648
18691976
17192257
8388392
7898932
16464493
19369195
12920017
15466214
19690332
11134045
19534553
10995751
7867743
8223433
8248196
10567369
19933846
17563371
1518847
11730323
18983981
16186792
16135787
15951569
19058874
15212693
10748187
9560161
9925641
9733512
18083107
11104681
9006895
17569879
21071413
7731720
1330321
93330262
19541618
15466476
12925710
11971971
11136732
11118451
10746662
|
MAPK3
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
21757713
21071439
19339977
19864431
|
MAPK3
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
15547943
20080742
14967450
12040186
15173823
12697810
11940578
16227978
12738796
16039586
9722592
17255949
15774499
15187187
19541618
19091303
19565474
17052211
11279232
9271440
18039929
18775330
10601235
12792650
11431469
|
MAPK3
|
RPS6KA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
25241761
23602568
8939914
12832467
17906627
|
MAPK3
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
15001544
16131083
8626671
14769130
9335553
15613682
12510059
15212693
9395471
14579029
|
MAPK3
|
RPS6KA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
23331499
15342917
18039929
12832467
23109003
8387505
14966081
9915826
21071413
17906627
9430688
11335727
18988627
11532940
10411321
|
MAPK3
|
RPS6KA3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
18156174
25241761
12832467
8939914
9915826
17906627
10980595
10856237
19282669
|
MAPK3
|
GRB10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
15952796
18669648
18220336
|
MAPK3
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17496910
18039929
19541618
21965663
20974802
19565474
15547943
12063245
12738796
11226259
|
MAPK3
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
16.0
|
1.0
|
Omnipath
|
14654779
21478863
19541618
21135229
16508002
19933846
15664191
8621729
|
MAPK3
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
29145629
7478566
23331499
8816480
7739560
17570479
9922370
|
MAPK3
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
16039586
28646232
|
MAPK3
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
15342917
16244323
15851026
18794886
19188143
|
MAPK3
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
14654779
23331499
19541618
18691976
16407412
19933846
9446616
9922370
15664191
18988627
|
MTOR
|
MLST8
|
â—¼ PHYSICAL_INTERACTION
|
|
|
88.0
|
1.0
|
ACSN
|
10702316
10722653
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16556040
16678438
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17461779
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20027184
20138985
20338997
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21533173
21621563
21708191
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
9069260
|
MLST8
|
PRR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
18.0
|
1.0
|
ACSN
|
12408816
12906785
16469695
17680028
18492954
18566586
19022819
19143635
19568798
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MLST8
|
MAPKAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MLST8
|
RICTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MLST8
|
DEPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
37.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17461779
17604271
17680028
18000759
18372248
18492954
19022819
19143635
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MLST8
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
MLST8
|
RPS6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MLST8
|
EIF4B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
MLST8
|
â—¼ SHARES_COMPLEX
|
|
|
88.0
|
1.0
|
ACSN
|
10702316
10722653
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16556040
16678438
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17461779
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20027184
20138985
20338997
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21533173
21621563
21708191
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
9069260
|
MLST8
|
RICTOR
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MLST8
|
PRR5
|
â—¼ SHARES_COMPLEX
|
|
|
18.0
|
1.0
|
ACSN
|
12408816
12906785
16469695
17680028
18492954
18566586
19022819
19143635
19568798
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MLST8
|
DEPTOR
|
â—¼ SHARES_COMPLEX
|
|
|
37.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17461779
17604271
17680028
18000759
18372248
18492954
19022819
19143635
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MLST8
|
RPTOR
|
â—¼ SHARES_COMPLEX
|
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
MLST8
|
RPS6
|
â—¼ SHARES_COMPLEX
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MLST8
|
EIF4B
|
â—¼ SHARES_COMPLEX
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MLST8
|
MAPKAP1
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MTOR
|
MLST8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
88.0
|
1.0
|
ACSN
|
10702316
10722653
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16556040
16678438
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17461779
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20027184
20138985
20338997
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21533173
21621563
21708191
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
9069260
|
AKT1
|
MLST8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17517883
17277771
18372248
12524439
17386266
|
PRKCA
|
MLST8
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
10679481
10871288
16492141
18851840
20027184
21474067
|
MLST8
|
RPTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
MLST8
|
AKT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
MLST8
|
SGK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
30.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
17461779
17680028
18000759
18492954
18570873
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20338997
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MLST8
|
DEPTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
37.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17461779
17604271
17680028
18000759
18372248
18492954
19022819
19143635
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MLST8
|
DEPTOR
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
37.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17461779
17604271
17680028
18000759
18372248
18492954
19022819
19143635
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MTOR
|
MLST8
|
â—¼ LOCALISATION
|
✅
|
|
88.0
|
1.0
|
ACSN
|
10702316
10722653
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16556040
16678438
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17461779
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20027184
20138985
20338997
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21533173
21621563
21708191
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
9069260
|
MLST8
|
RPTOR
|
â—¼ LOCALISATION
|
✅
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
RHEB
|
MLST8
|
â—¼ UP_REGULATES
|
✅
|
|
7.0
|
1.0
|
ACSN
|
12906785
16636147
17604271
18466115
19022819
19143635
23087689
|
RHEB
|
MLST8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
17604271
15854902
19299511
16636147
12718876
15878852
17470430
19143635
12906785
18466115
|
MLST8
|
SGK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
18000759
20027184
17680028
19151919
19720745
21157483
18925875
10722653
18570873
17461779
21474067
19143635
20338997
12408816
11274345
19568798
|
MLST8
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
35.0
|
1.0
|
Omnipath
|
18000759
20027184
21157483
11756412
11923280
16697215
20398329
17461779
18372248
20338997
15808505
20138985
20214616
21474067
19203586
15718470
19568798
15169778
19720745
17517883
18925875
10949026
11715018
19143635
17277771
18636226
9812896
17680028
19151919
10722653
20832730
18570873
17052453
12408816
11274345
|
MTOR
|
DEPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
37.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17461779
17604271
17680028
18000759
18372248
18492954
19022819
19143635
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MTOR
|
PRR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
18.0
|
1.0
|
ACSN
|
12408816
12906785
16469695
17680028
18492954
18566586
19022819
19143635
19568798
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
RICTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MTOR
|
RPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
MTOR
|
MAPKAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
41.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MTOR
|
EIF4B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
RPS6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
MAPKAP1
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MTOR
|
DEPTOR
|
â—¼ SHARES_COMPLEX
|
|
|
37.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17461779
17604271
17680028
18000759
18372248
18492954
19022819
19143635
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MTOR
|
EIF4B
|
â—¼ SHARES_COMPLEX
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
RPS6
|
â—¼ SHARES_COMPLEX
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
MTOR
|
RICTOR
|
â—¼ SHARES_COMPLEX
|
|
|
41.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MTOR
|
RPTOR
|
â—¼ SHARES_COMPLEX
|
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
MTOR
|
PRR5
|
â—¼ SHARES_COMPLEX
|
|
|
18.0
|
1.0
|
ACSN
|
12408816
12906785
16469695
17680028
18492954
18566586
19022819
19143635
19568798
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
PRKCA
|
MTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
10679481
10871288
16492141
18851840
20027184
21474067
|
MTOR
|
RPTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
MTOR
|
SGK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
30.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
17461779
17680028
18000759
18492954
18570873
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20338997
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MTOR
|
DEPTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
37.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17461779
17604271
17680028
18000759
18372248
18492954
19022819
19143635
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MTOR
|
AKT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
MTOR
|
DEPTOR
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
37.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17461779
17604271
17680028
18000759
18372248
18492954
19022819
19143635
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MTOR
|
RPTOR
|
â—¼ LOCALISATION
|
✅
|
|
72.0
|
1.0
|
ACSN
|
10702316
11108711
11274345
11756498
12150925
12408816
12533512
12709531
12713446
12844354
12867079
12906785
15314020
15749884
15755954
15905173
16286006
16469695
16679021
16713974
16915281
17052453
17053147
17368478
17404308
17604271
17680028
18000759
18046414
18048642
18372248
18391071
18423201
18492954
19022819
19143636
19151919
19225151
19244117
19339977
19446321
19568798
19597330
19706736
19720745
19864431
19930715
20138985
20547845
20647036
20805416
20832730
20932932
21157483
21177869
21233202
21474067
21981924
22504639
23087689
24795729
24973821
25002027
25682865
25730849
26159692
26597054
27328425
27331412
27510662
27572739
28216025
|
RHEB
|
MTOR
|
â—¼ UP_REGULATES
|
✅
|
|
7.0
|
1.0
|
ACSN
|
12906785
16636147
17604271
18466115
19022819
19143635
23087689
|
RPTOR
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
139.0
|
1.0
|
Omnipath
|
15268862
24403073
20427287
22258093
21321085
19446321
15467718
19875983
17461779
12665511
12719976
16631613
21045808
21177249
23911927
24337580
25446900
24516643
18614546
12718876
12747827
16603397
17043309
18519641
22544753
25007995
27043084
19145465
23953116
19619545
16919458
24375676
15459249
16837165
16847060
25332233
12150926
22424946
26348909
12150925
18955708
20381137
22356909
17386266
17565979
18030348
16354680
20169205
19114562
21071439
27329724
35561222
16798736
15809305
22493283
17277771
15661536
16962653
1683716516603397
17604271
18676370
16183647
18505677
23297343
23872070
24036451
15066126
18570873
21614075
18722121
12408816
17599906
|
TELO2
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
20427287
18160036
|
CHUK
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18519641
24990947
18490760
27027448
|
RHEB
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
35.0
|
1.0
|
Omnipath
|
18670866
18075516
18550814
16631613
18466115
16915281
23331499
15772076
16098514
20006481
15878852
21071413
23272152
19299511
15854902
19487463
20226003
19143635
17604271
16636147
17470430
12906785
|
TTI1
|
MTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
20427287
20810650
|
MTOR
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
111.0
|
1.0
|
Omnipath
|
25062042
17510057
17081983
15208671
22873724
16922504
23077579
12087098
28270148
16286006
15896331
25356520
17664694
21790669
26919095
26313911
21561857
10567431
16099428
21977024
14679009
11940578
15899889
15388791
12829246
21980324
22751450
12604610
9465032
20068231
10601311
28122439
19302577
21602892
15718470
15631631
23273915
18669648
21307646
10579915
23261705
20169205
25936802
25486097
24411482
12586835
23342114
15809305
14560963
22472346
11279232
15760907
9271440
27856330
12370290
23486913
12782654
11914378
24795562
19877273
28242756
11500364
26698305
14993219
20459645
23029019
16964243
15212693
25505994
|
MTOR
|
GRB10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
15952796
21659605
21659604
|
MTOR
|
AKT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20338882
17517883
18372248
19203586
27418134
17277771
15718470
26491696
|
MTOR
|
SGK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
18000759
20027184
21157483
17461779
11832334
20338997
21474067
19568798
10191262
19720745
18925875
21981278
21963429
30837283
19143635
9764820
28106162
17680028
19151919
10722653
18570873
12408816
11274345
|
MTOR
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
15.0
|
1.0
|
Omnipath
|
22570710
15952059
19561084
21282364
25973388
14769130
11287630
9335553
17698034
20863384
|
MTOR
|
DEPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
22017877
22017876
22017875
19446321
28086984
|
MTOR
|
RPS6KB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
12150925
11914378
17510057
21157483
17680028
19864431
12087098
15755954
16286006
9465032
15060135
11733037
14560963
12408816
20932932
23486913
19568798
|
MTOR
|
AKT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17517883
18372248
19203586
17277771
15718470
|
MTOR
|
ULK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
70.0
|
1.0
|
Omnipath
|
18000759
19225151
21157483
25759175
15755954
28464882
19446321
27681874
26417067
28518135
19706736
24119841
27325266
26906453
27731364
29686608
25026281
27935582
28366635
28674405
27617292
26869683
29507183
25679763
28389629
25686248
19568798
27387347
21383122
26118643
32134989
26887051
12150925
29540819
29849901
10995454
23136410
30093610
19864431
24358342
26844203
29787772
30127742
19690328
21460634
26447757
26589724
21258367
22770472
29057166
29752434
29066806
17680028
19151919
24998849
30174616
26734992
17595159
12408816
11274345
|
MTOR
|
ULK2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
12150925
19211836
18000759
19225151
21157483
17680028
19151919
19864431
15755954
19446321
19706736
12408816
11274345
19568798
|
MTOR
|
AKT1S1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
25.0
|
1.0
|
Omnipath
|
17604271
17386266
18030348
28978182
19114562
17517883
26876939
18570873
18372248
17277771
|
MTOR
|
EIF4EBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
132.0
|
1.0
|
Omnipath
|
17510057
17081983
11691836
22873724
18767875
16824195
19147279
23077579
24303063
28272965
19690332
11438723
12665511
17043358
19413330
10405182
20670887
19209957
19664995
15070431
9826548
12747827
10942774
16242075
9092573
12604610
20068231
9465032
21190521
23360111
17991864
25686248
9204908
11777913
18669648
12150926
8083223
20537536
12105188
17386266
24205284
17517883
26985829
19291795
23972597
16288292
17487921
8895571
17287340
9405468
20227039
12588975
12370290
17717968
23486913
19651622
10779345
26255626
18220336
16404421
18283322
10364159
15066126
12912989
17693255
15767663
|
MTOR
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
80.0
|
1.0
|
Omnipath
|
18000759
20027184
21157483
11756412
11923280
24670654
16697215
11438723
21592956
20398329
17461779
18372248
21177249
21045808
20338997
15808505
16221682
20138985
20489726
15899889
20214616
8978681
21474067
14970221
19203586
17660512
15718470
19568798
20333297
23006971
15169778
25241761
18566586
19720745
17517883
18925875
22084251
10949026
14761976
11715018
19143635
17277771
18636226
10910062
15047712
9812896
18505677
21343617
19844585
17680028
19151919
18566587
9736715
23872070
10722653
20832730
18570873
17013611
17052453
12408816
15364915
11274345
|
NRAS
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
PIK3CA
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
KRAS
|
PIK3R1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
9069260
25241761
10212255
11313862
9150145
16713569
15021914
|
INSR
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
34.0
|
1.0
|
Omnipath
|
15629149
17389395
8276809
18083107
11796522
8385099
20068231
8567177
16497976
15592455
17570479
9593725
7589433
14729945
17016520
10500481
|
IGF1R
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
8603569
17496910
25241761
8697095
7642582
17570479
18595745
7589433
|
PTEN
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
16288286
10648629
17218262
12040186
15584861
|
IRS1
|
PIK3R1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
60.0
|
1.0
|
Omnipath
|
12444011
11788580
14632132
14511371
19030972
16931767
7486683
21798082
11403293
12173038
8382612
12220227
12767520
10826997
16230374
7680095
23439647
19561084
16150444
12107746
10358772
11748924
12175651
7499365
7935461
15316008
9564850
16354680
16043515
12730242
11416002
7680644
23643389
21540285
8628286
15514089
11438664
8175658
9233603
1381348
25814554
|
PIK3R1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
10527852
16799564
19442713
|
PIK3R1
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
8596638
25241761
20713702
27107012
11733063
21825134
32814053
26496610
8139559
14729945
10358930
14665640
|
PIK3R1
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
9113989
8596638
21827948
12147247
11733063
22020336
24165795
31031754
14665640
|
PIK3R1
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17474147
19531499
25241761
|
RPTOR
|
RRAGA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
RPTOR
|
RPS6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
RPTOR
|
EIF4B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
RPTOR
|
DEPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
35.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17604271
17680028
18000759
18372248
18492954
19022819
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
RPTOR
|
DEPTOR
|
â—¼ SHARES_COMPLEX
|
|
|
35.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17604271
17680028
18000759
18372248
18492954
19022819
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
RPTOR
|
RPS6
|
â—¼ SHARES_COMPLEX
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
RPTOR
|
EIF4B
|
â—¼ SHARES_COMPLEX
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
AKT1
|
RPTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
18.0
|
1.0
|
ACSN
|
10722653
10949026
11715018
11756412
11923280
15169778
15808505
16697215
17052453
17680028
18372248
18570873
18636226
20138985
20214616
20398329
20832730
9812896
|
RPTOR
|
DEPTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
35.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17604271
17680028
18000759
18372248
18492954
19022819
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
RPTOR
|
DEPTOR
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
35.0
|
1.0
|
ACSN
|
11274345
11756498
12150925
12408816
12906785
15749884
15755954
16469695
16713974
17404308
17604271
17680028
18000759
18372248
18492954
19022819
19143636
19151919
19446321
19568798
19706736
19864431
20547845
20805416
21157483
21981924
22504639
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
RHEB
|
RPTOR
|
â—¼ UP_REGULATES
|
✅
|
|
7.0
|
1.0
|
ACSN
|
12906785
16636147
17604271
18466115
19022819
19143635
23087689
|
RPS6KA1
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
18220336
19369195
21325048
18722121
18439900
19413330
18669648
25361081
|
RRAGC
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
21816923
25561175
20006481
18497260
24337580
25446900
21981924
|
PRKAA1
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
21460634
18439900
|
RHEB
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17604271
15854902
19299511
16636147
24337580
15878852
17470430
19143635
16631613
12906785
18466115
25446900
|
AKT1S1
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
17604271
17510057
18030348
17386266
18215133
17517883
33230243
|
PRKAA2
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
9.0
|
1.0
|
Omnipath
|
18220336
19369195
18722121
18439900
20083114
19413330
18669648
|
EIF4EBP1
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
40.0
|
1.0
|
Omnipath
|
18337751
24403073
16824195
12665511
12747827
12604610
18606717
19272448
16837165
12150926
18955708
21071439
16798736
22493283
17502379
15066126
18722121
12912989
15767663
|
AKT1
|
RPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
29.0
|
1.0
|
Omnipath
|
18000759
21157483
11756412
11923280
16697215
20398329
17461779
18372248
15808505
20138985
20214616
19568798
15169778
19720745
17517883
10949026
11715018
19143635
17277771
18636226
9812896
17680028
19151919
10722653
20832730
18570873
17052453
12408816
11274345
|
RPTOR
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
16183647
12087098
12604610
9465032
28249155
12150926
|
SESN2
|
TSC2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
14651849
15509864
15980064
16054095
16054096
17244528
18692468
19037093
19197243
19339977
20484410
|
SESN2
|
TSC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
14651849
15509864
15980064
16054095
16054096
17244528
18692468
19037093
19197243
19339977
20484410
|
RICTOR
|
SGK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
26.0
|
1.0
|
ACSN
|
11154281
11500365
11900249
12648680
12820959
15071497
15340381
15459660
15688063
15703371
16469695
16697054
17884153
18570873
18636226
18925875
18931676
19143635
19584721
19622404
19686080
19809470
19847258
20338997
20832730
26159692
|
MAPKAP1
|
SGK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
30.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
16469695
17461779
17680028
18000759
18492954
18570873
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20338997
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
PDPK1
|
SGK1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
ACSN
|
11500365
11687500
11747822
12670391
15802604
16286006
17680028
18802401
19109239
19122654
20932932
|
PRR5
|
SGK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
18000759
20027184
17680028
19151919
19720745
21157483
18925875
10722653
18570873
17461779
21474067
19143635
20338997
12408816
11274345
19568798
|
PDPK1
|
SGK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
41.0
|
1.0
|
Omnipath
|
16286006
25384981
18802401
12387817
17916563
23331499
11807089
16189514
12023960
10191262
22042038
10357815
24760523
11500365
23317821
20932932
12912918
15209375
24864229
17680028
|
RICTOR
|
SGK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
21204013
15340381
12820959
18925875
19584721
18636226
20832730
18570873
19143635
11500365
20338997
15071497
15688063
11154281
|
MAPKAP1
|
SGK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
18000759
20027184
17680028
19151919
19720745
21157483
18925875
10722653
18570873
17461779
21474067
19143635
20338997
12408816
11274345
19568798
|
STK11
|
STRADA
|
â—¼ PHYSICAL_INTERACTION
|
|
|
8.0
|
1.0
|
ACSN
|
15509864
18687677
19197243
19942859
20160076
20484410
23030059
8910387
|
STK11
|
STRADA
|
â—¼ SHARES_COMPLEX
|
|
|
8.0
|
1.0
|
ACSN
|
15509864
18687677
19197243
19942859
20160076
20484410
23030059
8910387
|
PRKAA1
|
STK11
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
Reactome
|
14511394
15579580
8779952
14985505
14614828
11018120
|
PRKAA2
|
STK11
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
Reactome
|
14511394
15579580
8779952
14985505
14614828
11018120
|
RPS6KA1
|
STK11
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
28522753
11853558
25846811
11297520
|
STK11
|
PRKAA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
10642499
14976552
8910387
18693249
12764152
26489410
15509864
14614828
12413941
20160076
19197243
15980064
|
STK11
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23331499
12973359
25069613
20592207
|
STK11
|
PTEN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
25763354
17875968
15987703
16107342
11035045
12077256
18321849
23379765
21779440
12297295
25336918
|
STK11
|
PRKAA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
64.0
|
1.0
|
Omnipath
|
16434556
25792737
14985505
14976552
20489196
21062936
20656472
20616029
17255104
16041368
25696921
21399626
12391032
20160076
17244528
15980064
17054914
22517326
14532170
21918180
28694351
18693249
26771234
20801214
16600998
18195011
28723898
16912160
22039048
26068970
14614828
19884317
25679763
22575644
19197243
27864418
30022161
25683918
18303014
17287464
15327994
12764152
16054095
15509864
26506235
14511394
27181208
28625738
25874865
8910387
17276402
26247630
21680840
19414597
23418352
24289924
15383373
|
STK11
|
STRADA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
20562859
25241761
12805220
14676191
21860411
19513107
15561763
25852190
15733851
|
TNF
|
TNFRSF1A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
33.0
|
1.0
|
ACSN
|
11112697
11274345
11279185
12531547
12646658
1330325
1431106
14607933
14625680
15099563
15310755
15699106
17916596
18633355
19411070
20038811
20184663
21133840
21411734
21826665
21920725
22955274
23170255
23430059
23510023
23567181
23769623
24092389
26201938
26801188
28765050
8663014
8910423
|
TNF
|
TNFRSF1A
|
â—¼ PROTEIN_INTERACTION
|
|
|
33.0
|
1.0
|
ACSN
|
11112697
11274345
11279185
12531547
12646658
1330325
1431106
14607933
14625680
15099563
15310755
15699106
17916596
18633355
19411070
20038811
20184663
21133840
21411734
21826665
21920725
22955274
23170255
23430059
23510023
23567181
23769623
24092389
26201938
26801188
28765050
8663014
8910423
|
TNF
|
TNFRSF1A
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
98.0
|
1.0
|
Omnipath
|
17145710
19084540
8288897
11448951
23746843
22801493
14732063
2848815
9568681
2158863
8182064
9488135
23070005
20080539
11239407
26670046
14743216
21724995
21133840
24070898
25911380
7852363
2170974
17151142
26186194
27560715
25241761
23032187
24726327
20103630
8805640
11502070
19442713
3034874
23955153
18067990
22099304
15485837
22675546
12753742
1310388
12887920
19287455
10634209
2170559
1331108
24980434
22028622
|
TNF
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
22328823
22869320
19808894
12110133
11160134
12409308
22266116
21478880
11684411
25352752
24966659
29425748
16754954
25355439
22823902
18443205
24648009
26976796
25645159
23592917
|
TNFRSF1A
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23815148
21724995
10795740
24323043
10755617
|
FZD7
|
WNT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
10862746
20006983
17433286
23396967
15143170
15169958
21316585
16495441
20940229
23140633
|
DVL2
|
WNT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
WNT1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
WNT1
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
WNT1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
WNT1
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
WNT1
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
10862746
20006983
17433286
23396967
15143170
15169958
21316585
16495441
20940229
23140633
|
WNT1
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
14642436
15578921
|
WNT1
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
21.0
|
1.0
|
Omnipath
|
21078818
11029007
10557084
23331499
29444668
21071413
11448771
18988627
|
WNT1
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
15454084
1545408415454080
11448771
|
WNT1
|
FZD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
91476519147651
9147651
|
WNT1
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
10557084
22944199
15578921
16936075
24032637
|
WNT1
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
21078818
11336703
15578921
|
DVL2
|
FZD7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
23821037
15936275
10698942
9716412
17130287
9674432
17627283
11358862
11101902
12015986
14636582
|
FZD7
|
WNT11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
10862746
20006983
17433286
23396967
15143170
15169958
21316585
16495441
20940229
23140633
|
WNT2
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
23815780
|
WNT11
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
10862746
|
WNT3A
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18215320
|
WNT3
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
25892522
18313787
24032637
|
WNT5A
|
FZD7
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
10990458
|
PRKAA2
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
18692468
16959574
19339977
14651849
|
PRKAA2
|
ULK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
21205641
19584320
|
PRKAA2
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
18692468
19339977
14651849
|
WNT7A
|
FZD10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
12857724
18567805
|
WNT7B
|
FZD10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15923619
|
TSC2
|
TBC1D7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17658474
22795129
18466115
20095038
|
TSC2
|
TSC1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150915
12172553
12869586
12906785
14551205
14651849
15342917
15611338
15851026
16556040
16636147
16678438
16959574
17604271
17680028
17693255
18198340
18481918
18692468
18974095
19022819
19027299
19339977
20146692
21533173
21621563
21708191
23030059
26597054
27328425
9069260
|
TSC2
|
TSC1
|
â—¼ PROTEIN_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150915
12172553
12869586
12906785
14551205
14651849
15342917
15611338
15851026
16556040
16636147
16678438
16959574
17604271
17680028
17693255
18198340
18481918
18692468
18974095
19022819
19027299
19339977
20146692
21533173
21621563
21708191
23030059
26597054
27328425
9069260
|
AKT1
|
TSC2
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
18.0
|
1.0
|
ACSN
|
10722653
10949026
11715018
11756412
11923280
15169778
15808505
16697215
17052453
17680028
18372248
18570873
18636226
20138985
20214616
20398329
20832730
9812896
|
TSC2
|
RHEB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
ACSN
|
12906785
16636147
17680028
19022819
20146692
|
TSC2
|
TSC1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
31.0
|
1.0
|
ACSN
|
12150915
12172553
12869586
12906785
14551205
14651849
15342917
15611338
15851026
16556040
16636147
16678438
16959574
17604271
17680028
17693255
18198340
18481918
18692468
18974095
19022819
19027299
19339977
20146692
21533173
21621563
21708191
23030059
26597054
27328425
9069260
|
GSK3B
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
24795562
12511557
23265840
15972957
16959574
22980037
22732551
|
RPS6KA3
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
6.0
|
1.0
|
Omnipath
|
17570479
15342917
16244323
|
PRKAA1
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
19339977
33271062
14651849
16959574
15261145
28591720
18692468
20363874
|
AKT1
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
75.0
|
1.0
|
Omnipath
|
16873412
12820960
17018601
11756412
32308763
11923280
16697215
19690332
21893193
20398329
18372248
21177249
12438239
18466115
15808505
29042482
20138985
15342917
17597835
20214616
12271141
16702951
20837138
17570479
26844273
15169778
17386266
10949026
16288292
24590173
11715018
15661536
18636226
18411301
20028854
9812896
16636147
20169078
17680028
12172553
19664994
18707149
10722653
12150915
18570873
20832730
12364343
17052453
18283331
21666717
27451907
|
RPS6KA1
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
21.0
|
1.0
|
Omnipath
|
15342917
17081983
16244323
15963462
29351204
20068231
19690332
15757502
15851026
20045011
22980037
28289099
|
AKT2
|
TSC2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
12.0
|
1.0
|
Omnipath
|
12150915
12167664
12172553
19188143
|
TSC2
|
RHEB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
19.0
|
1.0
|
Omnipath
|
15340059
15854902
23331499
16636147
12869586
17680028
21071413
20146692
12771962
20226003
12906785
12842888
|
TSC2
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
84.0
|
1.0
|
Omnipath
|
12167664
16424383
12511557
21134130
14551205
10915759
11741832
15340059
20166753
23331499
15342917
9580671
21071413
16464865
15851026
11290735
9809973
15851513
12869586
10807585
15963462
10585443
11741833
20412061
20226003
11175345
25263562
16339216
18411301
16636147
14651849
17658474
17693255
12176984
17077083
|
RICTOR
|
MAPKAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
45.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
15718470
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19203586
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
22475393
22924465
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
DEPTOR
|
MAPKAP1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
25.0
|
1.0
|
ACSN
|
11274345
11756498
12408816
12906785
16469695
17461779
17680028
18000759
18492954
19022819
19143635
19151919
19446321
19568798
19706736
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
MAPKAP1
|
PRR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
18.0
|
1.0
|
ACSN
|
12408816
12906785
16469695
17680028
18492954
18566586
19022819
19143635
19568798
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
DEPTOR
|
MAPKAP1
|
â—¼ SHARES_COMPLEX
|
|
|
25.0
|
1.0
|
ACSN
|
11274345
11756498
12408816
12906785
16469695
17461779
17680028
18000759
18492954
19022819
19143635
19151919
19446321
19568798
19706736
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
RICTOR
|
MAPKAP1
|
â—¼ SHARES_COMPLEX
|
|
|
45.0
|
1.0
|
ACSN
|
10722653
11274345
11756498
12408816
12906785
15718470
16469695
16556040
16678438
17461779
17680028
18000759
18481918
18492954
18566586
18570873
18925875
19022819
19027299
19143635
19151919
19203586
19446321
19568798
19706736
19720745
20027184
20338997
21157483
21474067
21533173
21621563
21708191
21981924
22475393
22924465
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9069260
|
MAPKAP1
|
PRR5
|
â—¼ SHARES_COMPLEX
|
|
|
18.0
|
1.0
|
ACSN
|
12408816
12906785
16469695
17680028
18492954
18566586
19022819
19143635
19568798
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
PRKCA
|
MAPKAP1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
10679481
10871288
16492141
18851840
20027184
21474067
|
MAPKAP1
|
AKT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
MAPKAP1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
18000759
20027184
21157483
11756412
11923280
16697215
20398329
17461779
18372248
20338997
15808505
20138985
20214616
21474067
19203586
15718470
19568798
15169778
19720745
17517883
18925875
10949026
11715018
19143635
17277771
18636226
16962653
9812896
19844585
17680028
19151919
10722653
20832730
18570873
17052453
12408816
11274345
|
RICTOR
|
PRR5
|
â—¼ PHYSICAL_INTERACTION
|
|
|
18.0
|
1.0
|
ACSN
|
12408816
12906785
16469695
17680028
18492954
18566586
19022819
19143635
19568798
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
RICTOR
|
DEPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
25.0
|
1.0
|
ACSN
|
11274345
11756498
12408816
12906785
16469695
17461779
17680028
18000759
18492954
19022819
19143635
19151919
19446321
19568798
19706736
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
RICTOR
|
DEPTOR
|
â—¼ SHARES_COMPLEX
|
|
|
25.0
|
1.0
|
ACSN
|
11274345
11756498
12408816
12906785
16469695
17461779
17680028
18000759
18492954
19022819
19143635
19151919
19446321
19568798
19706736
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
|
RICTOR
|
PRR5
|
â—¼ SHARES_COMPLEX
|
|
|
18.0
|
1.0
|
ACSN
|
12408816
12906785
16469695
17680028
18492954
18566586
19022819
19143635
19568798
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
PRKCA
|
RICTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
6.0
|
1.0
|
ACSN
|
10679481
10871288
16492141
18851840
20027184
21474067
|
AKT1
|
RICTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
AKT1
|
RICTOR
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
45.0
|
1.0
|
ACSN
|
10722653
10949026
11274345
11715018
11756412
11756498
11923280
12408816
12906785
15169778
15808505
16469695
16697215
17052453
17461779
17680028
18000759
18372248
18492954
18570873
18636226
18925875
19022819
19143635
19151919
19568798
19720745
20027184
20138985
20214616
20338997
20398329
20832730
21157483
21474067
21981924
23087689
24795729
24973821
25002027
25730849
26159692
27331412
28216025
9812896
|
RPS6KB1
|
RICTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
35.0
|
1.0
|
Omnipath
|
17053147
25049885
19339977
16286006
25596749
20647036
20418915
11108711
22484804
28700668
21487027
28315487
18423201
19935711
23639840
23615631
21233202
23544169
25241761
19720745
12713446
28342808
15809305
21438886
15905173
22193713
20832730
19995915
17052453
|
AKT1
|
RICTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
46.0
|
1.0
|
Omnipath
|
18000759
20027184
21157483
11756412
11923280
16697215
20398329
17461779
18372248
21177249
20338997
19402821
15808505
20138985
21339740
16603397
20214616
21474067
16919458
15718470
19568798
17545609
15169778
18566586
25241761
19720745
18925875
22990118
10949026
11715018
19143635
18636226
18411301
9812896
21343617
17680028
19151919
18566587
10722653
20832730
18570873
17052453
12408816
11274345
|
EIF4EBP1
|
EIF4E
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
111.0
|
1.0
|
Omnipath
|
24211447
24722188
35044719
16824195
18957614
8521827
25416956
11553333
10405182
22509910
11605658
17254965
16271312
17689282
22586265
16648488
16467844
12747827
16242075
10772338
12604610
12867426
12747804
10330171
21798997
12482586
16189514
15550948
21191102
12071973
10406811
18955708
12105188
20224576
17353931
26186194
8816458
17316564
15094042
10753870
16798736
10022874
32296183
19834456
10698949
15153109
15661536
11146653
12588975
16504179
10394359
7935836
7651417
22678294
20880835
10364159
23584478
15767663
|
PRKCB
|
EIF4E
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
8662663
12897141
9155017
11723111
95301551
11463832
9878069
|
PRKCA
|
EIF4E
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
1911648
8662663
2355012
12897141
9155017
17570479
11723111
95301551
11463832
9878069
|
RHOA
|
PTEN
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
32.0
|
1.0
|
ACSN
|
10953004
11698448
11729192
11739775
11992112
12194823
12361600
12740575
12778124
14657501
14744429
15761148
15793569
17517963
18037882
18423981
20008297
20351293
20535745
21178402
21642958
21840487
22949611
24857661
24919149
26885855
27048821
27066895
7479854
9362522
9660866
9822605
|
PTEN
|
AKT1
|
â—¼ DOWN_REGULATES
|
✅
|
-
|
22.0
|
1.0
|
ACSN
|
10753747
11747822
12040186
15721744
16288286
16982858
17218262
17409395
19440036
19847259
19945467
20609352
21084277
22179046
22465479
23732914
24030100
24254977
25364523
26597054
27328425
27572739
|
GSK3B
|
PTEN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
25.0
|
1.0
|
Omnipath
|
20080742
19797085
16107342
12040186
23379765
16611981
10671551
16039586
17570479
12615961
25763354
19575820
17444818
20537194
26339505
23210979
17052453
18455992
16371461
11274345
12297295
|
AKT1
|
PTEN
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
23.0
|
1.0
|
Omnipath
|
19903340
15987703
10790335
20596030
10592173
20605778
10866658
12077256
11035045
16107342
12297295
|
PTEN
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
16288286
10648629
17218262
12040186
15584861
|
PTEN
|
SOS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
16288286
10648629
17218262
12040186
15584861
|
PTEN
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
16288286
10648629
17218262
12040186
15584861
|
HRAS
|
RAF1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
RAF1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
53.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
9069260
9510155
|
RAF1
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
RAF1
|
LAMTOR2
|
â—¼ SHARES_COMPLEX
|
|
|
53.0
|
1.0
|
ACSN
|
10086337
10567412
10811803
10843677
10982827
11034387
11062502
11385609
11447289
11532940
11777939
11907067
12040186
12175651
12419216
12479806
12566895
12640133
12782630
14585353
14764585
15169888
15516985
15536084
15547943
15567848
15574420
15735649
15863030
16102570
16227978
16488589
16582911
16887996
17178906
17395718
17496910
17673906
18039929
19289794
19449109
19541618
19565474
19568798
19615955
21102635
22435554
24027568
26552706
7510700
8551221
9069260
9510155
|
RAF1
|
HRAS
|
â—¼ SHARES_COMPLEX
|
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
RAF1
|
HRAS
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
14.0
|
1.0
|
ACSN
|
10358164
11532940
12566895
14764585
15516985
16102570
19289794
19565474
24027568
7510700
8551221
9069260
9763606
9846483
|
KRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
53.0
|
1.0
|
Omnipath
|
10958680
12750173
9516156
12932319
9665134
10783161
8805624
1386920
1639773
8340422
8601312
19595761
23331499
16041367
21071413
8332195
9446616
10882715
25852190
10531446
1996324
19029954
8503013
16093354
19541618
23153539
16293107
1708096
19933846
26721396
11136732
10205168
20802526
31980649
7760835
18775988
8307946
12917261
11134016
20080631
8180183
1990291
|
AKT1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
51.0
|
1.0
|
Omnipath
|
19197339
11971957
18767875
20230923
10576742
20068231
17570479
16189514
18669648
25241761
18691976
10576741
10618391
20688159
21745501
12087097
12801936
12048182
22798428
16854453
19058874
11997508
|
HRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
147.0
|
1.0
|
Omnipath
|
17145710
18273062
9523700
1639773
8601312
19595761
20133694
11032808
9154803
10882715
14654780
1996324
19222999
16301319
11948414
8530446
7969158
11313862
9150145
20080631
1990291
12750173
15031288
12932319
9665134
8805624
8340422
1386920
23331499
16916524
16041367
23180781
18988627
20178605
15688026
15664191
22169110
11733498
7862125
8180183
19063885
12391160
9144171
8035810
9020159
14724584
19696784
21779497
9261098
12173045
12620389
8628317
19914712
1708096
19933846
26721396
7730360
10205168
8332187
16803888
18775988
12917261
9099670
10545207
25684575
8670882
10783161
12379659
10887184
17569879
21071413
8332195
7523381
10531446
24929361
8503013
16093354
19541618
10369681
8911690
18073111
11136732
10922060
7760835
11134016
|
PRKCG
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
8288587
17053865
|
PRKAA1
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
27.0
|
1.0
|
Omnipath
|
19651622
12801936
19007248
11971957
20166139
20068231
9091312
10576742
9710607
11997508
|
PRKCB
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8288587
1386920
12917261
22826029
|
RHEB
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
15854902
16803888
15150271
16189514
9001246
19222999
|
PRKCA
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
27.0
|
1.0
|
Omnipath
|
1386920
23331499
9447975
8321321
12551925
8288587
7935389
12917261
9922370
15664191
93309588
1437148
|
NRAS
|
RAF1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
46.0
|
1.0
|
Omnipath
|
9867809
12750173
12932319
9001246
9665134
8805624
1386920
1639773
8340422
8601312
19595761
23331499
21071413
8332195
10531446
10882715
7811320
1996324
18988627
21779497
8636091
8503013
7766599
16093354
19541618
8180183
1708096
19933846
32296183
9525741
8876196
11136732
10205168
21478863
7760835
18775988
12917261
11134016
18641128
20080631
9488663
1990291
|
RAF1
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
47.0
|
1.0
|
Omnipath
|
7565670
12750173
18799465
16364241
11909642
19219045
21988832
23331499
15342917
8933152
9671314
8393135
9808624
8223433
16189514
18988627
18669648
19541618
16293107
10969079
10567369
8157000
11136732
11948414
7898932
9069260
18039929
19369195
8607979
10327068
17116858
24746704
12920017
16129686
19058874
15466214
|
RAF1
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
143.0
|
1.0
|
Omnipath
|
10757792
18337766
18799465
15342917
23728975
26496610
15866172
17053865
11242034
9351825
9677429
8157000
7992057
11948414
11604401
16129686
10677502
12695496
19197339
7565670
12750173
7936666
1326789
19219045
23331499
18556463
10976102
18988627
15485920
15175348
18691976
16407412
10409742
9311917
17192257
7898932
8621729
23934108
11684694
21336309
7624324
12920017
11948406
15466214
11042690
12907640
9032297
27169363
12876277
8933152
8223433
8248196
8131746
12594221
10969079
10567369
17979178
17724343
24746704
19058874
10958680
8090753
21071413
7731720
7873542
1330321
8503013
16093354
19541618
8394352
15466476
25155755
11136732
9069260
94178255
8607979
10327068
10359597
8039496
20212043
|
PDPK1
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
10228164
15314172
11689445
28539435
11726503
19879889
8635462
|
PIK3R2
|
HRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
HRAS
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
HRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
SOS2
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
17496910
12628188
17673906
21779497
|
SOS1
|
HRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
41.0
|
1.0
|
Omnipath
|
12628188
10208427
16713569
10913276
23331499
18454158
15507210
10592173
17673906
17496910
26721396
20133692
19141281
23132018
11560935
9447984
9690470
17084389
|
HRAS
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
9069260
9113989
9235916
21779497
11739523
10545207
|
HRAS
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
9069260
9113989
8052307
24412244
17540175
9931431
11313862
14724584
10592173
9150145
8665852
10783161
|
HRAS
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
36.0
|
1.0
|
Omnipath
|
17145710
7706312
14970219
18567582
12932319
8073291
1386920
23331499
8601312
9154803
18988627
8668348
21779497
19541618
19933846
17563371
18098337
16803888
26165597
24441586
16135787
12917261
15710605
10545207
|
DVL1
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
LRP6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL1
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
DVL1
|
WNT3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
RHEB
|
DEPTOR
|
â—¼ PHYSICAL_INTERACTION
|
|
|
22.0
|
1.0
|
ACSN
|
12150925
12408816
12906785
15755954
16469695
17680028
18466115
18492954
19022819
19143635
19568798
19864431
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
26597054
28216025
|
RHEB
|
DEPTOR
|
â—¼ SHARES_COMPLEX
|
|
|
22.0
|
1.0
|
ACSN
|
12150925
12408816
12906785
15755954
16469695
17680028
18466115
18492954
19022819
19143635
19568798
19864431
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
26597054
28216025
|
TSC1
|
RHEB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
12906785
14551205
16636147
17604271
17680028
17693255
19022819
20146692
|
AKT1
|
RHEB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17517883
17277771
18372248
12524439
17386266
|
RHEB
|
DEPTOR
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
22.0
|
1.0
|
ACSN
|
12150925
12408816
12906785
15755954
16469695
17680028
18466115
18492954
19022819
19143635
19568798
19864431
21157483
21981924
23087689
24795729
24973821
25002027
25730849
26159692
26597054
28216025
|
TSC1
|
RHEB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
17604271
16636147
20006481
17680028
20146692
14551205
17693255
|
RHEB
|
AKT1S1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
10.0
|
1.0
|
Omnipath
|
17604271
17510057
16636147
12820960
12869586
17386266
19446321
19143635
17277771
18466115
|
RHEB
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
18.0
|
1.0
|
Omnipath
|
19651622
20166139
16803888
18691976
20068231
18452278
12214276
15150271
18669648
|
AKT2
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
19609947
12048203
10485710
|
AKT1
|
CHUK
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
31.0
|
1.0
|
Omnipath
|
15710601
12048203
25241761
19442713
11278366
10485711
15800029
19609947
17570479
17660512
18515365
19088076
10485710
|
CHUK
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
91.0
|
1.0
|
Omnipath
|
9346484
24911653
20932476
28514442
11971985
16970925
12210728
9346485
17965022
16713569
12486103
9891086
15456791
11057907
20434986
16129692
16260493
21903422
21724995
16286467
14743216
16319058
18949366
10779355
25748427
25852190
12244103
11585904
9751060
15218526
10094049
10837071
9914500
21575199
9721103
25241761
10195894
9689078
15214841
21784860
17561400
21640763
16285893
10733566
16186825
16493424
10022904
12709429
12351658
10968790
12547194
15691841
15620648
15327770
11864612
11460167
14636585
17693255
17072322
9346241
|
RPS6KA1
|
DEPTOR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
22017877
22017876
|
EIF4B
|
RPS6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
EIF4B
|
RPS6
|
â—¼ SHARES_COMPLEX
|
|
|
31.0
|
1.0
|
ACSN
|
12150925
12408816
12844354
12867079
12906785
15755954
15905173
16286006
16469695
16679021
17368478
17680028
18391071
18492954
19022819
19339977
19568798
19597330
19864431
20647036
21157483
21177869
21233202
21981924
23087689
24795729
24973821
25002027
25730849
26159692
28216025
|
RPS6KB1
|
EIF4B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
50.0
|
1.0
|
Omnipath
|
17053147
25220053
19339977
16286006
20647036
17664694
11108711
19413330
19664995
15507151
16083285
20068231
16763566
18423201
22579465
29494492
21233202
19720745
12713446
15071500
29547541
23317821
22253885
19651622
15905173
17924679
16404421
18707149
20832730
29301334
17052453
15212693
|
AKT1
|
EIF4B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18836482
17570479
25749412
|
RPS6KA1
|
EIF4B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
15187187
21233202
17924679
16286006
16083285
15071500
17664694
16763566
19114553
19413330
15239952
|
AKT1
|
SKP2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23807222
28446188
22733130
19270695
20160512
19549334
21963805
|
DVL2
|
WNT11
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
23821037
15936275
10698942
9716412
17130287
9674432
17627283
11358862
11101902
12015986
14636582
|
DVL2
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
LRP6
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
GSK3B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
DVL2
|
WNT3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL2
|
WNT5A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
11.0
|
1.0
|
Reactome
|
23821037
15936275
10698942
9716412
17130287
9674432
17627283
11358862
11101902
12015986
14636582
|
DVL2
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
PRKCG
|
DVL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
12958364
11940581
21386996
11313945
15567848
|
PRKCA
|
DVL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
12958364
11940581
21386996
11313945
15567848
|
FZD4
|
DVL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
12958364
27096005
23331499
|
PRKCB
|
DVL2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
12958364
11940581
21386996
11313945
15567848
|
LRP6
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
LRP6
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
LRP6
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
LRP6
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
LRP6
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
FZD8
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
11448771
21078818
11029007
20093360
|
GSK3B
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
22357953
23331499
19107203
21606194
16890161
21709260
16340998
16365045
19366350
21406690
16341017
17318175
|
WNT3A
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
23400998
21078818
19339249
12897152
14739301
24265322
16890161
22726442
19910923
15578921
20093360
22491013
18772438
21944579
|
WNT3
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18528331
15578921
|
WNT5A
|
LRP6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
28143772
19056682
15578921
23462101
18606138
|
WNT8B
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
DVL3
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
GSK3B
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
WNT11
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
10862746
20006983
17433286
23396967
15143170
15169958
21316585
16495441
20940229
23140633
|
WNT3A
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
WNT8A
|
FZD1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
WNT5A
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10557084
|
WNT3
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10557084
|
WNT3A
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
21078818
10557084
11029007
10601008
|
WNT2
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
10557084
|
WNT7B
|
FZD1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15923619
|
WNT2B
|
FZD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
24032637
21856951
|
WNT7B
|
FZD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
15923619
24032637
|
WNT5A
|
FZD4
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
10990458
16602827
|
TSC1
|
TBC1D7
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17658474
22795129
18466115
20095038
|
AKT1
|
TSC1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
18.0
|
1.0
|
ACSN
|
10722653
10949026
11715018
11756412
11923280
15169778
15808505
16697215
17052453
17680028
18372248
18570873
18636226
20138985
20214616
20398329
20832730
9812896
|
AKT1
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
23.0
|
1.0
|
Omnipath
|
12167664
11756412
11923280
16697215
20398329
18372248
15808505
20138985
20214616
15169778
10949026
16288292
11715018
18636226
9812896
17680028
12172553
10722653
12150915
18570873
20832730
17052453
|
IKBKB
|
TSC1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
26.0
|
1.0
|
Omnipath
|
23144589
22408430
20300203
22264792
21559457
22435559
18075516
20146692
22003905
22017429
17693255
22980037
18716620
19188143
|
PDPK1
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
10228164
15314172
11689445
28539435
11726503
19879889
8635462
|
PDPK1
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
10228164
15314172
11689445
28539435
11726503
19879889
8635462
|
PDPK1
|
AKT1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
8.0
|
1.0
|
ACSN
|
11687500
11747822
12670391
15802604
17680028
18802401
19109239
19122654
|
IGF1R
|
PDPK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20044479
11054117
17570479
20643654
|
PDPK1
|
AKT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
35.0
|
1.0
|
Omnipath
|
15743829
15191648
10679787
23331499
19203586
15718470
26491696
26937223
9374542
24169049
15890450
28589878
9512493
12048203
10822383
12434148
20059950
11134526
|
PDPK1
|
AKT3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
9512493
12162751
10208883
23603119
19203586
15718470
|
PDPK1
|
PRKCB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15209375
17115692
9889098
16189514
11376011
|
PDPK1
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
70.0
|
1.0
|
Omnipath
|
17081983
12429015
15208671
18326039
16286006
11438723
21561857
18802401
19864428
16099428
7545671
7489717
27149630
15388791
12183455
10601311
9465032
26582459
29257917
12967624
24604594
15718470
9427642
10209156
23769967
12586835
15809305
9218810
11500365
14560963
9271440
20932932
12370290
11914378
11684675
17680028
14993219
19570988
9445476
|
PDPK1
|
RPS6KA3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
25241761
10480933
17906627
19956600
10856237
28314444
|
PDPK1
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
8131746
8394352
15175348
15466476
94178255
7731720
7624324
8157000
8039496
8621729
|
PDPK1
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
156.0
|
1.0
|
Omnipath
|
15505410
12538620
12176337
19951971
24352480
11752451
19401591
11369519
10698680
10601311
15718470
24950409
20481595
24169049
10570282
16798838
14993273
11500365
9368760
19844585
17680028
7637810
9169478
26256536
7722458
9094314
12750173
11438723
18802401
9252186
23331499
18456494
9104825
10592173
16189514
20361045
18988627
11278835
20163786
20333297
20041157
12808134
19602588
8630736
10207050
11241670
10438924
9868760
25912234
20153221
25582703
11445557
21775285
12149249
14666721
18596232
9512493
23397142
11809791
12167717
21798082
16033886
10679787
16787925
29562639
15550174
21071413
8978681
10833263
19203586
10226025
26937223
14500673
20161206
11136732
11825911
11042193
9642236
22569334
18662999
9736715
12242303
11313365
11598012
11134526
|
PDPK1
|
PRKCA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15209375
11078882
10698939
9889098
|
PDPK1
|
RPS6KA2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
19369195
10480933
17192257
17906627
|
PDPK1
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15175348
15466476
|
PDPK1
|
RPS6KA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
20058876
18767875
10480933
7642538
17906627
27028868
9430688
|
PDPK1
|
RPS6KB2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
18.0
|
1.0
|
Omnipath
|
15209375
17680028
16286006
12713446
11733037
11500365
14560963
18802401
20932932
9445476
|
IRS1
|
SOS1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
7.0
|
1.0
|
Reactome
|
8316835
8810325
9832424
8621421
8530377
9852124
9003010
|
IGF1R
|
IRS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
15.0
|
1.0
|
ACSN
|
10086337
10826997
11274345
12175651
12444011
12556535
12655147
12767520
16931767
17145802
17673906
19030972
21540285
24103846
24782617
|
AKT1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
17570479
17640984
10497255
|
RPS6KB1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
47.0
|
1.0
|
Omnipath
|
21283818
17081983
16953237
24931005
11287630
15249583
27898058
16914728
25379019
23565163
15364919
15533996
19121779
9312143
17709744
20074531
22523661
23958494
16129690
23006971
23898460
26474286
28342808
17507185
25813876
26926384
15306821
20932932
34013180
15199052
18498745
18952604
18220336
12006582
19369195
29496905
27889207
26666849
|
PRKCA
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
10.0
|
1.0
|
Omnipath
|
22869320
15364919
16574739
17570479
15516986
15069075
|
INSR
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
64.0
|
1.0
|
Omnipath
|
17145710
10655627
7651388
25472611
1385403
18083107
12220227
23331499
28328746
7504175
19534553
7499194
7537849
7935368
11572799
11781100
10592173
17570479
17575262
18988627
12446583
15629149
10455177
15870194
11416002
12101187
17167487
8530377
8626379
8662806
11606564
2159922
8626723
16020478
16582879
|
IKBKB
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
30.0
|
1.0
|
Omnipath
|
10722755
19651622
24337154
18443205
23050932
15199052
20953398
25381390
16129690
29767231
11606564
18077418
14583092
15613682
16099428
12351658
|
IGF1R
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
44.0
|
1.0
|
Omnipath
|
7541045
12444011
19030972
10082579
16931767
21798082
12220227
11259577
12767520
10826997
23331499
17827393
7504175
21071413
7559507
11572799
27856640
12175651
17570479
15829723
18988627
15629149
11557037
20670944
8530377
21540285
8776723
25886138
8662806
|
RPS6KA1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
17709744
15364919
17081983
21798082
|
IGF1
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
11.0
|
1.0
|
Omnipath
|
26474286
28545881
26956053
25886138
15952059
18762365
22362362
19762915
11160134
22941977
|
INS
|
IRS1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
40.0
|
1.0
|
Omnipath
|
25309812
25472611
23891856
20150288
29069585
24036112
21518983
11160134
19357636
22198320
17579213
21677282
11684411
23983791
28955049
25760026
21850561
22832498
19808019
22698915
23815272
18443205
20601126
16150913
25383313
27695421
23115649
22728334
19752148
19171749
27819676
16516141
22418434
19542202
25381390
22516431
24763529
26866272
23695665
23431498
|
IRS1
|
PIK3CD
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
16931767
12175651
|
IRS1
|
PIK3R2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
11120660
7559478
10358772
16931767
12730242
12175651
7499365
15316008
|
IRS1
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
13.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
9415396
16931767
12175651
10417350
7542745
25814554
|
IRS1
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
23.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
16354680
16150444
16931767
10592173
12175651
1380456
23643389
1381348
11313948
9374521
20966354
9624169
|
IRS1
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
12767520
10826997
12444011
21540285
19030972
16931767
14623899
11416002
12175651
|
IGF1
|
IGF1R
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
4.0
|
1.0
|
ACSN
|
11237532
12181198
17145802
19631971
|
INS
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
23331499
1851182
18988627
|
IGF1
|
IGF1R
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
30.0
|
1.0
|
Omnipath
|
21798082
23331499
8452530
21071413
12067807
1852007
21645859
8408032
14604834
19258508
11287679
23675206
19029956
2877871
|
IGF1R
|
GRB10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
19165858
8776723
8764099
8621530
12697834
9506989
|
IGF1R
|
PIK3R3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
17496910
25241761
9415396
9524259
|
AKT1
|
SLC38A9
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17517883
17277771
18372248
12524439
17386266
|
AKT1
|
RRAGA
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17517883
17277771
18372248
12524439
17386266
|
AKT1
|
RRAGB
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17517883
17277771
18372248
12524439
17386266
|
AKT1
|
RRAGC
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17517883
17277771
18372248
12524439
17386266
|
AKT1
|
RRAGD
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
5.0
|
1.0
|
Reactome
|
17517883
17277771
18372248
12524439
17386266
|
GRB10
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
11809791
15722337
|
INS
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
29432553
23912456
11679435
23866690
17335965
24646332
23798298
|
PIK3CA
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
25793261
19117013
21041639
24950409
21816939
|
PRR5
|
AKT1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
36.0
|
1.0
|
Omnipath
|
18000759
20027184
21157483
11756412
11923280
24670654
16697215
21592956
20398329
17461779
18372248
20338997
15808505
20138985
20214616
21474067
15718470
19568798
15169778
18566586
19720745
18925875
10949026
11715018
19143635
18636226
9812896
17680028
19151919
10722653
20832730
18570873
17052453
12408816
11274345
|
AKT1
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
27.0
|
1.0
|
Omnipath
|
19651622
20058876
14688280
11510412
25241761
20230923
20068231
18452278
11410590
17570479
10869359
18669648
|
AKT1
|
PRKAA1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
19376078
16340011
16083285
26506913
27784766
24467442
|
AKT1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
99.0
|
1.0
|
Omnipath
|
17428466
15207235
17145710
12052830
10729337
8250835
11756412
11923280
16914735
17623045
16697215
8524413
12054501
20398329
18372248
21506126
20028971
12040186
15808505
16543730
20138985
23331499
21303971
16009706
10385618
20214616
23180781
9373175
16039586
15829723
18988627
16282323
11577096
11035810
18669648
18216173
15169778
12851486
16123141
11882383
23109003
9065430
18691976
22094462
10949026
22710759
11715018
12459251
18636226
17192257
11254732
11278246
20858269
9812896
9582355
15023346
17680028
19369195
7945242
12900420
23552696
18387957
10722653
20832730
18570873
12147701
18505846
17052453
17693255
18218901
|
AKT1
|
AKT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
11546794
14500673
12176337
11445557
9736715
12149249
11278835
|
AKT1
|
EIF4EBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
32.0
|
1.0
|
Omnipath
|
17081983
11691836
18767875
12665511
19413330
10405182
19664995
10942774
9092573
20068231
9465032
11777913
18669648
8083223
12105188
17287340
9405468
12370290
19651622
10779345
10364159
12912989
|
AKT1
|
IKBKB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
15184909
25241761
22689577
15856005
10485711
17660512
|
AKT1
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
11943559
23331499
25241761
21071413
12183455
15149849
11438723
|
AKT1
|
AKT1S1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
63.0
|
1.0
|
Omnipath
|
18000759
17081983
17510057
12820960
21157483
11756412
11923280
16697215
19690332
19446321
20398329
17461779
18372248
19413330
15808505
20138985
23415227
20214616
12524439
20068231
14973226
19568798
18669648
17329361
15169778
12869586
17386266
19720745
17517883
11352916
10949026
11715018
19143635
17277771
18636226
19651622
9812896
17680028
19151919
10722653
20832730
18570873
17052453
12408816
11274345
|
PRKCA
|
INSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
26.0
|
1.0
|
Omnipath
|
15212693
2110001
12472845
17570479
8454604
1956339
10819237
7926007
92065884
8463287
|
PRKCA
|
CLIP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
4.0
|
1.0
|
Omnipath
|
20519438
17570479
|
PRKCA
|
KRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
20802526
34333552
23331499
25713064
27791178
18458061
9922370
18182391
16483930
|
INS
|
INSR
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
37.0
|
1.0
|
Omnipath
|
8393875
21743783
21317886
24296476
26374090
29069585
26245346
16956584
19902173
20332342
23363978
23331499
18988627
23302862
22832498
2550426
15870194
11278498
19752148
29512653
23304064
24633815
17227660
22521887
23223021
30197476
|
INSR
|
GRB10
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
9506989
15664450
10871840
8621530
9006901
19648926
7479769
12783867
12493740
|
INS
|
AKT2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
20338882
25304263
30179516
23832510
23801578
22307032
20041157
24725432
|
RPS6KB2
|
RPS6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
21233202
17081983
92042229
16083285
20146692
12713446
15471950
20647036
20832730
16810323
86287375
20932932
1985906
15358595
|
RPS6KB1
|
RPS6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
56.0
|
1.0
|
Omnipath
|
17053147
17081983
33676898
19339977
92042229
20484036
16286006
20647036
11438723
17360704
1737763
17121928
11108711
20227368
22408430
27312851
12668683
16083285
15051500
20146692
15471950
18423201
17570479
20039704
21460850
21602892
1985906
30034573
21233202
24662264
29892299
19720745
12586835
12713446
20464435
26824026
15809305
16810323
86287375
24396066
24578720
20616057
24205356
19203585
15905173
14993219
17726024
20832730
22530122
17052453
7705100
15358595
|
RPS6KA1
|
RPS6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
17.0
|
1.0
|
Omnipath
|
21233202
29892299
17081983
19369195
16083285
21418524
17360704
17664694
17287340
18187866
18669648
18974095
|
PIK3R3
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
9.0
|
1.0
|
Omnipath
|
8596638
22402981
9415396
11733063
26496610
25814554
|
NRAS
|
PIK3CA
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
8052307
7820549
9150145
8665852
21779497
|
PIK3CA
|
RPS6KB1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
20.0
|
1.0
|
Omnipath
|
15854902
19225151
20097763
21123297
30021155
24990947
20068231
19079619
15809305
20599721
14623952
11279232
34518212
33800846
18669648
|
KRAS
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
NRAS
|
MAP2K1
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
MAP2K1
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
MAP2K1
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
LAMTOR3
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
11266467
15547943
9733512
|
BRAF
|
MAP2K1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
67.0
|
1.0
|
Omnipath
|
20212043
7706312
25437913
9560161
7936666
14970219
18567582
18332145
8413257
23331499
15342917
21071413
7731720
7873542
26496610
10976102
18988627
17667937
16255777
8131746
16888650
15485920
8394352
15175348
15466476
19541618
25600339
25155755
17563371
16810323
8157000
17979178
18039929
94178255
23934108
7835430
7624324
24746704
16135787
7935374
8039496
8621729
|
MAP2K1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
14.0
|
1.0
|
Omnipath
|
17081983
21105670
16964243
14617795
30711629
18547980
8382613
17188038
17192257
15020233
|
KRAS
|
BRAF
|
â—¼ PHYSICAL_INTERACTION
|
|
|
14.0
|
1.0
|
Reactome
|
24937142
16294014
12932339
7744815
9020159
15035987
16364920
11325826
16041367
24347342
12932319
10205168
21441910
23993095
|
BRAF
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
BRAF
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
KRAS
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
1386920
23331499
19541618
8601312
14970219
18567582
16135787
12932319
17563371
12917261
19933846
21779497
17635919
19223544
15710605
8073291
|
NRAS
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
1386920
21478863
9368069
19541618
8601312
14970219
18567582
16135787
7935411
12932319
12917261
17563371
19933846
21779497
8073291
15710605
|
AKT3
|
BRAF
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
7.0
|
1.0
|
Omnipath
|
10869359
18451171
11293329
19493313
|
BRAF
|
MAP2K2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
19.0
|
1.0
|
Omnipath
|
23331499
15342917
18039929
19541618
7706312
15466476
25600339
7731720
16135787
17563371
33226073
8668348
17667937
16255777
|
MAP2K2
|
LAMTOR2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
RRAGA
|
RRAGC
|
â—¼ PHYSICAL_INTERACTION
|
|
|
999.0
|
1.0
|
STRING
|
36370105
|
MAP2K2
|
LAMTOR3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
21779496
9733512
12479806
15118098
17178906
15547943
|
GSK3B
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
GSK3B
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
GSK3B
|
WNT3A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
GSK3B
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
GSK3B
|
FZD2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
11336703
17529994
18077588
17569865
|
RPS6KA1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
16.0
|
1.0
|
Omnipath
|
11584304
11583116
23331499
8250835
7980435
8524413
24931005
19346560
12054501
16039586
12147701
11035810
22615844
16543730
|
RPS6KB1
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
13.0
|
1.0
|
Omnipath
|
17053147
21233202
8250835
15905173
19339977
19720745
16286006
12713446
20647036
20832730
18423201
11108711
17052453
|
AKT3
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
17.0
|
1.0
|
Omnipath
|
12851486
15023346
21303971
11882383
17680028
9065430
23109003
20214616
22094462
23552696
20398329
21506126
20028971
12040186
18218901
|
AKT2
|
GSK3B
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
20.0
|
1.0
|
Omnipath
|
17145710
21303971
11882383
17680028
9065430
20214616
22094462
23552696
12434148
20398329
21506126
26051358
16293724
20028971
12040186
9712142
18218901
|
GSK3B
|
EIF4EBP1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
8.0
|
1.0
|
Omnipath
|
23584478
17570479
27387559
18701453
|
KRAS
|
MAP2K2
|
â—¼ PHYSICAL_INTERACTION
|
|
|
6.0
|
1.0
|
Reactome
|
15035987
21779496
24957944
22510884
23352452
25907612
|
EIF4EBP1
|
EIF4E2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
28698298
17145710
17368478
15094042
|
AKT2
|
AKT1S1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
22.0
|
1.0
|
Omnipath
|
17329361
19651622
17081983
17386266
17517883
12524439
11352916
20068231
18372248
19413330
17277771
14973226
18669648
23682635
|
AKT3
|
AKT1S1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
-
|
5.0
|
1.0
|
Omnipath
|
17440074
17517883
18372248
17277771
|
PRKAA1
|
ULK1
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
24820971
23372762
28295473
21460634
19584320
21205641
21258367
28389629
34421918
34224814
25980607
32978258
|
NRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
KRAS
|
PIK3CB
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
PIK3R3
|
PIK3CB
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
8596638
22402981
11733063
25814554
|
NRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
KRAS
|
SOS1
|
â—¼ ENZYMATIC_REACTION
|
✅
|
|
11.0
|
1.0
|
Reactome
|
19946327
11429702
11157491
18757403
21666749
21711248
18381441
19103595
21160078
9857065
20179196
|
SOS1
|
NRAS
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
23331499
7923364
11560935
9690470
21779497
8493579
|
PIK3R2
|
KRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
PIK3R2
|
NRAS
|
â—¼ PHYSICAL_INTERACTION
|
|
|
12.0
|
1.0
|
Reactome
|
31135801
24897931
8665852
17998941
11136978
21779505
8052307
12121613
1716764
26085527
21779497
12094235
|
WNT2
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
23815780
|
WNT3
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
18528331
15454084
|
WNT3A
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
22653731
20093360
22303445
|
WNT5A
|
FZD8
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
20093360
21518267
|
FZD8
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
11448771
21078818
|
WNT3A
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
FZD2
|
DVL3
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL3
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
DVL3
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
4.0
|
1.0
|
Reactome
|
17234765
18077588
14636582
22411803
|
WNT4
|
FZD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
12325120
|
WNT4
|
FZD6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
15.0
|
1.0
|
Omnipath
|
10557084
15265686
21541287
|
WNT3A
|
FZD6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
11.0
|
1.0
|
Omnipath
|
21128903
21665003
|
WNT3A
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
17117926
22753465
24032637
|
WNT3A
|
FZD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
18215320
19910923
|
WNT7A
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
12857724
23331499
18567805
1285772412857720
|
WNT7A
|
FZD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15705594
|
WNT5A
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
16273260
21903638
15578921
17804197
24032637
|
WNT5A
|
FZD2
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
2808370
9389482
19008118
24032637
19910923
|
WNT5A
|
FZD6
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
7.0
|
1.0
|
Omnipath
|
16273260
21665003
|
WNT5A
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
12.0
|
1.0
|
Omnipath
|
23331499
11029007
9054360
|
WNT2
|
FZD5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
5.0
|
1.0
|
Omnipath
|
18302287
24032637
|
WNT2
|
FZD3
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
4.0
|
1.0
|
Omnipath
|
19038973
24032637
|
WNT2
|
FZD9
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
8.0
|
1.0
|
Omnipath
|
23331499
12138115
19038973
|
FZD2
|
WNT8A
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
FZD2
|
WNT8B
|
â—¼ PHYSICAL_INTERACTION
|
|
|
10.0
|
1.0
|
Reactome
|
11448771
11029007
15459103
12205098
22000856
22653731
11357136
15084453
23256519
23791946
|
WNT7B
|
LRP5
|
â—¼ POST_TRANSLATIONAL_REGULATION
|
✅
|
+
|
6.0
|
1.0
|
Omnipath
|
15578921
15923619
|