Protein list:

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Protein:

Eg: PBRM1 | ARID1A | BRCA1
Function:

Eg: Homologous recombination
Path:


Eg: SMC5 > DMC1 | PBRM1 > BRCA2
Relationship:

Full list of relationships
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Filter Table:
SourceTargetRelationship TypeDirectedSignDB ScorePKG ScoreDatabaseReferences
BLVRA ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15870194
EP300 CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 23403292 24998469
JUN FBXW7 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21460851 20638938
HSP90AA1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
HSP90AA1 AKT1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 12799359 11988487
HIF1A HSP90AA1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14726529 20068160
BAAT KAT5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
OTUB1 SOD1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 108050 32814053
SQSTM1 CUL3 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 15983046 22872865
SQSTM1 SOD1 â—¼   COLOCALIZATION 2.0 0.8 intact 8141566 21252941
CREB1 PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7721872 12658356
JUN HPGDS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 8617242 8206948
FN1 BCAR1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 16581250 8649368
TINF2 TERF1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 11701125 5214767
JUN MAPK10 â—¼   ENZYMATIC_REACTION ✅ 2.0 0.8 Reactome 18793328 10871633
HIF1A JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15794924 19828020
JUN AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12832543 11192249
JUN PRKN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20638938 21113145
JUN CYP3A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 14742674
JUN MAPK10 â—¼   PHOSPHORYLATION ✅ 2.0 0.8 intact 19527717 7148309
BLVRA JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15870194
PRKN JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20418918
HIF1A CREBBP â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 17382325 5219810
CREBBP ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 12573436
LRRK2 AHCYL1 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 29513927 201700444
HSP90AB1 HIF1A â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 18538669 6550889
HIF1A HDAC5 â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 19071119 6802010
HIF1A FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 16601206 15192019
CREB1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7499271
PTPRF AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 15896785
EZH2 BMI1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 21465172 19351856
CREB1 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 10909971 22554507
GSK3A CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 7798217 12162494
CREB1 HSD3B1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 21826657
CREB1 LDHC â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 18930904
HNF1A CFTR â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 19782160 17848139
ARNT CYP1A2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 15664428 15144902
AHCYL1 ITPR2 â—¼   PHYSICAL_INTERACTION 2.0 0.8 Reactome 11904675 16754674
HNF1A CYP27A1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 11406622 10528998
EPAS1 KCNJ11 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 2.0 0.8 Omnipath 22403787 24898587
TERF1 ACD â—¼   PHYSICAL_INTERACTION 2.0 0.8 intact 0605303103 16880378
PRKN VDAC1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 2.0 0.8 Omnipath 20098416
HIF1A HSP90AB1 â—¼   PHYSICAL_INTERACTION 801.0 0.8 STRING 36370105
HSP90AB1 LRRK2 â—¼   PHYSICAL_INTERACTION 807.0 0.8 STRING 36370105
CREBBP FGFR1 â—¼   PHYSICAL_INTERACTION 810.0 0.81 STRING 36370105
EP300 ATF2 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 10327051 24069158
CUL3 CUL5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 21145461 22709582
EPAS1 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 23275444 15261140 22807441 25689462
HDAC6 EP300 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 19344692 15102857 12718889 22778253 23133622
KAT5 BMI1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 27295567 16169070
LRRK2 PCNA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
LRRK2 LDHA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
LRRK2 VDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 21370995
LRRK2 CKAP5 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
LRRK2 HACD3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 31046837 24725412
INSR HACD3 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 30300385 25687571
VCAM1 LDHA â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
LDHA LDHC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
IKZF1 MKLN1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
DGUOK DNM1L â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 26186194
VCAM1 VDAC1 â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
VCAM1 LDHB â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 22623428 19738201
LDHB LDHC â—¼   PROTEIN_INTERACTION 0.82 0.82 HIPPIE 28514442 33961781
AKT1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 820.0 0.82 STRING 36370105
HDAC6 CFTR â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 31501480 22069321 14675537
IDS GALNS â—¼   PROTEIN_INTERACTION 0.83 0.83 HIPPIE 28514442 33961781 26186194
EP300 PCNA â—¼   PHYSICAL_INTERACTION 831.0 0.83 STRING 36370105
IGF1R INS â—¼   PHYSICAL_INTERACTION 835.0 0.83 STRING 36370105
HSP90AB1 HSPA8 â—¼   PHYSICAL_INTERACTION 841.0 0.84 STRING 36370105
CAND1 CUL5 â—¼   PHYSICAL_INTERACTION 847.0 0.84 STRING 36370105
HIF1A JUN â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 25879517 19738058 11739718
AKT1 ARNT â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 15833858 28628118 28205554
CFTR LDHA â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 26618866 31324722 29924966
CFTR HACD3 â—¼   PROTEIN_INTERACTION 0.85 0.85 HIPPIE 31324722 29924966 17110338
PARK2 UBE2E2 â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
IGF1R INSR â—¼   PHYSICAL_INTERACTION 854.0 0.85 STRING 36370105
MAX KAT2A â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 10611234 12660246
OTUB1 PCNA â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 26752685 18954305
CREB1 JUN â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 2138276 25609649
ELOC CUL3 â—¼   PROTEIN_INTERACTION 0.86 0.86 HIPPIE 21145461 21988832
ATP6AP1 ATP6V1C1 â—¼   PHYSICAL_INTERACTION 862.0 0.86 STRING 36370105
CAND1 CUL5 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 28514442 21249194 31253590 12504025 21145461 22405651
AKT1 EP300 â—¼   PROTEIN_INTERACTION 0.87 0.87 HIPPIE 21901101 15224190 21775285 20333651 18182168 11116148
GABARAPL1 SQSTM1 â—¼   PHYSICAL_INTERACTION 870.0 0.87 STRING 36370105
CFTR HSPA8 â—¼   PHYSICAL_INTERACTION 872.0 0.87 STRING 36370105
POT1 TERF1 â—¼   PHYSICAL_INTERACTION 873.0 0.87 STRING 36370105
HDAC6 SQSTM1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
ACD TERF1 â—¼   PHYSICAL_INTERACTION 874.0 0.87 STRING 36370105
CFTR ELOC â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 26618866 31324722 29924966 17110338
IKZF1 IKZF3 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 9155026 26823144 33961781 10204490
ACD TERF1 â—¼   PROTEIN_INTERACTION 0.88 0.88 HIPPIE 28514442 15383534 15231715 16880378 26496610 33961781 26186194
FBXW7 JUN â—¼   PHYSICAL_INTERACTION 884.0 0.88 STRING 36370105
INS IGF1R â—¼   PHYSICAL_INTERACTION ✅ + 0.88 0.88 Signor 1851182
AKT1 EP300 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
HDAC6 HSP90AA1 â—¼   PHYSICAL_INTERACTION 885.0 0.88 STRING 36370105
CREBBP JUN â—¼   PHYSICAL_INTERACTION 887.0 0.88 STRING 36370105
DNM1L LRRK2 â—¼   PHYSICAL_INTERACTION 888.0 0.88 STRING 36370105
CREB1 EP300 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
HSP90AA1 HSP90AB1 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
HSPA8 LRRK2 â—¼   PHYSICAL_INTERACTION 889.0 0.89 STRING 36370105
INS INSR â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 2550426 11278498 29512653 23302862
LDHB LDHA â—¼   PROTEIN_INTERACTION 0.89 0.89 HIPPIE 28514442 32296183 25416956 21988832 25910212 22863883 33961781 21516116 22939629
EPAS1 ARNT â—¼   PHYSICAL_INTERACTION ✅ 0.89 0.89 mint 24981860
LDHA LDHB â—¼   PHYSICAL_INTERACTION 890.0 0.89 STRING 36370105
CFTR VCP â—¼   PHYSICAL_INTERACTION 891.0 0.89 STRING 36370105
POT1 TINF2 â—¼   PHYSICAL_INTERACTION 897.0 0.89 STRING 36370105
JUN ATF2 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 8027667 20102225 28514442 16511568 23661758 15546613 26496610 2320002 20195357 10327051 1827203 9445037 20511396 10207054 25609649 33961781
COPS5 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11707426 18926707
CUL5 ELOC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 24438103 21199876 15574593 21145461 30166453 24076655 23806657 31253590 11384984 16530799 20463065 14564014 17351129 22479405 24402281 24390335 23098073 32513959 33961781 24390320
EP300 KAT2A â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 23667505 23555303 21559432
EP300 PCNA â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 11268218 16713569 18263614 12937166 24939902 14988403 33742100
EP300 JUN â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 27956703 21268080 21937452 24069158 11689449 14630807 11980644 10327051 12437352 12471036 24636898
EP300 HNF1A â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 35140242 15598887 11978637
EP300 ARNT â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 12573436 10999956
EP300 HDAC6 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 3.0 0.9 Omnipath 15102857 19344692
FN1 ITGA4 â—¼   ENZYMATIC_REACTION ✅ 3.0 0.9 ACSN 20644254 22067905 24202395
TINF2 ACD â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 28514442 32296183 16189514 21044950 25416956 16713569 15383534 15181449 15231715 25910212 16880378 26496610 33961781
JUN VCAM1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 9468519 16271621
CUL3 CAND1 â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21249194 16449638 22013077 12609982 21145461 22405651 26286618
FGFR1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 25241761 15929978
CREBBP HNF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 10777539
LRRK2 DNM1L â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 22228096 22639965 24282027 29541021 23813973
HIF1A ELOC â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 21658608 17558023 12050673 17244529 12004076 19940151 18323857 17353276 17965024
HIF1A TUBB3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 18178340 21176881
HIF1A HK2 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 19828020 19689405
HIF1A HK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 11557773 14672622 16782875
EPAS1 FLT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 15192019 18625704 19616846
HSPA8 CFTR â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 25961502 2799391 2204156
HSPA8 HDAC6 â—¼   PHYSICAL_INTERACTION 3.0 0.9 Reactome 25961502 2799391 2204156
IKZF1 IKZF3 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 3.0 0.9 Omnipath 17383641
EPAS1 ARNT â—¼   PROTEIN_INTERACTION 0.9 0.9 HIPPIE 23434853 15192019 16181639 9079689 19845609 23275444 33591636 26160453 19129502 32461361 14668441 24981860 11018023 23796364
AKT1 GSK3A â—¼   PHYSICAL_INTERACTION 900.0 0.9 STRING 36370105
EP300 JUN â—¼   PHYSICAL_INTERACTION 911.0 0.91 STRING 36370105
ACD TINF2 â—¼   PHYSICAL_INTERACTION 914.0 0.91 STRING 36370105
CAND1 CUL3 â—¼   PHYSICAL_INTERACTION 917.0 0.91 STRING 36370105
COPS5 CUL3 â—¼   PHYSICAL_INTERACTION 918.0 0.91 STRING 36370105
HIF1A HSP90AA1 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
HSP90AA1 LRRK2 â—¼   PHYSICAL_INTERACTION 919.0 0.92 STRING 36370105
ATP6AP1 ATP6V1F â—¼   PHYSICAL_INTERACTION 922.0 0.92 STRING 36370105
HSP90AA1 HSPA8 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
TERF1 TINF2 â—¼   PHYSICAL_INTERACTION 937.0 0.93 STRING 36370105
FBXW7 JUN â—¼   PROTEIN_INTERACTION 0.94 0.94 HIPPIE 14739463 31843895 30044990 29225075 16023596 28036276 33086033 29346117
ATP6V1C1 ATP6V1F â—¼   PHYSICAL_INTERACTION 941.0 0.94 STRING 36370105
AKT1 HSP90AA1 â—¼   PHYSICAL_INTERACTION 946.0 0.94 STRING 36370105
HIF1A EP300 â—¼   PHYSICAL_INTERACTION ✅ 0.96 0.96 mint 17382325 5219810
CREB1 EP300 â—¼   PROTEIN_INTERACTION 0.96 0.96 HIPPIE 12665587 21268077 10506141 21212407 11313407 7870179 17476304 22787115 26944191 33846793
JUN MAPK10 â—¼   PHYSICAL_INTERACTION 962.0 0.96 STRING 36370105
HIF1A EP300 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 15280364 19589782 16543236 11823643 22807441 19666581 16189267 18047470 15342390 12042299 19680224 22735262 23448368 26135796 23618863 14691445 19696166 11959990 27320910 16847340 24821806 22789427 17906695 8917528 20620956 20000859 15261140 16081065 12778114 22219185 15154850 25192544 22075993 19071119 22908229 19940151 21187066 24421387 23880760 11940656 23966271 26826385 26944191 12588875 23746844 11063749 27808477 19074848 20603618 15155277 18268343 20829524 21148070 12914934 17502379 22684029 17382325 26751287
TINF2 TERF1 â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 17589526 15316005 21044950 15133513 25416956 19487455 15383534 15181449 16880378 10581025 26496610 20811636 28216227 33961781 26186194 16169070 11701125
HIF1A ARNT â—¼   PROTEIN_INTERACTION 0.97 0.97 HIPPIE 28514442 17916562 9159130 24434214 20049704 9704006 11606485 27684187 19168635 11829741 23458834 19845609 16861921 9079689 19251694 11593383 27320910 15850782 15833858 20562859 14764593 12391259 26496610 17197389 8663540 15479785 26160453 14668441 24056783 11025203 28205554 23796364 23363003 20458141 23086815 17213817 21620138 15615775 7836384 15319539 12393189 11782478 15347669 20932347 21512126 10085255 21435239 26350169 15031145 20603618 28628118 20699359 10671489 33961781 34592152 16520375 12810720 16954218 18024476
INS INSR â—¼   PHYSICAL_INTERACTION 972.0 0.97 STRING 36370105
ATF2 JUN â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CREB1 CREBBP â—¼   PHYSICAL_INTERACTION 984.0 0.98 STRING 36370105
CREBBP HIF1A â—¼   PHYSICAL_INTERACTION 994.0 0.99 STRING 36370105
IDH3A IDH3G â—¼   PHYSICAL_INTERACTION 996.0 0.99 STRING 36370105
ACD POT1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
ARNT EPAS1 â—¼   PHYSICAL_INTERACTION 997.0 0.99 STRING 36370105
EP300 HIF1A â—¼   PHYSICAL_INTERACTION 998.0 0.99 STRING 36370105
ATF2 INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 10909971 17337306 21278380
ATF2 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 16.0 1.0 Omnipath 10366004 10327051 8530413 12052888 15068801 12751796 9502786 9141200 9252389 11238729 12903123 19255142 11736649 16511568 9819389
ATF2 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 21479385 8335091 10471826 8703044 9151819
MAPK13 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 15187187 19436832 9207191 10581204 15140942 20506250 21614932 19135240 16393692 12244047 11274345
MAPK10 ATF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 19436832 20506250 16393692 8654373 20028971 11274345
ATF2 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 31.0 1.0 Omnipath 25609649 20102225 15546613 2320002 10327051 1827203 9445037 26496610 20195357 16511568 20511396 10207054 8027667 23661758 31515488 18641343 1828107
COPS5 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 25609649 20093369 18926707 10766246 16713569 8837781
PCNA EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 7.0 1.0 Omnipath 18263614 11268218 16713569
AKT1 EP300 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 21.0 1.0 Omnipath 17623675 18182168 16926151 20333651 19158375 17964260 17570479 11116148 25904863 21901101 23275565 16024795
EP300 HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 75.0 1.0 Omnipath 24821806 12573436 17145710 16847340 12588875 19589782 11940656 25192544 11959990 18519678 23448368 22219185 11823643 12042299 15342390 23746844 19071119 19680224 27808477 15154850 19696166 8917528 17906695 18268343 22735262 21148070 15261140 19940151 23880760 22807441 35430356 14691445 12914934 20000859 12778114 26751287 16081065 22789427 16543236 24421387 17382325 17502379 22684029 21187066 19074848 23618863 23966271 20603618
FBXW7 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 6.0 1.0 Omnipath 14739463 28036276 18930588 16023596
HDAC6 HSP90AA1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 19158084 18591380 18266962
HSP90AA1 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 19356729 18266962 10995457 25714412 16189514 12176997 12586360 15843522
SQSTM1 CUL3 â—¼   ENZYMATIC_REACTION ✅ 10.0 1.0 ACSN 14744430 15340068 16252010 18545270 19427028 20531300 21981924 25002027 26587781 28574505
GABARAPL1 SQSTM1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 17580304 20562859 23022382 21691068 25416956 31053714 16189514 32296183 21617041 19250911
VCP CUL3 â—¼   PHYSICAL_INTERACTION 6.0 1.0 Reactome 33444648 11733065 28115426 15652483 10811609 29153394
AKT1 VCP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 16551632 19335618 16027165
JUN PCNA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 22550165 19940138 1352831 15205327 23078099
IDH3A IDH3G â—¼   PROTEIN_INTERACTION 1.0 1.0 HIPPIE 28514442 10677231 14681455 28098230 33961781 26186194 14555658 26344197
VCAM1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 22623428 19738201 11751331
FN1 ITGA4 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 9117345 9842903 19738201 11010812
PTPRF BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 15588985 10320483 10822386
FGFR1 BCAR1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 11019781 12601080
TINF2 POT1 â—¼   PHYSICAL_INTERACTION 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
TINF2 POT1 â—¼   SHARES_COMPLEX 14.0 1.0 ACSN 10581025 10850490 11349150 15231715 16166375 18680434 18828880 19454690 19965504 22064479 22634377 7502076 9326951 9822378
ACD TINF2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 25910212 16880378 15181449 25416956 21044950 15383534 31515488 26496610 16713569 15231715
MAPK13 MAX â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 12738796 18039929 11274345 15187187
CREB1 JUN â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 5.0 1.0 Omnipath 10471787 8647095 10403485 2140898
JUN GCLC â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 10.0 1.0 Omnipath 10751553 11007940 11233143 11912197 9610371 9613591 10350652 16054171 10218647
JUN FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 24342046 21479385 11052809 9756884 23744703 10325245 11896591 10421838
JUN INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 8.0 1.0 Omnipath 1310538 9062890 9270011 7862133 20424231 22563476 14578290 8264634
JUN EGF â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 15075211 15772294 19937979 15375216 10617690 18625220 15238218 7629150 8885243 12954631 10973489 16214953 14518567
GSK3A JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 14.0 1.0 Omnipath 1846781 24214991 91332050 1516134 1956339 16023596 92065884 1651323
CREBBP JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 12.0 1.0 Omnipath 8028671 10327051 2138276 9659924 9786917 16713569 17296604 8545107 18443043 16055710
MAPK10 JUN â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 30.0 1.0 Omnipath 17143273 20506250 16824735 8654373 20028971 16007099 21988832 12167088 16393692 1922387 16076903 22327296 19527717 21757544 19436832 17670986 14523011 11274345 20395206 11562357
JUN CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 2138276 1827203 18641343 8290251
ARNT CREBBP â—¼   PHYSICAL_INTERACTION 8.0 1.0 Reactome 11959990 11063749 7836384 11959977 9632793 17804822 9822602 10202154
HIF1A CREBBP â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 12542982 20547241 17452336 15907483 19489936 15342390 15184875
CREB1 CREBBP â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 47.0 1.0 Omnipath 10866654 18599546 15585582 7870178 8028671 11313407 16007092 8413673 11564156 15691881 9829964 15073328 20403362 11259575 17476304 17707401 20541704 16799563 7870179 11123304 27789289 7913207 12933667 8663317 8004670 11483993 12198160 9413984
LRRK2 AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 6.0 1.0 Omnipath 24916379 21658387
ARNT HIF1A â—¼   PHYSICAL_INTERACTION 999.0 1.0 STRING 36370105
ELOC HIF1A â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059
HIF1A HK2 â—¼   ENZYMATIC_REACTION ✅ 66.0 1.0 ACSN 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622
HIF1A LDHA â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 9.0 1.0 Omnipath 15794924 19828020 8089148 9632793 9746763 8955077 9748288 16319523
HIF1A EPAS1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 20513003 18174278 16924414 19030186
HIF1A INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14612449 11457733 18752464 17878221
HIF1A AKT1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 5.0 1.0 Omnipath 19144925 17220299 17488804 14726529 15277220
ARNT HIF1A â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 36.0 1.0 Omnipath 17213817 8816435 17197389 14764593 12393189 12810720 15319539 23363003 9079689 11829741 15479785 26496610 12391259 17916562 24434214 11606485 20562859 9704006 21620138 11782478 20932347 15347669 8927054 21435239 19168635 9159130 14668441 20049704 20603618
HIF1A FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 11528470 9278421 16887934 9295307
ARNT FLT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 15.0 1.0 Omnipath 7539918 1823643 12829734 9159130 13130303 9746763 12080085 11566883 10403805 8943284 15451019 11528470 9278421 16887934 9295307
EZH2 FGFR1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ - 17.0 1.0 Omnipath 22179855 22312437 21512140 23933322 24737471 23932971 23918806 19053175 19502792 24928441 23424038 24032713 24474760 20634887 18704159 24652950 22072987
FGFR1 LDHA â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 8.0 1.0 Omnipath 28516914 34452627 21969607 28218905 33572095
INS IGF1R â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 11.0 1.0 Omnipath 23331499 1851182 18988627
INS AKT1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 7.0 1.0 Omnipath 29432553 23912456 11679435 23866690 17335965 24646332 23798298
AKT1 BMI1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 22505453 23092893
AKT1 EZH2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 12.0 1.0 Omnipath 22391560 24526064 29864144 34230470 16224021 26517694
AKT1 HK2 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 29985480 31435020
AKT1 CREB1 â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 35.0 1.0 Omnipath 11175347 11756412 12356771 15733869 20452955 20398329 11160957 10217147 19216069 20214616 11463845 9829964 7958915 12235136 16680151 17646672 9687510 8887554 11698596 8688081 17680028 9528766 11018520 11969286 12519783 11909979 15725726
AKT1 GSK3A â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 110.0 1.0 Omnipath 15772344 19797085 23549785 20371716 11884598 25584893 11583116 11520785 14550568 19920184 15710331 21530327 9065430 16188907 24632852 12515807 11289110 24879152 20110348 12890758 15333638 14633703 11803463 16123357 8524413 21868755 12054501 23142783 25714023 16585200 15808505 22497526 16767165 19117997 14744935 19443725 21118801 18691976 18209096 11563975 17192257 11085518 19369195 19043530 11896604 10716737 19914182 19996208 21441927 32645325 15805282 21464307 34381779 16223362 12181443 15755769 11331582 11035810 21445305 27331409 16987514 11340086 15723049 22499768 18701488 11749387 20686112 11509608 19413330 20233866 15950778 20708687 14660586 17386267 11577096 15371448 11956225 12649200 16476742 11254732 21575859 14988390 11779850 19574224 20739666 17200115
MLXIP HK2 â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11557773 11744734 14672622 15199147 16782875 17143338 18458340 8955077 9192621
MLXIP LDHA â—¼   ENZYMATIC_REACTION ✅ 9.0 1.0 ACSN 11557773 11744734 14672622 15199147 16782875 17143338 18458340 8955077 9192621
CREB1 FN1 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 13.0 1.0 Omnipath 2170405 22357921 8648265 15908479 1845987 8803927 2542772 15608673 1404598 1320003 12372774
HSPA8 CFTR â—¼   POST_TRANSLATIONAL_REGULATION ✅ - 4.0 1.0 Omnipath 21148293 10666020 19878303 21697503
PTPRF INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 20.0 1.0 Omnipath 23331499 7852302 10734133 15588985 11158333 10592173 1321126 8732688 19910497 8995282 1303753
INS INSR â—¼   POST_TRANSLATIONAL_REGULATION ✅ + 37.0 1.0 Omnipath 8393875 21743783 21317886 24296476 26374090 29069585 26245346 16956584 19902173 20332342 23363978 23331499 18988627 23302862 22832498 2550426 15870194 11278498 19752148 29512653 23304064 24633815 17227660 22521887 23223021 30197476
HNF1A INS â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 14.0 1.0 Omnipath 12712243 1142872 15933209 10491332 17210751 9822613 11994285 14521933 18949455 11428722 1380153 10331424 17116178
HNF1A CYP3A4 â—¼   TRANSCRIPTIONAL_REGULATION ✅ + 4.0 1.0 Omnipath 14742674
ELOC EPAS1 â—¼   PHYSICAL_INTERACTION 12.0 1.0 Reactome 11292861 9122164 10878807 12821933 12101228 11292862 10823831 11504942 11454738 10944113 11358837 11024059